Q1G1A4

PR
Gene name
LAS1 (LSS, At3g45130, T14D3.70)
Protein name
Lanosterol synthase
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G45130
EC number
5.4.99.7: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-116 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1G1A4

Entry ID Method Resolution Chain Position Source
AF-Q1G1A4-F1 Predicted AlphaFoldDB

148 variants for Q1G1A4

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06223509 3 R>M No 1000Genomes
ENSVATH06223506 27 N>D No 1000Genomes
ENSVATH06223506 27 N>Y No 1000Genomes
ENSVATH14363222 28 Q>K No 1000Genomes
ENSVATH12491576 28 Q>P No 1000Genomes
ENSVATH00399373 32 S>F No 1000Genomes
ENSVATH14363221 33 E>A No 1000Genomes
ENSVATH12491575 36 H>Y No 1000Genomes
ENSVATH06223504 40 H>N No 1000Genomes
ENSVATH06223503 43 S>C No 1000Genomes
tmp_3_16517360_T_A 55 S>C No 1000Genomes
tmp_3_16516382_C_G 67 E>D No 1000Genomes
tmp_3_16516377_C_T 69 G>E No 1000Genomes
tmp_3_16516329_T_A 85 E>V No 1000Genomes
ENSVATH06223469 86 R>G No 1000Genomes
ENSVATH14363169 90 E>A No 1000Genomes
ENSVATH06223468 92 V>E No 1000Genomes
ENSVATH06223467 96 T>S No 1000Genomes
tmp_3_16516290_C_T 98 R>K No 1000Genomes
ENSVATH06223466 106 I>T No 1000Genomes
ENSVATH12491359 107 L>H No 1000Genomes
tmp_3_16516242_C_G 114 W>S No 1000Genomes
ENSVATH06223465 125 L>F No 1000Genomes
ENSVATH06223448 140 G>A No 1000Genomes
ENSVATH12491342 144 A>S No 1000Genomes
tmp_3_16515928_C_T 152 R>H No 1000Genomes
ENSVATH14363165 167 H>Y No 1000Genomes
ENSVATH06223444 168 V>I No 1000Genomes
ENSVATH06223443 173 T>I No 1000Genomes
ENSVATH06223441 178 V>A No 1000Genomes
tmp_3_16515753_C_G 178 V>L No 1000Genomes
ENSVATH12491311 187 M>I No 1000Genomes
ENSVATH06223438 191 L>I No 1000Genomes
ENSVATH14363164 196 G>A No 1000Genomes
ENSVATH06223436 203 S>R No 1000Genomes
ENSVATH06223435 208 H>R No 1000Genomes
ENSVATH06223434 209 G>D No 1000Genomes
ENSVATH12491309 213 F>C No 1000Genomes
tmp_3_16515621_G_T 222 L>I No 1000Genomes
tmp_3_16515528_G_A 225 L>F No 1000Genomes
ENSVATH12491281 229 E>A No 1000Genomes
ENSVATH02430130 231 S>T No 1000Genomes
ENSVATH06223425 240 L>V No 1000Genomes
tmp_3_16515439_C_T 254 M>I No 1000Genomes
ENSVATH06223422 276 R>H No 1000Genomes
tmp_3_16515371_G_T 277 T>N No 1000Genomes
tmp_3_16515360_T_C 281 I>V No 1000Genomes
tmp_3_16515329_A_T 291 I>N No 1000Genomes
ENSVATH06223419 294 H>Q No 1000Genomes
ENSVATH02430129 299 D>G No 1000Genomes
ENSVATH14363163 302 R>S No 1000Genomes
tmp_3_16515293_T_C 303 N>S No 1000Genomes
ENSVATH02430127 320 V>F No 1000Genomes
ENSVATH02430127 320 V>I No 1000Genomes
ENSVATH14363162 323 S>N No 1000Genomes
tmp_3_16515165_A_T 325 L>Q No 1000Genomes
ENSVATH12491263 327 K>Q No 1000Genomes
ENSVATH02430126 331 P>S No 1000Genomes
ENSVATH02430126 331 P>T No 1000Genomes
ENSVATH06223408 334 E>K No 1000Genomes
ENSVATH12491262 335 R>K No 1000Genomes
tmp_3_16515124_T_C 339 N>D No 1000Genomes
ENSVATH12491261 339 N>K No 1000Genomes
tmp_3_16515112_T_G 343 N>H No 1000Genomes
tmp_3_16515109_G_T 344 H>N No 1000Genomes
ENSVATH12491259 344 H>Q No 1000Genomes
ENSVATH12491260 344 H>R No 1000Genomes
ENSVATH06223407 347 Q>E No 1000Genomes
ENSVATH06223406 347 Q>P No 1000Genomes
