Q9WVC5

PR
Gene name
Trpc7 (Trp7, Trrp8)
Protein name
Short transient receptor potential channel 7
Names
TrpC7, Transient receptor protein 7, TRP-7, mTRP7
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:26946
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9WVC5

Entry ID Method Resolution Chain Position Source
AF-Q9WVC5-F1 Predicted AlphaFoldDB

40 variants for Q9WVC5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389289773 23 R>H No EVA
rs3389298013 74 V>M No EVA
rs3404525141 124 A>V No EVA
rs3403453567 126 L>H No EVA
rs3389289903 176 E>* No EVA
rs3404231528 238 P>R No EVA
rs3403991466 238 P>T No EVA
rs3404390646 240 L>F No EVA
rs3389287152 261 N>S No EVA
rs3389215110 284 T>K No EVA
rs3389244396 289 A>E No EVA
rs3389260510 292 N>Y No EVA
rs3389260581 294 D>N No EVA
rs3389270776 310 R>L No EVA
rs3389282577 383 S>N No EVA
rs3389284533 414 K>N No EVA
rs3389244366 459 W>R No EVA
rs3389215064 467 V>M No EVA
rs3389297997 500 Q>E No EVA
rs3389284477 502 Y>* No EVA
rs3389293710 519 P>Q No EVA
rs3389289709 521 V>A No EVA
rs3389280136 597 M>V No EVA
rs3389286791 633 V>A No EVA
rs3402806018 639 K>* No EVA
rs3404524329 640 Y>* No EVA
rs3412921390 640 Y>S No EVA
rs3404316182 669 I>T No EVA
rs3389282567 730 I>K No EVA
rs3402806022 748 M>I No EVA
rs3403990322 748 M>T No EVA
rs3403450900 751 S>F No EVA
rs3404220371 752 K>E No EVA
rs3389284531 770 A>V No EVA
rs3389284495 782 K>R No EVA
rs3389284545 818 S>R No EVA
rs3389270786 842 S>I No EVA
rs3389289772 844 K>M No EVA
rs3389253557 845 F>L No EVA
rs3389289766 853 H>P No EVA

No associated diseases with Q9WVC5

5 regional properties for Q9WVC5

Type Name Position InterPro Accession
repeat Ankyrin repeat 42 - 71 IPR002110-1
repeat Ankyrin repeat 77 - 105 IPR002110-2
repeat Ankyrin repeat 163 - 192 IPR002110-3
domain Ion transport domain 393 - 683 IPR005821
domain Transient receptor ion channel domain 198 - 260 IPR013555

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Nucleus envelope
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cation channel complex An ion channel complex through which cations pass.
cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

2 GO annotations of molecular function

Name Definition
inositol 1,4,5 trisphosphate binding Binding to inositol 1,4,5 trisphosphate.
store-operated calcium channel activity A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.

4 GO annotations of biological process

Name Definition
calcium ion transmembrane transport A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
manganese ion transport The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of cytosolic calcium ion concentration Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
single fertilization The union of male and female gametes to form a zygote.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O18784 TRPC1 Short transient receptor potential channel 1 Bos taurus (Bovine) PR
P79100 TRPC4 Short transient receptor potential channel 4 Bos taurus (Bovine) PR
P19334 trp Transient receptor potential protein Drosophila melanogaster (Fruit fly) PR
P48994 trpl Transient-receptor-potential-like protein Drosophila melanogaster (Fruit fly) PR
Q9UL62 TRPC5 Short transient receptor potential channel 5 Homo sapiens (Human) PR
Q9Y210 TRPC6 Short transient receptor potential channel 6 Homo sapiens (Human) PR
Q13507 TRPC3 Short transient receptor potential channel 3 Homo sapiens (Human) PR
Q9UBN4 TRPC4 Short transient receptor potential channel 4 Homo sapiens (Human) PR
P48995 TRPC1 Short transient receptor potential channel 1 Homo sapiens (Human) PR
Q9HCX4 TRPC7 Short transient receptor potential channel 7 Homo sapiens (Human) PR
Q61143 Trpc6 Short transient receptor potential channel 6 Mus musculus (Mouse) PR
Q9QX29 Trpc5 Short transient receptor potential channel 5 Mus musculus (Mouse) PR
Q9R244 Trpc2 Short transient receptor potential channel 2 Mus musculus (Mouse) PR
Q61056 Trpc1 Short transient receptor potential channel 1 Mus musculus (Mouse) PR
Q9QUQ5 Trpc4 Short transient receptor potential channel 4 Mus musculus (Mouse) PR
Q9QZC1 Trpc3 Short transient receptor potential channel 3 Mus musculus (Mouse) PR
Q9QX01 Trpc1 Short transient receptor potential channel 1 Rattus norvegicus (Rat) PR
O35119 Trpc4 Short transient receptor potential channel 4 Rattus norvegicus (Rat) PR
Q9JMI9 Trpc3 Short transient receptor potential channel 3 Rattus norvegicus (Rat) PR
Q9R283 Trpc2 Short transient receptor potential channel 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MLGSNTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS AEYGNIPVVR
70 80 90 100 110 120
KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK ENLARVGDAL LLAISKGYVR
130 140 150 160 170 180
IVEAILSHPA FAQGQRLTLS PLEQELRDDD FYAYDEDGTR FSHDITPIIL AAHCQEYEIV
190 200 210 220 230 240
HILLLKGARI ERPHDYFCKC NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL
250 260 270 280 290 300
TALELSNELA RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNLQVW
310 320 330 340 350 360
SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV KFLAVFGVSI
370 380 390 400 410 420
GLPFLAIAYW IAPCSKLGQT LRSPFMKFVA HAVSFTIFLG LLVVNASDRF EGVKTLPNET
430 440 450 460 470 480
FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM IWSECKEIWE EGPREYVLHL WNLLDFGMLS
490 500 510 520 530 540
IFVASFTARF MAFLKASEAQ LYVDQYVQDV TLHNVSLPPE VAYFTYARDK WWPSDPQIIS
550 560 570 580 590 600
EGLYAIAVVL SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL
610 620 630 640 650 660
YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY VLYGVYNVTM
670 680 690 700 710 720
VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD EGRTLPAPFN LVPSPKSFYY
730 740 750 760 770 780
LIMRIKMCLI ELCQSKAKRC ENDLEMGMLN SKFRKTRYQA GMRNSENLTA NSTFSKPTRY
790 800 810 820 830 840
QKIMKRLIKR YVLKAQVDRE NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ
850 860
LSEKFGKNLN KDHLRVNQGK DI