Q9FR95

PR
Gene name
PEN1 (04C11, At4g15340, dl3715c, FCAALL.158)
Protein name
Arabidiol synthase
Names
Pentacyclic triterpene synthase 1, AtPEN1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G15340
EC number
4.2.1.124: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

10-80 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FR95

Entry ID Method Resolution Chain Position Source
AF-Q9FR95-F1 Predicted AlphaFoldDB

178 variants for Q9FR95

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06675075 9 K>E No 1000Genomes
tmp_4_8760558_C_T 11 G>E No 1000Genomes
ENSVATH06675074 11 G>R No 1000Genomes
tmp_4_8760551_A_T 13 D>E No 1000Genomes
tmp_4_8760553_C_T 13 D>N No 1000Genomes
tmp_4_8760487_C_T 35 G>S No 1000Genomes
tmp_4_8760486_C_A 35 G>V No 1000Genomes
ENSVATH06675070 36 S>F No 1000Genomes
ENSVATH06675069 41 A>V No 1000Genomes
ENSVATH14202749 43 V>G No 1000Genomes
tmp_4_8760450_C_G 47 R>P No 1000Genomes
tmp_4_8760443_A_T 49 N>K No 1000Genomes
ENSVATH02841421 53 N>I No 1000Genomes
ENSVATH14202748 54 R>S No 1000Genomes
tmp_4_8760424_G_C 56 H>D No 1000Genomes
ENSVATH02841420 56 H>R No 1000Genomes
ENSVATH06675067 57 Y>D No 1000Genomes
ENSVATH06675067 57 Y>N No 1000Genomes
ENSVATH06675054 71 R>K No 1000Genomes
ENSVATH00507353 74 G>C No 1000Genomes
ENSVATH00507353 74 G>S No 1000Genomes
ENSVATH11780360 82 V>M No 1000Genomes
ENSVATH14202747 84 V>I No 1000Genomes
ENSVATH06675051 90 I>L No 1000Genomes
ENSVATH06675050 91 R>K No 1000Genomes
ENSVATH06675049 95 A>V No 1000Genomes
tmp_4_8760184_C_T 98 A>T No 1000Genomes
ENSVATH06675048 99 L>F No 1000Genomes
tmp_4_8760178_T_C 100 K>E No 1000Genomes
tmp_4_8760137_A_C 113 D>E No 1000Genomes
tmp_4_8760112_C_T 122 G>S No 1000Genomes
tmp_4_8760086_T_A 130 L>F No 1000Genomes
ENSVATH11780308 146 V>I No 1000Genomes
ENSVATH06675037 149 R>C No 1000Genomes
ENSVATH00507349 153 I>L No 1000Genomes
ENSVATH00507347 153 I>M No 1000Genomes
ENSVATH00507348 153 I>R No 1000Genomes
ENSVATH11780305 162 E>K No 1000Genomes
tmp_4_8759794_C_T 164 G>D No 1000Genomes
tmp_4_8759792_C_A 165 G>W No 1000Genomes
ENSVATH11780284 171 E>Q No 1000Genomes
tmp_4_8759755_A_G 177 F>S No 1000Genomes
tmp_4_8759742_G_T,C 181 I>M No 1000Genomes
tmp_4_8759728_A_T 186 L>* No 1000Genomes
ENSVATH11780283 193 A>V No 1000Genomes
ENSVATH00507345 204 T>S No 1000Genomes
tmp_4_8759660_A_G 209 W>R No 1000Genomes
tmp_4_8759641_C_T 215 G>D No 1000Genomes
ENSVATH06675031 226 C>F No 1000Genomes
tmp_4_8759500_G_A 236 S>F No 1000Genomes
tmp_4_8759493_G_C 238 C>W No 1000Genomes
ENSVATH02841396 250 S>F No 1000Genomes
