O23390

PR
Gene name
BARS1 (PEN2, At4g15370, dl3730c, FCAALL.279)
Protein name
Baruol synthase
Names
AtBARS1, Pentacyclic triterpene synthase 2, AtPEN2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G15370
EC number
5.4.99.57: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O23390

Entry ID Method Resolution Chain Position Source
AF-O23390-F1 Predicted AlphaFoldDB

116 variants for O23390

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06675577 7 G>D No 1000Genomes
ENSVATH06675576 17 F>L No 1000Genomes
ENSVATH11783259 33 N>D No 1000Genomes
ENSVATH11783258 37 P>S No 1000Genomes
ENSVATH02841899 48 R>Q No 1000Genomes
tmp_4_8779541_T_C 49 N>D No 1000Genomes
tmp_4_8779507_C_G 60 S>T No 1000Genomes
ENSVATH14203374 62 D>G No 1000Genomes
tmp_4_8779484_G_T 68 Q>K No 1000Genomes
ENSVATH11783255 76 E>G No 1000Genomes
tmp_4_8779323_T_C 89 K>E No 1000Genomes
tmp_4_8779316_G_A 91 T>M No 1000Genomes
tmp_4_8779301_T_A 96 K>M No 1000Genomes
ENSVATH02841881 103 L>I No 1000Genomes
tmp_4_8779278_G_C 104 L>V No 1000Genomes
tmp_4_8779269_T_A 107 T>S No 1000Genomes
tmp_4_8779059_T_C 142 K>E No 1000Genomes
tmp_4_8779044_C_T 147 E>K No 1000Genomes
ENSVATH11783232 149 R>H No 1000Genomes
ENSVATH11783225 166 W>R No 1000Genomes
ENSVATH02841861 170 V>I No 1000Genomes
tmp_4_8778623_T_C 175 N>S No 1000Genomes
tmp_4_8778614_C_T 178 C>Y No 1000Genomes
ENSVATH02841859 179 S>T No 1000Genomes
ENSVATH02841857 195 H>Y No 1000Genomes
tmp_4_8778558_C_A 197 D>Y No 1000Genomes
ENSVATH02841855 198 K>E No 1000Genomes
tmp_4_8778545_G_A 201 A>V No 1000Genomes
ENSVATH11783204 215 A>S No 1000Genomes
ENSVATH06675561 219 P>T No 1000Genomes
ENSVATH02841839 246 F>L No 1000Genomes
ENSVATH02841837 251 F>L No 1000Genomes
tmp_4_8778166_A_G 251 F>S No 1000Genomes
tmp_4_8778157_T_C 254 N>S No 1000Genomes
ENSVATH06675551 260 I>V No 1000Genomes
ENSVATH02841830 276 N>K No 1000Genomes
tmp_4_8777972_G_A 280 T>I No 1000Genomes
tmp_4_8777930_G_A 294 P>L No 1000Genomes
ENSVATH00507504 295 E>D No 1000Genomes
ENSVATH02841826 296 P>A No 1000Genomes
tmp_4_8777924_G_A 296 P>L No 1000Genomes
ENSVATH02841825 299 N>K No 1000Genomes
ENSVATH02841824 301 S>N No 1000Genomes
ENSVATH14203340 305 A>S No 1000Genomes
ENSVATH11783105 305 A>V No 1000Genomes
ENSVATH11782734 313 D>V No 1000Genomes
tmp_4_8776589_A_T 320 F>L No 1000Genomes
tmp_4_8776585_G_T 322 Q>K No 1000Genomes
ENSVATH14203287 323 D>Y No 1000Genomes
tmp_4_8776573_A_T 326 W>R No 1000Genomes
ENSVATH06675532 328 G>S No 1000Genomes
ENSVATH02841780 330 H>Q No 1000Genomes
ENSVATH02841779 331 V>I No 1000Genomes
tmp_4_8776483_C_T 356 E>K No 1000Genomes
tmp_4_8776480_G_A 357 L>F No 1000Genomes
tmp_4_8776459_C_A 364 A>S No 1000Genomes
ENSVATH06675531 370 G>C No 1000Genomes
ENSVATH06675530 374 P>L No 1000Genomes
tmp_4_8776306_C_G 385 C>S No 1000Genomes
ENSVATH06675522 389 D>N No 1000Genomes
ENSVATH02841769 402 V>I No 1000Genomes
ENSVATH02841767 415 I>F No 1000Genomes
tmp_4_8776078_G_A 421 Q>* No 1000Genomes
ENSVATH02841761 422 V>L No 1000Genomes
tmp_4_8776048_C_G 431 V>L No 1000Genomes
ENSVATH02841757 439 D>H No 1000Genomes
ENSVATH00507498 445 R>K No 1000Genomes
ENSVATH02841754 456 E>K No 1000Genomes
tmp_4_8775948_G_A 464 P>L No 1000Genomes
ENSVATH06675517 467 D>N No 1000Genomes
ENSVATH06675516 469 M>V No 1000Genomes
ENSVATH11782727 519 V>E No 1000Genomes
tmp_4_8775677_T_C 523 Y>C No 1000Genomes
tmp_4_8775669_C_T 526 V>I No 1000Genomes
tmp_4_8775665_T_C 527 D>G No 1000Genomes
tmp_4_8775657_G_A 530 L>F No 1000Genomes
ENSVATH02841721 546 D>E No 1000Genomes
tmp_4_8774660_C_T 557 V>I No 1000Genomes
ENSVATH14203220 571 V>L No 1000Genomes
tmp_4_8774508_G_A 574 A>V No 1000Genomes
tmp_4_8774497_T_C 578 K>E No 1000Genomes
ENSVATH06675488 586 E>K No 1000Genomes
ENSVATH00507491 601 D>N No 1000Genomes
ENSVATH00507490 602 L>F No 1000Genomes
tmp_4_8774419_T_C 604 M>V No 1000Genomes
ENSVATH06675483 627 G>S No 1000Genomes
ENSVATH06675482 631 A>G No 1000Genomes
ENSVATH11782518 640 A>T No 1000Genomes
ENSVATH02841714 642 R>C No 1000Genomes
tmp_4_8774296_C_A 645 V>F No 1000Genomes
ENSVATH06675480 646 R>H No 1000Genomes
ENSVATH06675478 651 T>N No 1000Genomes
ENSVATH06675477 654 T>M No 1000Genomes
ENSVATH02841712 654 T>P No 1000Genomes
ENSVATH02841712 654 T>S No 1000Genomes
ENSVATH02841709 671 I>S No 1000Genomes
tmp_4_8774208_A_G 674 I>T No 1000Genomes
ENSVATH02841707 674 I>V No 1000Genomes
tmp_4_8774190_A_T 680 V>E No 1000Genomes
tmp_4_8774165_C_G 688 M>I No 1000Genomes
ENSVATH14203219 689 V>L No 1000Genomes
ENSVATH02841706 693 G>R No 1000Genomes
ENSVATH08342457 694 N>D No 1000Genomes
ENSVATH08342456 697 K>E No 1000Genomes
ENSVATH02841705 700 P>L No 1000Genomes
ENSVATH14203218 701 L>F No 1000Genomes
tmp_4_8774116_G_A 705 R>C No 1000Genomes
ENSVATH02841702 715 M>L No 1000Genomes
tmp_4_8774061_T_G 723 Q>P No 1000Genomes
ENSVATH06675474 738 P>A No 1000Genomes
tmp_4_8773847_T_A 740 Y>F No 1000Genomes
ENSVATH06675473 743 M>I No 1000Genomes
tmp_4_8773830_G_A 746 L>F No 1000Genomes
tmp_4_8773793_C_A 758 G>V No 1000Genomes
tmp_4_8773791_G_A 759 L>F No 1000Genomes
tmp_4_8773788_A_T 760 L>R No 1000Genomes

