Q2NL00
PR
Gene name |
GSTT1 |
Protein name |
Glutathione S-transferase theta-1 |
Names |
GST class-theta-1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:517724 |
EC number |
2.5.1.18: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2NL00
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2NL00-F1 | Predicted | AlphaFoldDB |
106 variants for Q2NL00
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs519909027 | 31 | R>H | No | EVA | |
| rs439045613 | 38 | G>V | No | EVA | |
| rs459244631 | 39 | Q>L | No | EVA | |
| rs482186732 | 40 | H>P | No | EVA | |
| rs450934663 | 40 | H>Q | No | EVA | |
| rs481544736 | 42 | S>I | No | EVA | |
| rs446950473 | 42 | S>R | No | EVA | |
| rs461380311 | 42 | S>R | No | EVA | |
| rs481544736 | 42 | S>T | No | EVA | |
| rs434590969 | 43 | D>A | No | EVA | |
| rs465970698 | 43 | D>Y | No | EVA | |
| rs876566583 | 46 | A>S | No | EVA | |
| rs445053494 | 47 | Q>H | No | EVA | |
| rs465121389 | 48 | V>L | No | EVA | |
| rs436726221 | 50 | P>R | No | EVA | |
| rs456748679 | 53 | K>* | No | EVA | |
| rs436078512 | 54 | V>G | No | EVA | |
| rs473848451 | 54 | V>L | No | EVA | |
| rs452936317 | 55 | P>Q | No | EVA | |
| rs41856326 | 56 | I>V | No | EVA | |
| rs439046786 | 59 | D>E | No | EVA | |
| rs459203976 | 62 | F>S | No | EVA | |
| rs476174517 | 68 | V>G | No | EVA | |
| rs461750609 | 69 | A>G | No | EVA | |
| rs441619361 | 69 | A>S | No | EVA | |
| rs458168960 | 75 | A>D | No | EVA | |
| rs440913278 | 75 | A>P | No | EVA | |
| rs384569078 | 76 | R>C | No | EVA | |
| rs478220661 | 77 | K>R | No | EVA | |
| rs450250132 | 78 | Y>N | No | EVA | |
| rs470528848 | 79 | K>N | No | EVA | |
| rs480642187 | 80 | V>G | No | EVA | |
| rs449254350 | 85 | Y>D | No | EVA | |
| rs434872324 | 96 | D>A | No | EVA | |
| rs434872324 | 96 | D>G | No | EVA | |
| rs432966738 | 98 | Y>* | No | EVA | |
| rs451867809 | 98 | Y>H | No | EVA | |
| rs451867809 | 98 | Y>N | No | EVA | |
| rs464305902 | 98 | Y>S | No | EVA | |
| rs456332569 | 99 | L>P | No | EVA | |
| rs476526849 | 100 | A>V | No | EVA | |
| rs472215045 | 103 | H>Y | No | EVA | |
| rs440827163 | 104 | T>A | No | EVA | |
| rs457682418 | 106 | L>M | No | EVA | |
| rs443813049 | 107 | R>G | No | EVA | |
| rs463957336 | 108 | R>G | No | EVA | |
| rs453479434 | 110 | C>R | No | EVA | |
| rs466177121 | 115 | W>C | No | EVA | |
| rs461267315 | 120 | L>V | No | EVA | |
| rs480985992 | 122 | V>G | No | EVA | |
| rs460168511 | 132 | M>K | No | EVA | |
| rs477089731 | 133 | L>P | No | EVA | |
| rs1117556600 | 137 | L>P | No | EVA | |
| rs469509662 | 139 | E>G | No | EVA | |
| rs438195059 | 141 | D>E | No | EVA | |
| rs448646065 | 142 | M>V | No | EVA | |
| rs468920677 | 146 | V>G | No | EVA | |
| rs434285155 | 148 | E>* | No | EVA | |
| rs453970892 | 150 | K>E | No | EVA | |
| rs470854828 | 153 | Q>L | No | EVA | |
| rs433203545 | 155 | K>N | No | EVA | |
| rs456627634 | 165 | L>P | No | EVA | |
| rs456627634 | 165 | L>Q | No | EVA | |
| rs475575143 | 168 | L>Q | No | EVA | |
| rs444242671 | 170 | A>D | No | EVA | |
| rs474884939 | 171 | I>L | No | EVA | |
| rs440374025 | 171 | I>S | No | EVA | |
| rs460130713 | 172 | T>S | No | EVA | |
| rs477000021 | 174 | L>P | No | EVA | |
| rs439242724 | 175 | M>L | No | EVA | |
| rs462663925 | 175 | M>R | No | EVA | |
| rs483243281 | 176 | H>D | No | EVA | |
| rs448641722 | 176 | H>P | No | EVA | |
| rs468649296 | 176 | H>Q | No | EVA | |
| rs448641722 | 176 | H>R | No | EVA | |
| rs433026920 | 183 | Q>P | No | EVA | |
| rs456378739 | 185 | F>L | No | EVA | |
| rs476216225 | 185 | F>S | No | EVA | |
| rs435177392 | 186 | K>N | No | EVA | |
