Q9FZI2

PR
Gene name
LUP5 (At1g66960, F1O19.4)
Protein name
Lupeol synthase 5
Names
AtLUP5
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G66960
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FZI2

Entry ID Method Resolution Chain Position Source
AF-Q9FZI2-F1 Predicted AlphaFoldDB

136 variants for Q9FZI2

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH01487878 3 R>K No 1000Genomes
tmp_1_24989656_C_A 3 R>S No 1000Genomes
tmp_1_24989621_T_G 15 Y>S No 1000Genomes
ENSVATH05085997 17 F>S No 1000Genomes
tmp_1_24989565_C_T 34 A>T No 1000Genomes
ENSVATH01487876 41 T>A No 1000Genomes
ENSVATH00127810 55 S>F No 1000Genomes
tmp_1_24989499_G_C 56 R>G No 1000Genomes
tmp_1_24989498_C_T 56 R>H No 1000Genomes
tmp_1_24989053_T_G 71 K>N No 1000Genomes
ENSVATH05085982 73 A>P No 1000Genomes
tmp_1_24989045_T_C 74 K>R No 1000Genomes
ENSVATH05085981 78 V>M No 1000Genomes
ENSVATH05085980 79 I>S No 1000Genomes
ENSVATH01487858 81 P>R No 1000Genomes
tmp_1_24989000_G_A 89 A>V No 1000Genomes
tmp_1_24988994_G_C 91 T>S No 1000Genomes
tmp_1_24988989_C_T 93 E>K No 1000Genomes
ENSVATH13752445 98 A>V No 1000Genomes
tmp_1_24988955_G_A 104 A>V No 1000Genomes
tmp_1_24988902_C_T 122 G>R No 1000Genomes
ENSVATH05085979 125 C>F No 1000Genomes
tmp_1_24988887_G_T 127 L>I No 1000Genomes
ENSVATH13752433 135 Y>F No 1000Genomes
ENSVATH00127808 139 H>Q No 1000Genomes
ENSVATH05085969 153 L>I No 1000Genomes
ENSVATH00127807 180 T>A No 1000Genomes
ENSVATH13752429 190 G>R No 1000Genomes
ENSVATH14434930 191 V>I No 1000Genomes
ENSVATH05085963 200 A>E No 1000Genomes
tmp_1_24988290_T_A 202 K>* No 1000Genomes
ENSVATH00127805 215 I>T No 1000Genomes
ENSVATH05085962 218 P>S No 1000Genomes
ENSVATH05085961 223 V>I No 1000Genomes
ENSVATH01487848 232 D>E No 1000Genomes
ENSVATH05085953 246 L>V No 1000Genomes
tmp_1_24988058_G_T 250 L>I No 1000Genomes
ENSVATH13752418 275 K>N No 1000Genomes
tmp_1_24987867_T_C 280 I>V No 1000Genomes
ENSVATH01487842 298 E>K No 1000Genomes
ENSVATH05085946 303 K>R No 1000Genomes
ENSVATH13752416 304 A>G No 1000Genomes
ENSVATH13752416 304 A>V No 1000Genomes
ENSVATH13752415 306 H>N No 1000Genomes
ENSVATH00127801 335 L>F No 1000Genomes
tmp_1_24987634_G_A 336 L>F No 1000Genomes
ENSVATH05085938 338 S>N No 1000Genomes
ENSVATH14434928 342 N>S No 1000Genomes
ENSVATH00127799 348 K>Q No 1000Genomes
ENSVATH05085937 351 Q>L No 1000Genomes
tmp_1_24987573_T_C 356 H>R No 1000Genomes
ENSVATH05085931 386 P>R No 1000Genomes
ENSVATH13752411 386 P>S No 1000Genomes
tmp_1_24987398_C_A 387 D>Y No 1000Genomes
ENSVATH00127798 389 N>D No 1000Genomes
tmp_1_24987380_T_G 393 K>Q No 1000Genomes
tmp_1_24987361_G_C 399 P>R No 1000Genomes
ENSVATH05085929 403 W>* No 1000Genomes
ENSVATH14434927 409 M>I No 1000Genomes
ENSVATH05085920 416 S>C No 1000Genomes
ENSVATH00127793 416 S>T No 1000Genomes
tmp_1_24987017_T_G 420 M>L No 1000Genomes
ENSVATH14434926 431 S>N No 1000Genomes
ENSVATH00127792 434 R>C No 1000Genomes
