Q9Z1Q9

PR
Gene name
Vars1 (Bat6, G7a, Vars, Vars2)
Protein name
Valine--tRNA ligase
Names
Protein G7a, Valyl-tRNA synthetase, ValRS
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:22321
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

189-311 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9Z1Q9

Entry ID Method Resolution Chain Position Source
AF-Q9Z1Q9-F1 Predicted AlphaFoldDB

64 variants for Q9Z1Q9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3407561454 37 H>P No EVA
rs3407274835 121 L>H No EVA
rs3407960779 128 P>PQV*SEFLPFSSLSPGDPD No EVA
rs3389460286 140 N>I No EVA
rs3389457876 165 V>M No EVA
rs3389437342 178 P>S No EVA
rs3389460247 184 W>* No EVA
rs3389426796 198 P>T No EVA
rs3389426817 199 E>K No EVA
rs3389452558 211 S>L No EVA
rs3406621593 228 Q>* No EVA
rs3389457819 230 T>I No EVA
rs3389460276 279 Y>F No EVA
rs3407561507 322 Y>H No EVA
rs3389448996 331 N>D No EVA
rs3389460262 333 R>Q No EVA
rs3389469418 342 P>S No EVA
rs3389426781 345 V>A No EVA
rs3389451383 403 R>W No EVA
rs3389465639 407 G>D No EVA
rs3389406839 426 I>S No EVA
rs3389460295 464 E>D No EVA
rs3389460307 478 C>R No EVA
rs3389473969 479 T>P No EVA
rs3389406874 481 N>T No EVA
rs3389459247 483 A>T No EVA
rs3389437420 485 S>T No EVA
rs3389426838 486 D>H No EVA
rs3389371019 499 L>P No EVA
rs3389448968 531 V>M No EVA
rs3389469369 597 Q>P No EVA
rs3389456508 598 N>Y No EVA
rs3389459250 611 I>N No EVA
rs3389426795 633 F>Y No EVA
rs3389406883 637 K>E No EVA
rs3389448934 659 V>M No EVA
rs3389456482 718 W>* No EVA
rs3389469377 738 H>L No EVA
rs3389469367 758 T>I No EVA
rs3389465636 768 R>W No EVA
rs3389416910 776 K>R No EVA
rs3389456484 798 S>T No EVA
rs3389452545 799 I>V No EVA
rs3389406837 802 W>* No EVA
rs3389456488 805 Q>* No EVA
rs3389426827 832 M>T No EVA
rs3389451440 840 T>I No EVA
rs3389469417 875 V>I No EVA
rs3389460311 882 Q>H No EVA
rs3407693606 885 Y>H No EVA
rs3389451357 903 E>D No EVA
rs3389457799 929 T>R No EVA
rs3389460248 969 P>S No EVA
rs3389452552 983 D>N No EVA
rs3389451400 998 N>K No EVA
rs3389469337 1008 A>V No EVA
rs3389456433 1016 F>L No EVA
rs3389460257 1034 N>S No EVA
rs3389469373 1037 D>N No EVA
rs3389451353 1092 E>K No EVA
rs3389465650 1129 T>I No EVA
rs3389465607 1143 G>D No EVA
rs3389426835 1154 Q>H No EVA
rs3389406880 1178 A>S No EVA

