Q61143
PR
Gene name |
Trpc6 |
Protein name |
Short transient receptor potential channel 6 |
Names |
TrpC6, Calcium entry channel, Transient receptor protein 6, TRP-6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:22068 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q61143
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6CV9 | EM | 380 A | A/B/C/D | 94-930 | PDB |
| AF-Q61143-F1 | Predicted | AlphaFoldDB |
28 variants for Q61143
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs260621270 | 20 | G>E | No | EVA | |
| rs3389024635 | 22 | G>D | No | EVA | |
| rs46306095 | 70 | I>V | No | EVA | |
| rs3389022064 | 71 | L>I | No | EVA | |
| rs256071439 | 96 | I>V | No | EVA | |
| rs3389028350 | 108 | G>S | No | EVA | |
| rs219135890 | 121 | H>R | No | EVA | |
| rs3389016739 | 206 | Y>N | No | EVA | |
| rs1134584477 | 255 | T>I | No | EVA | |
| rs3388998394 | 458 | M>R | No | EVA | |
| rs3400046404 | 484 | R>M | No | EVA | |
| rs3400046443 | 484 | R>S | No | EVA | |
| rs3399275367 | 485 | M>L | No | EVA | |
| rs3389017610 | 493 | M>V | No | EVA | |
| rs1134749299 | 494 | E>G | No | EVA | |
| rs3389019773 | 501 | V>L | No | EVA | |
| rs3389024608 | 543 | R>S | No | EVA | |
| rs3389016776 | 597 | L>F | No | EVA | |
| rs3389022097 | 610 | A>D | No | EVA | |
| rs3389011329 | 635 | K>I | No | EVA | |
| rs3389022141 | 641 | I>N | No | EVA | |
| rs3389004107 | 646 | A>T | No | EVA | |
| rs3388998354 | 649 | I>F | No | EVA | |
| rs3388973104 | 781 | K>E | No | EVA | |
| rs3389019730 | 864 | R>G | No | EVA | |
| rs3399808735 | 868 | Q>H | No | EVA | |
| rs3388973046 | 879 | N>K | No | EVA | |
| rs261460733 | 907 | D>E | No | EVA |
No associated diseases with Q61143
4 regional properties for Q61143
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Ankyrin repeat | 96 - 182 | IPR002110-1 |
| repeat | Ankyrin repeat | 217 - 249 | IPR002110-2 |
| domain | Ion transport domain | 449 - 737 | IPR005821 |
| domain | Transient receptor ion channel domain | 252 - 314 | IPR013555 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cation channel complex | An ion channel complex through which cations pass. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| slit diaphragm | A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration. |
10 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| actinin binding | Binding to actinin, any member of a family of proteins that crosslink F-actin. |
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| cation channel activity | Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. |
| clathrin binding | Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. |
| inositol 1,4,5 trisphosphate binding | Binding to inositol 1,4,5 trisphosphate. |
| ion channel activity | Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| store-operated calcium channel activity | A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| cellular response to hydrogen peroxide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| manganese ion transport | The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| negative regulation of dendrite morphogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. |
| positive regulation of calcium ion transport | Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| positive regulation of ion transmembrane transporter activity | Any process that activates or increases the activity of an ion transporter. |
| positive regulation of neuron differentiation | Any process that activates or increases the frequency, rate or extent of neuron differentiation. |
| positive regulation of peptidyl-threonine phosphorylation | Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| regulation of cytosolic calcium ion concentration | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. |
