Q99186
Gene name |
APM4 (AMP1, YOL062C, O1210) |
Protein name |
AP-2 complex subunit mu |
Names |
Adaptin medium chain APM4, Clathrin assembly protein complex 2 mu medium chain, Clathrin coat assembly protein AP50, Clathrin coat-associated protein AP50, Mu2-adaptin, Plasma membrane adaptor AP-2 50 kDa protein |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOL062C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99186
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99186-F1 | Predicted | AlphaFoldDB |
13 variants for Q99186
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-211986 | 4 | G>S | No | SGRP | |
| s15-211773 | 75 | A>T | No | SGRP | |
| s15-211732 | 88 | D>E | No | SGRP | |
| s15-211613 | 128 | L>S | No | SGRP | |
| s15-211509 | 163 | T>A | No | SGRP | |
| s15-211500 | 166 | A>T | No | SGRP | |
| s15-211421 | 192 | F>S | No | SGRP | |
| s15-211227 | 257 | D>N | No | SGRP | |
| s15-211164 | 278 | G>R | No | SGRP | |
| s15-211160 | 279 | S>N | No | SGRP | |
| s15-210999 | 333 | V>I | No | SGRP | |
| s15-210795 | 401 | P>A | No | SGRP | |
| s15-210630 | 456 | S>T | No | SGRP |
No associated diseases with Q99186
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| AP-2 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| clathrin adaptor activity | Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| clathrin-dependent endocytosis | An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q00776 | APM1 | AP-1 complex subunit mu-1-I | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P38700 | APM2 | Adaptin medium chain homolog APM2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q96CW1 | AP2M1 | AP-2 complex subunit mu | Homo sapiens (Human) | PR |
| Q8CDJ8 | Ston1 | Stonin-1 | Mus musculus (Mouse) | PR |
| P84091 | Ap2m1 | AP-2 complex subunit mu | Mus musculus (Mouse) | PR |
| P35603 | dpy-23 | AP-2 complex subunit mu | Caenorhabditis elegans | PR |
| O23140 | AP2M | AP-2 complex subunit mu | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MISGVLVYSS | RGELVLNKFF | KNSLKRSISD | IFRVQVINNL | DVRSPVLTLG | STTFHHIRSR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HGDNLWLVTI | TRSNANSAAI | WEFLYKLDAV | MNAYRLDREE | ALKEEFMIVH | EMLDIMLGGN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GIPIDTELNS | VIAQMSVKPV | RNMGGLLDSP | DGNDVLSSSS | SPTSSAGELH | FPKFLTKRSS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SFLGQGDSTS | DFYDNNKITW | RPKGIIHKKD | EVFLYVNERI | NILVSRDGSI | LKSYVDGTID |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ITTHLSGTPI | CRFGLNDSLG | MQSEDEKKWL | AQQQRHSGSD | FGNKNFIPKA | AAGSVLLEDC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KFHECVSLDK | FNRNHIIEFV | PPDGSMELMK | YHVRDNINLP | FKVTPIVTHS | TRDNEIDYRI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLKSLFPGKL | SAKDVVLHIP | VPPSTVDCKI | SVSNGHCKFV | PEENAMIWRF | NKYNGLTENT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSAVTVSTSD | TTQLNLQQWT | RPPISLEFEV | MMFSNSGLVV | RYFTISGKDS | KHRAVKWIKY |
| 490 | |||||
| ISKAGSYEVR | Y |