Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q6YW46

Entry ID Method Resolution Chain Position Source
AF-Q6YW46-F1 Predicted AlphaFoldDB

No variants for Q6YW46

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6YW46

No associated diseases with Q6YW46

4 regional properties for Q6YW46

Type Name Position InterPro Accession
domain Elongation factor 1B gamma, C-terminal 257 - 418 IPR001662
domain Glutathione S-transferase, N-terminal 1 - 82 IPR004045
domain Glutathione S-transferase, C-terminal 129 - 197 IPR004046
domain Glutathione S-transferase, C-terminal-like 87 - 215 IPR010987

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
glutathione transferase activity Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome.

1 GO annotations of biological process

Name Definition
response to chemical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2NL00 GSTT1 Glutathione S-transferase theta-1 Bos taurus (Bovine) PR
Q3SZV3 EEF1G Elongation factor 1-gamma Bos taurus (Bovine) PR
A2Q127 EEF1G Elongation factor 1-gamma Equus caballus (Horse) PR
P0CG30 GSTT2B Glutathione S-transferase theta-2B Homo sapiens (Human) PR
P26640 VARS1 Valine--tRNA ligase Homo sapiens (Human) PR
P26641 EEF1G Elongation factor 1-gamma Homo sapiens (Human) PR
Q9Z1Q9 Vars1 Valine--tRNA ligase Mus musculus (Mouse) PR
Q9D8N0 Eef1g Elongation factor 1-gamma Mus musculus (Mouse) PR
Q29387 EEF1G Elongation factor 1-gamma Sus scrofa (Pig) PR
Q04462 Vars1 Valine--tRNA ligase Rattus norvegicus (Rat) PR
P30713 Gstt2 Glutathione S-transferase theta-2 Rattus norvegicus (Rat) PR
Q68FR6 Eef1g Elongation factor 1-gamma Rattus norvegicus (Rat) PR
Q5Z627 Os06g0571400 Elongation factor 1-gamma 3 Oryza sativa subsp japonica (Rice) PR
Q9ZRI7 Os02g0220600 Elongation factor 1-gamma 1 Oryza sativa subsp japonica (Rice) PR
P54412 eef-1G Probable elongation factor 1-gamma Caenorhabditis elegans PR
Q6PE25 eef1g Elongation factor 1-gamma Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MALVLHAGSG NKNAFKALIA AEYSGVKVEL VKNFQMGVSN KTPEFLKMNP IGKIPVLETP
70 80 90 100 110 120
DGPVFESNAI ARYVTRSKAD NPLYGSSLIE YAHIEQWNDF SATEVDANIG KWLYPRLGIA
130 140 150 160 170 180
PYVAVSEEAA IAALKRSLGA LNTHLASNTY LVGHSVTLAD IVMTCNLYMG FARIMTKSFT
190 200 210 220 230 240
SEFPHVERYF WTMVNQPNFK KVLGDVKQAE SVPPVQKKAP PPKEQKPKEA KKEAPKEAPK
250 260 270 280 290 300
PKAVEKPEEE EEAPKPKPKN PLDLLPPSKM ILDEWKRLYS NTKTNFREVA IKGFWDMYDP
310 320 330 340 350 360
EGYSLWFCDY KYNDENTVSF VTMNKVGGFL QRMDLCRKYA FGKMLVIGSE PPFKVKGLWL
370 380 390 400 410
FRGPEIPKFV MDEVYDMELY EWTKVDISDE AQKERVSAMI EDLEPFEGES LLDAKCFK