| single fertilization | The union of male and female gametes to form a zygote. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18784 | TRPC1 | Short transient receptor potential channel 1 | Bos taurus (Bovine) | PR |
| P79100 | TRPC4 | Short transient receptor potential channel 4 | Bos taurus (Bovine) | PR |
| P19334 | trp | Transient receptor potential protein | Drosophila melanogaster (Fruit fly) | PR |
| P48994 | trpl | Transient-receptor-potential-like protein | Drosophila melanogaster (Fruit fly) | PR |
| Q9UL62 | TRPC5 | Short transient receptor potential channel 5 | Homo sapiens (Human) | PR |
| Q13507 | TRPC3 | Short transient receptor potential channel 3 | Homo sapiens (Human) | PR |
| Q9UBN4 | TRPC4 | Short transient receptor potential channel 4 | Homo sapiens (Human) | PR |
| P48995 | TRPC1 | Short transient receptor potential channel 1 | Homo sapiens (Human) | PR |
| Q9HCX4 | TRPC7 | Short transient receptor potential channel 7 | Homo sapiens (Human) | PR |
| Q9Y210 | TRPC6 | Short transient receptor potential channel 6 | Homo sapiens (Human) | PR |
| Q9QX29 | Trpc5 | Short transient receptor potential channel 5 | Mus musculus (Mouse) | PR |
| Q9WVC5 | Trpc7 | Short transient receptor potential channel 7 | Mus musculus (Mouse) | PR |
| Q9R244 | Trpc2 | Short transient receptor potential channel 2 | Mus musculus (Mouse) | PR |
| Q61056 | Trpc1 | Short transient receptor potential channel 1 | Mus musculus (Mouse) | PR |
| Q9QUQ5 | Trpc4 | Short transient receptor potential channel 4 | Mus musculus (Mouse) | PR |
| Q9QZC1 | Trpc3 | Short transient receptor potential channel 3 | Mus musculus (Mouse) | PR |
| Q9QX01 | Trpc1 | Short transient receptor potential channel 1 | Rattus norvegicus (Rat) | PR |
| O35119 | Trpc4 | Short transient receptor potential channel 4 | Rattus norvegicus (Rat) | PR |
| Q9JMI9 | Trpc3 | Short transient receptor potential channel 3 | Rattus norvegicus (Rat) | PR |
| Q9R283 | Trpc2 | Short transient receptor potential channel 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQSPRFVTR | RGGSLKAAPG | AGTRRNESQD | YLLMDELGDD | GYPQLPLPPY | GYYPSFRGNE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NRLTHRRQTI | LREKGRRLAN | RGPAYMFNDH | STSLSIEEER | FLDAAEYGNI | PVVRKMLEEC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HSLNVNCVDY | MGQNALQLAV | ANEHLEITEL | LLKKENLSRV | GDALLLAISK | GYVRIVEAIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NHPAFAEGKR | LATSPSQSEL | QQDDFYAYDE | DGTRFSHDVT | PIILAAHCQE | YEIVHTLLRK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GARIERPHDY | FCKCTECSQK | QKHDSFSHSR | SRINAYKGLA | SPAYLSLSSE | DPVMTALELS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NELAVLANIE | KEFKNDYRKL | SMQCKDFVVG | LLDLCRNTEE | VEAILNGDAE | TRQPGDFGRP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLSRLKLAIK | YEVKKFVAHP | NCQQQLLSIW | YENLSGLRQQ | TMAVKFLVVL | AVAIGLPFLA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LIYWCAPCSK | MGKILRGPFM | KFVAHAASFT | IFLGLLVMNA | ADRFEGTKLL | PNETSTDNAR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QLFRMKTSCF | SWMEMLIISW | VIGMIWAECK | EIWTQGPKEY | LFELWNMLDF | GMLAIFAASF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IARFMAFWHA | SKAQSIIDAN | DTLKDLTKVT | LGDNVKYYNL | ARIKWDPTDP | QIISEGLYAI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AVVLSFSRIA | YILPANESFG | PLQISLGRTV | KDIFKFMVIF | IMVFVAFMIG | MFNLYSYYIG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AKQNEAFTTV | EESFKTLFWA | IFGLSEVKSV | VINYNHKFIE | NIGYVLYGVY | NVTMVIVLLN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MLIAMINSSF | QEIEDDADVE | WKFARAKLWF | SYFEEGRTLP | VPFNLVPSPK | SLLYLLLKFK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KWMCELIQGQ | KQGFQEDAEM | NKRNEEKKFG | ISGSHEDLSK | FSLDKNQLAH | NKQSSTRSSE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DYHLNSFSNP | PRQYQKIMKR | LIKRYVLQAQ | IDKESDEVNE | GELKEIKQDI | SSLRYELLEE |
| 910 | 920 | ||||
| KSQNTEDLAE | LIRKLGERLS | LEPKLEESRR |