P38605
PR
Gene name |
CAS1 (CYC, At2g07050, T4E14.16) |
Protein name |
Cycloartenol synthase |
Names |
AtCYC, 2,3-epoxysqualene--cycloartenol cyclase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G07050 |
EC number |
5.4.99.8: Transferring other groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38605
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38605-F1 | Predicted | AlphaFoldDB |
70 variants for P38605
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05311405 | 14 | L>F | No | 1000Genomes | |
| tmp_2_2924702_T_A | 25 | F>Y | No | 1000Genomes | |
| ENSVATH05311407 | 30 | P>Q | No | 1000Genomes | |
| ENSVATH01684970 | 34 | T>A | No | 1000Genomes | |
| ENSVATH01684971 | 34 | T>N | No | 1000Genomes | |
| ENSVATH01684972 | 36 | E>D | No | 1000Genomes | |
| ENSVATH01684976 | 50 | D>E | No | 1000Genomes | |
| ENSVATH05311409 | 62 | L>I | No | 1000Genomes | |
| ENSVATH14104594 | 66 | Q>H | No | 1000Genomes | |
| ENSVATH01685013 | 74 | S>I | No | 1000Genomes | |
| ENSVATH01685014 | 77 | L>I | No | 1000Genomes | |
| ENSVATH11896125 | 79 | Q>L | No | 1000Genomes | |
| ENSVATH05311425 | 81 | K>N | No | 1000Genomes | |
| ENSVATH05311426 | 88 | V>A | No | 1000Genomes | |
| ENSVATH14104831 | 89 | T>I | No | 1000Genomes | |
| ENSVATH01685015 | 92 | M>V | No | 1000Genomes | |
| tmp_2_2925709_C_T | 96 | T>M | No | 1000Genomes | |
| tmp_2_2925765_C_G | 115 | P>A | No | 1000Genomes | |
| tmp_2_2925899_C_G | 133 | S>C | No | 1000Genomes | |
| tmp_2_2926145_G_A | 160 | E>K | No | 1000Genomes | |
| ENSVATH05311433 | 203 | D>E | No | 1000Genomes | |
| ENSVATH01685046 | 231 | S>P | No | 1000Genomes | |
| ENSVATH01685046 | 231 | S>T | No | 1000Genomes | |
| ENSVATH11896132 | 249 | I>V | No | 1000Genomes | |
| ENSVATH01685088 | 281 | V>I | No | 1000Genomes | |
| tmp_2_2927159_A_C | 282 | L>F | No | 1000Genomes | |
| ENSVATH11896538 | 291 | V>E | No | 1000Genomes | |
| tmp_2_2927209_A_G | 299 | N>S | No | 1000Genomes | |
| ENSVATH05311459 | 327 | K>R | No | 1000Genomes | |
| ENSVATH05311459 | 327 | K>T | No | 1000Genomes | |
| ENSVATH14104995 | 348 | T>A | No | 1000Genomes | |
| tmp_2_2927619_A_G | 350 | I>M | No | 1000Genomes | |
| tmp_2_2927617_A_G | 350 | I>V | No | 1000Genomes | |
| tmp_2_2927893_C_T | 382 | P>S | No | 1000Genomes | |
| ENSVATH01685149 | 430 | L>F | No | 1000Genomes | |
| tmp_2_2928396_G_A | 432 | E>K | No | 1000Genomes | |
| tmp_2_2928402_T_C | 434 | Y>H | No | 1000Genomes | |
| tmp_2_2928563_T_A | 459 | N>K | No | 1000Genomes | |
| tmp_2_2928564_T_A | 460 | Y>N | No | 1000Genomes | |
| tmp_2_2928639_A_G | 485 | T>A | No | 1000Genomes | |
| tmp_2_2928735_C_G | 492 | A>G | No | 1000Genomes | |
| tmp_2_2928741_T_G | 494 | L>W | No | 1000Genomes | |
| ENSVATH00214485 | 501 | A>E | No | 1000Genomes | |
| ENSVATH05311477 | 505 | E>D | No | 1000Genomes | |
| ENSVATH14105000 | 511 | R>W | No | 1000Genomes | |
| tmp_2_2928806_G_A | 516 | V>I | No | 1000Genomes | |
| ENSVATH01685176 | 539 | P>S | No | 1000Genomes | |
| ENSVATH00214487 | 589 | I>T | No | 1000Genomes | |
| ENSVATH01685188 | 589 | I>V | No | 1000Genomes | |
| ENSVATH00214488 | 625 | L>M | No | 1000Genomes | |
| ENSVATH01685205 | 632 | L>V | No | 1000Genomes | |
| ENSVATH01685206 | 636 | P>S | No | 1000Genomes | |
| ENSVATH01685207 | 637 | H>Y | No | 1000Genomes | |
| ENSVATH00214489 | 640 | K>E | No | 1000Genomes | |
| ENSVATH05311492 | 640 | K>N | No | 1000Genomes | |
| tmp_2_2929669_A_C | 648 | K>N | No | 1000Genomes | |
| ENSVATH11896904 | 670 | L>I | No | 1000Genomes | |
| ENSVATH01685216 | 689 | G>D | No | 1000Genomes | |
| ENSVATH11897506 | 693 | A>S | No | 1000Genomes | |
