O81078
PR
Gene name |
GLR2.9 (At2g29100, T9I4.18) |
Protein name |
Glutamate receptor 2.9 |
Names |
Ligand-gated ion channel 2.9 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G29100 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O81078
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O81078-F1 | Predicted | AlphaFoldDB |
112 variants for O81078
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14568078 | 3 | T>A | No | 1000Genomes | |
| tmp_2_12504878_A_G | 12 | V>A | No | 1000Genomes | |
| ENSVATH05621816 | 16 | L>V | No | 1000Genomes | |
| ENSVATH05621815 | 20 | V>F | No | 1000Genomes | |
| ENSVATH05621814 | 29 | E>K | No | 1000Genomes | |
| ENSVATH05621813 | 34 | V>I | No | 1000Genomes | |
| ENSVATH05621811 | 43 | S>P | No | 1000Genomes | |
| tmp_2_12504711_G_C | 68 | L>V | No | 1000Genomes | |
| ENSVATH05621810 | 71 | H>Q | No | 1000Genomes | |
| ENSVATH01921880 | 79 | T>I | No | 1000Genomes | |
| ENSVATH05621794 | 92 | T>N | No | 1000Genomes | |
| tmp_2_12504005_C_T | 95 | V>M | No | 1000Genomes | |
| ENSVATH01921874 | 120 | P>S | No | 1000Genomes | |
| ENSVATH05621793 | 136 | S>I | No | 1000Genomes | |
| ENSVATH13462926 | 151 | R>G | No | 1000Genomes | |
| ENSVATH13462925 | 194 | S>N | No | 1000Genomes | |
| tmp_2_12503691_C_G | 199 | E>D | No | 1000Genomes | |
| tmp_2_12503681_C_T | 203 | D>N | No | 1000Genomes | |
| tmp_2_12503660_G_A | 210 | R>C | No | 1000Genomes | |
| tmp_2_12503645_T_C | 215 | R>G | No | 1000Genomes | |
| tmp_2_12503638_G_A | 217 | A>V | No | 1000Genomes | |
| tmp_2_12503614_T_A | 225 | E>V | No | 1000Genomes | |
| ENSVATH05621789 | 229 | A>T | No | 1000Genomes | |
| tmp_2_12503596_C_A | 231 | R>L | No | 1000Genomes | |
| tmp_2_12503585_T_C | 235 | I>V | No | 1000Genomes | |
| tmp_2_12503558_C_T | 244 | E>K | No | 1000Genomes | |
| tmp_2_12503554_C_T | 245 | G>E | No | 1000Genomes | |
| tmp_2_12503525_T_C | 255 | T>A | No | 1000Genomes | |
| ENSVATH05621788 | 262 | N>K | No | 1000Genomes | |
| tmp_2_12503494_C_T | 265 | R>H | No | 1000Genomes | |
| ENSVATH05621787 | 269 | T>I | No | 1000Genomes | |
| ENSVATH05621787 | 269 | T>S | No | 1000Genomes | |
| ENSVATH05621785 | 287 | G>E | No | 1000Genomes | |
| ENSVATH13462921 | 287 | G>R | No | 1000Genomes | |
| tmp_2_12503408_T_C | 294 | K>E | No | 1000Genomes | |
| tmp_2_12503384_G_A | 302 | P>S | No | 1000Genomes | |
| ENSVATH14568069 | 307 | D>G | No | 1000Genomes | |
| tmp_2_12503297_T_C | 331 | T>A | No | 1000Genomes | |
| tmp_2_12503275_T_A | 338 | N>I | No | 1000Genomes | |
| ENSVATH14568068 | 340 | S>N | No | 1000Genomes | |
| ENSVATH05621784 | 341 | T>I | No | 1000Genomes | |
| ENSVATH14568067 | 347 | T>I | No | 1000Genomes | |
| tmp_2_12503222_G_A | 356 | L>F | No | 1000Genomes | |
| tmp_2_12503209_C_T | 360 | S>N | No | 1000Genomes | |
| ENSVATH13462919 | 366 | S>L | No | 1000Genomes | |
| tmp_2_12503167_G_A | 374 | A>V | No | 1000Genomes | |
| tmp_2_12503147_C_A | 381 | D>Y | No | 1000Genomes | |
| tmp_2_12503105_C_T | 395 | V>I | No | 1000Genomes | |
| ENSVATH13462918 | 396 | G>E | No | 1000Genomes | |
| ENSVATH14568066 | 396 | G>R | No | 1000Genomes | |
| tmp_2_12503078_A_G | 404 | F>L | No | 1000Genomes | |
| ENSVATH05621779 | 410 | G>R | No | 1000Genomes | |
