AiPD: Autoinhibited Protein Database

P26641

Gene name	EEF1G (EF1G, PRO1608)
Protein name	Elongation factor 1-gamma
Names	EF-1-gamma, eEF-1B gamma
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1937
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

186-309 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

186-309 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for P26641

Entry ID	Method	Resolution	Chain	Position	Source
1PBU	NMR	-	A	276-437	PDB
5DQS	X-ray	210 A	A	2-218	PDB
5JPO	X-ray	200 A	A/B/C/D	1-218	PDB
AF-P26641-F1	Predicted				AlphaFoldDB

273 variants for P26641

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA6047353 rs768353853	2	A>G		No	ClinGen ExAC TOPMed gnomAD
CA6047352 rs768353853	2	A>V		No	ClinGen ExAC TOPMed gnomAD
CA380974864 rs1263820894	3	A>V		No	ClinGen TOPMed gnomAD
rs1161150304 CA380974840	5	T>N		No	ClinGen gnomAD
CA380974821 rs1413092890	8	T>K		No	ClinGen gnomAD
rs755301699 CA6047321	9	Y>*		No	ClinGen ExAC gnomAD
TCGA novel	15	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6047319 rs780270066	20	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1590712240 CA380974725	22	A>T		No	ClinGen Ensembl
rs376492856 CA6047317	23	Q>E		No	ClinGen ESP ExAC gnomAD
CA380974696 COSM3809824 rs1219940474	26	G>E	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
CA6047316 rs767489822	26	G>W		No	ClinGen ExAC
rs1340939647 CA380974688	27	A>V		No	ClinGen TOPMed
CA6047314 rs200194191	28	Q>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA223045476 rs11549617	32	L>F		No	ClinGen Ensembl
rs368954257 CA6047312 COSM689203	33	S>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA6047311 rs11545772	34	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6047310 rs11545772	34	A>T		No	ClinGen ExAC TOPMed gnomAD
CA380974651 rs1290577244	34	A>V		No	ClinGen gnomAD
rs1258782166 CA380974646	35	P>S		No	ClinGen Ensembl
rs1456269075 CA380974555	43	T>S		No	ClinGen TOPMed gnomAD
rs1165820378 CA380974530	45	R>H		No	ClinGen gnomAD
TCGA novel	46	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6047308 rs376656441	47	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6047307 rs770416963	48	E>G		No	ClinGen ExAC gnomAD
TCGA novel	48	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1037404551 CA223045460	48	E>Q		No	ClinGen gnomAD
rs11545769 CA223045449	50	L>P		No	ClinGen Ensembl
rs11549641 CA223045445	54	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs748691710 CA6047306	56	G>C		No	ClinGen ExAC gnomAD
CA380974401 rs748691710	56	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA380974396 rs1429500740	56	G>V		No	ClinGen gnomAD
CA380974385 rs1170867307	57	K>R		No	ClinGen TOPMed
CA380974308 rs1235761626	61	F>V		No	ClinGen gnomAD
CA223045227 rs11549636	62	E>*		No	ClinGen gnomAD
rs867944273 CA223045225	62	E>D		No	ClinGen Ensembl
rs11549636 CA380974301	62	E>K		No	ClinGen gnomAD
rs764076137 CA6047296	63	G>D		No	ClinGen ExAC gnomAD
rs1252676888 CA380974287	64	D>G		No	ClinGen gnomAD
rs1230841842 CA380974279	65	D>G		No	ClinGen gnomAD
rs752473849 CA6047293	73	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs761237813 CA6047291	74	A>T		No	ClinGen ExAC
rs369982241 CA6047290	75	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA380974112 rs765903056	78	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs765903056 CA6047289	78	Y>N		No	ClinGen ExAC TOPMed gnomAD
rs201175165 CA223045103	80	S>I		No	ClinGen 1000Genomes
