Q9SYN1

PR
Gene name
PEN6 (At1g78500, T30F21.16)
Protein name
Seco-amyrin synthase
Names
Alpha-seco-amyrin synthase, Beta-seco-amyrin synthase, Pentacyclic triterpene synthase 6, AtPEN6
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G78500
EC number
5.4.99.52: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SYN1

Entry ID Method Resolution Chain Position Source
AF-Q9SYN1-F1 Predicted AlphaFoldDB

68 variants for Q9SYN1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05168968 4 L>M No 1000Genomes
ENSVATH05168969 5 K>M No 1000Genomes
ENSVATH13835255 11 G>R No 1000Genomes
ENSVATH14491895 13 E>D No 1000Genomes
ENSVATH05168970 13 E>V No 1000Genomes
ENSVATH14491896 14 T>S No 1000Genomes
tmp_1_29531736_G_C 31 D>H No 1000Genomes
tmp_1_29531742_G_T 33 D>Y No 1000Genomes
tmp_1_29531812_G_A 56 R>H No 1000Genomes
ENSVATH13835263 77 Q>P No 1000Genomes
ENSVATH07697981 87 A>T No 1000Genomes
ENSVATH05168976 95 A>G No 1000Genomes
tmp_1_29532080_C_T 97 T>M No 1000Genomes
tmp_1_29532095_G_A 102 G>E No 1000Genomes
tmp_1_29532097_A_C 103 I>L No 1000Genomes
tmp_1_29532158_G_C 123 C>S No 1000Genomes
tmp_1_29532348_G_A 154 R>H No 1000Genomes
ENSVATH14491898 168 I>V No 1000Genomes
tmp_1_29532516_C_A 169 H>Q No 1000Genomes
ENSVATH14491900 185 C>F No 1000Genomes
ENSVATH05168982 191 V>E No 1000Genomes
tmp_1_29532598_G_A 197 D>N No 1000Genomes
ENSVATH14491901 253 P>S No 1000Genomes
tmp_1_29533044_T_A 273 L>M No 1000Genomes
tmp_1_29533077_C_A 284 P>T No 1000Genomes
ENSVATH05168988 285 L>F No 1000Genomes
tmp_1_29533151_T_G 308 N>K No 1000Genomes
ENSVATH01555785 321 F>L No 1000Genomes
ENSVATH01555786 324 E>D No 1000Genomes
ENSVATH01555787 329 C>G No 1000Genomes
ENSVATH05168994 331 H>R No 1000Genomes
ENSVATH01555789 336 N>H No 1000Genomes
ENSVATH00147971 343 C>F No 1000Genomes
ENSVATH13835291 349 Q>E No 1000Genomes
ENSVATH05168995 353 R>Q No 1000Genomes
tmp_1_29533400_A_T 368 Y>F No 1000Genomes
tmp_1_29533554_T_A 393 F>Y No 1000Genomes
tmp_1_29533586_A_G 404 I>V No 1000Genomes
ENSVATH01555800 437 D>A No 1000Genomes
tmp_1_29533785_A_T 441 D>V No 1000Genomes
ENSVATH01555802 444 R>T No 1000Genomes
ENSVATH01555803 452 S>N No 1000Genomes
ENSVATH01555804 455 N>D No 1000Genomes
tmp_1_29533886_G_A 475 A>T No 1000Genomes
tmp_1_29534086_C_T 508 P>S No 1000Genomes
ENSVATH00147976 511 L>F No 1000Genomes
tmp_1_29534266_G_A 543 A>T No 1000Genomes
ENSVATH01555818 585 E>D No 1000Genomes
tmp_1_29534558_C_T 587 P>S No 1000Genomes
ENSVATH01555819 596 K>Q No 1000Genomes
ENSVATH00147983 596 K>R No 1000Genomes
tmp_1_29534599_T_A 600 N>K No 1000Genomes
ENSVATH05169007 643 N>S No 1000Genomes
tmp_1_29534730_G_A 644 C>Y No 1000Genomes
ENSVATH00147986 649 K>R No 1000Genomes
tmp_1_29534747_G_T 650 A>S No 1000Genomes
tmp_1_29534751_T_C 651 V>A No 1000Genomes
ENSVATH05169008 667 S>N No 1000Genomes
ENSVATH00147987 678 L>P No 1000Genomes
tmp_1_29534847_G_T 683 R>I No 1000Genomes
tmp_1_29534885_C_T 696 L>F No 1000Genomes
tmp_1_29534955_C_T 719 S>F No 1000Genomes
tmp_1_29534984_G_A 729 E>K No 1000Genomes
tmp_1_29535082_A_T 737 M>L No 1000Genomes
ENSVATH13835320 744 A>E No 1000Genomes
ENSVATH14491904 763 R>H No 1000Genomes
ENSVATH14491915 766 L>R No 1000Genomes
tmp_1_29535173_G_A 767 C>Y No 1000Genomes