ENSVATH11780281 256 G>E No 1000Genomes
tmp_4_8758619_A_T 262 Y>* No 1000Genomes
tmp_4_8758603_T_G 268 M>L No 1000Genomes
ENSVATH11780172 271 S>T No 1000Genomes
tmp_4_8758574_T_G 277 K>N No 1000Genomes
tmp_4_8758576_T_G 277 K>Q No 1000Genomes
ENSVATH06675005 280 A>G No 1000Genomes
tmp_4_8758564_T_C 281 T>A No 1000Genomes
ENSVATH00507327 282 P>S No 1000Genomes
tmp_4_8758500_T_C 302 N>S No 1000Genomes
ENSVATH06675004 304 R>K No 1000Genomes
ENSVATH00507325 307 R>* No 1000Genomes
ENSVATH02841304 314 D>Y No 1000Genomes
ENSVATH11780057 316 C>Y No 1000Genomes
ENSVATH00507315 318 P>S No 1000Genomes
ENSVATH11780056 319 S>P No 1000Genomes
ENSVATH11780055 319 S>Y No 1000Genomes
tmp_4_8757827_A_T 321 F>L No 1000Genomes
ENSVATH02841303 322 L>F No 1000Genomes
ENSVATH11779984 323 Q>K No 1000Genomes
ENSVATH06674976 323 Q>P No 1000Genomes
tmp_4_8757804_C_T 329 G>D No 1000Genomes
tmp_4_8757771_C_G 340 R>P No 1000Genomes
ENSVATH06674975 342 P>R No 1000Genomes
ENSVATH14202701 342 P>T No 1000Genomes
ENSVATH06674974 344 N>K No 1000Genomes
ENSVATH11779983 344 N>S No 1000Genomes
ENSVATH02841302 349 Q>E No 1000Genomes
tmp_4_8757741_G_A 350 A>V No 1000Genomes
ENSVATH06674973 353 R>* No 1000Genomes
ENSVATH06674972 353 R>Q No 1000Genomes
tmp_4_8757694_T_A 366 N>Y No 1000Genomes
tmp_4_8757690_C_A 367 R>I No 1000Genomes
ENSVATH11779982 374 V>E No 1000Genomes
tmp_4_8757670_C_T 374 V>M No 1000Genomes
tmp_4_8757667_G_A 375 P>S No 1000Genomes
tmp_4_8757581_C_A,T 380 M>I No 1000Genomes
tmp_4_8757568_C_T 385 V>I No 1000Genomes
ENSVATH06674964 386 E>K No 1000Genomes
ENSVATH11779976 390 G>R No 1000Genomes
ENSVATH02841291 391 E>D No 1000Genomes
tmp_4_8757541_T_G 394 K>Q No 1000Genomes
tmp_4_8757519_G_C 401 S>C No 1000Genomes
tmp_4_8757501_C_G 407 G>A No 1000Genomes
tmp_4_8757290_G_T 428 H>N No 1000Genomes
ENSVATH02841277 429 F>L No 1000Genomes
ENSVATH06674959 433 G>D No 1000Genomes
ENSVATH00507310 434 V>A No 1000Genomes
tmp_4_8757272_C_A 434 V>F No 1000Genomes
ENSVATH00507310 434 V>G No 1000Genomes
ENSVATH11779930 438 V>A No 1000Genomes
ENSVATH06674958 444 S>T No 1000Genomes
tmp_4_8757194_C_A 460 E>* No 1000Genomes
ENSVATH06674957 462 P>S No 1000Genomes
tmp_4_8757157_T_C 472 H>R No 1000Genomes
tmp_4_8757151_G_A 474 S>L No 1000Genomes
ENSVATH14202699 482 D>E No 1000Genomes
ENSVATH14202698 493 T>S No 1000Genomes
tmp_4_8756992_A_C 500 C>W No 1000Genomes
ENSVATH02841270 513 Q>E No 1000Genomes
tmp_4_8756943_C_T 517 V>M No 1000Genomes
tmp_4_8756925_C_A 523 A>S No 1000Genomes
ENSVATH02841269 527 L>I No 1000Genomes