rs765132516 CA6047275	81	N>S		No	ClinGen ExAC gnomAD
CA380974014 rs1283505997	82	E>K		No	ClinGen gnomAD
CA380973968 rs1205587441	85	R>Q		No	ClinGen gnomAD
rs936366211 CA223045100	85	R>W		No	ClinGen Ensembl
CA380973935 rs1352945446	88	T>I		No	ClinGen gnomAD
rs1590711652 CA380973942	88	T>P		No	ClinGen Ensembl
CA380973929 rs1263830645	89	P>S		No	ClinGen gnomAD
CA380973896 rs1356394154	91	A>V		No	ClinGen gnomAD
CA380973888 COSM467139 rs1565262742	92	A>V	kidney Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1590711643 CA380973847	95	V>G		No	ClinGen Ensembl
CA380973853 rs1398571275	95	V>M		No	ClinGen gnomAD
rs1590711638 CA380973836	96	V>G		No	ClinGen Ensembl
CA380973810 rs1590711635	99	V>G		No	ClinGen Ensembl
CA380973806 rs1305470901	100	S>N		No	ClinGen TOPMed gnomAD
CA223045095 rs17851072	102	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs765954334 CA6047272	104	S>C		No	ClinGen ExAC gnomAD
rs1402884316 CA380973768	105	D>N		No	ClinGen gnomAD
COSM395457 rs1162240425 CA380973712	109	P>A	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA6047268 rs763563679	110	A>P		No	ClinGen ExAC gnomAD
CA223045086 rs1010573000	117	T>I		No	ClinGen TOPMed gnomAD
rs1188994204 CA380973366	125	K>E		No	ClinGen TOPMed
CA380973358 rs1193633559	125	K>R		No	ClinGen gnomAD
rs1343255737 CA380972616	127	A>G		No	ClinGen gnomAD
rs199942278 CA6047253	129	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA223044856 rs201995941	130	N>S		No	ClinGen 1000Genomes
CA6047250 rs750054941	140	G>E		No	ClinGen ExAC gnomAD
CA380972377 rs1565262588	141	L>M		No	ClinGen Ensembl
CA6047249 rs767052909	144	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1167641484 CA380972226	148	T>M		No	ClinGen TOPMed
rs759950976 CA6047245	154	G>D		No	ClinGen ExAC gnomAD
CA6047241 rs773540936	162	I>V		No	ClinGen ExAC gnomAD
CA380971929 rs1212031704	166	C>R		No	ClinGen gnomAD
rs1169443576 CA380971909	167	T>I		No	ClinGen TOPMed
CA6047236 rs749209857	170	W>C		No	ClinGen ExAC gnomAD
CA223044782 rs926697998	173	K>T		No	ClinGen Ensembl
TCGA novel	176	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1287054647 CA380971353	177	E>K		No	ClinGen gnomAD
CA380971332 rs1345701548	180	F>L		No	ClinGen gnomAD
CA380971323 rs1161441685	181	R>C		No	ClinGen gnomAD
rs377344394 CA6047222	183	A>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs377344394 CA380971309	183	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6047223 rs773579698	183	A>P		No	ClinGen ExAC TOPMed gnomAD
rs773579698 CA380971310	183	A>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	183	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1476397110 CA380971296	185	P>L		No	ClinGen gnomAD
CA6047219 rs768757371	187	T>A		No	ClinGen ExAC gnomAD
rs1486510908 CA380971269	189	R>H		No	ClinGen gnomAD
rs1486510908 CA380971267	189	R>L		No	ClinGen gnomAD
CA380971207 rs1272174776	197	Q>H		No	ClinGen gnomAD
TCGA novel	198	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780903665 CA6047213	201	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs745605867 CA223042129 COSM3383653	201	R>W	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA380971174 rs1213750071	202	A>T		No	ClinGen gnomAD
rs754430580 CA6047208	206	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	207	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1326828687 CA380971084	209	L>V		No	ClinGen gnomAD