| ENSVATH13462917 | 411 | L>I | No | 1000Genomes | |
| tmp_2_12503051_C_T | 413 | D>N | No | 1000Genomes | |
| ENSVATH05621778 | 414 | A>E | No | 1000Genomes | |
| tmp_2_12503036_T_A | 418 | N>Y | No | 1000Genomes | |
| ENSVATH01921872 | 419 | K>I | No | 1000Genomes | |
| ENSVATH05621776 | 421 | T>K | No | 1000Genomes | |
| tmp_2_12503017_G_A | 424 | P>L | No | 1000Genomes | |
| ENSVATH13462916 | 425 | V>M | No | 1000Genomes | |
| tmp_2_12502943_C_T | 449 | V>I | No | 1000Genomes | |
| tmp_2_12502888_G_A | 467 | T>I | No | 1000Genomes | |
| tmp_2_12502818_T_A | 490 | L>F | No | 1000Genomes | |
| tmp_2_12502819_A_G | 490 | L>S | No | 1000Genomes | |
| tmp_2_12502817_C_T | 491 | V>I | No | 1000Genomes | |
| tmp_2_12502808_C_G | 494 | E>Q | No | 1000Genomes | |
| tmp_2_12502759_T_G | 510 | Q>P | No | 1000Genomes | |
| ENSVATH13462915 | 532 | Y>F | No | 1000Genomes | |
| ENSVATH05621766 | 533 | A>V | No | 1000Genomes | |
| tmp_2_12502515_C_A | 548 | V>L | No | 1000Genomes | |
| ENSVATH05621765 | 554 | E>K | No | 1000Genomes | |
| tmp_2_12502490_T_A | 556 | K>M | No | 1000Genomes | |
| tmp_2_12502396_G_C | 587 | F>L | No | 1000Genomes | |
| tmp_2_12502365_G_T | 598 | P>T | No | 1000Genomes | |
| tmp_2_12502349_A_G | 603 | I>T | No | 1000Genomes | |
| tmp_2_12502346_C_T | 604 | G>D | No | 1000Genomes | |
| tmp_2_12502329_A_T | 610 | S>T | No | 1000Genomes | |
| tmp_2_12502305_G_T | 618 | H>N | No | 1000Genomes | |
| tmp_2_12502104_C_A | 633 | V>F | No | 1000Genomes | |
| tmp_2_12502055_A_G | 649 | L>P | No | 1000Genomes | |
| tmp_2_12502002_C_T | 667 | D>N | No | 1000Genomes | |
| ENSVATH01921866 | 671 | N>Y | No | 1000Genomes | |
| ENSVATH14568064 | 672 | R>K | No | 1000Genomes | |
| tmp_2_12501921_C_G | 694 | E>Q | No | 1000Genomes | |
| ENSVATH05621760 | 703 | A>S | No | 1000Genomes | |
| tmp_2_12501851_C_A | 717 | G>V | No | 1000Genomes | |
| tmp_2_12501792_A_G | 737 | S>P | No | 1000Genomes | |
| ENSVATH05621758 | 739 | Y>F | No | 1000Genomes | |
| tmp_2_12501586_C_G | 777 | V>L | No | 1000Genomes | |
| ENSVATH01921863 | 807 | S>R | No | 1000Genomes | |
| tmp_2_12501462_G_A | 818 | T>I | No | 1000Genomes | |
| ENSVATH01921862 | 819 | A>D | No | 1000Genomes | |
| tmp_2_12501453_G_T | 821 | S>Y | No | 1000Genomes | |
| ENSVATH01921861 | 826 | V>L | No | 1000Genomes | |
| tmp_2_12501417_T_C | 833 | Y>C | No | 1000Genomes | |
| ENSVATH05621754 | 835 | H>R | No | 1000Genomes | |
| tmp_2_12501381_T_C | 845 | D>G | No | 1000Genomes | |
| tmp_2_12501311_G_T | 868 | F>L | No | 1000Genomes | |
| tmp_2_12501267_T_C | 883 | K>R | No | 1000Genomes | |
| ENSVATH00253376 | 884 | T>I | No | 1000Genomes | |
| ENSVATH00253375 | 886 | S>N | No | 1000Genomes | |
| ENSVATH05621752 | 894 | P>L | No | 1000Genomes | |
| tmp_2_12501232_A_T | 895 | W>R | No | 1000Genomes | |
| ENSVATH13462900 | 898 | S>C | No | 1000Genomes | |
| ENSVATH01921860 | 899 | P>Q | No | 1000Genomes | |
| ENSVATH13462899 | 903 | R>K | No | 1000Genomes | |
| ENSVATH05621751 | 910 | V>M | No | 1000Genomes | |
| ENSVATH05621750 | 912 | F>Y | No | 1000Genomes | |
| ENSVATH05621749 | 915 | S>R | No | 1000Genomes | |
| tmp_2_12501153_G_A | 921 | T>M | No | 1000Genomes | |
| ENSVATH01921859 | 930 | G>R | No | 1000Genomes | |