No associated diseases with Q9Z1Q9

6 regional properties for Q9Z1Q9

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 343 - 354 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 308 - 938 IPR002300
domain Glutathione S-transferase, C-terminal 126 - 198 IPR004046
domain Glutathione S-transferase, C-terminal-like 89 - 219 IPR010987
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 983 - 1130 IPR013155
domain Valyl tRNA synthetase, anticodon-binding domain 937 - 1074 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2NL00 GSTT1 Glutathione S-transferase theta-1 Bos taurus (Bovine) PR
Q3SZV3 EEF1G Elongation factor 1-gamma Bos taurus (Bovine) PR
P07118 valS Valine--tRNA ligase Escherichia coli (strain K12) PR
Q5ST30 VARS2 Valine--tRNA ligase, mitochondrial Homo sapiens (Human) PR
P0CG30 GSTT2B Glutathione S-transferase theta-2B Homo sapiens (Human) PR
P26641 EEF1G Elongation factor 1-gamma Homo sapiens (Human) PR
P26640 VARS1 Valine--tRNA ligase Homo sapiens (Human) PR
Q9D8N0 Eef1g Elongation factor 1-gamma Mus musculus (Mouse) PR
Q29387 EEF1G Elongation factor 1-gamma Sus scrofa (Pig) PR
Q68FR6 Eef1g Elongation factor 1-gamma Rattus norvegicus (Rat) PR
P30713 Gstt2 Glutathione S-transferase theta-2 Rattus norvegicus (Rat) PR
Q04462 Vars1 Valine--tRNA ligase Rattus norvegicus (Rat) PR
Q5TM74 VARS2 Valine--tRNA ligase, mitochondrial Macaca mulatta (Rhesus macaque) PR
Q6YW46 Os02g0220500 Elongation factor 1-gamma 2 Oryza sativa subsp japonica (Rice) PR
Q9ZRI7 Os02g0220600 Elongation factor 1-gamma 1 Oryza sativa subsp japonica (Rice) PR
Q5Z627 Os06g0571400 Elongation factor 1-gamma 3 Oryza sativa subsp japonica (Rice) PR
P54412 eef-1G Probable elongation factor 1-gamma Caenorhabditis elegans PR
Q9U1Q4 glp-4 Valine--tRNA ligase Caenorhabditis elegans PR
P93736 TWN2 Valine--tRNA ligase, mitochondrial 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q6PE25 eef1g Elongation factor 1-gamma Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSILYVSPHP DAFPSLRALI AARYGEAGDG PGWGGPHPRI CLQPPPSSRT PFPPPRLPAL
70 80 90 100 110 120
EQGPGGLWVW GAPAVAQLLW PAGLGGPGGS RAAVLVQQWV SYADTELIPA ACGATLPALG
130 140 150 160 170 180
LRGPGQDPQA ALGALGKALN PLEDWLRLHT YLAGDAPTLA DLAAVTALLL PFRYVLDPSA
190 200 210 220 230 240
RRIWGNVTRW FNTCVRQPEF RAVLGEVALY SGARSVTQQP GSEVIAPQKT PAQLKKEAKK
250 260 270 280 290 300
REKLEKFQQK QKTQQQPPHG EKKPKPEKKE KRDPGVITYD LPTPPGEKKD VSGAMPDSYS
310 320 330 340 350 360
PQYVEAAWYP WWERQGFFKP EYGRPSVSAP NPRGVFMMCI PPPNVTGSLH LGHALTNAIQ
370 380 390 400 410 420
DSLTRWHRMR GETTLWNPGC DHAGIATQVV VEKKLWKERG LNRHQLGREA FLEEVWKWKA
430 440 450 460 470 480
EKGDRIYHQL KKLGSSLDWD RACFTMDPKL SATVTEAFVR LHEEGVIYRS TRLVNWSCTL
490 500 510 520 530 540
NSAISDIEVD KKELTGRTLL PVPGYKEKVE FGVLVSFAYK VQGSDSDEEV VVATTRIETM
550 560 570 580 590 600
LGDVAVAVHP KDPRYQHLKG KCVVHPFLSR SLPIVFDDFV DMEFGTGAVK ITPAHDQNDY
610 620 630 640 650 660
EVGQRHRLEA ISIMDSKGAL INVPPPFLGL PRFEARKAVL AALKERGLFR GVKDNPMVVP
670 680 690 700 710 720
LCNRSKDVVE PLLRPQWYVR CGEMAQAASA AVTRGDLRIL PEAHQRTWHS WMDNIRDWCI
730 740 750 760 770 780
SRQLWWGHRI PAYFITVHDP AVPPGEDPDG RYWVSGRTEA EAREKAAREF GVSPDKISLQ
790 800 810 820 830 840
QDEDVLDTWF SSGLFPFSIF GWPNQSEDLS VFYPGTLLET GHDILFFWVA RMVMLGLKLT
850 860 870 880 890 900
GKLPFREVYL HAIVRDAHGR KMSKSLGNVI DPLDVIHGVS LQGLYDQLLN SNLDPSEVEK
910 920 930 940 950 960
AKEGQKADFP AGIPECGTDA LRFGLCAYTS QGRDINLDVN RILGYRHFCN KLWNATKFAL
970 980 990 1000 1010 1020
RGLGKGFVPS ATSKPEGHES LVDRWIRSRL TEAVRLSNEG FQAYDFPAIT TAQYSFWLYE
1030 1040 1050 1060 1070 1080
LCDVYLECLK PVLNGVDQVA AECARQTLYT CLDVGLRLLS PFMPFVTEEL FQRLPRRTPK
1090 1100 1110 1120 1130 1140
APASLCVTPY PEPSECSWKD PEAEAALELA LSITRAVRSL RADYNLTRTR PDCFLEVADE
1150 1160 1170 1180 1190 1200
ATGALASAVS GYVQALASAG VVAVLALGAP APQGCAVAVA SDRCSIHLQL QGLVDPAREL
1210 1220 1230 1240 1250 1260
GKLQAKRSEA QRQAQRLQER RAASSYSAKV PLEVQEADEA KLQQTEAELR KVDEAIALFQ
KML