Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35119
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35119-F1 | Predicted | AlphaFoldDB |
No variants for O35119
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O35119 | |||||
No associated diseases with O35119
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| calcium channel complex | An ion channel complex through which calcium ions pass. |
| cation channel complex | An ion channel complex through which cations pass. |
| caveola | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cortical cytoskeleton | The portion of the cytoskeleton that lies just beneath the plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-catenin binding | Binding to a catenin beta subunit. |
| cadherin binding | Binding to cadherin, a type I membrane protein involved in cell adhesion. |
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| inositol 1,4,5 trisphosphate binding | Binding to inositol 1,4,5 trisphosphate. |
| store-operated calcium channel activity | A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion import | The directed movement of calcium ions into a cell or organelle. |
| calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| gamma-aminobutyric acid secretion | The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues. |
| manganese ion transport | The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| oligodendrocyte differentiation | The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. |
| positive regulation of store-operated calcium entry | Any process that activates or increases the frequency, rate or extent of store-operated calcium entry. |
| regulation of action potential firing rate | Any process that regulates the frequency of action potentials in a spike train. |
| regulation of calcium ion transport | Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of cytosolic calcium ion concentration | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18784 | TRPC1 | Short transient receptor potential channel 1 | Bos taurus (Bovine) | PR |
| P79100 | TRPC4 | Short transient receptor potential channel 4 | Bos taurus (Bovine) | PR |
| P19334 | trp | Transient receptor potential protein | Drosophila melanogaster (Fruit fly) | PR |
| P48994 | trpl | Transient-receptor-potential-like protein | Drosophila melanogaster (Fruit fly) | PR |
| Q9UL62 | TRPC5 | Short transient receptor potential channel 5 | Homo sapiens (Human) | PR |
| Q9Y210 | TRPC6 | Short transient receptor potential channel 6 | Homo sapiens (Human) | PR |
| Q13507 | TRPC3 | Short transient receptor potential channel 3 | Homo sapiens (Human) | PR |
| P48995 | TRPC1 | Short transient receptor potential channel 1 | Homo sapiens (Human) | PR |
| Q9HCX4 | TRPC7 | Short transient receptor potential channel 7 | Homo sapiens (Human) | PR |
| Q9UBN4 | TRPC4 | Short transient receptor potential channel 4 | Homo sapiens (Human) | PR |
| Q9WVC5 | Trpc7 | Short transient receptor potential channel 7 | Mus musculus (Mouse) | PR |
| Q9QZC1 | Trpc3 | Short transient receptor potential channel 3 | Mus musculus (Mouse) | PR |
| Q9QX29 | Trpc5 | Short transient receptor potential channel 5 | Mus musculus (Mouse) | PR |
| Q61143 | Trpc6 | Short transient receptor potential channel 6 | Mus musculus (Mouse) | PR |
| Q9R244 | Trpc2 | Short transient receptor potential channel 2 | Mus musculus (Mouse) | PR |
| Q61056 | Trpc1 | Short transient receptor potential channel 1 | Mus musculus (Mouse) | PR |
| Q9QUQ5 | Trpc4 | Short transient receptor potential channel 4 | Mus musculus (Mouse) | PR |
| Q9JMI9 | Trpc3 | Short transient receptor potential channel 3 | Rattus norvegicus (Rat) | PR |
| Q9QX01 | Trpc1 | Short transient receptor potential channel 1 | Rattus norvegicus (Rat) | PR |
| Q9R283 | Trpc2 | Short transient receptor potential channel 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQFYYKRNV | NAPYRDRIPL | RIVRAESELS | PSEKAYLNAV | EKGDYASVKK | SLEEAEIYFK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ININCIDPLG | RTALLIAIEN | ENLELIELLL | SFNVYVGDAL | LHAIRKEVVG | AVELLLNHKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSGEKQVPPI | LLDKQFSEFT | PDITPIILAA | HTNNYEIIKL | LVQKGVSVPR | PHEVRCNCVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CVSSSDVDSL | RHSRSRLNIY | KALASPSLIA | LSSEDPFLTA | FQLSWELQEL | SKVENEFKSE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YEELSRQCKQ | FAKDLLDQTR | SSRELEIILN | YRDDNSLIEE | QSGNDLARLK | LAIKYRQKEF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VAQPNCQQLL | ASRWYDEFPG | WRRRHWAVKM | VTCFIIGLLF | PVFSVCYLIA | PKSPLGLFIR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KPFIKFICHT | ASYLTFLFLL | LLASQHIDRS | DLNRQGPPPT | IVEWMILPWV | LGFIWGEIKQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MWDGGLQDYI | HDWWNLMDFV | MNSLYLATIS | LKIVAFVKYS | ALNPRESWDM | WHPTLVAEAL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FAIANIFSSL | RLISLFTANS | HLGPLQISLG | RMLLDILKFL | FIYCLVLLAF | ANGLNQLYFY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YEETKGLSCK | GIRCEKQNNA | FSTLFETLQS | LFWSIFGLIN | LYVTNVKAQH | EFTDFVGATM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FGTYNVISLV | VLLNMLIAMM | NNSYQLIADH | ADIEWKFART | KLWMSYFEEG | GTLPTPFNVI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PSPKSLWYLV | KWIWTHLCKK | KMRRKPESFG | TIGRRAADNL | RRHHQYQEVM | RNLVKRYVAA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MIREAKTEEG | LTEENVKELK | QDISSFRFEV | LGLLRGSKLS | TIQSANAASS | ASSADSDEKS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| HSEGNGKDKR | KNLSLFDLTT | LIHPRSAVIA | SERHNLSNGS | ALVVQEPPRE | KQRKVNFVAD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IKNFGLFHRR | SKQNAAEQNA | NQIFSVSEEI | TRQQAAGALE | RNIQLESKGL | ASRGDRSIPG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LNEQCVLVDH | RERNTDTLGL | QVGKRVCSSF | KSEKVVVEDT | VPIIPKEKHA | QEEDSSIDYD |
| 970 | |||||
| LSPTDTVAHE | DYVTTRL |