P93736
PR
Gene name |
TWN2 |
Protein name |
Valine--tRNA ligase, mitochondrial 1 |
Names |
AtSYV1, Protein TWIN 2, Valyl-tRNA synthetase, ValRS |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G14610 |
EC number |
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P93736
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P93736-F1 | Predicted | AlphaFoldDB |
55 variants for P93736
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04576895 | 22 | S>F | No | 1000Genomes | |
| ENSVATH00023440 | 36 | V>L | No | 1000Genomes | |
| ENSVATH11214509 | 83 | R>T | No | 1000Genomes | |
| ENSVATH13896887 | 85 | A>S | No | 1000Genomes | |
| ENSVATH11214507 | 104 | K>N | No | 1000Genomes | |
| tmp_1_5013414_C_T | 106 | S>N | No | 1000Genomes | |
| tmp_1_5013339_C_G | 131 | R>T | No | 1000Genomes | |
| ENSVATH00023437 | 144 | T>A | No | 1000Genomes | |
| tmp_1_5013179_G_T | 157 | D>E | No | 1000Genomes | |
| tmp_1_5013153_G_C | 166 | S>C | No | 1000Genomes | |
| ENSVATH00023433 | 296 | Y>H | No | 1000Genomes | |
| tmp_1_5011793_C_T | 330 | E>K | No | 1000Genomes | |
| tmp_1_5011534_T_A,C | 416 | N>I | No | 1000Genomes | |
| tmp_1_5011534_T_A,C | 416 | N>S | No | 1000Genomes | |
| ENSVATH13896869 | 455 | T>K | No | 1000Genomes | |
| tmp_1_5011328_T_A | 455 | T>S | No | 1000Genomes | |
| ENSVATH13896868 | 462 | A>S | No | 1000Genomes | |
| tmp_1_5011277_C_T | 472 | A>T | No | 1000Genomes | |
| tmp_1_5010965_T_C | 531 | N>S | No | 1000Genomes | |
| ENSVATH11214431 | 532 | K>R | No | 1000Genomes | |
| ENSVATH13896867 | 571 | Y>N | No | 1000Genomes | |
| tmp_1_5010624_T_A | 597 | D>V | No | 1000Genomes | |
| tmp_1_5010618_C_T | 599 | R>Q | No | 1000Genomes | |
| ENSVATH11214427 | 605 | K>T | No | 1000Genomes | |
| tmp_1_5010564_G_A | 617 | P>L | No | 1000Genomes | |
| ENSVATH11214414 | 692 | H>Q | No | 1000Genomes | |
| ENSVATH11214425 | 692 | H>Y | No | 1000Genomes | |
| tmp_1_5010176_T_C | 711 | N>D | No | 1000Genomes | |
| tmp_1_5010089_C_G | 740 | V>L | No | 1000Genomes | |
| tmp_1_5010065_G_A | 748 | P>S | No | 1000Genomes | |
| tmp_1_5010053_T_C | 752 | T>A | No | 1000Genomes | |
| ENSVATH11214412 | 760 | V>I | No | 1000Genomes | |
| tmp_1_5009927_A_C | 766 | S>A | No | 1000Genomes | |
| tmp_1_5009894_C_T | 777 | V>I | No | 1000Genomes | |
| ENSVATH04576861 | 806 | T>I | No | 1000Genomes | |
| tmp_1_5009789_T_C | 812 | M>V | No | 1000Genomes | |
| ENSVATH13896865 | 831 | V>A | No | 1000Genomes | |
| ENSVATH11214408 | 835 | D>N | No | 1000Genomes | |
| ENSVATH00023429 | 835 | D>V | No | 1000Genomes | |
| tmp_1_5009596_T_C | 876 | E>G | No | 1000Genomes | |
| ENSVATH04576860 | 879 | H>N | No | 1000Genomes | |
| tmp_1_5009489_C_T | 912 | A>T | No | 1000Genomes | |
| ENSVATH11214406 | 912 | A>V | No | 1000Genomes | |
| ENSVATH13896844 | 921 | S>A | No | 1000Genomes | |
| tmp_1_5009054_G_C | 987 | H>Q | No | 1000Genomes | |
| tmp_1_5008860_T_G | 1024 | K>T | No | 1000Genomes | |
| ENSVATH00023425 | 1028 | E>K | No | 1000Genomes | |
| tmp_1_5008843_C_G | 1030 | D>H | No | 1000Genomes | |
| ENSVATH01050986 | 1061 | S>N | No | 1000Genomes | |
| tmp_1_5008632_T_C | 1066 | E>G | No | 1000Genomes | |
| ENSVATH13896841 | 1067 | E>A | No | 1000Genomes | |
| ENSVATH04576855 | 1079 | N>S | No | 1000Genomes | |
| ENSVATH04576854 | 1096 | A>V | No | 1000Genomes | |
| tmp_1_5008539_C_T | 1097 | R>H | No | 1000Genomes | |
| tmp_1_5008534_C_T | 1099 | A>T | No | 1000Genomes |
No associated diseases with P93736
4 regional properties for P93736
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 177 - 188 | IPR001412 |
