P0CG29

PR
Gene name
GSTT2
Protein name
Glutathione S-transferase theta-2
Names
GST class-theta-2
Species
Homo sapiens (Human)
KEGG Pathway
hsa:2953
EC number
2.5.1.18: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

188-244 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P0CG29

Entry ID Method Resolution Chain Position Source
4MPF X-ray 210 A A/B 1-244 PDB
AF-P0CG29-F1 Predicted AlphaFoldDB

91 variants for P0CG29

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1216830090 10 V>M No TOPMed
rs1287189250 15 R>H No TOPMed
rs1229523599 27 P>S No TOPMed
rs1361692845 29 E>G No TOPMed
gnomAD
rs967822924 36 V>I No TOPMed
gnomAD
rs566742951 38 G>V No 1000Genomes
ExAC
gnomAD
rs774867938 40 H>Q No ExAC
TOPMed
gnomAD
rs768041902 41 K>R No ExAC
gnomAD
rs1420434774 42 S>N No gnomAD
rs755644674 46 L>S No ExAC
gnomAD
rs765950548 49 N>H No ExAC
gnomAD
rs1377081364 52 G>E No gnomAD
rs538967136 54 L>M No 1000Genomes
ExAC
gnomAD
rs373232513 56 T>M No ESP
ExAC
gnomAD
rs373232513 56 T>R No ESP
ExAC
gnomAD
rs1209339317 58 K>N No gnomAD
rs1235182142 59 D>N No gnomAD
rs780166121 60 G>S No ExAC
gnomAD
rs749468888 61 D>H No ExAC
gnomAD
rs748054210 62 F>I No Ensembl
rs774743685 64 L>F No ExAC
TOPMed
gnomAD
rs138324852 66 E>* No 1000Genomes
ESP
ExAC
gnomAD
rs138324852 66 E>K No 1000Genomes
ESP
ExAC
gnomAD
rs1126752 68 S>L No ExAC
gnomAD
rs1423733082 69 A>D No gnomAD
rs749344097 76 C>R No ExAC
gnomAD
rs554852319 80 T>M No 1000Genomes
ExAC
TOPMed
gnomAD
rs907996021 81 P>L No TOPMed
gnomAD
rs575041715 83 H>R No 1000Genomes
rs779100179 88 D>N No ExAC
gnomAD
rs1363927597 92 R>C No gnomAD
rs1215117944 92 R>P No gnomAD
rs772421128 94 R>C No ExAC
gnomAD
rs772421128 94 R>G No ExAC
gnomAD
rs1250569570 94 R>H No gnomAD
rs1601563335 101 W>L No Ensembl
rs761203948 107 R>C No ExAC
TOPMed
gnomAD
rs1292142415 107 R>H No gnomAD
rs1197490779 108 G>S No gnomAD
rs771320882 109 T>I No ExAC
gnomAD
rs776340540 110 F>S No ExAC
gnomAD
rs759114120 111 G>V No ExAC
gnomAD
rs764989870 113 P>A No ExAC
TOPMed
gnomAD
rs775227515 113 P>L No ExAC
gnomAD
rs764989870 113 P>T No ExAC
TOPMed
gnomAD
rs762683728 115 W>* No ExAC
gnomAD
rs2301423 118 V>M No 1000Genomes
ESP
ExAC
gnomAD
rs757729836 120 G>R No ExAC
gnomAD
rs1344361793 121 P>S No gnomAD
rs750798235 122 L>F No ExAC
gnomAD
rs562918381 123 I>T No 1000Genomes
ExAC
gnomAD
rs1481331892 125 V>I No gnomAD
rs1199445168 126 Q>* No gnomAD
rs767991031 126 Q>H No ExAC
gnomAD
rs778647648 127 V>M No ExAC
gnomAD
rs140195 129 K>* No 1000Genomes
ExAC
TOPMed
gnomAD
rs140195 129 K>E No 1000Genomes
ExAC
TOPMed
gnomAD
rs140195 129 K>Q No 1000Genomes
ExAC
TOPMed
gnomAD
rs1601563570 133 E>Q No Ensembl
rs1305861180 134 R>C No gnomAD
rs760459318 134 R>H No ExAC
gnomAD
rs548564711 135 N>K No 1000Genomes
ExAC
gnomAD
rs1302560958 138 A>V No gnomAD
rs60718122 139 M>I No 1000Genomes
ESP
ExAC
gnomAD
rs1231751104 145 W>* No gnomAD
rs146675046 147 E>K No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1342982953 151 L>M No gnomAD
rs1601563610 152 G>W No Ensembl
rs4987176 153 D>N No ExAC
gnomAD
rs1266445806 158 A>G No gnomAD
rs139143959 158 A>T No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1375002300 165 A>V No TOPMed
rs756477347 174 M>T No ExAC
TOPMed
gnomAD
rs1458115949 176 P>L No TOPMed
gnomAD
rs1208166121 181 Y>C No TOPMed
rs1278665398 184 F>S No TOPMed
rs1430731069 187 R>Q No gnomAD
rs1052550288 188 P>L No TOPMed
gnomAD
rs1300528304 189 R>* No gnomAD
rs1204500993 189 R>Q No TOPMed
rs1348378735 194 R>H No TOPMed
rs201176441 196 R>* No 1000Genomes
ExAC
gnomAD
rs201176441 196 R>G No 1000Genomes
ExAC
gnomAD
rs1601563779 197 V>M No Ensembl
rs892243933 204 E>K No TOPMed
rs1281072238 206 C>R No TOPMed
rs1228772519 209 A>S No TOPMed
rs569368007 216 I>L No 1000Genomes
rs1295520477 216 I>T No gnomAD
rs1395062772 235 A>T No gnomAD
rs200087397 241 A>T No 1000Genomes
TOPMed
gnomAD

No associated diseases with P0CG29

5 regional properties for P0CG29

Type Name Position InterPro Accession
domain Glutathione S-transferase, N-terminal 1 - 82 IPR004045
domain Glutathione S-transferase, C-terminal 127 - 198 IPR004046
domain Glutathione S-transferase, C-terminal-like 88 - 224 IPR010987
domain Glutathione S-transferase Theta, N-terminal 3 - 78 IPR040075
domain Glutathione S-transferase Theta, C-terminal 91 - 216 IPR040077

Functions

Description
EC Number 2.5.1.18 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm, cytosol
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
glutathione transferase activity Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.

1 GO annotations of biological process

Name Definition
glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2NL00 GSTT1 Glutathione S-transferase theta-1 Bos taurus (Bovine) PR
P0CG30 GSTT2B Glutathione S-transferase theta-2B Homo sapiens (Human) PR
P30713 Gstt2 Glutathione S-transferase theta-2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS LGKLPTLKDG
70 80 90 100 110 120
DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG WHADCIRGTF GIPLWVQVLG
130 140 150 160 170 180
PLIGVQVPKE KVERNRTAMD QALQWLEDKF LGDRPFLAGQ QVTLADLMAL EELMQPVALG
190 200 210 220 230 240
YELFEGRPRL AAWRGRVEAF LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI
ARIP