Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9QZC1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QZC1-F1 | Predicted | AlphaFoldDB |
39 variants for Q9QZC1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388623017 | 75 | M>V | No | EVA | |
| rs3388621027 | 92 | G>D | No | EVA | |
| rs3388628636 | 116 | V>E | No | EVA | |
| rs3388627417 | 117 | V>M | No | EVA | |
| rs3388624822 | 162 | A>T | No | EVA | |
| rs3388623392 | 183 | I>N | No | EVA | |
| rs3388624841 | 222 | D>G | No | EVA | |
| rs1134492609 | 236 | E>K | No | EVA | |
| rs3388609300 | 237 | V>G | No | EVA | |
| rs3388628057 | 252 | H>R | No | EVA | |
| rs3388609277 | 281 | K>M | No | EVA | |
| rs3392933457 | 289 | L>F | No | EVA | |
| rs3392702931 | 289 | L>S | No | EVA | |
| rs3392923460 | 292 | S>A | No | EVA | |
| rs3392938897 | 292 | S>Y | No | EVA | |
| rs3388630426 | 298 | L>I | No | EVA | |
| rs3388620983 | 385 | H>Y | No | EVA | |
| rs3392901903 | 431 | I>N | No | EVA | |
| rs3388623033 | 445 | F>I | No | EVA | |
| rs3392713286 | 553 | F>L | No | EVA | |
| rs3388628112 | 555 | Q>* | No | EVA | |
| rs3392987971 | 560 | Q>L | No | EVA | |
| rs3392702929 | 562 | Y>D | No | EVA | |
| rs3392901892 | 584 | F>* | No | EVA | |
| rs3392901892 | 584 | F>* | No | EVA | |
| rs3392945376 | 614 | R>Q | No | EVA | |
| rs3388624326 | 652 | A>* | No | EVA | |
| rs3412480709 | 652 | A>D | No | EVA | |
| rs3388626830 | 654 | M>I | No | EVA | |
| rs3388622964 | 660 | L>H | No | EVA | |
| rs3388624351 | 745 | V>I | No | EVA | |
| rs3388628068 | 765 | L>F | No | EVA | |
| rs3388624393 | 768 | P>H | No | EVA | |
| rs3388624396 | 787 | N>K | No | EVA | |
| rs3388627396 | 840 | I>K | No | EVA | |
| rs3388627435 | 878 | Y>F | No | EVA | |
| rs3388624363 | 879 | E>D | No | EVA | |
| rs3388623057 | 880 | L>F | No | EVA | |
| rs3388631020 | 897 | K>N | No | EVA |
No associated diseases with Q9QZC1
4 regional properties for Q9QZC1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Ankyrin repeat | 100 - 185 | IPR002110-1 |
| repeat | Ankyrin repeat | 221 - 250 | IPR002110-2 |
| domain | Ion transport domain | 479 - 743 | IPR005821 |
| domain | Transient receptor ion channel domain | 256 - 318 | IPR013555 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cation channel complex | An ion channel complex through which cations pass. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium activated cation channel activity | Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. |
| inositol 1,4,5 trisphosphate binding | Binding to inositol 1,4,5 trisphosphate. |
| store-operated calcium channel activity | A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| manganese ion transport | The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| positive regulation of calcium ion transport into cytosol | Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. |
| positive regulation of cardiac muscle hypertrophy in response to stress | Any process that activates or increases the frequency, rate or extent of cardiac muscle hypertrophy in response to stress. |
| regulation of cytosolic calcium ion concentration | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. |
| response to ATP | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. |
| response to calcium ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| single fertilization | The union of male and female gametes to form a zygote. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18784 | TRPC1 | Short transient receptor potential channel 1 | Bos taurus (Bovine) | PR |
| P79100 | TRPC4 | Short transient receptor potential channel 4 | Bos taurus (Bovine) | PR |