CA599550696 rs1565261606	210	C>*	Variant assessed as Somatic; 4.652e-05 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs77818737 CA223042096	210	C>S		No	ClinGen Ensembl
rs1169662800 CA380971053	211	E>A		No	ClinGen TOPMed
CA6047207 rs766947119	213	M>I		No	ClinGen ExAC
rs1371538513 CA380971012	214	A>S		No	ClinGen gnomAD
rs1170247235 CA380971006	214	A>V		No	ClinGen gnomAD
rs756548804 CA6047206	215	Q>R		No	ClinGen ExAC gnomAD
rs750880029 CA380970978	217	D>N		No	ClinGen ExAC gnomAD
rs750880029 CA6047205	217	D>Y		No	ClinGen ExAC gnomAD
CA380970367 rs1376630288	218	A>V		No	ClinGen gnomAD
rs765288776 CA6047177	220	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	220	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA223041645 rs865829861	222	A>V		No	ClinGen Ensembl
rs1467149918 CA380970277	223	E>G		No	ClinGen gnomAD
CA223041622 rs11549631	224	T>N		No	ClinGen Ensembl
CA380970229 rs371597439	225	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs11545771 CA223041621	225	Q>K		No	ClinGen Ensembl
TCGA novel	228	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1270713648 CA380970156	229	D>V		No	ClinGen TOPMed
CA6047175 rs368054471	230	T>I		No	ClinGen ESP ExAC gnomAD
CA380970129 rs1198987409	231	P>L		No	ClinGen TOPMed
COSM1250957 rs1485198635 CA380970113	232	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs772756652 CA6047172	232	R>W		No	ClinGen ExAC gnomAD
CA380970071 rs1565261407	234	E>G		No	ClinGen Ensembl
CA380970078 rs1239748235	234	E>Q		No	ClinGen TOPMed
rs747786772 CA223041587	236	G>C		No	ClinGen ExAC TOPMed gnomAD
rs747786772 CA6047170	236	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1242363325 CA380970020	238	R>Q		No	ClinGen gnomAD
CA6047169 rs778611401	238	R>W		No	ClinGen ExAC gnomAD
TCGA novel	240	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380969971 rs1260278609	242	Q>P		No	ClinGen gnomAD
rs768249627 CA6047168	244	P>L		No	ClinGen ExAC gnomAD
TCGA novel	245	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371308314 CA380969891	248	R>G		No	ClinGen ESP ExAC gnomAD
CA380969886 rs781687410	248	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6047166 rs781687410	248	R>P		No	ClinGen ExAC TOPMed gnomAD
CA380969888 rs781687410	248	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs371308314 CA6047167	248	R>W		No	ClinGen ESP ExAC gnomAD
TCGA novel	251	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1565261378 CA380969842	252	K>Q		No	ClinGen Ensembl
rs757574790 CA6047165	254	A>V		No	ClinGen ExAC gnomAD
TCGA novel	255	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6047162 rs758677352	257	P>L		No	ClinGen ExAC gnomAD
rs759624665 CA6047159	264	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1453812305 CA380969656	265	E>A		No	ClinGen gnomAD
CA223041530 rs1047756579	266	C>R		No	ClinGen TOPMed gnomAD
CA380969635 rs1162284205	266	C>W		No	ClinGen gnomAD
CA380969633 rs1474765701	267	E>Q		No	ClinGen gnomAD
CA380969610 rs1340552971	268	Q>H		No	ClinGen TOPMed
CA380969615 rs1257881782	268	Q>P		No	ClinGen TOPMed gnomAD
rs372879019 CA6047158	269	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs760522344 CA6047156	270	L>P		No	ClinGen ExAC gnomAD
rs1219132279 CA380969569	272	A>V		No	ClinGen TOPMed
rs773114543 CA6047155	278	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1466274086 CA380969500	278	D>N		No	ClinGen gnomAD
rs1335726607 CA380969470	280	F>Y		No	ClinGen gnomAD
CA380969458 rs923344557	281	A>S		No	ClinGen TOPMed gnomAD
