Q9FJV8

PR
Gene name
MRN1 (PEN5, At5g42600, MFO20.1)
Protein name
Marneral synthase
Names
AtMRN1, Pentacyclic triterpene synthase 5, AtPEN5
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G42600
EC number
5.4.99.53: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-119 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FJV8

Entry ID Method Resolution Chain Position Source
AF-Q9FJV8-F1 Predicted AlphaFoldDB

104 variants for Q9FJV8

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_17053573_G_A 3 R>K No 1000Genomes
ENSVATH07304296 8 A>T No 1000Genomes
ENSVATH12387614 10 A>P No 1000Genomes
tmp_5_17053594_C_T 10 A>V No 1000Genomes
ENSVATH00697054 12 Q>E No 1000Genomes
ENSVATH12387655 13 D>E No 1000Genomes
tmp_5_17053614_T_C 17 F>L No 1000Genomes
ENSVATH12387656 37 P>L No 1000Genomes
ENSVATH07304298 41 A>G No 1000Genomes
ENSVATH03323967 45 E>Q No 1000Genomes
ENSVATH14569646 48 L>I No 1000Genomes
ENSVATH12387657 49 N>S No 1000Genomes
ENSVATH00697055 51 A>S No 1000Genomes
ENSVATH07304299 53 N>I No 1000Genomes
tmp_5_17053735_T_C 57 F>S No 1000Genomes
ENSVATH00697056 64 F>L No 1000Genomes
tmp_5_17053903_G_C 72 E>Q No 1000Genomes
ENSVATH03323977 83 R>I No 1000Genomes
ENSVATH03323978 86 D>G No 1000Genomes
ENSVATH14569647 87 A>T No 1000Genomes
tmp_5_17054044_G_C 119 E>Q No 1000Genomes
tmp_5_17054204_T_A 133 C>S No 1000Genomes
ENSVATH00697058 142 K>Q No 1000Genomes
ENSVATH07304308 146 L>V No 1000Genomes
tmp_5_17054274_T_C 156 M>T No 1000Genomes
ENSVATH03324010 162 E>D No 1000Genomes
tmp_5_17054639_A_G 162 E>G No 1000Genomes
ENSVATH14569650 166 W>* No 1000Genomes
ENSVATH14569651 168 L>V No 1000Genomes
ENSVATH03324011 170 V>M No 1000Genomes
tmp_5_17054690_C_A 179 T>K No 1000Genomes
tmp_5_17054723_G_A 190 G>E No 1000Genomes
ENSVATH00697062 195 H>L No 1000Genomes
ENSVATH03324012 199 K>E No 1000Genomes
ENSVATH00697063 199 K>R No 1000Genomes
tmp_5_17054755_G_A 201 A>T No 1000Genomes
tmp_5_17054768_C_G 205 A>G No 1000Genomes
tmp_5_17054810_C_T 219 P>L No 1000Genomes
ENSVATH03324021 246 M>I No 1000Genomes
ENSVATH03324022 247 L>F No 1000Genomes
tmp_5_17055007_C_A 249 S>Y No 1000Genomes
tmp_5_17055010_T_C 250 F>S No 1000Genomes
tmp_5_17055015_C_T 252 P>S No 1000Genomes
tmp_5_17055189_A_G 275 K>E No 1000Genomes
ENSVATH07304334 276 K>R No 1000Genomes
ENSVATH03324026 277 F>Y No 1000Genomes
ENSVATH03324027 279 A>S No 1000Genomes
tmp_5_17055214_C_T 283 A>V No 1000Genomes
ENSVATH12387816 284 L>F No 1000Genomes
tmp_5_17055223_T_A 286 L>Q No 1000Genomes
tmp_5_17055273_A_C 303 S>R No 1000Genomes
ENSVATH14569668 305 A>D No 1000Genomes
ENSVATH03324028 310 A>T No 1000Genomes
ENSVATH07304345 332 L>I No 1000Genomes
ENSVATH12387819 335 N>D No 1000Genomes
ENSVATH07304346 342 L>F No 1000Genomes
ENSVATH07304348 349 R>K No 1000Genomes
tmp_5_17055512_C_G 353 T>S No 1000Genomes
tmp_5_17055985_C_G 406 A>G No 1000Genomes
tmp_5_17056412_C_T 422 A>V No 1000Genomes
tmp_5_17056423_C_A 426 L>I No 1000Genomes
tmp_5_17056449_G_T,A 434 M>I No 1000Genomes
ENSVATH07304372 435 D>N No 1000Genomes
tmp_5_17056456_G_A 437 E>K No 1000Genomes
tmp_5_17056466_CA_TA,C 440 S>L No 1000Genomes
ENSVATH07304374 461 D>N No 1000Genomes
ENSVATH07304375 475 T>S No 1000Genomes
ENSVATH07304377 480 E>D No 1000Genomes
tmp_5_17056592_G_C 482 G>A No 1000Genomes
ENSVATH12387974 483 L>F No 1000Genomes
tmp_5_17056608_T_G 487 D>E No 1000Genomes
tmp_5_17056624_A_C,T 493 I>L No 1000Genomes
ENSVATH07304386 498 H>L No 1000Genomes
ENSVATH07304385 498 H>Y No 1000Genomes
tmp_5_17056739_C_G 499 F>L No 1000Genomes
tmp_5_17056748_G_C 502 M>I No 1000Genomes
ENSVATH07304387 506 F>L No 1000Genomes
tmp_5_17056777_A_G 512 D>G No 1000Genomes
ENSVATH14569699 532 G>C No 1000Genomes
ENSVATH07304394 539 A>V No 1000Genomes
tmp_5_17057163_T_C 554 V>A No 1000Genomes
ENSVATH07304405 558 V>I No 1000Genomes
ENSVATH00697077 561 Q>R No 1000Genomes
ENSVATH07304412 575 V>A No 1000Genomes
ENSVATH07304412 575 V>G No 1000Genomes
ENSVATH07304413 578 K>R No 1000Genomes
ENSVATH03324066 594 K>R No 1000Genomes
ENSVATH03324067 597 L>V No 1000Genomes
ENSVATH03324068 602 D>E No 1000Genomes
ENSVATH03324073 637 G>D No 1000Genomes
ENSVATH03324072 637 G>S No 1000Genomes
ENSVATH03324074 638 N>D No 1000Genomes
tmp_5_17057542_A_G 651 N>S No 1000Genomes
ENSVATH12388061 656 E>K No 1000Genomes
ENSVATH12388063 669 K>R No 1000Genomes
tmp_5_17057611_C_G 674 S>C No 1000Genomes
ENSVATH07304416 678 V>M No 1000Genomes
ENSVATH07304418 692 L>I No 1000Genomes
ENSVATH07304419 694 G>V No 1000Genomes
ENSVATH12388135 703 P>L No 1000Genomes
ENSVATH07304422 718 I>T No 1000Genomes
ENSVATH14569708 754 N>D No 1000Genomes
ENSVATH14569709 754 N>K No 1000Genomes
ENSVATH12388142 757 R>L No 1000Genomes

