Q9QX29
PR
Gene name |
Trpc5 (Trp5, Trrp5) |
Protein name |
Short transient receptor potential channel 5 |
Names |
TrpC5, Capacitative calcium entry channel 2, CCE2, Transient receptor protein 5, TRP-5, mTRP5, Trp-related protein 5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:22067 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9QX29
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6AEI | EM | 289 A | A/B/C/D | 1-765 | PDB |
| AF-Q9QX29-F1 | Predicted | AlphaFoldDB |
51 variants for Q9QX29
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3412458735 | 6 | Y>H | No | EVA | |
| rs3389577093 | 16 | D>Y | No | EVA | |
| rs3389544281 | 29 | L>M | No | EVA | |
| rs3412458739 | 38 | S>G | No | EVA | |
| rs3410789984 | 82 | N>Y | No | EVA | |
| rs3389557499 | 86 | M>L | No | EVA | |
| rs3412190668 | 103 | A>LLADGVE* | No | EVA | |
| rs3389544244 | 109 | V>I | No | EVA | |
| rs3389570937 | 122 | S>N | No | EVA | |
| rs3412374251 | 131 | M>V | No | EVA | |
| rs3409508079 | 133 | D>N | No | EVA | |
| rs3412374225 | 195 | S>Y | No | EVA | |
| rs3412374236 | 240 | E>Q | No | EVA | |
| rs3412151381 | 242 | E>* | No | EVA | |
| rs3412457615 | 247 | Q>P | No | EVA | |
| rs3389588098 | 304 | Q>L | No | EVA | |
| rs3412188539 | 310 | L>G | No | EVA | |
| rs3389577852 | 323 | R>P | No | EVA | |
| rs3412051190 | 324 | R>K | No | EVA | |
| rs3389570985 | 329 | V>I | No | EVA | |
| rs3389485936 | 339 | F>L | No | EVA | |
| rs3389591089 | 387 | H>R | No | EVA | |
| rs3389581187 | 400 | P>L | No | EVA | |
| rs3389577827 | 431 | I>T | No | EVA | |
| rs3389571355 | 534 | G>V | No | EVA | |
| rs3389573364 | 543 | E>A | No | EVA | |
| rs3389571413 | 547 | I>F | No | EVA | |
| rs3389527432 | 568 | L>I | No | EVA | |
| rs3389577817 | 633 | D>N | No | EVA | |
| rs3411813262 | 652 | D>G | No | EVA | |
| rs3412372323 | 655 | G>A | No | EVA | |
| rs3389578358 | 656 | T>A | No | EVA | |
| rs3411813292 | 700 | T>I | No | EVA | |
| rs3389535050 | 713 | Y>N | No | EVA | |
| rs3389588070 | 717 | I>M | No | EVA | |
| rs3411400402 | 727 | A>S | No | EVA | |
| rs3389527374 | 760 | L>H | No | EVA | |
| rs3411813257 | 790 | G>R | No | EVA | |
| rs3410787488 | 802 | V>L | No | EVA | |
| rs3411400330 | 808 | A>T | No | EVA | |
| rs3411400380 | 808 | A>V | No | EVA | |
| rs3389585802 | 820 | R>I | No | EVA | |
| rs253553874 | 824 | A>T | No | EVA | |
| rs3389573329 | 876 | H>N | No | EVA | |
| rs29282906 | 877 | C>Y | No | EVA | |
| rs3389588023 | 887 | M>K | No | EVA | |
| rs29282908 | 899 | Q>E | No | EVA | |
| rs3412151698 | 919 | E>K | No | EVA | |
| rs3389557526 | 921 | P>T | No | EVA | |
| rs3412279076 | 965 | D>G | No | EVA | |
| rs3389544214 | 969 | E>A | No | EVA |
No associated diseases with Q9QX29
4 regional properties for Q9QX29
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Ankyrin repeat | 38 - 118 | IPR002110-1 |
| repeat | Ankyrin repeat | 141 - 170 | IPR002110-2 |
| domain | Ion transport domain | 376 - 635 | IPR005821 |
| domain | Transient receptor ion channel domain | 176 - 238 | IPR013555 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| calcium channel complex | An ion channel complex through which calcium ions pass. |
| cation channel complex | An ion channel complex through which cations pass. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| growth cone | The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| actinin binding | Binding to actinin, any member of a family of proteins that crosslink F-actin. |
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| clathrin binding | Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. |
| inositol 1,4,5 trisphosphate binding | Binding to inositol 1,4,5 trisphosphate. |
| store-operated calcium channel activity | A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| manganese ion transport | The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| negative regulation of dendrite morphogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. |
| neuron apoptotic process | Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| phosphatidylserine exposure on apoptotic cell surface | A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity. |
| positive regulation of axon extension | Any process that activates or increases the frequency, rate or extent of axon extension. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| positive regulation of neuron differentiation | Any process that activates or increases the frequency, rate or extent of neuron differentiation. |
