Q9LVY2

PR
Gene name
PEN3 (At5g36150, MAB16.10)
Protein name
Tirucalladienol synthase
Names
Pentacyclic triterpene synthase 3, AtPEN3
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G36150
EC number
5.4.99.56: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9LVY2

Entry ID Method Resolution Chain Position Source
AF-Q9LVY2-F1 Predicted AlphaFoldDB

114 variants for Q9LVY2

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH12017977 8 A>P No 1000Genomes
ENSVATH12017976 13 D>N No 1000Genomes
tmp_5_14225374_A_C 17 C>G No 1000Genomes
ENSVATH03252630 21 N>K No 1000Genomes
ENSVATH00676881 22 F>Y No 1000Genomes
ENSVATH03252629 33 N>D No 1000Genomes
tmp_5_14225302_A_G 41 S>P No 1000Genomes
ENSVATH07225738 71 R>W No 1000Genomes
ENSVATH03252623 83 R>I No 1000Genomes
ENSVATH03252623 83 R>K No 1000Genomes
ENSVATH03252621 88 K>E No 1000Genomes
tmp_5_14225079_C_G 88 K>N No 1000Genomes
tmp_5_14225078_T_A 89 K>* No 1000Genomes
tmp_5_14225056_T_A 96 K>I No 1000Genomes
ENSVATH03252618 97 N>K No 1000Genomes
ENSVATH07225737 104 H>R No 1000Genomes
tmp_5_14225012_A_G 111 S>P No 1000Genomes
ENSVATH07225736 116 W>* No 1000Genomes
ENSVATH03252617 118 S>A No 1000Genomes
tmp_5_14224982_C_T 121 A>T No 1000Genomes
ENSVATH03252613 143 V>F No 1000Genomes
tmp_5_14224804_C_G 151 E>D No 1000Genomes
ENSVATH07225711 162 D>Y No 1000Genomes
tmp_5_14223683_C_T 180 V>I No 1000Genomes
tmp_5_14223673_T_C 183 Y>C No 1000Genomes
ENSVATH07225709 206 K>* No 1000Genomes
tmp_5_14223444_C_T 229 G>E No 1000Genomes
ENSVATH08520486 238 P>A No 1000Genomes
tmp_5_14223412_G_A 240 P>S No 1000Genomes
tmp_5_14223381_A_C 250 F>C No 1000Genomes
ENSVATH12017650 270 Y>F No 1000Genomes
tmp_5_14223078_C_A 273 G>C No 1000Genomes
tmp_5_14223070_T_A 275 K>N No 1000Genomes
tmp_5_14223069_A_T 276 F>I No 1000Genomes
tmp_5_14223068_A_T 276 F>Y No 1000Genomes
ENSVATH03252550 279 K>T No 1000Genomes
ENSVATH12017649 297 A>D No 1000Genomes
tmp_5_14223006_C_A 297 A>S No 1000Genomes
ENSVATH07225700 300 V>I No 1000Genomes
ENSVATH03252549 301 W>* No 1000Genomes
ENSVATH14523898 302 S>R No 1000Genomes
ENSVATH03252548 303 Q>L No 1000Genomes
ENSVATH03252547 306 S>N No 1000Genomes
tmp_5_14222976_G_A 307 R>* No 1000Genomes
tmp_5_14222975_C_T 307 R>Q No 1000Genomes
ENSVATH07225698 311 E>A No 1000Genomes
ENSVATH12017604 316 P>L No 1000Genomes
ENSVATH03252541 318 S>T No 1000Genomes
ENSVATH03252540 327 L>F No 1000Genomes
ENSVATH03252540 327 L>I No 1000Genomes
ENSVATH03252540 327 L>V No 1000Genomes
ENSVATH14523884 328 V>F No 1000Genomes
ENSVATH07225697 329 H>R No 1000Genomes
ENSVATH12017603 330 M>V No 1000Genomes
tmp_5_14222783_T_C 334 N>D No 1000Genomes
ENSVATH00676856 334 N>S No 1000Genomes
tmp_5_14222776_A_T 336 L>* No 1000Genomes
tmp_5_14222758_T_C 342 N>S No 1000Genomes
tmp_5_14222732_G_A,T 351 R>* No 1000Genomes
tmp_5_14222728_G_A 352 T>M No 1000Genomes
ENSVATH03252539 354 M>V No 1000Genomes
ENSVATH12017602 358 H>Y No 1000Genomes
tmp_5_14222668_A_T 372 V>E No 1000Genomes
tmp_5_14222457_G_C 380 A>G No 1000Genomes
ENSVATH07225691 382 W>G No 1000Genomes
ENSVATH07225690 382 W>L No 1000Genomes
ENSVATH07225689 386 P>L No 1000Genomes
ENSVATH07225688 388 S>I No 1000Genomes
ENSVATH07225687 390 Y>C No 1000Genomes
tmp_5_14222415_T_C 394 H>R No 1000Genomes
ENSVATH14523880 397 R>* No 1000Genomes
tmp_5_14222383_C_A 405 A>S No 1000Genomes
tmp_5_14222364_A_T 411 I>N No 1000Genomes
ENSVATH07225681 430 A>G No 1000Genomes
ENSVATH07225679 431 A>S No 1000Genomes
ENSVATH07225678 433 V>I No 1000Genomes
tmp_5_14222207_G_A 439 P>S No 1000Genomes
ENSVATH00676849 440 T>M No 1000Genomes
ENSVATH07225677 442 I>T No 1000Genomes
ENSVATH07225676 446 S>F No 1000Genomes
tmp_5_14222150_G_T 458 P>T No 1000Genomes
ENSVATH00676847 462 I>V No 1000Genomes
ENSVATH14523879 466 R>G No 1000Genomes
tmp_5_14222121_G_C 467 D>E No 1000Genomes
tmp_5_14222076_C_T 482 W>* No 1000Genomes
ENSVATH03252499 500 S>N No 1000Genomes
ENSVATH12017313 502 S>* No 1000Genomes
ENSVATH03252498 502 S>P No 1000Genomes
tmp_5_14221744_C_T 504 E>K No 1000Genomes
tmp_5_14221721_T_G 511 E>D No 1000Genomes
ENSVATH03252495 526 Q>E No 1000Genomes
ENSVATH00676841 528 R>K No 1000Genomes
tmp_5_14221414_C_T 564 E>K No 1000Genomes
ENSVATH14523864 577 M>I No 1000Genomes
tmp_5_14221335_T_A 590 K>I No 1000Genomes
tmp_5_14221167_C_A 646 R>L No 1000Genomes
ENSVATH00676837 650 D>E No 1000Genomes
tmp_5_14221149_T_G 652 Q>P No 1000Genomes
tmp_5_14221143_C_A 654 G>V No 1000Genomes
ENSVATH03252488 658 W>L No 1000Genomes
tmp_5_14221126_C_G 660 E>Q No 1000Genomes
ENSVATH07225657 661 S>N No 1000Genomes
tmp_5_14221121_A_T 661 S>R No 1000Genomes
ENSVATH03252487 669 N>K No 1000Genomes
ENSVATH07225656 672 P>S No 1000Genomes
ENSVATH07225655 674 E>K No 1000Genomes
ENSVATH00676836 679 D>N No 1000Genomes
tmp_5_14220990_C_T 705 R>H No 1000Genomes
ENSVATH07225654 718 G>D No 1000Genomes
ENSVATH07225647 736 N>K No 1000Genomes
tmp_5_14220777_GC_AC,G 748 A>V No 1000Genomes
tmp_5_14220774_A_G 749 L>P No 1000Genomes
tmp_5_14220754_T_A 756 I>L No 1000Genomes
tmp_5_14220751_G_A 757 R>W No 1000Genomes