| domain | Aminoacyl-tRNA synthetase, class Ia | 149 - 772 | IPR002300 |
| domain | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | 817 - 963 | IPR013155 |
| domain | Valyl tRNA synthetase, anticodon-binding domain | 771 - 910 | IPR033705 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.9 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| valine-tRNA ligase activity | Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| embryo development ending in seed dormancy | The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. |
| valyl-tRNA aminoacylation | The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P07118 | valS | Valine--tRNA ligase | Escherichia coli (strain K12) | PR |
| P26640 | VARS1 | Valine--tRNA ligase | Homo sapiens (Human) | PR |
| Q5ST30 | VARS2 | Valine--tRNA ligase, mitochondrial | Homo sapiens (Human) | PR |
| Q9Z1Q9 | Vars1 | Valine--tRNA ligase | Mus musculus (Mouse) | PR |
| Q04462 | Vars1 | Valine--tRNA ligase | Rattus norvegicus (Rat) | PR |
| Q5TM74 | VARS2 | Valine--tRNA ligase, mitochondrial | Macaca mulatta (Rhesus macaque) | PR |
| Q9U1Q4 | glp-4 | Valine--tRNA ligase | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLLFLRRAK | PLFVSCCSAT | HSRSSFLSPT | LTNQLVRSFH | GSRTMSESEK | KILTEEELER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKKKEEKAKE | KELKKQKALE | KERLAELKAK | QAKDGTNVPK | KSAKKSSKRD | ASEENPEDFV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DPETPLGERK | RLSSQMAKQY | SPATVEKSWY | AWWEKSDLFK | ADAKSSKPPF | VIVLPPPNVT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GALHIGHALT | SAIEDTIIRW | KRMSGYNALW | VPGVDHAGIA | TQVVVEKKIM | RDRGMTRHDV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GREEFVKEVW | KWKNQYGGTI | LTQLRRLGAS | LDWSRECFTM | DEQRSKAVTE | AFVRLYKEGL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IYRDIRLVNW | DCILRTAISD | VEVEYIDIKE | KTLLKVPGYE | KPVEFGLLTS | FAYPLEGGLG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EVIVATTRVE | TMLGDTAIAI | HPDDARYKHL | HGKFAVHPFN | GRKLPIICDG | ILVDPNFGTG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CVKITPAHDP | NDCEVGKRHK | LEFINIFTDD | GKINTNGGSD | FAGMPRFAAR | EAVVEALQKQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GLYRGAKNNE | MRLGLCSRTN | DVIEPMIKPQ | WYVNCSMIGK | EALDVAITDE | NKKLEFVPKQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YTAEWRRWLE | NIRDWCISRQ | LWWGHRIPAW | YATLEEDQLK | EVGAYSDHWV | VARTEDDARE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EAAQKFLGKK | FELTRDPDVL | DTWFSSGLFP | LSVLGWPDVT | DDFKAFYPTS | VLETGHDILF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FWVARMVMMG | MKLGGEVPFS | KVYFHPMIRD | AHGRKMSKSL | GNVIDPLEVI | NGVTLEGLHK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| RLEEGNLDPK | EVIVAKEGQV | KDFPNGIPEC | GTDALRFALV | SYTAQSDKIN | LDILRVVGYR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QWCNKLWNAV | RFAMMKLGDG | YTPPQTLSPE | TMPFSCQWIL | SVLNKAISKT | VVSLDAFEFS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DAANTIYAWW | QYQFCDVYIE | AIKPYFAGDN | PTFASERAHA | QHALWISLET | GLRLLHPFMP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| FVTEELWQRL | PAPKDTERKA | SIMICDYPSA | IENWSNEKVE | SEMDTVLATV | KCMRALRAGL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LEKQKNERLP | AFALCENNVT | SEIVKSHELE | IRTLANLSSL | EVVSKGQHAA | PPGSSVETVN |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ENLKVYLEVD | GAINTEAEQE | KIRNKIGELQ | KQKEKLQKMM | SVSTYEEKVP | ANIKEDNANK |
| 1090 | 1100 | ||||
| LAKILQEFDF | FEKESARLAA | ETSNSGNQ |