O18784
Gene name |
TRPC1 (TRP1) |
Protein name |
Short transient receptor potential channel 1 |
Names |
TrpC1, Transient receptor protein 1, TRP-1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282100 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O18784
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O18784-F1 | Predicted | AlphaFoldDB |
No variants for O18784
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O18784 | |||||
No associated diseases with O18784
5 regional properties for O18784
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Ankyrin repeat | 46 - 77 | IPR002110-1 |
| repeat | Ankyrin repeat | 83 - 113 | IPR002110-2 |
| repeat | Ankyrin repeat | 158 - 187 | IPR002110-3 |
| domain | Ion transport domain | 394 - 656 | IPR005821 |
| domain | Transient receptor ion channel domain | 193 - 255 | IPR013555 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cation channel complex | An ion channel complex through which cations pass. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| inositol 1,4,5 trisphosphate binding | Binding to inositol 1,4,5 trisphosphate. |
| store-operated calcium channel activity | A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| manganese ion transport | The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of cytosolic calcium ion concentration | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P79100 | TRPC4 | Short transient receptor potential channel 4 | Bos taurus (Bovine) | PR |
| P19334 | trp | Transient receptor potential protein | Drosophila melanogaster (Fruit fly) | PR |
| P48994 | trpl | Transient-receptor-potential-like protein | Drosophila melanogaster (Fruit fly) | PR |
| Q9UL62 | TRPC5 | Short transient receptor potential channel 5 | Homo sapiens (Human) | PR |
| Q9Y210 | TRPC6 | Short transient receptor potential channel 6 | Homo sapiens (Human) | PR |
| Q13507 | TRPC3 | Short transient receptor potential channel 3 | Homo sapiens (Human) | PR |
| Q9UBN4 | TRPC4 | Short transient receptor potential channel 4 | Homo sapiens (Human) | PR |
| Q9HCX4 | TRPC7 | Short transient receptor potential channel 7 | Homo sapiens (Human) | PR |
| P48995 | TRPC1 | Short transient receptor potential channel 1 | Homo sapiens (Human) | PR |
| Q9WVC5 | Trpc7 | Short transient receptor potential channel 7 | Mus musculus (Mouse) | PR |
| Q9QZC1 | Trpc3 | Short transient receptor potential channel 3 | Mus musculus (Mouse) | PR |
| Q9QUQ5 | Trpc4 | Short transient receptor potential channel 4 | Mus musculus (Mouse) | PR |
| Q9QX29 | Trpc5 | Short transient receptor potential channel 5 | Mus musculus (Mouse) | PR |
| Q61143 | Trpc6 | Short transient receptor potential channel 6 | Mus musculus (Mouse) | PR |
| Q9R244 | Trpc2 | Short transient receptor potential channel 2 | Mus musculus (Mouse) | PR |
| Q61056 | Trpc1 | Short transient receptor potential channel 1 | Mus musculus (Mouse) | PR |
| O35119 | Trpc4 | Short transient receptor potential channel 4 | Rattus norvegicus (Rat) | PR |
| Q9JMI9 | Trpc3 | Short transient receptor potential channel 3 | Rattus norvegicus (Rat) | PR |
| Q9R283 | Trpc2 | Short transient receptor potential channel 2 | Rattus norvegicus (Rat) | PR |
| Q9QX01 | Trpc1 | Short transient receptor potential channel 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMAALYPSTD | LSGASSSSLP | SSPSSSSPNE | VMALKDVREV | KEENTLNEKL | FLLACDKGDY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YMVKEILEEN | SSGDLNINCV | DVLGRNAVTI | TIENENLDIL | QLLLDYGCQS | ADALLVAIDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVVGAVDILL | NHRPKRSSRP | TIVKLMERIQ | NPEYSTTMDV | APVILAAHRN | NYEILTMLLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QDVSLPKPHA | VGCECTLCSA | KNKKDSLRHS | RFRLDIYRCL | ASPALIMLTE | EDPILGAFEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SADLKELSLV | EVEFRNDYEE | LARQCKMFAK | DLLAQARNSR | ELEVILNHTS | NDEPLDKRGL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEERMNLSRL | KLAIKYNQKE | FVSQSNCQQF | LNTVWFGQMS | GYRRKPTCKK | IMTVLTVGIF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WPVLSLCYLI | APKSQFGRII | HTPFMKFIIH | GASYFTFLLL | LNLYSLVYHE | DKKNTMGPAL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ERIDYLLILW | IIGMIWSDIK | RLWYEGLEDF | LEESRNQLSF | VMNSLYLATF | ALKEEAHNKF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HDFADRKDWD | AFHPTLVAEG | LFAFANVLSY | LRLFFYVYTS | SILGPLQISM | GRMLQDFGKF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LGMFLLVLFS | FTIGLTQLYD | KGYTPKEQKD | CVGIFCEQQS | NDTFHSFIGT | CFALFWYIFS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LAHVAILCTR | FSYGEELQSF | VGAFIVGTYN | VVVVIVLTKL | LVAMLHKSFQ | LIANHEDKEW |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KFARAKLWLS | YFDDKCTLPP | PFNIIPSPKT | ICYMISSLSK | WICSHTSKGK | VKRQNSLKEW |
| 730 | 740 | 750 | 760 | 770 | 780 |
| RHLNEKRDEN | YQKVMCCLVR | RYLTSMRQKM | QSTDQATVEN | LNELRQDLSK | FRNEIRDLLG |
| 790 | |||||
| FRTSKYAMFY | PRN |