CA223041492 rs923344557	281	A>T		No	ClinGen TOPMed gnomAD
CA6047153 rs761595268	281	A>V		No	ClinGen ExAC TOPMed gnomAD
CA380969439 rs1453841335	282	H>Q		No	ClinGen gnomAD
rs774106674 CA6047152	282	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA6047151 rs768303087	283	L>V		No	ClinGen ExAC TOPMed gnomAD
CA380969423 rs1408495907	284	P>L		No	ClinGen gnomAD
rs748772853 CA6047150	285	K>R		No	ClinGen ExAC gnomAD
CA223041482 rs933785027	286	S>G		No	ClinGen Ensembl
CA380969402 rs1460657967	286	S>N		No	ClinGen gnomAD
rs1193126567 CA380967316	287	T>N		No	ClinGen gnomAD
rs1437614734 CA380967288	291	D>G		No	ClinGen gnomAD
rs1179848229 CA380967292	291	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA380967284 rs1274229889	292	E>K		No	ClinGen gnomAD
rs1346392960 CA380967258	295	R>C		No	ClinGen gnomAD
rs774160028 CA6047132	295	R>H		No	ClinGen ExAC gnomAD
CA380967251 rs1183911827	296	K>R		No	ClinGen TOPMed gnomAD
rs766058630 CA223033844	299	N>S		No	ClinGen TOPMed gnomAD
rs768287095 CA6047131	301	D>G		No	ClinGen ExAC TOPMed gnomAD
CA380967216 rs1439659444	301	D>N		No	ClinGen TOPMed gnomAD
CA380967207 rs1431363420	302	T>S		No	ClinGen gnomAD
rs769166593 CA6047128	303	L>F		No	ClinGen ExAC TOPMed gnomAD
CA6047127 rs574398844	303	L>H		No	ClinGen ExAC TOPMed gnomAD
CA380967202 rs574398844	303	L>R		No	ClinGen ExAC TOPMed gnomAD
rs769166593 CA6047129	303	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	304	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380967195 rs1395191536	304	S>F		No	ClinGen TOPMed
rs1175550717 CA380967186	306	A>S		No	ClinGen gnomAD
CA380967172 rs1469870243	308	P>L		No	ClinGen gnomAD
rs575608451 CA6047125	313	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1465667927 CA380967103	317	D>G		No	ClinGen TOPMed
CA223033803 rs779116430	318	G>C		No	ClinGen ExAC TOPMed gnomAD
rs779116430 CA6047123	318	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	319	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6047122 rs555740719	323	Y>F		No	ClinGen 1000Genomes ExAC gnomAD
rs749445275 CA6047121	325	E>G		No	ClinGen ExAC gnomAD
rs1437879128 CA380967037	325	E>K		No	ClinGen gnomAD
TCGA novel	325	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	325	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6047120 rs780220758	327	R>C		No	ClinGen ExAC TOPMed gnomAD
rs756104285 CA6047119	327	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs750407493 CA6047118	329	P>L		No	ClinGen ExAC TOPMed gnomAD
CA380966987 rs1353265564	329	P>S		No	ClinGen gnomAD
TCGA novel	331	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6047116 rs757122560	331	E>D		No	ClinGen ExAC
CA6047117 rs767502960	331	E>Q		No	ClinGen ExAC gnomAD
CA380966854 rs1247211043	337	M>V		No	ClinGen TOPMed
CA6047114 rs763784154	340	N>S		No	ClinGen ExAC gnomAD
rs1425878046 CA380966620	346	F>L		No	ClinGen gnomAD
CA380966602 rs1418015966	348	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs763992037 CA380966599	348	R>L		No	ClinGen ExAC TOPMed gnomAD
rs763992037 CA6047096	348	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	353	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1248178233 CA380966519	355	N>D		No	ClinGen gnomAD
rs752420312 CA6047094	356	A>G		No	ClinGen ExAC gnomAD
rs752420312 CA380966496	356	A>V		No	ClinGen ExAC gnomAD
CA380966470 rs1222059466	358	A>S		No	ClinGen gnomAD
rs776194268 CA6047091	362	L>H		No	ClinGen ExAC gnomAD
