P79100

PR
Gene name
TRPC4
Protein name
Short transient receptor potential channel 4
Names
TrpC4, Capacitative calcium entry channel 1, CCE1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:282102
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

156-225 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P79100

Entry ID Method Resolution Chain Position Source
AF-P79100-F1 Predicted AlphaFoldDB

No variants for P79100

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P79100

No associated diseases with P79100

4 regional properties for P79100

Type Name Position InterPro Accession
repeat Ankyrin repeat 69 - 98 IPR002110-1
repeat Ankyrin repeat 141 - 173 IPR002110-2
domain Ion transport domain 374 - 631 IPR005821
domain Transient receptor ion channel domain 176 - 238 IPR013555

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cation channel complex An ion channel complex through which cations pass.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
inositol 1,4,5 trisphosphate binding Binding to inositol 1,4,5 trisphosphate.
store-operated calcium channel activity A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.

3 GO annotations of biological process

Name Definition
calcium ion transmembrane transport A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
manganese ion transport The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of cytosolic calcium ion concentration Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O18784 TRPC1 Short transient receptor potential channel 1 Bos taurus (Bovine) PR
P19334 trp Transient receptor potential protein Drosophila melanogaster (Fruit fly) PR
P48994 trpl Transient-receptor-potential-like protein Drosophila melanogaster (Fruit fly) PR
Q9UL62 TRPC5 Short transient receptor potential channel 5 Homo sapiens (Human) PR
Q9Y210 TRPC6 Short transient receptor potential channel 6 Homo sapiens (Human) PR
Q13507 TRPC3 Short transient receptor potential channel 3 Homo sapiens (Human) PR
P48995 TRPC1 Short transient receptor potential channel 1 Homo sapiens (Human) PR
Q9HCX4 TRPC7 Short transient receptor potential channel 7 Homo sapiens (Human) PR
Q9UBN4 TRPC4 Short transient receptor potential channel 4 Homo sapiens (Human) PR
Q9WVC5 Trpc7 Short transient receptor potential channel 7 Mus musculus (Mouse) PR
Q9QZC1 Trpc3 Short transient receptor potential channel 3 Mus musculus (Mouse) PR
Q9QX29 Trpc5 Short transient receptor potential channel 5 Mus musculus (Mouse) PR
Q61143 Trpc6 Short transient receptor potential channel 6 Mus musculus (Mouse) PR
Q9R244 Trpc2 Short transient receptor potential channel 2 Mus musculus (Mouse) PR
Q61056 Trpc1 Short transient receptor potential channel 1 Mus musculus (Mouse) PR
Q9QUQ5 Trpc4 Short transient receptor potential channel 4 Mus musculus (Mouse) PR
Q9QX01 Trpc1 Short transient receptor potential channel 1 Rattus norvegicus (Rat) PR
Q9JMI9 Trpc3 Short transient receptor potential channel 3 Rattus norvegicus (Rat) PR
Q9R283 Trpc2 Short transient receptor potential channel 2 Rattus norvegicus (Rat) PR
O35119 Trpc4 Short transient receptor potential channel 4 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAQFYYKRNV NAPYRDRIPL RIVRAESELS PSEKAYLNAV EKGDYASVKK SLEEAEIYFK
70 80 90 100 110 120
ININCIDPLG RTALLIAIEN ENLELIELLL SFNVYVGDAL LHAIRKEVVG AVELLLNHKK
130 140 150 160 170 180
PSGEKQVPPI LLDKQFSEFT PDITPIILAA HTNNYEIIKL LVQKGVSVPR PHEVRCNCVE
190 200 210 220 230 240
CVSSSDVDSL RHSRSRLNIY KALASPSLIA LSSEDPFLTA FQLSWELQEL SKVENEFKSE
250 260 270 280 290 300
YEELSRQCKQ FAKDLLDQTR SSRELEIILN YRDDNSLLEE QSGNDLARLK LAIKYRQKEF
310 320 330 340 350 360
VAQPNCQQLL ASRWYDEFPG WRRRHWAVKM VTCFIVGLLF PVFSVCYLIA PKSPLGLFIR
370 380 390 400 410 420
KPFIKFICHT ASYLTFLFLL LLASQHIDRS DLNRQGPPPT IVEWMILPWV LGFIWGEIKQ
430 440 450 460 470 480
MWDGGLQDYI HDWWNLMDFV MNSLYLATIS LKIVAFVKYS ALNPRESWDM WHPTLVAEAL
490 500 510 520 530 540
FAIANIFSSL RLISLFTANS HLGPLQISLG RMLLDILKFL FIYCLVLLAF ANGLNQLYFY
550 560 570 580 590 600
YEETKGLSCK GIRCEKQNNA FSTLFETLQS LFWSIFGLIN LYVTNVKAQH EFTEFVGATM
610 620 630 640 650 660
FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART KLWMSYFEEG GTLPTPFNVI
670 680 690 700 710 720
PSPKSLWYLI KWIWTHLCKK KMRRKPESFG TIGRRAADNL RRHHQYQEVM RNLVKRYVAA
730 740 750 760 770 780
MIRDAKTEEG LTEENFKELK QDISSFRFEV LGLLRGSKLS TVQSAQGTKE SSNSADSDEK
790 800 810 820 830 840
SDNEGSSKDK KKNFSLFDLT TLIHPRSAAI AAERHTISNG SALVVQEPPR EKQRKVNFVT
850 860 870 880 890 900
DIRHFGLFHR RSKQHAAAEQ NANQIFSVSE GVARQQAEGP LERSIQLESR TLASRGDLNI
910 920 930 940 950 960
PGLSEQCILV DHRERNTDSL GVQVSKRVCS FKSEKVVVED TVPIIPKEKK HAKEEDSSAD
970
YDANLTDTIT HEDYVTTRL