ENSVATH06674930 533 D>N No 1000Genomes
tmp_4_8755745_T_G 537 I>L No 1000Genomes
ENSVATH14202670 539 A>V No 1000Genomes
tmp_4_8755730_G_A 542 P>S No 1000Genomes
tmp_4_8755718_T_G 546 K>Q No 1000Genomes
tmp_4_8755714_G_C 547 T>S No 1000Genomes
tmp_4_8755705_T_A 550 E>V No 1000Genomes
ENSVATH00507296 559 Q>E No 1000Genomes
ENSVATH00507295 564 E>D No 1000Genomes
tmp_4_8755579_C_T 564 E>K No 1000Genomes
ENSVATH06674924 569 E>K No 1000Genomes
ENSVATH02841218 571 T>A No 1000Genomes
ENSVATH11779667 575 I>M No 1000Genomes
tmp_4_8755417_G_A 586 P>S No 1000Genomes
tmp_4_8755400_T_A,C 591 K>N No 1000Genomes
tmp_4_8755396_C_T,A 593 V>F No 1000Genomes
tmp_4_8755396_C_T,A 593 V>I No 1000Genomes
ENSVATH06674921 598 T>I No 1000Genomes
ENSVATH00507291 599 N>K No 1000Genomes
tmp_4_8755369_T_C 602 K>E No 1000Genomes
ENSVATH14202668 605 E>K No 1000Genomes
ENSVATH14202667 605 E>V No 1000Genomes
ENSVATH11779666 606 D>N No 1000Genomes
ENSVATH00507290 607 L>M No 1000Genomes
ENSVATH11779665 620 V>L No 1000Genomes
ENSVATH11779632 622 F>C No 1000Genomes
tmp_4_8755299_C_T 625 G>E No 1000Genomes
ENSVATH00507289 626 T>A No 1000Genomes
ENSVATH06674919 627 L>F No 1000Genomes
ENSVATH11779631 634 V>L No 1000Genomes
ENSVATH11779630 637 G>R No 1000Genomes
ENSVATH06674918 639 T>I No 1000Genomes
tmp_4_8755227_G_T 649 A>E No 1000Genomes
ENSVATH06674917 663 W>* No 1000Genomes
tmp_4_8755182_C_G 664 G>A No 1000Genomes
tmp_4_8755165_A_C,T 670 C>G No 1000Genomes
tmp_4_8755165_A_C,T 670 C>S No 1000Genomes
ENSVATH06674914 672 R>K No 1000Genomes
tmp_4_8755150_A_C 675 Y>D No 1000Genomes
tmp_4_8755117_C_G 686 V>L No 1000Genomes
ENSVATH02841213 687 S>N No 1000Genomes
tmp_4_8755108_C_A 689 G>* No 1000Genomes
ENSVATH02841212 691 A>G No 1000Genomes
tmp_4_8755102_C_T 691 A>T No 1000Genomes
ENSVATH11779629 697 M>I No 1000Genomes
tmp_4_8755080_C_A 698 G>V No 1000Genomes
tmp_4_8755048_G_C,A 709 H>D No 1000Genomes
tmp_4_8755047_T_A 709 H>L No 1000Genomes
tmp_4_8755048_G_C,A 709 H>Y No 1000Genomes
tmp_4_8755030_C_T 715 V>M No 1000Genomes
tmp_4_8755023_T_G 717 N>T No 1000Genomes
tmp_4_8755005_C_T 723 G>D No 1000Genomes
ENSVATH11779614 729 E>K No 1000Genomes
tmp_4_8754774_C_T 733 V>I No 1000Genomes
tmp_4_8754747_A_C 742 Y>D No 1000Genomes
ENSVATH00507286 749 Y>F No 1000Genomes
ENSVATH06674903 753 A>P No 1000Genomes
ENSVATH06674902 759 Q>H No 1000Genomes
tmp_4_8754696_G_T 759 Q>K No 1000Genomes
tmp_4_8754695_T_C 759 Q>R No 1000Genomes
tmp_4_8754692_G_C 760 A>G No 1000Genomes
ENSVATH14202666 764 L>F No 1000Genomes
ENSVATH14202624 767 P>G No 1000Genomes

