P0CG30

PR
Gene name
GSTT2B (GSTT2)
Protein name
Glutathione S-transferase theta-2B
Names
Glutathione S-transferase theta-2, GST class-theta-2
Species
Homo sapiens (Human)
KEGG Pathway
hsa:653689
EC number
2.5.1.18: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

188-244 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P0CG30

Entry ID Method Resolution Chain Position Source
1LJR X-ray 320 A A/B 1-244 PDB
2LJR X-ray 320 A A/B 1-244 PDB
3LJR X-ray 330 A A/B 1-244 PDB
4MPG X-ray 195 A A/B 1-244 PDB
AF-P0CG30-F1 Predicted AlphaFoldDB

173 variants for P0CG30

Variant ID(s) Position Change Description Diseaes Association Provenance
TCGA novel 16 A>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1219201187 18 Y>C No TOPMed
rs1296363585 21 A>S No TOPMed
rs1344352868 21 A>V No TOPMed
rs1490577862 25 G>V No TOPMed
rs1223475832 29 E>G No TOPMed
rs1244829205 33 V>M No TOPMed
rs1488098577 36 V>I No TOPMed
TCGA novel 38 G>W Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1601555402 39 Q>K No Ensembl
rs768219280 40 H>Q No ExAC
TOPMed
gnomAD
rs1601555392 40 H>Y No Ensembl
rs1408689226 41 K>E No gnomAD
rs1601555386 42 S>C No Ensembl
rs1601555382 42 S>R No Ensembl
rs1485562685 44 E>G No TOPMed
rs1177801576 44 E>K No gnomAD
rs1601555371 45 F>V No Ensembl
rs748809075 49 N>H No ExAC
gnomAD
rs1569027846 51 L>M No Ensembl
rs1440965698 52 G>E No gnomAD
rs1182897778 54 L>M No gnomAD
rs1258460277 55 P>L No TOPMed
rs1412501773 56 T>M Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TOPMed
rs1316606486 59 D>N No gnomAD
rs1601555329 61 D>A No Ensembl
rs1225607623 61 D>E No TOPMed
gnomAD
rs1601555321 63 I>L No Ensembl
TCGA novel 64 L>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1601555317 65 T>S No Ensembl
rs781652428 66 E>* No ExAC
TOPMed
gnomAD
rs781652428 66 E>K No ExAC
TOPMed
gnomAD
rs1258156102 68 S>* No TOPMed
gnomAD
rs1258156102 68 S>L No TOPMed
gnomAD
TCGA novel 69 A>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1380325405 70 I>V No TOPMed
rs1485420209 76 C>Y No gnomAD
rs1277474130 77 K>T No TOPMed
rs777871541 80 T>M No ExAC
TOPMed
gnomAD
rs777871541 80 T>R No ExAC
TOPMed
gnomAD
rs1357381035 81 P>L No TOPMed
gnomAD
rs1216018726 82 D>Y No TOPMed
rs1362276717 83 H>N No TOPMed
gnomAD
rs1487022628 83 H>R No TOPMed
rs1294017931 84 W>C No gnomAD
TCGA novel 84 W>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs758408159 85 Y>H No ExAC
TOPMed
gnomAD
rs1263055755 87 S>P No TOPMed
rs1363192467 92 R>C No TOPMed
gnomAD
rs1162429390 92 R>H No gnomAD
rs1162429390 92 R>P No gnomAD
rs1601554290 93 A>V No Ensembl
rs1021931656 94 R>C No TOPMed
gnomAD
rs1021931656 94 R>G No TOPMed
gnomAD
rs1370190810 94 R>H No gnomAD
rs1427721905 97 E>A No gnomAD
rs1168219827 97 E>K No gnomAD
rs779942846 98 Y>H No ExAC
TOPMed
gnomAD
rs894869081 99 L>P No TOPMed
rs1297399062 101 W>* No TOPMed
rs1489905899 103 A>S No gnomAD
TCGA novel 103 A>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs200489938 104 D>N Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No TOPMed
gnomAD
NCI-TCGA
rs566389135 107 R>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
1000Genomes
TOPMed
gnomAD
rs750357703 107 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ExAC
TOPMed
gnomAD
NCI-TCGA
rs767289273 108 G>D No ExAC
TOPMed
gnomAD
rs761523379 109 T>I No ExAC
TOPMed
gnomAD
rs1314803938 110 F>S No TOPMed
rs1222044268 111 G>V No TOPMed
gnomAD
rs1302144216 113 P>A No TOPMed
gnomAD
rs751153388 113 P>L No ExAC
gnomAD
rs1302144216 113 P>T No TOPMed
gnomAD
rs1190611328 114 L>P No TOPMed
rs1392190679 115 W>* No gnomAD
rs1472500811 117 Q>H No TOPMed
rs138877875 118 V>M No 1000Genomes
ExAC
gnomAD
TCGA novel 120 G>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1268817153 120 G>W No TOPMed
rs763818860 121 P>S No ExAC
rs1456458048 122 L>H No TOPMed
rs752433557 123 I>F No ExAC
TOPMed
gnomAD
rs530553575 123 I>T No 1000Genomes
ExAC
TOPMed
gnomAD
rs1237781833 125 V>I No gnomAD
rs777130714 126 Q>H No ExAC
TOPMed
gnomAD
rs771408936 127 V>M No ExAC
gnomAD
rs565068798 129 E>K No 1000Genomes
TOPMed
gnomAD