ENSVATH06223403 354 H>Q No 1000Genomes
ENSVATH12491258 354 H>Y No 1000Genomes
tmp_3_16515045_A_G 365 I>T No 1000Genomes
tmp_3_16514900_G_A 384 S>F No 1000Genomes
tmp_3_16514898_C_T 385 E>K No 1000Genomes
tmp_3_16514892_A_T 387 F>I No 1000Genomes
tmp_3_16514891_A_T 387 F>Y No 1000Genomes
ENSVATH14363161 388 K>Q No 1000Genomes
tmp_3_16514883_G_C 390 H>D No 1000Genomes
ENSVATH14363158 415 L>Q No 1000Genomes
tmp_3_16514715_C_T 421 A>T No 1000Genomes
tmp_3_16514703_T_C 425 I>V No 1000Genomes
ENSVATH14363157 426 L>F No 1000Genomes
tmp_3_16514696_G_A 427 A>V No 1000Genomes
ENSVATH12491226 433 D>E No 1000Genomes
ENSVATH12491225 435 G>S No 1000Genomes
ENSVATH12491214 436 L>W No 1000Genomes
ENSVATH06223390 437 M>I No 1000Genomes
tmp_3_16514660_T_A 439 K>M No 1000Genomes
ENSVATH12491213 440 K>N No 1000Genomes
ENSVATH06223389 443 N>D No 1000Genomes
ENSVATH12491207 455 S>C No 1000Genomes
ENSVATH12491205 460 L>M No 1000Genomes
ENSVATH12491184 475 G>A No 1000Genomes
tmp_3_16514466_C_T 475 G>R No 1000Genomes
tmp_3_16514433_C_T 486 A>T No 1000Genomes
tmp_3_16514424_A_C 489 L>V No 1000Genomes
ENSVATH14363156 491 A>V No 1000Genomes
ENSVATH00399363 492 A>T No 1000Genomes
tmp_3_16514293_C_T 498 M>I No 1000Genomes
ENSVATH12491177 500 V>I No 1000Genomes
ENSVATH12491176 501 N>T No 1000Genomes
ENSVATH06223381 509 E>D No 1000Genomes
tmp_3_16514246_T_G 514 D>A No 1000Genomes
ENSVATH14363134 515 A>V No 1000Genomes
tmp_3_16514226_A_C 521 S>A No 1000Genomes
ENSVATH06223380 526 N>Y No 1000Genomes
tmp_3_16514137_A_G 529 F>L No 1000Genomes
ENSVATH06223379 540 E>Q No 1000Genomes
ENSVATH12491119 557 Y>N No 1000Genomes
ENSVATH06223376 558 Q>P No 1000Genomes
tmp_3_16513869_G_T 563 T>K No 1000Genomes
tmp_3_16513833_G_A 575 T>M No 1000Genomes
ENSVATH06223371 576 L>F No 1000Genomes
tmp_3_16513821_C_T 579 S>N No 1000Genomes
ENSVATH02430112 586 V>I No 1000Genomes
tmp_3_16513787_G_C 590 N>K No 1000Genomes
ENSVATH14363133 591 K>I No 1000Genomes
tmp_3_16513777_C_G 594 E>Q No 1000Genomes
ENSVATH12491084 596 I>N No 1000Genomes
ENSVATH06223370 597 E>G No 1000Genomes
ENSVATH06223364 621 G>S No 1000Genomes
tmp_3_16513611_A_C 622 I>M No 1000Genomes
ENSVATH12491082 626 L>F No 1000Genomes
ENSVATH12491079 664 N>K No 1000Genomes
tmp_3_16513465_G_A 671 P>L No 1000Genomes
ENSVATH06223363 671 P>S No 1000Genomes
ENSVATH06223363 671 P>T No 1000Genomes
tmp_3_16513462_C_G 672 G>A No 1000Genomes
ENSVATH06223362 673 N>I No 1000Genomes
ENSVATH02430106 674 K>N No 1000Genomes
ENSVATH00399360 675 S>T No 1000Genomes
tmp_3_16513447_A_T 677 I>N No 1000Genomes
tmp_3_16513321_G_T 693 A>D No 1000Genomes
ENSVATH06223356 694 S>C No 1000Genomes
ENSVATH12491041 697 P>L No 1000Genomes
ENSVATH14363128 698 M>I No 1000Genomes
ENSVATH06223355 698 M>K No 1000Genomes
ENSVATH12491040 701 H>Y No 1000Genomes
ENSVATH02430103 702 R>H No 1000Genomes
ENSVATH14363127 705 K>N No 1000Genomes
ENSVATH12491037 720 Q>E No 1000Genomes
ENSVATH12491003 731 M>T No 1000Genomes
tmp_3_16513097_A_G 740 I>T No 1000Genomes
ENSVATH06223348 746 L>F No 1000Genomes
ENSVATH12491002 750 R>H No 1000Genomes
ENSVATH06223347 754 L>M No 1000Genomes
ENSVATH12491001 755 S>P No 1000Genomes
tmp_3_16513045_TC_T 757 L>= No 1000Genomes

