B6EXY6

PR
Gene name
BAS
Protein name
Beta-amyrin synthase
Names
AtBAS, Lupeol synthase 4, AtLUP4
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G78950
EC number
5.4.99.39: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B6EXY6

Entry ID Method Resolution Chain Position Source
AF-B6EXY6-F1 Predicted AlphaFoldDB

60 variants for B6EXY6

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05171160 3 R>K No 1000Genomes
tmp_1_29688650_T_G 8 E>D No 1000Genomes
tmp_1_29688639_T_C 12 D>G No 1000Genomes
ENSVATH05171157 32 P>L No 1000Genomes
tmp_1_29688565_G_A 37 P>S No 1000Genomes
ENSVATH13837399 41 H>N No 1000Genomes
ENSVATH05171156 49 I>S No 1000Genomes
tmp_1_29688491_G_C 61 S>R No 1000Genomes
tmp_1_29688479_C_T 65 W>* No 1000Genomes
ENSVATH05171141 78 R>G No 1000Genomes
ENSVATH05171140 78 R>L No 1000Genomes
ENSVATH05171139 84 V>I No 1000Genomes
ENSVATH14492861 91 T>N No 1000Genomes
tmp_1_29688054_C_T 98 A>T No 1000Genomes
ENSVATH05171138 105 F>L No 1000Genomes
tmp_1_29688006_C_T 114 G>S No 1000Genomes
tmp_1_29687716_C_A 133 C>F No 1000Genomes
ENSVATH00148667 146 S>L No 1000Genomes
ENSVATH05171128 148 H>Y No 1000Genomes
tmp_1_29687660_T_C 152 I>V No 1000Genomes
ENSVATH05171127 194 D>V No 1000Genomes
ENSVATH13837382 205 R>Q No 1000Genomes
ENSVATH14492859 218 P>L No 1000Genomes
tmp_1_29687242_G_T 238 P>Q No 1000Genomes
tmp_1_29687243_G_T 238 P>T No 1000Genomes
ENSVATH05171126 246 L>I No 1000Genomes
ENSVATH05171126 246 L>V No 1000Genomes
ENSVATH13837381 251 P>L No 1000Genomes
ENSVATH13837379 275 R>Q No 1000Genomes
tmp_1_29686973_A_C 276 F>C No 1000Genomes
ENSVATH13837378 288 R>H No 1000Genomes
tmp_1_29686887_G_T 305 R>S No 1000Genomes
tmp_1_29686752_G_C 321 Q>E No 1000Genomes
ENSVATH01557592 339 W>L No 1000Genomes
ENSVATH05171121 353 A>E No 1000Genomes
ENSVATH13837372 354 M>I No 1000Genomes
ENSVATH05171120 372 V>I No 1000Genomes
ENSVATH05171118 395 L>I No 1000Genomes
tmp_1_29686456_T_A 397 R>* No 1000Genomes
ENSVATH05171117 399 S>F No 1000Genomes
tmp_1_29686286_A_C 425 M>R No 1000Genomes
tmp_1_29686241_A_T 440 V>E No 1000Genomes
tmp_1_29686106_T_A 455 E>V No 1000Genomes
ENSVATH13837366 475 F>I No 1000Genomes
ENSVATH05171111 523 L>V No 1000Genomes
ENSVATH05171107 542 K>T No 1000Genomes
ENSVATH13837364 551 E>K No 1000Genomes
tmp_1_29685425_G_A 595 A>V No 1000Genomes
ENSVATH13837363 596 A>V No 1000Genomes
ENSVATH13837362 649 L>H No 1000Genomes
tmp_1_29685133_G_A 664 S>F No 1000Genomes
ENSVATH05171103 671 I>K No 1000Genomes
ENSVATH00148659 674 V>E No 1000Genomes
ENSVATH05171102 686 A>T No 1000Genomes
ENSVATH05171101 691 I>V No 1000Genomes
tmp_1_29684868_T_A 699 D>V No 1000Genomes
tmp_1_29684862_A_G 701 I>T No 1000Genomes
ENSVATH13837361 705 R>S No 1000Genomes
ENSVATH05171099 707 A>V No 1000Genomes
ENSVATH13837357 728 V>G No 1000Genomes

No associated diseases with B6EXY6

3 regional properties for B6EXY6

Type Name Position InterPro Accession
conserved_site Terpene synthase, conserved site 606 - 620 IPR002365
domain Squalene cyclase, C-terminal 416 - 753 IPR032696
domain Squalene cyclase, N-terminal 104 - 405 IPR032697

Functions

Description
EC Number 5.4.99.39 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

1 GO annotations of molecular function

Name Definition
beta-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin.

1 GO annotations of biological process

Name Definition
triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38604 ERG7 Lanosterol synthase ERG7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6Z2X6 Os02g0139700 Cycloartenol synthase Oryza sativa subsp japonica (Rice) PR
O23390 BARS1 Baruol synthase Arabidopsis thaliana (Mouse-ear cress) PR
P38605 CAS1 Cycloartenol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q1G1A4 LAS1 Lanosterol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJV8 MRN1 Marneral synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FR95 PEN1 Arabidiol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FZI2 LUP5 Lupeol synthase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVY2 PEN3 Tirucalladienol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9SYN1 PEN6 Seco-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FI37 THAS1 Thalianol synthase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWRLKIGEGN GDDPYLFTTN NFAGRQTWEF DPDGGSPEER HSVVEARRIF YDNRFHVKAS
70 80 90 100 110 120
SDLLWRMQFL REKKFEQRIA PVKVEDSEKV TFETATSALR RGIHFFSALQ ASDGHWPAEN
130 140 150 160 170 180
AGPLFFLPPL VFCLYITGHL DEVFTSEHRK EILRYIYCHQ KEDGGWGLHI EGHSTMFCTT
190 200 210 220 230 240
LNYICMRILG ESPDGGHDNA CGRAREWILS HGGVTYIPSW GKTWLSILGV FDWSGSNPMP
250 260 270 280 290 300
PEFWILPSFF PVHPAKMWSY CRMVYLPMSY LYGKRFVGPI TSLILQLRKE LYLQPYEEIN
310 320 330 340 350 360
WMKVRHLCAK EDTYYPRPLV QELVWDSLYI FAEPFLARWP FNKLLREKAL QLAMKHIHYE
370 380 390 400 410 420
DENSRYITIG CVEKVLCMLA CWVEDPNGDY FKKHLSRISD YLWMAEDGMK MQSFGSQLWD
430 440 450 460 470 480
TGFAMQALLA SNLSSEISDV LRRGHEFIKN SQVGENPSGD YKSMYRHISK GAWTFSDRDH
490 500 510 520 530 540
GWQVSDCTAH GLKCCLLFSM LAPDIVGPKQ DPERLHDSVN ILLSLQSKNG GMTAWEPAGA
550 560 570 580 590 600
PKWLELLNPT EMFSDIVIEH EYSECTSSAI QALSLFKQLY PDHRTTEITA FIKKAAEYLE
610 620 630 640 650 660
NMQTRDGSWY GNWGICFTYG TWFALAGLAA AGKTFNDCEA IRKGVQFLLA AQKDNGGWGE
670 680 690 700 710 720
SYLSCSKKIY IAQVGEISNV VQTAWALMGL IHSGQAERDP IPLHRAAKLI INSQLESGDF
730 740 750
PQQQATGVFL KNCTLHYAAY RNIHPLWALA EYRARVSLP