No associated diseases with O23390

No regional properties for O23390

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O23390

Functions

Description
EC Number 5.4.99.57 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

2 GO annotations of molecular function

Name Definition
baruol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol.
beta-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin.

2 GO annotations of biological process

Name Definition
tetracyclic triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings.
triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38604 ERG7 Lanosterol synthase ERG7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6Z2X6 Os02g0139700 Cycloartenol synthase Oryza sativa subsp japonica (Rice) PR
B6EXY6 BAS Beta-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
P38605 CAS1 Cycloartenol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q1G1A4 LAS1 Lanosterol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJV8 MRN1 Marneral synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FR95 PEN1 Arabidiol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FZI2 LUP5 Lupeol synthase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVY2 PEN3 Tirucalladienol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9SYN1 PEN6 Seco-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FI37 THAS1 Thalianol synthase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWRLRIGAKA KDNTHLFTTN NYVGRQIWEF DANAGSPEEL AEVEEARRNF SNNRSRFKAS
70 80 90 100 110 120
ADLLWRMQFL REKKFEQKIP RVIVEDAEKI TYEDAKTALR RGLLYFTALQ ADDGHWPAEN
130 140 150 160 170 180
AGSIFFNAPF VICLYITGHL EKIFTHEHRV ELLRYMYNHQ NEDGGWGLHV ESPSNMFCSV
190 200 210 220 230 240
INYICLRILG VEAGHDDKGS ACARARKWIL DHGGATYSPL IGKAWLSVLG VYDWSGCKPI
250 260 270 280 290 300
PPEFWFLPSF FPVNGGTLWI YLRDIFMGLS YLYGKNFVAT STPLILQLRE EIYPEPYTNI
310 320 330 340 350 360
SWRQARNRCA KEDLYYPQSF LQDLFWKGVH VFSENILNRW PFNNLIRQRA LRTTMELVHY
370 380 390 400 410 420
HDEATRYITG GSVPKVIAVF HMLACWVEDP ESDYFKKHLA RVPDFIWIGE DGLKIQSFGS
430 440 450 460 470 480
QVWDTALSLH VFIDGFDDDV DEEIRSTLLK GYDYLEKSQV TENPPGDYMK MFRHMAKGGW
490 500 510 520 530 540
TFSDQDQGWP VSDCTAESLE CCLFFESMSS EFIGKKMDVE KLYDAVDFLL YLQSDNGGIT
550 560 570 580 590 600
AWQPADGKLV EFIEDAVVEH EYVECTGSAI VALAQFNKQF PGYKKEEVER FITKGVKYIE
610 620 630 640 650 660
DLQMVDGSWY GNWGVCFIYG TFFAVRGLVA AGKCYNNCEA IRRAVRFILD TQNTEGGWGE
670 680 690 700 710 720
SYLSCPRKKY IPLIGNKTNV VNTGQALMVL IMGNQMKRDP LPVHRAAKVL INSQMDNGDF
730 740 750
PQQEIMGVFK MNVMLHFPTY RNMFTLWALT HYTKALRGL