No associated diseases with Q1G1A4

3 regional properties for Q1G1A4

Type Name Position InterPro Accession
conserved_site Terpene synthase, conserved site 603 - 617 IPR002365
domain Squalene cyclase, C-terminal 413 - 751 IPR032696
domain Squalene cyclase, N-terminal 107 - 402 IPR032697

Functions

Description
EC Number 5.4.99.7 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

1 GO annotations of molecular function

Name Definition
lanosterol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.

1 GO annotations of biological process

Name Definition
triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38604 ERG7 Lanosterol synthase ERG7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6Z2X6 Os02g0139700 Cycloartenol synthase Oryza sativa subsp japonica (Rice) PR
B6EXY6 BAS Beta-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
O23390 BARS1 Baruol synthase Arabidopsis thaliana (Mouse-ear cress) PR
P38605 CAS1 Cycloartenol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJV8 MRN1 Marneral synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FR95 PEN1 Arabidiol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FZI2 LUP5 Lupeol synthase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVY2 PEN3 Tirucalladienol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9SYN1 PEN6 Seco-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FI37 THAS1 Thalianol synthase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWRLKLSEGD EESVNQHVGR QFWEYDNQFG TSEERHHINH LRSNFTLNRF SSKHSSDLLY
70 80 90 100 110 120
RFQCWKEKGK GMERLPQVKV KEGEERLINE EVVNVTLRRS LRFYSILQSQ DGFWPGDYGG
130 140 150 160 170 180
PLFLLPALVI GLYVTEVLDG TLTAQHQIEI RRYLYNHQNK DGGWGLHVEG NSTMFCTVLS
190 200 210 220 230 240
YVALRLMGEE LDGGDGAMES ARSWIHHHGG ATFIPSWGKF WLSVLGAYEW SGNNPLPPEL
250 260 270 280 290 300
WLLPYSLPFH PGRMWCHCRM VYLPMSYLYG RRFVCRTNGT ILSLRRELYT IPYHHIDWDT
310 320 330 340 350 360
ARNQCAKEDL YYPHPKIQDV LWSCLNKFGE PLLERWPLNN LRNHALQTVM QHIHYEDQNS
370 380 390 400 410 420
HYICIGPVNK VLNMLCCWVE SSNSEAFKSH LSRIKDYLWV AEDGMKMQGY NGSQLWDVTL
430 440 450 460 470 480
AVQAILATNL VDDYGLMLKK AHNYIKNTQI RKDTSGDPGL WYRHPCKGGW GFSTGDNPWP
490 500 510 520 530 540
VSDCTAEALK AALLLSQMPV NLVGEPMPEE HLVDAVNFIL SLQNKNGGFA SYELTRSYPE
550 560 570 580 590 600
LEVINPSETF GDIIIDYQYV ECTSAAIQGL VLFTTLNSSY KRKEIVGSIN KAVEFIEKTQ
610 620 630 640 650 660
LPDGSWYGSW GVCFTYATWF GIKGMLASGK TYESSLCIRK ACGFLLSKQL CCGGWGESYL
670 680 690 700 710 720
SCQNKVYTNL PGNKSHIVNT SWALLALIEA GQASRDPMPL HRGAKSLINS QMEDGDYPQQ
730 740 750
EILGVFNRNC MISYSAYRNI FPIWALGEYR KLMLSL