| positive regulation of peptidyl-threonine phosphorylation | Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| regulation of cytosolic calcium ion concentration | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. |
| regulation of membrane hyperpolarization | Any process that modulates the frequency, rate or extent of membrane hyperpolarization. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18784 | TRPC1 | Short transient receptor potential channel 1 | Bos taurus (Bovine) | PR |
| P79100 | TRPC4 | Short transient receptor potential channel 4 | Bos taurus (Bovine) | PR |
| P19334 | trp | Transient receptor potential protein | Drosophila melanogaster (Fruit fly) | PR |
| P48994 | trpl | Transient-receptor-potential-like protein | Drosophila melanogaster (Fruit fly) | PR |
| Q9Y210 | TRPC6 | Short transient receptor potential channel 6 | Homo sapiens (Human) | PR |
| Q13507 | TRPC3 | Short transient receptor potential channel 3 | Homo sapiens (Human) | PR |
| Q9UBN4 | TRPC4 | Short transient receptor potential channel 4 | Homo sapiens (Human) | PR |
| P48995 | TRPC1 | Short transient receptor potential channel 1 | Homo sapiens (Human) | PR |
| Q9HCX4 | TRPC7 | Short transient receptor potential channel 7 | Homo sapiens (Human) | PR |
| Q9UL62 | TRPC5 | Short transient receptor potential channel 5 | Homo sapiens (Human) | PR |
| Q61143 | Trpc6 | Short transient receptor potential channel 6 | Mus musculus (Mouse) | PR |
| Q9WVC5 | Trpc7 | Short transient receptor potential channel 7 | Mus musculus (Mouse) | PR |
| Q9R244 | Trpc2 | Short transient receptor potential channel 2 | Mus musculus (Mouse) | PR |
| Q61056 | Trpc1 | Short transient receptor potential channel 1 | Mus musculus (Mouse) | PR |
| Q9QUQ5 | Trpc4 | Short transient receptor potential channel 4 | Mus musculus (Mouse) | PR |
| Q9QZC1 | Trpc3 | Short transient receptor potential channel 3 | Mus musculus (Mouse) | PR |
| Q9QX01 | Trpc1 | Short transient receptor potential channel 1 | Rattus norvegicus (Rat) | PR |
| O35119 | Trpc4 | Short transient receptor potential channel 4 | Rattus norvegicus (Rat) | PR |
| Q9JMI9 | Trpc3 | Short transient receptor potential channel 3 | Rattus norvegicus (Rat) | PR |
| Q9R283 | Trpc2 | Short transient receptor potential channel 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQLYYKKVN | YSPYRDRIPL | QIVRAETELS | AEEKAFLSAV | EKGDYATVKQ | ALQEAEIYYN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VNINCMDPLG | RSALLIAIEN | ENLEIMELLL | NHSVYVGDAL | LYAIRKEVVG | AVELLLSYRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSGEKQVPTL | MMDTQFSEFT | PDITPIMLAA | HTNNYEIIKL | LVQKRVTIPR | PHQIRCNCVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CVSSSEVDSL | RHSRSRLNIY | KALASPSLIA | LSSEDPILTA | FRLGWELKEL | SKVENEFKAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YEELSQQCKL | FAKDLLDQAR | SSRELEIILN | HRDDHSEELD | PQKYHDLAKL | KVAIKYHQKE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FVAQPNCQQL | LATLWYDGFP | GWRRKHWVVK | LLTCMTIGFL | FPMLSIAYLI | SPRSNLGLFI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KKPFIKFICH | TASYLTFLFM | LLLASQHIVR | TDLHVQGPPP | TVVEWMILPW | VLGFIWGEIK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EMWDGGFTEY | IHDWWNLMDF | AMNSLYLATI | SLKIVAYVKY | NGSRPREEWE | MWHPTLIAEA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LFAISNILSS | LRLISLFTAN | SHLGPLQISL | GRMLLDILKF | LFIYCLVLLA | FANGLNQLYF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YYETRAIDEP | NNCKGIRCEK | QNNAFSTLFE | TLQSLFWSVF | GLLNLYVTNV | KARHEFTEFV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GATMFGTYNV | ISLVVLLNML | IAMMNNSYQL | IADHADIEWK | FARTKLWMSY | FDEGGTLPPP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FNIIPSPKSF | LYLGNWFNNT | FCPKRDPDGR | RRRHNLRSFT | ERHADSLIQN | QHYQEVIRNL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VKRYVAAMIR | NSKTNEGLTE | ENFKELKQDI | SSFRYEVLDL | LGNRKHPRRS | LSTSSADFSQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RDDTNDGSGG | ARAKSKSVSF | NVGCKKKACH | GAPLIRTVPR | ASGAQGKPKS | ESSSKRSFMG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PSFKKLGLFF | SKFNGQTSEP | TSEPMYTISD | GIAQQHCMWQ | DIRYSQMEKG | KAEACSQSQM |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NLGEVELGEI | RGAAARSSEC | PLACSSSLHC | ASGICSSNSK | LLDSSEDVFE | TWGEACDLLM |
| 970 | |||||
| HKWGDGQEEQ | VTTRL |