| P19334 | trp | Transient receptor potential protein | Drosophila melanogaster (Fruit fly) | PR |
| P48994 | trpl | Transient-receptor-potential-like protein | Drosophila melanogaster (Fruit fly) | PR |
| Q9UL62 | TRPC5 | Short transient receptor potential channel 5 | Homo sapiens (Human) | PR |
| Q9Y210 | TRPC6 | Short transient receptor potential channel 6 | Homo sapiens (Human) | PR |
| Q9UBN4 | TRPC4 | Short transient receptor potential channel 4 | Homo sapiens (Human) | PR |
| P48995 | TRPC1 | Short transient receptor potential channel 1 | Homo sapiens (Human) | PR |
| Q9HCX4 | TRPC7 | Short transient receptor potential channel 7 | Homo sapiens (Human) | PR |
| Q13507 | TRPC3 | Short transient receptor potential channel 3 | Homo sapiens (Human) | PR |
| Q61056 | Trpc1 | Short transient receptor potential channel 1 | Mus musculus (Mouse) | PR |
| Q61143 | Trpc6 | Short transient receptor potential channel 6 | Mus musculus (Mouse) | PR |
| Q9QUQ5 | Trpc4 | Short transient receptor potential channel 4 | Mus musculus (Mouse) | PR |
| Q9QX29 | Trpc5 | Short transient receptor potential channel 5 | Mus musculus (Mouse) | PR |
| Q9R244 | Trpc2 | Short transient receptor potential channel 2 | Mus musculus (Mouse) | PR |
| Q9WVC5 | Trpc7 | Short transient receptor potential channel 7 | Mus musculus (Mouse) | PR |
| Q9QX01 | Trpc1 | Short transient receptor potential channel 1 | Rattus norvegicus (Rat) | PR |
| O35119 | Trpc4 | Short transient receptor potential channel 4 | Rattus norvegicus (Rat) | PR |
| Q9R283 | Trpc2 | Short transient receptor potential channel 2 | Rattus norvegicus (Rat) | PR |
| Q9JMI9 | Trpc3 | Short transient receptor potential channel 3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTKVKKCRE | PARVTLPAPE | EEEDGEAEGG | ESQRRRRGWR | GVNGGLEPPC | PRAPPSPGPD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ASSEGSPSRW | RTAGMRDKGR | RQAVRGPAFM | FGARGPSLTA | EEERFLDAAE | YGNIPVVRKM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LEESRTLNVN | CVDYMGQNAL | QLAVGNEHLE | VTELLLKKEN | LARIGDALLL | AISKGYVRIV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAILGHPGFA | ASRRLTLSPC | EQELRDDDFY | AYDEDGTRFS | PDITPIILAA | HCHKYEVVHL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLLKGARIER | PHDYFCRCSD | CAEKQRLDAF | SHSRSRINAY | KGLASPAYLS | LSSEDPVLTA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LELSNELAKL | ANIEKEFKND | YRKLSMQCKD | FVVGVLDLCR | DSEEVEAILN | GDLESAEPLE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RHGHKASLSR | VKLAIKYEVK | KFVAHPNCQQ | QLLTIWYENL | SGLREQTIAI | KCLVVLVVAL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GLPFLAIGYW | IAPCSRLGKI | LRSPFMKFVA | HAASFIIFLG | LLVFNASDRF | EGITTLPNIT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VIDYPKQIFR | VKTTQFTWTE | MLIMVWVLGM | MWSECKELWL | EGPREYIVQL | WNVLDFGMLS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IFIAAFTARF | LAFLQATKAQ | QYVDSHVQES | DLSEVTLPPE | VQYFTYARDK | WLPSDPQIIS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EGLYAIAVVL | SFSRIAYILP | ANESFGPLQI | SLGRTVKDIF | KFMVLFIMVF | LAFMIGMFIL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YSYYLGAKVN | PAFTTVEESF | KTLFWSIFGL | SEVTSVVLKY | DHKFIENIGY | VLYGIYNVTM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VVVLLNMLIA | MINSSYQEIE | DDSDVEWKFA | RSKLWLSYFD | DGKTLPPPFS | LVPSPKSFVY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FIMRITNFSK | CRRRRLQKDL | ELGMGNSKSR | LNLFTQSNSR | VFESHSFNSI | LNQPTRYQQI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| MKRLIKRYVL | KAQVDKENDE | VNEGELKEIK | QDISSLRYEL | LEDKSQATEE | LAILIHKLSE |
| KLNPSVLRCE |