Q9FI37

PR
Gene name
THAS1
Protein name
Thalianol synthase 1
Names
AtTHAS1, Oxidosqualene cyclase, Pentacyclic triterpene synthase 4, AtPEN4
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G48010
EC number
5.4.99.31: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-80 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FI37

Entry ID Method Resolution Chain Position Source
AF-Q9FI37-F1 Predicted AlphaFoldDB

57 variants for Q9FI37

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_19457023_C_A 8 P>Q No 1000Genomes
ENSVATH14608803 45 D>N No 1000Genomes
tmp_5_19457373_G_A 94 D>N No 1000Genomes
ENSVATH07367069 97 T>I No 1000Genomes
ENSVATH07367069 97 T>K No 1000Genomes
ENSVATH12619846 98 A>S No 1000Genomes
tmp_5_19457386_C_T 98 A>V No 1000Genomes
tmp_5_19457404_T_A 104 L>H No 1000Genomes
ENSVATH12619847 107 T>I No 1000Genomes
ENSVATH03385796 139 H>Q No 1000Genomes
tmp_5_19457670_G_A 147 E>K No 1000Genomes
ENSVATH14608804 170 V>I No 1000Genomes
ENSVATH12619854 171 E>A No 1000Genomes
ENSVATH12619876 173 H>Q No 1000Genomes
ENSVATH00718192 199 R>G No 1000Genomes
ENSVATH14608816 201 G>D No 1000Genomes
ENSVATH12619877 210 M>V No 1000Genomes
tmp_5_19458172_C_T 248 P>S No 1000Genomes
tmp_5_19458333_T_A 262 L>* No 1000Genomes
ENSVATH07367086 270 S>A No 1000Genomes
tmp_5_19458365_T_A 273 Y>N No 1000Genomes
ENSVATH03385803 280 P>T No 1000Genomes
tmp_5_19458431_G_A 295 E>K No 1000Genomes
tmp_5_19458465_G_A 306 R>Q No 1000Genomes
tmp_5_19459028_G_A 312 E>K No 1000Genomes
ENSVATH12619899 321 L>S No 1000Genomes
tmp_5_19459066_G_C 324 L>F No 1000Genomes
ENSVATH07367098 330 H>Q No 1000Genomes
tmp_5_19459136_C_G 348 Q>E No 1000Genomes
ENSVATH00718193 359 H>Q No 1000Genomes
tmp_5_19459351_A_G 389 S>G No 1000Genomes
tmp_5_19459420_A_G 412 I>V No 1000Genomes
tmp_5_19459553_A_G 421 D>G No 1000Genomes
ENSVATH07367102 435 D>Y No 1000Genomes
ENSVATH07367103 441 E>D No 1000Genomes
ENSVATH07367104 442 I>M No 1000Genomes
ENSVATH07367106 444 T>I No 1000Genomes
ENSVATH07367107 455 K>E No 1000Genomes
tmp_5_19459670_A_T 460 E>V No 1000Genomes
tmp_5_19459698_G_C 469 M>I No 1000Genomes
tmp_5_19459711_A_G 474 T>A No 1000Genomes
tmp_5_19459883_T_C 502 F>L No 1000Genomes
ENSVATH07367109 512 G>E No 1000Genomes
tmp_5_19459964_T_C 529 Y>H No 1000Genomes
tmp_5_19460664_C_G 571 T>R No 1000Genomes
ENSVATH09538919 582 N>K No 1000Genomes
tmp_5_19460745_C_A 598 T>K No 1000Genomes
tmp_5_19460852_G_T 634 V>L No 1000Genomes
ENSVATH14608833 641 S>C No 1000Genomes
ENSVATH00718204 641 S>N No 1000Genomes
tmp_5_19460915_G_A 655 D>N No 1000Genomes
ENSVATH00718205 659 P>T No 1000Genomes
tmp_5_19460968_C_A 672 S>R No 1000Genomes
ENSVATH00718206 689 A>G No 1000Genomes
tmp_5_19461033_T_C 694 V>A No 1000Genomes
tmp_5_19461081_G_A 710 R>H No 1000Genomes
ENSVATH14608834 740 L>H No 1000Genomes

