Q9SHV2

PR
Gene name
GLR2.3 (At2g24710, F27A10.2)
Protein name
Glutamate receptor 2.3
Names
Ligand-gated ion channel 2.3
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G24710
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

776-895 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SHV2

Entry ID Method Resolution Chain Position Source
AF-Q9SHV2-F1 Predicted AlphaFoldDB

195 variants for Q9SHV2

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH01886106 2 R>K No 1000Genomes
ENSVATH05581017 3 T>I No 1000Genomes
ENSVATH01886104 4 E>D No 1000Genomes
ENSVATH05581016 4 E>K No 1000Genomes
tmp_2_10520534_G_A 6 L>F No 1000Genomes
ENSVATH05581014 13 V>L No 1000Genomes
ENSVATH05581011 21 N>T No 1000Genomes
tmp_2_10520480_G_A 24 Q>* No 1000Genomes
ENSVATH05581008 35 V>I No 1000Genomes
ENSVATH01886101 36 V>I No 1000Genomes
ENSVATH01886100 39 V>D No 1000Genomes
ENSVATH00245472 40 D>G No 1000Genomes
tmp_2_10520432_C_T 40 D>N No 1000Genomes
ENSVATH13380927 42 S>* No 1000Genomes
ENSVATH01886099 42 S>P No 1000Genomes
ENSVATH01886098 43 H>Y No 1000Genomes
ENSVATH01886097 45 K>E No 1000Genomes
ENSVATH01886094 55 I>L No 1000Genomes
ENSVATH01886093 56 S>G No 1000Genomes
ENSVATH01886092 56 S>T No 1000Genomes
ENSVATH01886091 62 N>H No 1000Genomes
ENSVATH01886090 62 N>S No 1000Genomes
ENSVATH14546003 73 V>I No 1000Genomes
tmp_2_10520329_C_T 74 G>D No 1000Genomes
ENSVATH14546002 77 K>N No 1000Genomes
ENSVATH01886084 78 S>N No 1000Genomes
ENSVATH09378617 93 N>K No 1000Genomes
ENSVATH01886058 95 Q>H No 1000Genomes
tmp_2_10519493_G_C 109 H>D No 1000Genomes
ENSVATH01886051 119 R>Q No 1000Genomes
ENSVATH13380896 120 V>A No 1000Genomes
tmp_2_10519429_G_A 130 P>L No 1000Genomes
ENSVATH01886049 131 I>F No 1000Genomes
tmp_2_10519412_G_A 136 R>C No 1000Genomes
ENSVATH01886044 153 P>A No 1000Genomes
ENSVATH13380895 159 K>E No 1000Genomes
tmp_2_10519341_T_G 159 K>N No 1000Genomes
tmp_2_10519339_A_T 160 L>* No 1000Genomes
ENSVATH14545984 201 A>S No 1000Genomes
ENSVATH01886034 202 I>M No 1000Genomes
ENSVATH13380874 210 S>F No 1000Genomes
ENSVATH13380873 214 L>F No 1000Genomes
ENSVATH13380872 214 L>H No 1000Genomes
ENSVATH01886031 225 L>I No 1000Genomes
ENSVATH01886030 230 Y>S No 1000Genomes
ENSVATH01886028 231 D>A No 1000Genomes
ENSVATH01886029 231 D>H No 1000Genomes
ENSVATH01886029 231 D>Y No 1000Genomes
ENSVATH13380871 243 L>F No 1000Genomes
ENSVATH05580989 248 P>T No 1000Genomes
ENSVATH14545983 253 I>F No 1000Genomes
ENSVATH01886026 256 N>D No 1000Genomes
ENSVATH01886025 261 D>N No 1000Genomes
ENSVATH13380870 265 I>T No 1000Genomes
tmp_2_10519019_C_T 267 E>K No 1000Genomes
ENSVATH05580988 268 T>M No 1000Genomes
ENSVATH01886022 269 A>G No 1000Genomes
tmp_2_10518992_C_G 276 V>L No 1000Genomes