rs1383161750 132 V>A No gnomAD
rs973346975 133 E>G No TOPMed
gnomAD
rs973346975 133 E>V No TOPMed
gnomAD
rs146707612 134 R>C No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs143373337 134 R>H No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1444515828 135 N>I No TOPMed
gnomAD
rs559226733 135 N>K No 1000Genomes
ExAC
TOPMed
gnomAD
rs1444515828 135 N>S No TOPMed
gnomAD
rs1190091989 136 R>G No TOPMed
gnomAD
rs1601554001 136 R>K No Ensembl
VAR_033982
rs1622002
 139 M>I No UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs781173784 139 M>T No ExAC
gnomAD
rs1208214524 139 M>V No TOPMed
rs1353801698 140 D>E No TOPMed
gnomAD
rs746773229 144 Q>R No ExAC
gnomAD
rs1284705680 145 W>C No TOPMed
gnomAD
rs1358703775 145 W>R No TOPMed
gnomAD
rs777674229 146 L>P No ExAC
gnomAD
TCGA novel 147 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs202149554 147 E>K No ExAC
rs573690145 148 D>G No 1000Genomes
ExAC
TOPMed
gnomAD
rs1400798585 150 F>L No gnomAD
TCGA novel 151 L>M Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1375437280 151 L>P No gnomAD
rs1362566248 151 L>V No TOPMed
gnomAD
rs1386475742 152 G>E No gnomAD
rs1424067822 152 G>R No gnomAD
rs766876218 153 D>E No ExAC
gnomAD
rs144128236 153 D>N No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1385296568 157 L>V No TOPMed
rs149948097 158 A>T No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1219703593 160 Q>E No TOPMed
gnomAD
rs1290526557 160 Q>H No gnomAD
rs767811348 160 Q>R No ExAC
TOPMed
gnomAD
rs762166526 161 Q>H No ExAC
TOPMed
gnomAD
rs1337241649 162 V>L No gnomAD
rs1269329480 165 A>D No gnomAD
rs1269329480 165 A>G No gnomAD
rs1601553898 167 L>H No Ensembl
TCGA novel 169 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs774549127 172 E>D No ExAC
TOPMed
gnomAD
TCGA novel 174 M>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1351721710 175 Q>H No TOPMed
rs966553592 176 P>L No TOPMed
rs1265148794 176 P>S No TOPMed
gnomAD
rs959310838 180 G>R No TOPMed
gnomAD
rs959310838 180 G>S Variant assessed as Somatic; impact. [NCI-TCGA] No TOPMed
gnomAD
NCI-TCGA
rs1261516675 182 E>K Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No TOPMed
gnomAD
NCI-TCGA
TCGA novel 182 E>Q Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1473163148 187 R>P No TOPMed
rs1473163148 187 R>Q No TOPMed
rs1223066707 187 R>W No TOPMed
gnomAD
rs1183709967 188 P>L No TOPMed
rs1368440322 189 R>* No TOPMed
gnomAD
rs1368440322 189 R>G No TOPMed
gnomAD
rs1003626883 189 R>Q No TOPMed
gnomAD
rs1440086936 191 A>S No TOPMed
gnomAD
TCGA novel 192 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1332625795 193 W>R No TOPMed
gnomAD
rs1414682437 194 R>C No TOPMed
rs1449546830 194 R>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TOPMed
rs200376763 196 R>* No 1000Genomes
ExAC
gnomAD
rs1404279804 196 R>Q No TOPMed
gnomAD
TCGA novel 201 L>M Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1311012108 201 L>P No TOPMed
rs1285888925 204 E>K Variant assessed as Somatic; impact. [NCI-TCGA] No TOPMed
NCI-TCGA
rs1413502775 207 Q>R No gnomAD
TCGA novel 209 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1601553608 210 H>Y No Ensembl
TCGA novel 213 I>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1601553602 218 E>A No Ensembl
rs1235767844 219 Q>* No TOPMed
rs1482985302 220 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TOPMed
rs1468149272 224 T>I Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
gnomAD
TCGA novel 225 L>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1601553592 225 L>R No Ensembl
rs1601553588 226 P>Q No Ensembl
rs1237559707 228 P>L No TOPMed
gnomAD
TCGA novel 231 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 232 A>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1179119399 234 Q>E No TOPMed
gnomAD
rs1332115451 239 R>* Variant assessed as Somatic; impact. [NCI-TCGA] No TOPMed
NCI-TCGA
rs1458932518 239 R>Q No gnomAD
rs1358027603 240 I>N No TOPMed
rs201431473 241 A>T No 1000Genomes
TOPMed
gnomAD
rs1203302388 244 P>S No gnomAD
TCGA novel 245 P>= Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA

No associated diseases with P0CG30

5 regional properties for P0CG30

Type Name Position InterPro Accession
domain Glutathione S-transferase, N-terminal 1 - 82 IPR004045
domain Glutathione S-transferase, C-terminal 127 - 198 IPR004046
domain Glutathione S-transferase, C-terminal-like 88 - 224 IPR010987
domain Glutathione S-transferase Theta, N-terminal 3 - 78 IPR040075
domain Glutathione S-transferase Theta, C-terminal 91 - 216 IPR040077

Functions

Description
EC Number 2.5.1.18 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name Definition
glutathione transferase activity Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.

1 GO annotations of biological process

Name Definition
glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZV3 EEF1G Elongation factor 1-gamma Bos taurus (Bovine) PR
Q2NL00 GSTT1 Glutathione S-transferase theta-1 Bos taurus (Bovine) PR
P26641 EEF1G Elongation factor 1-gamma Homo sapiens (Human) PR
P26640 VARS1 Valine--tRNA ligase Homo sapiens (Human) PR
P0CG29 GSTT2 Glutathione S-transferase theta-2 Homo sapiens (Human) PR
Q9Z1Q9 Vars1 Valine--tRNA ligase Mus musculus (Mouse) PR
Q9D8N0 Eef1g Elongation factor 1-gamma Mus musculus (Mouse) PR
Q29387 EEF1G Elongation factor 1-gamma Sus scrofa (Pig) PR
Q04462 Vars1 Valine--tRNA ligase Rattus norvegicus (Rat) PR
Q68FR6 Eef1g Elongation factor 1-gamma Rattus norvegicus (Rat) PR
P30713 Gstt2 Glutathione S-transferase theta-2 Rattus norvegicus (Rat) PR
Q6YW46 Os02g0220500 Elongation factor 1-gamma 2 Oryza sativa subsp japonica (Rice) PR
Q9ZRI7 Os02g0220600 Elongation factor 1-gamma 1 Oryza sativa subsp japonica (Rice) PR
Q5Z627 Os06g0571400 Elongation factor 1-gamma 3 Oryza sativa subsp japonica (Rice) PR
P54412 eef-1G Probable elongation factor 1-gamma Caenorhabditis elegans PR
Q6PE25 eef1g Elongation factor 1-gamma Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS LGKLPTLKDG
70 80 90 100 110 120
DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG WHADCIRGTF GIPLWVQVLG
130 140 150 160 170 180
PLIGVQVPEE KVERNRTAMD QALQWLEDKF LGDRPFLAGQ QVTLADLMAL EELMQPVALG
190 200 210 220 230 240
YELFEGRPRL AAWRGRVEAF LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI
ARIP