No associated diseases with Q9FI37

3 regional properties for Q9FI37

Type Name Position InterPro Accession
conserved_site Terpene synthase, conserved site 611 - 625 IPR002365
domain Squalene cyclase, C-terminal 417 - 758 IPR032696
domain Squalene cyclase, N-terminal 105 - 398 IPR032697

Functions

Description
EC Number 5.4.99.31 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

2 GO annotations of molecular function

Name Definition
beta-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin.
thalianol synthase activity Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol).

6 GO annotations of biological process

Name Definition
response to gravity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.
response to light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
root development The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo.
thalianol metabolic process The chemical reactions and pathways involving the triterpene thalianol.
tricyclic triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings.
triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38604 ERG7 Lanosterol synthase ERG7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6Z2X6 Os02g0139700 Cycloartenol synthase Oryza sativa subsp japonica (Rice) PR
B6EXY6 BAS Beta-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
O23390 BARS1 Baruol synthase Arabidopsis thaliana (Mouse-ear cress) PR
P38605 CAS1 Cycloartenol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q1G1A4 LAS1 Lanosterol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJV8 MRN1 Marneral synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FR95 PEN1 Arabidiol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9FZI2 LUP5 Lupeol synthase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVY2 PEN3 Tirucalladienol synthase Arabidopsis thaliana (Mouse-ear cress) PR
Q9SYN1 PEN6 Seco-amyrin synthase Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWRLRTGPKA GEDTHLFTTN NYAGRQIWEF DANAGSPQEI AEVEDARHKF SDNTSRFKTT
70 80 90 100 110 120
ADLLWRMQFL REKKFEQKIP RVIIEDARKI KYEDAKTALK RGLLYFTALQ ADDGHWPAEN
130 140 150 160 170 180
SGPNFYTPPF LICLYITGHL EKIFTPEHVK ELLRHIYNMQ NEDGGWGLHV ESHSVMFCTV
190 200 210 220 230 240
INYVCLRIVG EEVGHDDQRN GCAKAHKWIM DHGGATYTPL IGKALLSVLG VYDWSGCNPI
250 260 270 280 290 300
PPEFWLLPSS FPVNGGTLWI YLRDTFMGLS YLYGKKFVAP PTPLILQLRE ELYPEPYAKI
310 320 330 340 350 360
NWTQTRNRCG KEDLYYPRSF LQDLFWKSVH MFSESILDRW PLNKLIRQRA LQSTMALIHY
370 380 390 400 410 420
HDESTRYITG GCLPKAFHML ACWIEDPKSD YFKKHLARVR EYIWIGEDGL KIQSFGSQLW
430 440 450 460 470 480
DTALSLHALL DGIDDHDVDD EIKTTLVKGY DYLKKSQITE NPRGDHFKMF RHKTKGGWTF
490 500 510 520 530 540
SDQDQGWPVS DCTAESLECC LFFESMPSEL IGKKMDVEKL YDAVDYLLYL QSDNGGIAAW
550 560 570 580 590 600
QPVEGKAWLE WLSPVEFLED TIVEYEYVEC TGSAIAALTQ FNKQFPGYKN VEVKRFITKA
610 620 630 640 650 660
AKYIEDMQTV DGSWYGNWGV CFIYGTFFAV RGLVAAGKTY SNCEAIRKAV RFLLDTQNPE
670 680 690 700 710 720
GGWGESFLSC PSKKYTPLKG NSTNVVQTAQ ALMVLIMGDQ MERDPLPVHR AAQVLINSQL
730 740 750 760
DNGDFPQQEI MGTFMRTVML HFPTYRNTFS LWALTHYTHA LRRLLP