tmp_2_10518964_T_C 285 K>R No 1000Genomes
ENSVATH01886019 287 P>Q No 1000Genomes
ENSVATH13380869 318 A>V No 1000Genomes
ENSVATH00245465 335 K>N No 1000Genomes
ENSVATH13380867 339 T>I No 1000Genomes
tmp_2_10518791_C_T 343 V>I No 1000Genomes
tmp_2_10518764_A_G 352 S>P No 1000Genomes
tmp_2_10518751_G_C 356 P>R No 1000Genomes
ENSVATH05580985 360 Q>E No 1000Genomes
ENSVATH05580983 361 T>I No 1000Genomes
ENSVATH01886010 363 L>S No 1000Genomes
ENSVATH01886009 364 T>K No 1000Genomes
ENSVATH09378609 365 V>I No 1000Genomes
ENSVATH01886008 373 E>D No 1000Genomes
ENSVATH05580982 375 R>H No 1000Genomes
ENSVATH01886006 377 F>V No 1000Genomes
ENSVATH00245463 378 R>S No 1000Genomes
ENSVATH13380866 379 G>R No 1000Genomes
ENSVATH05580981 382 Q>* No 1000Genomes
ENSVATH01886004 391 I>M No 1000Genomes
ENSVATH05580980 391 I>V No 1000Genomes
ENSVATH05580978 403 K>T No 1000Genomes
ENSVATH09378607 405 G>E No 1000Genomes
ENSVATH01885997 419 I>M No 1000Genomes
ENSVATH01885996 420 S>T No 1000Genomes
tmp_2_10518553_A_C 422 L>* No 1000Genomes
ENSVATH01885993 431 H>N No 1000Genomes
ENSVATH01885991 433 V>I No 1000Genomes
ENSVATH01885989 439 D>H No 1000Genomes
ENSVATH00245462 440 S>F No 1000Genomes
ENSVATH00245462 440 S>Y No 1000Genomes
ENSVATH07894859 446 Q>E No 1000Genomes
ENSVATH13380834 449 T>N No 1000Genomes
ENSVATH01885987 450 K>N No 1000Genomes
ENSVATH01885984 462 T>A No 1000Genomes
ENSVATH00245461 465 T>A No 1000Genomes
tmp_2_10518337_C_T 494 R>Q No 1000Genomes
ENSVATH00245459 495 E>A No 1000Genomes
ENSVATH05580974 496 L>M No 1000Genomes
ENSVATH01885975 507 F>S No 1000Genomes
ENSVATH01885975 507 F>Y No 1000Genomes
ENSVATH05580973 510 P>L No 1000Genomes
ENSVATH14545978 514 T>A No 1000Genomes
ENSVATH01885974 517 N>D No 1000Genomes
ENSVATH00245458 517 N>T No 1000Genomes
ENSVATH01885973 518 Y>H No 1000Genomes
ENSVATH14545977 520 D>E No 1000Genomes
ENSVATH01885971 523 Y>H No 1000Genomes
ENSVATH13380833 527 L>P No 1000Genomes
tmp_2_10518130_C_A 535 G>V No 1000Genomes
ENSVATH00245457 541 V>A No 1000Genomes
ENSVATH13380828 545 S>F No 1000Genomes
tmp_2_10518059_C_T 559 G>R No 1000Genomes
ENSVATH01885969 573 I>K No 1000Genomes
ENSVATH01885967 576 M>V No 1000Genomes
ENSVATH01885966 589 I>L No 1000Genomes
ENSVATH01885964 596 C>F No 1000Genomes
ENSVATH01885963 603 Y>H No 1000Genomes
ENSVATH01885962 605 R>H No 1000Genomes
ENSVATH01885960 610 S>R No 1000Genomes
ENSVATH00245455 613 P>L No 1000Genomes
ENSVATH00245455 613 P>R No 1000Genomes
tmp_2_10517890_A_G 615 F>S No 1000Genomes
ENSVATH01885955 647 A>T No 1000Genomes
ENSVATH01885952 664 A>S No 1000Genomes
ENSVATH01885951 669 S>T No 1000Genomes
ENSVATH14545962 670 Q>H No 1000Genomes
ENSVATH01885950 671 K>E No 1000Genomes
