P30713
Gene name |
Gstt2 |
Protein name |
Glutathione S-transferase theta-2 |
Names |
GST 12-12, GST class-theta-2, Glutathione S-transferase 12, Glutathione S-transferase Yrs-Yrs |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:29487 |
EC number |
2.5.1.18: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P30713
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P30713-F1 | Predicted | AlphaFoldDB |
No variants for P30713
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P30713 | |||||
No associated diseases with P30713
5 regional properties for P30713
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glutathione S-transferase, N-terminal | 1 - 82 | IPR004045 |
| domain | Glutathione S-transferase, C-terminal | 127 - 198 | IPR004046 |
| domain | Glutathione S-transferase, C-terminal-like | 88 - 230 | IPR010987 |
| domain | Glutathione S-transferase Theta, N-terminal | 3 - 78 | IPR040075 |
| domain | Glutathione S-transferase Theta, C-terminal | 91 - 216 | IPR040077 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.18 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutathione peroxidase activity | Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. |
| glutathione transferase activity | Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to leukemia inhibitory factor | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. |
| glutathione metabolic process | The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. |
| response to salicylic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SZV3 | EEF1G | Elongation factor 1-gamma | Bos taurus (Bovine) | PR |
| Q2NL00 | GSTT1 | Glutathione S-transferase theta-1 | Bos taurus (Bovine) | PR |
| P26641 | EEF1G | Elongation factor 1-gamma | Homo sapiens (Human) | PR |
| P26640 | VARS1 | Valine--tRNA ligase | Homo sapiens (Human) | PR |
| P0CG30 | GSTT2B | Glutathione S-transferase theta-2B | Homo sapiens (Human) | PR |
| P0CG29 | GSTT2 | Glutathione S-transferase theta-2 | Homo sapiens (Human) | PR |
| Q9Z1Q9 | Vars1 | Valine--tRNA ligase | Mus musculus (Mouse) | PR |
| Q9D8N0 | Eef1g | Elongation factor 1-gamma | Mus musculus (Mouse) | PR |
| Q29387 | EEF1G | Elongation factor 1-gamma | Sus scrofa (Pig) | PR |
| Q04462 | Vars1 | Valine--tRNA ligase | Rattus norvegicus (Rat) | PR |
| Q68FR6 | Eef1g | Elongation factor 1-gamma | Rattus norvegicus (Rat) | PR |
| Q6YW46 | Os02g0220500 | Elongation factor 1-gamma 2 | Oryza sativa subsp japonica (Rice) | PR |
| Q9ZRI7 | Os02g0220600 | Elongation factor 1-gamma 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q5Z627 | Os06g0571400 | Elongation factor 1-gamma 3 | Oryza sativa subsp japonica (Rice) | PR |
| P54412 | eef-1G | Probable elongation factor 1-gamma | Caenorhabditis elegans | PR |
| Q6PE25 | eef1g | Elongation factor 1-gamma | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLELYLDLL | SQPSRAVYIF | AKKNGIPFQL | RTVDLLKGQH | LSEQFSQVNC | LKKVPVLKDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SFVLTESTAI | LIYLSSKYQV | ADHWYPADLQ | ARAQVHEYLG | WHADNIRGTF | GVLLWTKVLG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PLIGVQVPEE | KVERNRNSMV | LALQRLEDKF | LRDRAFIAGQ | QVTLADLMSL | EELIQPVALG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CNLFEGRPQL | TAWRERVEAF | LGAELCQEAH | NPIMSVLGQA | AKKTLPVPPP | EAHASMMLRI |
| ARIP |