No associated diseases with Q9LVY2

3 regional properties for Q9LVY2

Type Name Position InterPro Accession
conserved_site Terpene synthase, conserved site 606 - 620 IPR002365
domain Squalene cyclase, C-terminal 416 - 753 IPR032696
domain Squalene cyclase, N-terminal 102 - 405 IPR032697

Functions

Description
EC Number 5.4.99.56 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.

2 GO annotations of molecular function

Name Definition
beta-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin.
lupeol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol.

1 GO annotations of biological process

Name Definition
triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38604 ERG7 Lanosterol synthase ERG7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6Z2X6 Os02g0139700 Cycloartenol synthase Oryza sativa subsp japonica (Rice) PR
B6EXY6 BAS Beta-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
O23390 BARS1 Baruol synthase Arabidopsis thaliana (Mouse-ear cress) PR
P38605 CAS1 Cycloartenol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q1G1A4 LAS1 Lanosterol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJV8 MRN1 Marneral synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FR95 PEN1 Arabidiol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FZI2 LUP5 Lupeol synthase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SYN1 PEN6 Seco-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FI37 THAS1 Thalianol synthase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWRLRIGAKA GDDPHLCTTN NFLGRQIWEF DANAGSPAEL SEVDQARQNF SNNRSQYKAC
70 80 90 100 110 120
ADLLWRMQFL REKNFEQKIP RVRIEDAKKI TFEDAKNTLR RGIHYMAALQ SDDGHWPSEN
130 140 150 160 170 180
AGCIFFNAPF VICLYITGHL DKVFSEEHRK EMLRYMYNHQ NDDGGWGIDV ESHSFMFCTV
190 200 210 220 230 240
INYICLRIFG VDPDHDGESA CARARKWIID HGGATYTPLF GKAWLSVLGV YEWSGCKPIP
250 260 270 280 290 300
PEFWFFPSYF PINGGTLWIY LRDTFMAMSY LYGKKFVAKP TPLILQLREE LYPQPYAEIV
310 320 330 340 350 360
WSQARSRCAK EDLYYPQSLV QDLFWKLVHM FSENILNRWP FNKLIREKAI RTAMELIHYH
370 380 390 400 410 420
DEATRYITGG AVPKVFHMLA CWVEDPESDY FKKHLARVSH FIWIAEDGLK IQTFGSQIWD
430 440 450 460 470 480
TAFVLQVMLA ADVDDEIRPT LIKGYSYLRK SQFTENPPGD YINMFRDISK GGWGYSDKDQ
490 500 510 520 530 540
GWPVSDCISE SLECCLIFES MSSEFIGEKM EVERLYDAVN MLLYMQSRNG GISIWEAASG
550 560 570 580 590 600
KKWLEWLSPI EFIEDTILEH EYLECTGSAI VVLARFMKQF PGHRTEEVKK FITKGVKYIE
610 620 630 640 650 660
SLQIADGSWY GNWGICFIYG TFFAVRGLVA AGNTYDNCEA IRRAVRFLLD IQNGEGGWGE
670 680 690 700 710 720
SFLSCPNKNY IPLEGNKTDV VNTGQALMVL IMGGQMDRDP LPVHRAAKVL INSQMDNGDF
730 740 750
PQQEIRGVYK MNVMLNFPTF RNSFTLWALT HYTKAIRLLL