ENSVATH01885950 671 K>Q No 1000Genomes
ENSVATH14545961 680 S>N No 1000Genomes
ENSVATH01885947 684 E>D No 1000Genomes
ENSVATH05580965 692 Q>P No 1000Genomes
ENSVATH05580964 693 R>* No 1000Genomes
ENSVATH05580963 693 R>Q No 1000Genomes
ENSVATH05580962 698 L>H No 1000Genomes
ENSVATH13380826 699 G>E No 1000Genomes
ENSVATH05580961 702 K>R No 1000Genomes
ENSVATH00245453 704 R>S No 1000Genomes
ENSVATH05580960 704 R>T No 1000Genomes
ENSVATH14545960 713 P>A No 1000Genomes
tmp_2_10517498_A_G 714 F>S No 1000Genomes
tmp_2_10517493_T_G 716 T>P No 1000Genomes
tmp_2_10517489_G_T 717 A>E No 1000Genomes
ENSVATH01885943 717 A>P No 1000Genomes
ENSVATH01885942 721 D>A No 1000Genomes
ENSVATH01885940 728 P>T No 1000Genomes
ENSVATH13380825 729 K>E No 1000Genomes
ENSVATH01885939 730 K>N No 1000Genomes
ENSVATH01885938 733 V>I No 1000Genomes
ENSVATH13380802 778 A>G No 1000Genomes
ENSVATH01885929 793 A>E No 1000Genomes
ENSVATH07894833 794 M>L No 1000Genomes
ENSVATH01885928 797 E>Q No 1000Genomes
ENSVATH14545959 800 W>S No 1000Genomes
ENSVATH14545958 807 S>N No 1000Genomes
ENSVATH01885927 807 S>R No 1000Genomes
ENSVATH05580952 810 D>Y No 1000Genomes
ENSVATH01885925 812 I>N No 1000Genomes
ENSVATH01885925 812 I>T No 1000Genomes
ENSVATH01885926 812 I>V No 1000Genomes
ENSVATH01885924 814 N>H No 1000Genomes
ENSVATH01885923 814 N>K No 1000Genomes
ENSVATH01885922 818 N>Y No 1000Genomes
ENSVATH01885921 819 P>S No 1000Genomes
ENSVATH01885920 821 F>S No 1000Genomes
ENSVATH01885919 824 R>G No 1000Genomes
ENSVATH01885918 824 R>M No 1000Genomes
ENSVATH05580951 827 D>G No 1000Genomes
tmp_2_10517084_T_C 828 I>M No 1000Genomes
ENSVATH05580950 828 I>V No 1000Genomes
ENSVATH14545957 833 F>L No 1000Genomes
tmp_2_10517062_C_T 836 V>I No 1000Genomes
ENSVATH01885917 837 G>A No 1000Genomes
tmp_2_10517059_C_A 837 G>C No 1000Genomes
ENSVATH01885917 837 G>V No 1000Genomes
tmp_2_10517052_A_G 839 L>S No 1000Genomes
tmp_2_10517050_G_C 840 L>V No 1000Genomes
ENSVATH01885913 855 A>E No 1000Genomes
ENSVATH01885914 855 A>T No 1000Genomes
ENSVATH00245450 858 Q>H No 1000Genomes
ENSVATH01885912 863 D>N No 1000Genomes
ENSVATH01885911 864 K>E No 1000Genomes
ENSVATH14545955 864 K>R No 1000Genomes
ENSVATH05580948 866 E>D No 1000Genomes
tmp_2_10516967_C_T 867 M>I No 1000Genomes
tmp_2_10516968_A_T 867 M>K No 1000Genomes
tmp_2_10516966_T_A 868 S>C No 1000Genomes
ENSVATH05580947 868 S>N No 1000Genomes
ENSVATH05580946 869 P>S No 1000Genomes
ENSVATH14545933 872 S>P No 1000Genomes
ENSVATH07894830 876 M>K No 1000Genomes
ENSVATH14545932 876 M>V No 1000Genomes
ENSVATH07894827 882 T>A No 1000Genomes
ENSVATH07894826 883 Q>* No 1000Genomes
tmp_2_10516903_C_T 889 V>I No 1000Genomes
ENSVATH09378572 895 L>F No 1000Genomes
ENSVATH09598711 896 L>L No 1000Genomes