No associated diseases with Q9FJV8

3 regional properties for Q9FJV8

Type Name Position InterPro Accession
conserved_site Terpene synthase, conserved site 607 - 621 IPR002365
domain Squalene cyclase, C-terminal 420 - 753 IPR032696
domain Squalene cyclase, N-terminal 106 - 405 IPR032697

Functions

Description
EC Number 5.4.99.53 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

2 GO annotations of molecular function

Name Definition
beta-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin.
marneral synthase activity Catalysis of the reaction: oxidosqualene = marneral.

1 GO annotations of biological process

Name Definition
triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38604 ERG7 Lanosterol synthase ERG7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6Z2X6 Os02g0139700 Cycloartenol synthase Oryza sativa subsp japonica (Rice) PR
B6EXY6 BAS Beta-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
O23390 BARS1 Baruol synthase Arabidopsis thaliana (Mouse-ear cress) PR
P38605 CAS1 Cycloartenol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q1G1A4 LAS1 Lanosterol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FR95 PEN1 Arabidiol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FZI2 LUP5 Lupeol synthase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVY2 PEN3 Tirucalladienol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9SYN1 PEN6 Seco-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FI37 THAS1 Thalianol synthase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWRLRIGAEA RQDPHLFTTN NFAGRQIWEF DANGGSPEEL AEVEEARLNF ANNKSRFKAS
70 80 90 100 110 120
PDLFWRRQFL REKKFEQKIP RVRIEDAEKI TYEDAKTALR RGVLYYAACQ ANDGHWPSEV
130 140 150 160 170 180
SGSMFLDAPF VICLYITGHL EKIFTLEHVK ELLRYMYNTQ NEDGGWGLDV ESHSVMFCTV
190 200 210 220 230 240
LNYICLRILG VEPDHDGQKS ACARARKWIL DHGGATYAPM VAKAWLSVLG VYDWSGCKPL
250 260 270 280 290 300
PPEIWMLPSF SPINGGTLWI YIRDLLMGMS YLYGKKFVAT PTALILQLRE ELYPQPYSKI
310 320 330 340 350 360
IWSKARNRCA KEDLLYPKSF GQDLFWEGVH MLSENIINRW PLNKFVRQRA LRTTMELVHY
370 380 390 400 410 420
HDETTHYITG ACVAKPFHML ACWVEDPDGD YFKKHLARVP DFIWIAEDGL KFQLMGMQSW
430 440 450 460 470 480
NAALSLQVML AANMDDEIRS TLIKGYDFLK QSQISENPQG DHLKMFRDIT KGGWTFQDRE
490 500 510 520 530 540
QGLPISDGTA ESIECCIHFH RMPSEFIGEK MDVEKLYDAV NFLIYLQSDN GGMPVWEPAP
550 560 570 580 590 600
GKKWLEWLSP VEHVENTVVE QEYLECTGSV IAGLVCFKKE FPDHRPKEIE KLIKKGLKYI
610 620 630 640 650 660
EDLQMPDGSW YGNWGVCFTY GTLFAVRGLA AAGKTFGNSE AIRRAVQFIL NTQNAEGGWG
670 680 690 700 710 720
ESALSCPNKK YIPSKGNVTN VVNTGQAMMV LLIGGQMERD PSPVHRAAKV LINSQLDIGD
730 740 750 760
FPQQERRGIY MNMLLHYPTY RNMFSLWALA LYTNALRLLV S