Q9R283
PR
Gene name |
Trpc2 (Trp2) |
Protein name |
Short transient receptor potential channel 2 |
Names |
TrpC2, Transient receptor protein 2, TRP-2, rTrp2 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:102549471 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9R283
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9R283-F1 | Predicted | AlphaFoldDB |
4 variants for Q9R283
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs105534818 | 27 | I>T | No | EVA | |
| rs3319084495 | 1004 | G>E | No | EVA | |
| rs106099332 | 1010 | H>R | No | EVA | |
| rs198373979 | 1169 | E>* | No | EVA |
No associated diseases with Q9R283
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cation channel complex | An ion channel complex through which cations pass. |
| dendrite membrane | The portion of the plasma membrane surrounding a dendrite. |
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| damaged DNA binding | Binding to damaged DNA. |
| diacylglycerol binding | Binding to a diacylglycerol, a diester of glycerol and two fatty acids. |
| inositol 1,4,5 trisphosphate binding | Binding to inositol 1,4,5 trisphosphate. |
| store-operated calcium channel activity | A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| acrosome reaction | The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida. |
| calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| female courtship behavior | The behavior of a female, for the purpose of attracting a sexual partner. |
| inter-male aggressive behavior | Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious. |
| manganese ion transport | The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| mating behavior, sex discrimination | The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner. |
| negative regulation of male mating behavior | Any process that stops, prevents or reduces the frequency, rate or extent of male mating behavior. |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| regulation of cytosolic calcium ion concentration | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| response to pheromone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. |
| single fertilization | The union of male and female gametes to form a zygote. |
| single strand break repair | The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. |
| territorial aggressive behavior | Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18784 | TRPC1 | Short transient receptor potential channel 1 | Bos taurus (Bovine) | PR |
| P79100 | TRPC4 | Short transient receptor potential channel 4 | Bos taurus (Bovine) | PR |
| P19334 | trp | Transient receptor potential protein | Drosophila melanogaster (Fruit fly) | PR |
| P48994 | trpl | Transient-receptor-potential-like protein | Drosophila melanogaster (Fruit fly) | PR |
| Q9UL62 | TRPC5 | Short transient receptor potential channel 5 | Homo sapiens (Human) | PR |
| Q9Y210 | TRPC6 | Short transient receptor potential channel 6 | Homo sapiens (Human) | PR |
| Q13507 | TRPC3 | Short transient receptor potential channel 3 | Homo sapiens (Human) | PR |
| Q9UBN4 | TRPC4 | Short transient receptor potential channel 4 | Homo sapiens (Human) | PR |
| P48995 | TRPC1 | Short transient receptor potential channel 1 | Homo sapiens (Human) | PR |
| Q9HCX4 | TRPC7 | Short transient receptor potential channel 7 | Homo sapiens (Human) | PR |
| Q9WVC5 | Trpc7 | Short transient receptor potential channel 7 | Mus musculus (Mouse) | PR |
| Q9QZC1 | Trpc3 | Short transient receptor potential channel 3 | Mus musculus (Mouse) | PR |
| Q9QUQ5 | Trpc4 | Short transient receptor potential channel 4 | Mus musculus (Mouse) | PR |
| Q9QX29 | Trpc5 | Short transient receptor potential channel 5 | Mus musculus (Mouse) | PR |
| Q61143 | Trpc6 | Short transient receptor potential channel 6 | Mus musculus (Mouse) | PR |
| Q61056 | Trpc1 | Short transient receptor potential channel 1 | Mus musculus (Mouse) | PR |
| Q9R244 | Trpc2 | Short transient receptor potential channel 2 | Mus musculus (Mouse) | PR |
| O35119 | Trpc4 | Short transient receptor potential channel 4 | Rattus norvegicus (Rat) | PR |
| Q9JMI9 | Trpc3 | Short transient receptor potential channel 3 | Rattus norvegicus (Rat) | PR |
| Q9QX01 | Trpc1 | Short transient receptor potential channel 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLMSLTDSKE | GKNRSGVRMF | KDDDFLIPAS | GESWDRLRLT | CSQPFTRHQS | FGLAFLRVRS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLDSLSDPVK | DPSSPGSSGL | NQNSSDKLES | DPSPWLTNPS | IRRTFFPDPQ | TSTKEISALK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GMLKQLQPGP | LGRAARMVLS | AAHKAPPASV | VSPNNSHGEP | DSSHPERAEP | RAEEPNRKNN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ASRGKRRKVQ | EQRRPLSSSS | SQPNRRATGR | TKQRQQRPQA | KSDGSGVQAT | GQCPICTGSF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SIEALPRHAA | TCGESSPPQP | ASPTSLSSSE | SVLRCLHVAL | TPVPLIPKPN | WTEIVNKKLK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FPPTLLRAIQ | EGQLGLVQQL | LESGSDPSGA | GPGGPLRNVE | ESEDRSWREA | LNLAIRLGHE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VITDVLLANV | KFDFRQIHEA | LLVAVDTNQP | AVVRRLLARL | EREKGRKVDT | KSFSLAFFDS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SIDGSRFAPG | VTPLTLACQK | DLYEIAQLLM | DQGHTIARPH | PVSCACLECS | NARRYDLLKF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SLSRINTYRG | IASRAHLSLA | SEDAMLAAFQ | LSRELRRLAR | KEPEFKPQYI | ALESLCQDYG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FELLGMCRNQ | SEVTAVLNDL | GEDSETEPEA | EGLGQAFEEG | IPNLARLRLA | VNYNQKQFVA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HPICQQVLSS | IWCGNLAGWR | GSTTIWKLFV | AFLIFLTMPF | LCIGYWLAPK | SRLGRLLKIP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VLKFLLHSAS | YLWFLIFLLG | ESLVMETQLS | TFKGRSQSVW | ETSLHMIWVT | GFLWFECKEV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| WIEGLRSYLL | DWWNFLDVVI | LSLYLASFAL | RLLLAGLAYM | HCRDASDSST | CRYFTTAERS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EWRTEDPQFL | AEVLFAVTSM | LSFTRLAYIL | PAHESLGTLQ | ISIGKMIDDM | IRFMFILMII |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LTAFLCGLNN | IYVPYQETEK | LGNFNETFQF | LFWTMFGMEE | HSVVDMPQFL | VPEFVGRAMY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GIFTIVMVIV | LLNMLIAMIT | NSFQKIEDDA | DVEWKFARSK | LYLSYFREGL | TLPVPFNILP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SPKAAFYLLR | RIFRFICCGS | SCCKAKKSDY | PPIPTFTNPG | ARAGPGEGEH | VSYRLRVIKA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LVQRYIETAR | REFEETRRKD | LGNRLTELTK | TVSRLQSEVA | SVQKTVAAGG | ALRPPDGASI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LSRYITRVRN | SFQNLGPPAP | DTPAELTMPG | IVETEVSLED | SLDATGEAGT | PASGESSSSS |
| 1150 | 1160 | ||||
| SAHVLVHREQ | EAEGAGDLPL | GEDLETKGES |