| ENSVATH00214490 | 694 | E>D | No | 1000Genomes | |
| ENSVATH05311514 | 697 | R>W | No | 1000Genomes | |
| ENSVATH05311515 | 702 | R>G | No | 1000Genomes | |
| tmp_2_2930043_G_A | 704 | A>T | No | 1000Genomes | |
| tmp_2_2930070_G_A | 713 | E>K | No | 1000Genomes | |
| tmp_2_2930222_C_T | 736 | A>V | No | 1000Genomes | |
| tmp_2_2930261_A_T | 749 | Y>F | No | 1000Genomes | |
| ENSVATH11897507 | 750 | R>C | No | 1000Genomes | |
| ENSVATH14105189 | 750 | R>H | No | 1000Genomes | |
| ENSVATH01685230 | 751 | C>S | No | 1000Genomes | |
| tmp_2_2930288_G_A | 758 | G>E | No | 1000Genomes |
No associated diseases with P38605
Functions
| Description | ||
|---|---|---|
| EC Number | 5.4.99.8 | Transferring other groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cycloartenol synthase activity | Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| pentacyclic triterpenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings. |
| pollen development | The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates. |
| thylakoid membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38604 | ERG7 | Lanosterol synthase ERG7 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q6Z2X6 | Os02g0139700 | Cycloartenol synthase | Oryza sativa subsp japonica (Rice) | PR |
| B6EXY6 | BAS | Beta-amyrin synthase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O23390 | BARS1 | Baruol synthase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1G1A4 | LAS1 | Lanosterol synthase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJV8 | MRN1 | Marneral synthase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FR95 | PEN1 | Arabidiol synthase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FZI2 | LUP5 | Lupeol synthase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVY2 | PEN3 | Tirucalladienol synthase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SYN1 | PEN6 | Seco-amyrin synthase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FI37 | THAS1 | Thalianol synthase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWKLKIAEGG | SPWLRTTNNH | VGRQFWEFDP | NLGTPEDLAA | VEEARKSFSD | NRFVQKHSAD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLMRLQFSRE | NLISPVLPQV | KIEDTDDVTE | EMVETTLKRG | LDFYSTIQAH | DGHWPGDYGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PMFLLPGLII | TLSITGALNT | VLSEQHKQEM | RRYLYNHQNE | DGGWGLHIEG | PSTMFGSVLN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YVTLRLLGEG | PNDGDGDMEK | GRDWILNHGG | ATNITSWGKM | WLSVLGAFEW | SGNNPLPPEI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WLLPYFLPIH | PGRMWCHCRM | VYLPMSYLYG | KRFVGPITST | VLSLRKELFT | VPYHEVNWNE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ARNLCAKEDL | YYPHPLVQDI | LWASLHKIVE | PVLMRWPGAN | LREKAIRTAI | EHIHYEDENT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RYICIGPVNK | VLNMLCCWVE | DPNSEAFKLH | LPRIHDFLWL | AEDGMKMQGY | NGSQLWDTGF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AIQAILATNL | VEEYGPVLEK | AHSFVKNSQV | LEDCPGDLNY | WYRHISKGAW | PFSTADHGWP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ISDCTAEGLK | AALLLSKVPK | AIVGEPIDAK | RLYEAVNVII | SLQNADGGLA | TYELTRSYPW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LELINPAETF | GDIVIDYPYV | ECTSAAIQAL | ISFRKLYPGH | RKKEVDECIE | KAVKFIESIQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AADGSWYGSW | AVCFTYGTWF | GVKGLVAVGK | TLKNSPHVAK | ACEFLLSKQQ | PSGGWGESYL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SCQDKVYSNL | DGNRSHVVNT | AWAMLALIGA | GQAEVDRKPL | HRAARYLINA | QMENGDFPQQ |
| 730 | 740 | 750 | |||
| EIMGVFNRNC | MITYAAYRNI | FPIWALGEYR | CQVLLQQGE |