TCGA novel	363	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1590705988 CA380966380	365	T>P		No	ClinGen Ensembl
CA6047088 rs537780043	367	N>D		No	ClinGen ExAC TOPMed gnomAD
CA6047089 rs537780043	367	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs769084151 CA6047087	368	S>C		No	ClinGen ExAC
rs763167508 CA6047086	369	S>G		No	ClinGen ExAC gnomAD
CA380966276 rs1294285441	370	S>F		No	ClinGen gnomAD
rs775783117 CA6047085	370	S>P		No	ClinGen ExAC gnomAD
rs770207953 CA6047084	373	G>A		No	ClinGen ExAC gnomAD
TCGA novel	375	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs531635027 CA6047083	378	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781472642 CA6047082	382	L>P		No	ClinGen ExAC gnomAD
CA380966004 rs1451988963	384	F>L		No	ClinGen gnomAD
rs375447576	385	P>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA6047080 rs377564786	385	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA380965995 rs377564786	385	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1590705888 CA380965831	388	P>L		No	ClinGen Ensembl
rs933666964 CA223032901	388	P>S		No	ClinGen Ensembl
CA6047058 rs778716142	389	D>H		No	ClinGen ExAC TOPMed gnomAD
rs778716142 CA380965827	389	D>N		No	ClinGen ExAC TOPMed gnomAD
rs754724020 CA6047057	391	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA380965719 rs753508839	392	V>A		No	ClinGen ExAC TOPMed gnomAD
CA6047056 rs753508839	392	V>G		No	ClinGen ExAC TOPMed gnomAD
rs755624035 CA6047054	393	D>G		No	ClinGen ExAC
rs370127965 CA223032862	394	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed
rs1590705877 CA380965612	396	S>A		No	ClinGen Ensembl
CA6047052 rs767039896	397	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	399	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373136245 CA6047048	403	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1242764229 CA380965421	404	P>S		No	ClinGen TOPMed
rs1467091858 CA380965353	406	S>G		No	ClinGen gnomAD
CA380965290 rs1565259235	407	E>D		No	ClinGen Ensembl
CA6047046 rs575349463	407	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1234261482 CA380965291	407	E>V		No	ClinGen gnomAD
rs760949638 CA6047045	409	T>A		No	ClinGen ExAC gnomAD
rs761244656 CA6047043	411	T>M		No	ClinGen ExAC TOPMed gnomAD
rs568924560 CA223032794 COSM1231435	414	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	416	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6047041 rs774220906	417	F>S		No	ClinGen ExAC gnomAD
rs11545775 CA223032778	419	W>*		No	ClinGen Ensembl
rs1037376575 CA223032771	420	E>K		No	ClinGen Ensembl
rs1244476654 CA380964899	422	A>D		No	ClinGen gnomAD
CA380964901 rs1291875005	422	A>S		No	ClinGen gnomAD
rs749012768 CA6047039	424	Q>R		No	ClinGen ExAC gnomAD
CA6047038 rs779818188	425	H>Y		No	ClinGen ExAC gnomAD
CA223032754 rs555681172	426	V>M		No	ClinGen 1000Genomes TOPMed
rs3211579 CA223032730	427	G>C		No	ClinGen Ensembl
rs3211579 CA223032750	427	G>S		No	ClinGen Ensembl
rs369673180 CA223032688	428	K>R		No	ClinGen ESP TOPMed
CA6047034 rs190509559	429	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs186189172 CA6047033	431	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs990642606 CA223032635	432	Q>H		No	ClinGen Ensembl
rs765782856 CA6047032	432	Q>R		No	ClinGen ExAC gnomAD
rs3211580 CA223032614	435	I>M		No	ClinGen Ensembl
rs958815490 CA223032630	435	I>N		No	ClinGen Ensembl
rs3211581 CA223032606	436	F>V		No	ClinGen Ensembl
rs3211582 CA223032603	438	K>R		No	ClinGen Ensembl