No associated diseases with Q9FR95

3 regional properties for Q9FR95

Type Name Position InterPro Accession
conserved_site Terpene synthase, conserved site 611 - 625 IPR002365
domain Squalene cyclase, C-terminal 418 - 758 IPR032696
domain Squalene cyclase, N-terminal 102 - 384 IPR032697

Functions

Description
EC Number 4.2.1.124 Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

3 GO annotations of molecular function

Name Definition
arabidiol synthase activity Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol).
beta-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin.
lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

2 GO annotations of biological process

Name Definition
tricyclic triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings.
triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38604 ERG7 Lanosterol synthase ERG7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6Z2X6 Os02g0139700 Cycloartenol synthase Oryza sativa subsp japonica (Rice) PR
B6EXY6 BAS Beta-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
O23390 BARS1 Baruol synthase Arabidopsis thaliana (Mouse-ear cress) PR
P38605 CAS1 Cycloartenol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q1G1A4 LAS1 Lanosterol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJV8 MRN1 Marneral synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FZI2 LUP5 Lupeol synthase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVY2 PEN3 Tirucalladienol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9SYN1 PEN6 Seco-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FI37 THAS1 Thalianol synthase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWRLRIGAKA GNDTHLFTTN NYVGRQIWEF DANAGSPQEL AEVEEARRNF SNNRSHYKAS
70 80 90 100 110 120
ADLLWRMQFL REKGFEQKIP RVRVEDAAKI RYEDAKTALK RGLHYFTALQ ADDGHWPADN
130 140 150 160 170 180
SGPNFFIAPL VICLYITGHL EKIFTVEHRI ELIRYMYNHQ NEDGGWGLHV ESPSIMFCTV
190 200 210 220 230 240
INYICLRIVG VEAGHDDDQG STCTKARKWI LDHGGATYTP LIGKACLSVL GVYDWSGCKP
250 260 270 280 290 300
MPPEFWFLPS SFPINGGTLW IYLRDIFMGL SYLYGKKFVA TPTPLILQLQ EELYPEPYTK
310 320 330 340 350 360
INWRLTRNRC AKEDLCYPSS FLQDLFWKGV HIFSESILNR WPFNKLIRQA ALRTTMKLLH
370 380 390 400 410 420
YQDEANRYIT GGSVPKAFHM LACWVEDPEG EYFKKHLARV SDFIWIGEDG LKIQSFGSQL
430 440 450 460 470 480
WDTVMSLHFL LDGVEDDVDD EIRSTLVKGY DYLKKSQVTE NPPSDHIKMF RHISKGGWTF
490 500 510 520 530 540
SDKDQGWPVS DCTAESLKCC LLFERMPSEF VGQKMDVEKL FDAVDFLLYL QSDNGGITAW
550 560 570 580 590 600
EPADGKTWLE WFSPVEFVQD TVIEHEYVEC TGSAIVALTQ FSKQFPEFRK KEVERFITNG
610 620 630 640 650 660
VKYIEDLQMK DGSWCGNWGV CFIYGTLFAV RGLVAAGKTF HNCEPIRRAV RFLLDTQNQE
670 680 690 700 710 720
GGWGESYLSC LRKKYTPLAG NKTNIVSTGQ ALMVLIMGGQ MERDPLPVHR AAKVVINLQL
730 740 750 760
DNGDFPQQEV MGVFNMNVLL HYPTYRNIYS LWALTLYTQA LRRLQP