| rs455202301 | 187 | G>S | No | EVA | |
| rs440909064 | 190 | K>Q | No | EVA | |
| rs458175143 | 191 | L>M | No | EVA | |
| rs443875027 | 193 | A>V | No | EVA | |
| rs210970555 | 197 | R>C | No | EVA | |
| rs480619564 | 202 | V>G | No | EVA | |
| rs378431054 | 202 | V>M | No | EVA | |
| rs449278073 | 204 | E>G | No | EVA | |
| rs459770699 | 205 | V>A | No | EVA | |
| rs459770699 | 205 | V>G | No | EVA | |
| rs479898322 | 206 | L>P | No | EVA | |
| rs445363018 | 208 | Q>H | No | EVA | |
| rs464325363 | 209 | E>Q | No | EVA | |
| rs432994664 | 209 | E>V | No | EVA | |
| rs470047881 | 210 | A>D | No | EVA | |
| rs455163925 | 212 | E>G | No | EVA | |
| rs465646441 | 214 | I>L | No | EVA | |
| rs434401285 | 220 | S>F | No | EVA | |
| rs451304221 | 224 | D>G | No | EVA | |
| rs471981092 | 225 | P>R | No | EVA | |
| rs443814642 | 226 | T>P | No | EVA | |
| rs443814642 | 226 | T>S | No | EVA | |
| rs457565491 | 228 | K>Q | No | EVA | |
| rs474479668 | 228 | K>R | No | EVA | |
| rs459695173 | 231 | M>I | No | EVA | |
| rs443181612 | 231 | M>R | No | EVA | |
| rs438891437 | 240 | Q>R | No | EVA |
No associated diseases with Q2NL00
5 regional properties for Q2NL00
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glutathione S-transferase, N-terminal | 1 - 82 | IPR004045 |
| domain | Glutathione S-transferase, C-terminal | 128 - 200 | IPR004046 |
| domain | Glutathione S-transferase, C-terminal-like | 88 - 226 | IPR010987 |
| domain | Glutathione S-transferase Theta, N-terminal | 3 - 78 | IPR040075 |
| domain | Glutathione S-transferase Theta, C-terminal | 91 - 216 | IPR040077 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.18 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutathione transferase activity | Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| glutathione metabolic process | The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SZV3 | EEF1G | Elongation factor 1-gamma | Bos taurus (Bovine) | PR |
| P26641 | EEF1G | Elongation factor 1-gamma | Homo sapiens (Human) | PR |
| P26640 | VARS1 | Valine--tRNA ligase | Homo sapiens (Human) | PR |
| P0CG30 | GSTT2B | Glutathione S-transferase theta-2B | Homo sapiens (Human) | PR |
| P0CG29 | GSTT2 | Glutathione S-transferase theta-2 | Homo sapiens (Human) | PR |
| Q9Z1Q9 | Vars1 | Valine--tRNA ligase | Mus musculus (Mouse) | PR |
| Q9D8N0 | Eef1g | Elongation factor 1-gamma | Mus musculus (Mouse) | PR |
| Q29387 | EEF1G | Elongation factor 1-gamma | Sus scrofa (Pig) | PR |
| Q04462 | Vars1 | Valine--tRNA ligase | Rattus norvegicus (Rat) | PR |
| Q68FR6 | Eef1g | Elongation factor 1-gamma | Rattus norvegicus (Rat) | PR |
| P30713 | Gstt2 | Glutathione S-transferase theta-2 | Rattus norvegicus (Rat) | PR |
| Q6YW46 | Os02g0220500 | Elongation factor 1-gamma 2 | Oryza sativa subsp japonica (Rice) | PR |
| Q9ZRI7 | Os02g0220600 | Elongation factor 1-gamma 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q5Z627 | Os06g0571400 | Elongation factor 1-gamma 3 | Oryza sativa subsp japonica (Rice) | PR |
| P54412 | eef-1G | Probable elongation factor 1-gamma | Caenorhabditis elegans | PR |
| Q6PE25 | eef1g | Elongation factor 1-gamma | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLELYLDLL | SQPCRAIYIF | AKKNRIPFEL | RTVDLRKGQH | LSDAFAQVNP | LQKVPILKDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DFILTESVAI | LLYLARKYKV | PDHWYPQDLQ | ACARVDEYLA | WQHTALRRNC | LRALWHKVML |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PVFLGEPVSP | EMLATTLAEL | DMALQVLEGK | FLQDKAFLTG | SHISLADLVA | ITELMHPVGA |
| 190 | 200 | 210 | 220 | 230 | |
| GCQVFKGRPK | LAAWRQRVEA | AVGEVLFQEA | HEVILKAKDS | QPADPTLKQK | MLPKVLAMIQ |