No associated diseases with P26641

4 regional properties for P26641

Type	Name	Position	InterPro Accession
domain	Elongation factor 1B gamma, C-terminal	275 - 437	IPR001662
domain	Glutathione S-transferase, N-terminal	2 - 87	IPR004045
domain	Glutathione S-transferase, C-terminal	108 - 198	IPR004046
domain	Glutathione S-transferase, C-terminal-like	88 - 216	IPR010987

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
translation elongation factor activity	Functions in chain elongation during polypeptide synthesis at the ribosome.

2 GO annotations of biological process

Name	Definition
response to virus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
translational elongation	The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.

16 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2NL00	GSTT1	Glutathione S-transferase theta-1	Bos taurus (Bovine)	PR
Q3SZV3	EEF1G	Elongation factor 1-gamma	Bos taurus (Bovine)	PR
A2Q127	EEF1G	Elongation factor 1-gamma	Equus caballus (Horse)	PR
P0CG30	GSTT2B	Glutathione S-transferase theta-2B	Homo sapiens (Human)	PR
P26640	VARS1	Valine--tRNA ligase	Homo sapiens (Human)	PR
Q9Z1Q9	Vars1	Valine--tRNA ligase	Mus musculus (Mouse)	PR
Q9D8N0	Eef1g	Elongation factor 1-gamma	Mus musculus (Mouse)	PR
Q29387	EEF1G	Elongation factor 1-gamma	Sus scrofa (Pig)	PR
Q04462	Vars1	Valine--tRNA ligase	Rattus norvegicus (Rat)	PR
P30713	Gstt2	Glutathione S-transferase theta-2	Rattus norvegicus (Rat)	PR
Q68FR6	Eef1g	Elongation factor 1-gamma	Rattus norvegicus (Rat)	PR
Q5Z627	Os06g0571400	Elongation factor 1-gamma 3	Oryza sativa subsp japonica (Rice)	PR
Q9ZRI7	Os02g0220600	Elongation factor 1-gamma 1	Oryza sativa subsp japonica (Rice)	PR
Q6YW46	Os02g0220500	Elongation factor 1-gamma 2	Oryza sativa subsp japonica (Rice)	PR
P54412	eef-1G	Probable elongation factor 1-gamma	Caenorhabditis elegans	PR
Q6PE25	eef1g	Elongation factor 1-gamma	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MAAGTLYTYP	ENWRAFKALI	AAQYSGAQVR	VLSAPPHFHF	GQTNRTPEFL	RKFPAGKVPA
70	80	90	100	110	120
FEGDDGFCVF	ESNAIAYYVS	NEELRGSTPE	AAAQVVQWVS	FADSDIVPPA	STWVFPTLGI
130	140	150	160	170	180
MHHNKQATEN	AKEEVRRILG	LLDAYLKTRT	FLVGERVTLA	DITVVCTLLW	LYKQVLEPSF
190	200	210	220	230	240
RQAFPNTNRW	FLTCINQPQF	RAVLGEVKLC	EKMAQFDAKK	FAETQPKKDT	PRKEKGSREE
250	260	270	280	290	300
KQKPQAERKE	EKKAAAPAPE	EEMDECEQAL	AAEPKAKDPF	AHLPKSTFVL	DEFKRKYSNE
310	320	330	340	350	360
DTLSVALPYF	WEHFDKDGWS	LWYSEYRFPE	ELTQTFMSCN	LITGMFQRLD	KLRKNAFASV
370	380	390	400	410	420
ILFGTNNSSS	ISGVWVFRGQ	ELAFPLSPDW	QVDYESYTWR	KLDPGSEETQ	TLVREYFSWE
430
GAFQHVGKAF	NQGKIFK