tmp_1_24986972_C_T 435 D>N No 1000Genomes
tmp_1_24986963_A_G 438 Y>H No 1000Genomes
ENSVATH14434925 441 L>I No 1000Genomes
ENSVATH01487810 455 D>E No 1000Genomes
tmp_1_24986796_G_T,C 468 I>M No 1000Genomes
ENSVATH01487809 478 R>Q No 1000Genomes
tmp_1_24986749_A_G 484 V>A No 1000Genomes
tmp_1_24986732_C_A 490 E>* No 1000Genomes
ENSVATH00127790 504 D>V No 1000Genomes
ENSVATH01487804 506 T>I No 1000Genomes
ENSVATH01487803 508 E>K No 1000Genomes
tmp_1_24986586_T_G 510 I>L No 1000Genomes
ENSVATH01487802 518 S>F No 1000Genomes
tmp_1_24986558_A_G 519 V>A No 1000Genomes
ENSVATH01487794 527 S>G No 1000Genomes
ENSVATH14434864 529 N>I No 1000Genomes
ENSVATH01487785 552 L>F No 1000Genomes
tmp_1_24986275_A_C 552 L>V No 1000Genomes
ENSVATH01487783 556 A>G No 1000Genomes
ENSVATH01487784 556 A>S No 1000Genomes
ENSVATH01487782 562 Y>H No 1000Genomes
tmp_1_24986242_T_A 563 T>S No 1000Genomes
ENSVATH01487780 568 A>S No 1000Genomes
ENSVATH01487778 577 N>K No 1000Genomes
ENSVATH05085904 578 Q>K No 1000Genomes
tmp_1_24986190_T_C 580 Y>C No 1000Genomes
ENSVATH01487777 582 D>N No 1000Genomes
ENSVATH05085903 584 R>K No 1000Genomes
tmp_1_24986176_T_C 585 T>A No 1000Genomes
tmp_1_24986170_C_A 587 E>* No 1000Genomes
tmp_1_24986164_T_C 589 T>A No 1000Genomes
tmp_1_24986150_C_A 593 E>D No 1000Genomes
ENSVATH05085902 596 V>M No 1000Genomes
ENSVATH05085901 597 Q>E No 1000Genomes
ENSVATH01487776 601 S>R No 1000Genomes
ENSVATH01487775 602 K>E No 1000Genomes
ENSVATH01487774 604 L>M No 1000Genomes
ENSVATH05085900 604 L>S No 1000Genomes
ENSVATH01487772 612 S>N No 1000Genomes
ENSVATH07683227 622 W>L No 1000Genomes
tmp_1_24985926_T_C 636 N>S No 1000Genomes
tmp_1_24985919_A_T 638 C>* No 1000Genomes
tmp_1_24985920_C_T 638 C>Y No 1000Genomes
ENSVATH05085896 650 N>K No 1000Genomes
ENSVATH05085895 651 I>V No 1000Genomes
ENSVATH05085894 661 S>N No 1000Genomes
ENSVATH00127786 665 C>S No 1000Genomes
ENSVATH01487769 666 P>S No 1000Genomes
tmp_1_24985834_C_T,G 667 E>K No 1000Genomes
tmp_1_24985834_C_T,G 667 E>Q No 1000Genomes
ENSVATH14434860 668 Q>H No 1000Genomes
ENSVATH13752354 674 E>K No 1000Genomes
ENSVATH05085888 675 G>E No 1000Genomes
ENSVATH01487768 688 M>I No 1000Genomes
ENSVATH00127785 689 A>G No 1000Genomes
tmp_1_24985664_G_C 692 H>D No 1000Genomes
tmp_1_24985524_C_T 696 A>T No 1000Genomes
tmp_1_24985518_T_A 698 R>* No 1000Genomes
tmp_1_24985511_A_C 700 L>R No 1000Genomes
ENSVATH00127784 701 I>T No 1000Genomes
ENSVATH14434858 705 S>T No 1000Genomes
ENSVATH05085879 709 F>L No 1000Genomes
ENSVATH13752342 716 E>K No 1000Genomes
tmp_1_24985458_C_A 718 G>* No 1000Genomes
tmp_1_24985449_G_C,A 721 P>A No 1000Genomes
tmp_1_24985449_G_C,A 721 P>S No 1000Genomes
tmp_1_24985239_G_C 736 H>Q No 1000Genomes
ENSVATH13752331 739 T>S No 1000Genomes
tmp_1_24985219_A_C 743 I>S No 1000Genomes
tmp_1_24985190_G_A 753 R>W No 1000Genomes
ENSVATH00127780 758 I>R No 1000Genomes
tmp_1_24985165_G_A 761 A>V No 1000Genomes

