Q9U1Q4

PR
Gene name
glp-4
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_Y87G2A.5
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-108 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9U1Q4

Entry ID Method Resolution Chain Position Source
AF-Q9U1Q4-F1 Predicted AlphaFoldDB

No variants for Q9U1Q4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9U1Q4

No associated diseases with Q9U1Q4

4 regional properties for Q9U1Q4

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 127 - 138 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 92 - 719 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 765 - 914 IPR013155
domain Valyl tRNA synthetase, anticodon-binding domain 718 - 856 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

2 GO annotations of biological process

Name Definition
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P07118 valS Valine--tRNA ligase Escherichia coli (strain K12) PR
P26640 VARS1 Valine--tRNA ligase Homo sapiens (Human) PR
Q5ST30 VARS2 Valine--tRNA ligase, mitochondrial Homo sapiens (Human) PR
Q9Z1Q9 Vars1 Valine--tRNA ligase Mus musculus (Mouse) PR
Q04462 Vars1 Valine--tRNA ligase Rattus norvegicus (Rat) PR
Q5TM74 VARS2 Valine--tRNA ligase, mitochondrial Macaca mulatta (Rhesus macaque) PR
P93736 TWN2 Valine--tRNA ligase, mitochondrial 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSDPAGNRPK TEKELKKEAE KAAKLAKFEE KQKKLAEKKA AASDKPVKEA KAKKEQTVEA
70 80 90 100 110 120
AEPVDQTPTG QRKKIDGEIP AAYFPGYVES GWYSWWEKEG FFKPEYIDKL NPGSNPADSF
130 140 150 160 170 180
TVCIPPPNVT GNLHVGHALA TTVEDTITRF NRMHGKRTLF NPGCDHAGIA TQVVVEKRLK
190 200 210 220 230 240
RERGLTRHDL GRDRFNQEVW HWKNEKGDVI YDQFRKLGAS VDWDRAVFTM DPKMCRAVTE
250 260 270 280 290 300
AFIRMHESGT IYRSNRLVNW SCALRSAISD IEVDKKELTG STLIAVPGYD KKIEFGVLNS
310 320 330 340 350 360
FAYKIQGSDE EIVVSTTRIE TMLGDSGVAV HPDDQRYKHL VGKQCIHPFI PTRNLPIFAD
370 380 390 400 410 420
SFVEMEFGTG AVKITPAHDH NDYEVGIRQN LPFHNCITDD GLISQGCGEF SGMKRFDART
430 440 450 460 470 480
AVIEALKEKG LYRGKEDNPM VVPTCSRSKD VIEPILKPQW YVKCAHMAEK AVAAVANGDL
490 500 510 520 530 540
QIIPEFHKAT WNRWLESSRD WCISRQLWWG HRIPAYYISF ADGREQPLPE ENYWVSARTE
550 560 570 580 590 600
QEALAKAAQK FQVPEAEILL KWDEDVLDTW FSSGMWPFAV FGWPDATKDM DLFFPGAVLE
610 620 630 640 650 660
TGHDILFFWV ARMVFMAQEL TGKLPFKEIL LHAMIRDAHG RKMSKSLGNV IDPLDVIRGI
670 680 690 700 710 720
SLNDLQAQLL GGNLDEKEIA VAKEGQARDY PDGIPECGVD ALRFALLSYT SQGRDINLDV
730 740 750 760 770 780
LRVHGYRKFC NKLWQVVRFA LARISDKPEQ KPTFEINLKS ATPTDLWILS RLAKAVKETN
790 800 810 820 830 840
EALKAYNFTQ ATTVTYNFWL YDFCDVYVET IKPVLYGDNT TLRQVAISVL HKCIDTGLRL
850 860 870 880 890 900
ISPLMPFISE ELWQRMPRLD DSDYTSPSII VAQYPLTQKY EKYQNEKLEA AFEFAQELIG
910 920 930 940 950 960
KVRSLRADYD LKKTKITMQI LSETPEDESM LNDISAVITT LTFSEKVSIL NKCESDKIEK
970 980 990 1000 1010 1020
GSAHIACGGR CQVYINLTGI IDVPKEIEKL GAKLQKNQIS VKKIGDIQSS ADYEQKVPVD
1030 1040
IRALDQEKKA TLEKEIENIT AAIAQLKALN