No associated diseases with Q9SYN1

3 regional properties for Q9SYN1

Type Name Position InterPro Accession
conserved_site Terpene synthase, conserved site 612 - 626 IPR002365
domain Squalene cyclase, C-terminal 418 - 759 IPR032696
domain Squalene cyclase, N-terminal 105 - 373 IPR032697

Functions

Description
EC Number 5.4.99.52 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

3 GO annotations of molecular function

Name Definition
beta-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin.
lupeol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol.
oxidosqualene cyclase activity Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene.

1 GO annotations of biological process

Name Definition
triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38604 ERG7 Lanosterol synthase ERG7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6Z2X6 Os02g0139700 Cycloartenol synthase Oryza sativa subsp japonica (Rice) PR
B6EXY6 BAS Beta-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
O23390 BARS1 Baruol synthase Arabidopsis thaliana (Mouse-ear cress) PR
P38605 CAS1 Cycloartenol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q1G1A4 LAS1 Lanosterol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJV8 MRN1 Marneral synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FR95 PEN1 Arabidiol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FZI2 LUP5 Lupeol synthase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVY2 PEN3 Tirucalladienol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FI37 THAS1 Thalianol synthase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWRLKIGAKG GDETHLFTTN NYTGRQTWEF DADACSPEEL AEVDEARQNF SINRSRFKIS
70 80 90 100 110 120
ADLLWRMQFL REKKFEQKIP RVEIGDAENI TYKDAKTALR RGILYFKALQ AEDGHWPAEN
130 140 150 160 170 180
SGCLFFEAPF VICLYITGHL EKILTLEHRK ELLRYMYNHQ NEDGGWGIHV EGQSAMFCTV
190 200 210 220 230 240
INYICLRILG VEADLDDIKG SGCARARKWI LDHGGATYTP LIGKAWLSIL GVYDWSGCKP
250 260 270 280 290 300
IPPEVWMLPT FSPFNGGTLW IYFRDIFMGV SYLYGKKFVA TPTPLILQLR EELYPQPYDK
310 320 330 340 350 360
ILWSQARNQC AKEDLYYPQS FLQEMFWKCV HILSENILNR WPCNKLIRQK ALRTTMELLH
370 380 390 400 410 420
YQDEASRYFT GGCVPKPFHM LACWVEDPDG DYFKKHLARV PDYIWIGEDG LKIQSFGSQL
430 440 450 460 470 480
WDTAFSLQVM LAYQDVDDDD DEIRSTLIKG YSFLNKSQLT QNPPGDHRKM LKDIAKGGWT
490 500 510 520 530 540
FSDQDQGWPV SDCTAESLEC CLVFGSMPSE LIGEKMDVER LYDAVNLLLY FQSKNGGITV
550 560 570 580 590 600
WEAARGRTWL EWLSPVEFME DTIVEHEYVE CTGSAIVALA RFLKEFPEHR REEVEKFIKN
610 620 630 640 650 660
AVKYIESFQM PDGSWYGNWG VCFMYGTFFA VRGLVAAGKT YQNCEPIRKA VQFILETQNV
670 680 690 700 710 720
EGGWGESYLS CPNKKYTLLE GNRTNVVNTG QALMVLIMGG QMERDPLPVH RAAKVLINSQ
730 740 750 760
LDNGDFPQEE IMGVFKMNVM VHYATYRNIF TLWALTYYTK ALRVPLC