No associated diseases with Q9FZI2

3 regional properties for Q9FZI2

Type Name Position InterPro Accession
conserved_site Terpene synthase, conserved site 606 - 620 IPR002365
domain Squalene cyclase, C-terminal 416 - 754 IPR032696
domain Squalene cyclase, N-terminal 101 - 403 IPR032697

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

1 GO annotations of molecular function

Name Definition
beta-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin.

1 GO annotations of biological process

Name Definition
triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38604 ERG7 Lanosterol synthase ERG7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6Z2X6 Os02g0139700 Cycloartenol synthase Oryza sativa subsp japonica (Rice) PR
B6EXY6 BAS Beta-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
O23390 BARS1 Baruol synthase Arabidopsis thaliana (Mouse-ear cress) PR
P38605 CAS1 Cycloartenol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q1G1A4 LAS1 Lanosterol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJV8 MRN1 Marneral synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FR95 PEN1 Arabidiol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVY2 PEN3 Tirucalladienol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9SYN1 PEN6 Seco-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FI37 THAS1 Thalianol synthase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWRLKVGEGK GKDPYLFSSN NFVGRQTWEF DPKAGTREER TAVEEARRSF FDNRSRVKPS
70 80 90 100 110 120
SDLLWKMQFL KEAKFEQVIP PVKIDGGEAI TYEKATNALR RGVAFLSALQ ASDGHWPGEF
130 140 150 160 170 180
TGPLCMLPPL VFCLYITGHL EEVFDAEHRK EMLRYIYCHQ NEDGGWGFHI ESKSIMFTTT
190 200 210 220 230 240
LNYICLRILG VGPDGGLENA CKRARQWILS HGGVIYIPCW GKVWLSVLGI YDWSGVNPMP
250 260 270 280 290 300
PEIWLLPYFL PIHLGKAFSY TRITYMPISY LYGKKFVGQI TPLIMQLREE LHLQPYEEIN
310 320 330 340 350 360
WNKARHLCAK EDKYYPHPLV QDLIWDALHT FVEPLLASWP INKLVRKKAL QVAMKHIHYE
370 380 390 400 410 420
DENSHYITIG CIEKNLCMLA CWIDNPDGNH FKKHLSRIPD MMWVAEDGMK MQCFGSQLWM
430 440 450 460 470 480
TGFAVQALLA SDPRDETYDV LRRAHDYIKK SQVRDNPSGD FKSMYRHISK GGWTLSDRDH
490 500 510 520 530 540
GWQVSDCTAE AAKCCMLLST MPTDITGEKI NLEQLYDSVN LMLSLQSENG GFTAWEPVRA
550 560 570 580 590 600
YKWMELMNPT DLFANAMTER EYTECTSAVL QALVIFNQLY PDHRTKEITK SIEKAVQFIE
610 620 630 640 650 660
SKQLRDGSWY GSWGICFTYG TWFALCGLAA IGKTYNNCLS MRDGVHFLLN IQNEDGGWGE
670 680 690 700 710 720
SYMSCPEQRY IPLEGNRSNV VQTAWAMMAL IHAGQAKRDL IPLHSAAKFI ITSQLENGDF
730 740 750 760
PQQELLGASM STCMLHYSTY KDIFPPWALA EYRKAAFIHH ADL