Q04462

PR
Gene name
Vars1 (Vars, Vars2)
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25009
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

213-299 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q04462

Entry ID Method Resolution Chain Position Source
AF-Q04462-F1 Predicted AlphaFoldDB

3 variants for Q04462

Variant ID(s) Position Change Description Diseaes Association Provenance
rs106644674 653 I>V No EVA
rs106092597 842 E>G No EVA
rs8146176 1219 Q>R No EVA

No associated diseases with Q04462

6 regional properties for Q04462

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 344 - 355 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 309 - 939 IPR002300
domain Glutathione S-transferase, C-terminal 123 - 198 IPR004046
domain Glutathione S-transferase, C-terminal-like 89 - 219 IPR010987
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 984 - 1132 IPR013155
domain Valyl tRNA synthetase, anticodon-binding domain 938 - 1075 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2NL00 GSTT1 Glutathione S-transferase theta-1 Bos taurus (Bovine) PR
Q3SZV3 EEF1G Elongation factor 1-gamma Bos taurus (Bovine) PR
P07118 valS Valine--tRNA ligase Escherichia coli (strain K12) PR
Q5ST30 VARS2 Valine--tRNA ligase, mitochondrial Homo sapiens (Human) PR
P0CG30 GSTT2B Glutathione S-transferase theta-2B Homo sapiens (Human) PR
P26641 EEF1G Elongation factor 1-gamma Homo sapiens (Human) PR
P26640 VARS1 Valine--tRNA ligase Homo sapiens (Human) PR
Q9D8N0 Eef1g Elongation factor 1-gamma Mus musculus (Mouse) PR
Q9Z1Q9 Vars1 Valine--tRNA ligase Mus musculus (Mouse) PR
Q29387 EEF1G Elongation factor 1-gamma Sus scrofa (Pig) PR
Q68FR6 Eef1g Elongation factor 1-gamma Rattus norvegicus (Rat) PR
P30713 Gstt2 Glutathione S-transferase theta-2 Rattus norvegicus (Rat) PR
Q5TM74 VARS2 Valine--tRNA ligase, mitochondrial Macaca mulatta (Rhesus macaque) PR
Q6YW46 Os02g0220500 Elongation factor 1-gamma 2 Oryza sativa subsp japonica (Rice) PR
Q9ZRI7 Os02g0220600 Elongation factor 1-gamma 1 Oryza sativa subsp japonica (Rice) PR
Q5Z627 Os06g0571400 Elongation factor 1-gamma 3 Oryza sativa subsp japonica (Rice) PR
P54412 eef-1G Probable elongation factor 1-gamma Caenorhabditis elegans PR
Q9U1Q4 glp-4 Valine--tRNA ligase Caenorhabditis elegans PR
P93736 TWN2 Valine--tRNA ligase, mitochondrial 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q6PE25 eef1g Elongation factor 1-gamma Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSILYVSPHP DAFPSLRALI AARYGEAGDG PGWGGPHPRI CLQPPPSSRT PFPPPRLPAL
70 80 90 100 110 120
EQGPGGLWVW GAPAVAQLLW PAGLGGPGGS RAAVLVQQWV SYADTELTPA ACGATLPALG
130 140 150 160 170 180
LRGPGQDPQA ALGALGKALN PLEEWLRLHT YLAGDAPTLA DLAAVTALLL PFRYVLDPSA
190 200 210 220 230 240
RRIWGNVTRW FNTCVRQPEF RAVLGEVVLY SGARSVTQQP GSEITAPQKT AAQLKKEAKK
250 260 270 280 290 300
REKLEKFQQK QKTQQQQPAH GEKKPKPEKK EKRDPGVITY DLPTPPGEKK DVSGTMPDSY
310 320 330 340 350 360
SPQYVEAAWY PWWERQGFFK PEYGRPSVSA PNPRGVFMMC IPPPNVTGSL HLGHALTNAI
370 380 390 400 410 420
QDSLTRWHRM RGETTLWNPG CDHAGIATQV VVEKKLWKER GLNRHQLGRE AFLQEVWKWK
430 440 450 460 470 480
AEKGDRIYHQ LKKLGSSLDW DRACFTMDPK LSATVTEAFV RLHEEGVIYR STRLVNWSCT
490 500 510 520 530 540
LNSAISDIEV DKKELTGRTL LSVPGYKEKV EFGVLVSFAY KVQGSDSDEE VVVATTRIET
550 560 570 580 590 600
MLGDVAVAVH PKDPRYQHLK GKSVVHPFLS RSLPIVFDDF VDMEFGTGAV KITPAHDQND
610 620 630 640 650 660
YEVGQRHRLE AISIMDSKGA LVNVPPPFLG LPRFEARKAV LAALKEQGLF RGIKDNPMVV
670 680 690 700 710 720
PLCNRSKDVV EPLLRPQWYV RCGEMAQAAS AAVTRGDLRI LPEAHQRTWH SWMDNIRDWC
730 740 750 760 770 780
ISRQLWWGHR IPAYFITVHD PAVPPGEDPD GRYWVSGRTE AEAREKAARE FGVSPDKISL
790 800 810 820 830 840
QQDEDVLDTW FSSGLFPFSI FGWPNQSEDL SVFYPGTLLE TGHDILFFWV ARMVMLGLKL
850 860 870 880 890 900
TEKLPFREVY LHAIVRDAHG RKMSKSLGNV IDPLDVIHGV SLQGLHDQLL NSNLDPSEVE
910 920 930 940 950 960
KAKEGQRADF PAGIPECGTD ALRFGLCAYT SQGRDINLDV NRILGYRHFC NKLWNATKFA
970 980 990 1000 1010 1020
LRGLGKGFVP SPTSKPEGHE SLVDRWIRSR LAEAVRLSNE GFQAYDFPAV TTAQYSFWLY
1030 1040 1050 1060 1070 1080
ELCDVYLECL KPVLNGVDQV AADCARQTLY TCLDVGLRLL SPFMPFVTEE LFQRLPRRTP
1090 1100 1110 1120 1130 1140
NAPASLCVTP YPEPSECSWK DPEAEAALEL ALSITRAVRS LRADYNLTRT RPDCFLEVAD
1150 1160 1170 1180 1190 1200
EATGALASAV SAYVQTLASA GVVAVLALGA PAPQGCAVAV ASDRCSIHLQ LQGLVDPARE
1210 1220 1230 1240 1250 1260
LGKLQAKRSE AQRQAQRLQE RRAASGYSAK VPLEVQEADE VKLQQTEAEL RKVDEAIALF
QKML