No associated diseases with Q9SHV2

5 regional properties for Q9SHV2

Type Name Position InterPro Accession
domain Ionotropic glutamate receptor, C-terminal 453 - 803 IPR001320-1
domain Ionotropic glutamate receptor, C-terminal 803 - 838 IPR001320-2
domain Solute-binding protein family 3/N-terminal domain of MltF 478 - 802 IPR001638
domain Receptor, ligand binding region 48 - 391 IPR001828
domain Plant glutamate receptor, periplasmic ligand-binding domain 45 - 412 IPR044440

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
calcium channel activity Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
glutamate receptor activity Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
ligand-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

3 GO annotations of biological process

Name Definition
calcium ion transport The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
calcium-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
cellular response to amino acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O60391 GRIN3B Glutamate receptor ionotropic, NMDA 3B Homo sapiens (Human) PR
Q12879 GRIN2A Glutamate receptor ionotropic, NMDA 2A Homo sapiens (Human) PR
Q91ZU9 Grin3b Glutamate receptor ionotropic, NMDA 3B Mus musculus (Mouse) PR
P23819 Gria2 Glutamate receptor 2 Mus musculus (Mouse) PR
P35439 Grin1 Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Rat) PR
P19491 Gria2 Glutamate receptor 2 Rattus norvegicus (Rat) PR
Q8VHN2 Grin3b Glutamate receptor ionotropic, NMDA 3B Rattus norvegicus (Rat) PR
O04660 GLR2.1 Glutamate receptor 2.1 Arabidopsis thaliana (Mouse-ear cress) PR
O81078 GLR2.9 Glutamate receptor 2.9 Arabidopsis thaliana (Mouse-ear cress) PR
O81776 GLR2.4 Glutamate receptor 2.4 Arabidopsis thaliana (Mouse-ear cress) PR
Q84W41 GLR3.6 Glutamate receptor 3.6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8E7 GLR3.3 Glutamate receptor 3.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SDQ4 GLR3.7 Glutamate receptor 3.7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SHV1 GLR2.2 Glutamate receptor 2.2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRTEKLFFCI LLVFFFCLEF NRGQNNGKTL VDVGVVTDVD TSHSKVVMLC INMSISDFYS
70 80 90 100 110 120
SNPQFETRLV VNVGDSKSDV VGAAIAALDL IKNKQVKAIL GPWTSMQAHF LIEIGQKSRV
130 140 150 160 170 180
PIVSYSATSP ILTSLRSPYF LRATYEDSFQ VQPIKAIIKL FGWREVVPVY IDNTFGEGIM
190 200 210 220 230 240
PRLTDALQDI NVRIPYRSVI AINATDHEIS VELLKMMNMP TRVFLVHMYY DLASRFFIKA
250 260 270 280 290 300
KELGLMEPGY VWILTNGVID DLSLINETAV EAMEGVLGIK TYIPKSPDLE KFRSRWRSLF
310 320 330 340 350 360
PRVELSVYGL WAYDATTALA VAIEEAGTNN MTFSKVVDTG RNVSELEALG LSQFGPKLLQ
370 380 390 400 410 420
TLLTVQFRGL AGEFRFFRGQ LQPSVFEIVN IINTGEKSIG FWKEGNGLVK KLDQQASSIS
430 440 450 460 470 480
ALSTWKDHLK HIVWPGEADS VPKGWQIPTK GKKLRIGVPK RTGYTDLVKV TRDPITNSTV
490 500 510 520 530 540
VTGFCIDFFE AVIRELPYDV SYEFIPFEKP DGKTAGNYND LVYQVYLGRY DAVVGDTTIL
550 560 570 580 590 600
VNRSSYVDFT FPFIKSGVGL IVEMTDPVKR DYILFMKPLS WKLWLTSFIS FFLVGCTVWV
610 620 630 640 650 660
LEYKRNPDFS GPPRFQASTI CWFAFSTMVF APRERVFSFW ARALVIAWYF LVLVLTQSYT
670 680 690 700 710 720
ASLASLLTSQ KLNPTITSMS SLLEKGETVG YQRTSFILGK LKERGFPQSS LVPFDTAEEC
730 740 750 760 770 780
DELLSKGPKK GGVSGAFLEI PYLRLFLGQF CNTYKMVEEP FNVDGFGFVF PIGSPLVADV
790 800 810 820 830 840
SRAILKVAES PKAMELERAW FKKKEQSCPD PITNPDPNPS FTSRQLDIDS FLFLFVGVLL
850 860 870 880 890
VCVMALGNFT YCFLAKDQVS YLDKVEMSPC SSSQQMPVKR KTQLNMSQVH DQDSL