| ENSVATH05621748 | 931 | E>Q | No | 1000Genomes |
No associated diseases with O81078
5 regional properties for O81078
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ionotropic glutamate receptor, C-terminal | 444 - 788 | IPR001320-1 |
| domain | Ionotropic glutamate receptor, C-terminal | 788 - 819 | IPR001320-2 |
| domain | Solute-binding protein family 3/N-terminal domain of MltF | 468 - 787 | IPR001638 |
| domain | Receptor, ligand binding region | 46 - 396 | IPR001828 |
| domain | Plant glutamate receptor, periplasmic ligand-binding domain | 31 - 413 | IPR044440 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| glutamate receptor activity | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| signaling receptor activity | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| calcium-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. |
| cellular response to amino acid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O60391 | GRIN3B | Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (Human) | PR |
| Q12879 | GRIN2A | Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (Human) | PR |
| Q91ZU9 | Grin3b | Glutamate receptor ionotropic, NMDA 3B | Mus musculus (Mouse) | PR |
| P23819 | Gria2 | Glutamate receptor 2 | Mus musculus (Mouse) | PR |
| P35439 | Grin1 | Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Rat) | PR |
| P19491 | Gria2 | Glutamate receptor 2 | Rattus norvegicus (Rat) | PR |
| Q8VHN2 | Grin3b | Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Rat) | PR |
| O04660 | GLR2.1 | Glutamate receptor 2.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81776 | GLR2.4 | Glutamate receptor 2.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84W41 | GLR3.6 | Glutamate receptor 3.6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C8E7 | GLR3.3 | Glutamate receptor 3.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SDQ4 | GLR3.7 | Glutamate receptor 3.7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHV1 | GLR2.2 | Glutamate receptor 2.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHV2 | GLR2.3 | Glutamate receptor 2.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKTNNTFLSY | FVCGFLLMGV | GLGQNQTSEI | KVGVVLDLNT | TFSKICLTSI | KMAVSDFYAD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HPNYLTRLTL | HVRDSMEDTV | QASAAALDLI | KTEQVSAIIG | PINSMQADFM | IKLANKTQVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TITFSATSPL | LTSIKSPYFV | RATIDDSSQV | RAIASIFKFF | RWRRVVAIYV | DNEFGEGFMP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FLFDALQDVE | VKRSVIPPEA | IDDEIQKELR | KLMERQARVF | VVHMESSLAL | RVFQIARDIG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MMEEGYVWLM | TNGMTHMMRH | INNGRSLNTI | EGVLGVRSHV | PKSKELGDFR | LRWKRTFEKE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPSMRDDLNV | FALWAYDSIT | ALAKAVEKAN | TKSLWYDNGS | TLSKNRTDLG | NVGVSLYGPS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LQKAFSEVRF | NGLAGEFKLI | DGQLQSPKFE | IINFVGNEER | IIGFWTPRDG | LMDATSSNKK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TLGPVIWPGK | SKIVPKGWEI | PGKKLRVGVP | MKKGFFDFVK | VTINPITNKK | TPTGYAIEIF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EAALKELPYL | VIPEYVSFES | PNNYNNLVYQ | VYDKTWDAVV | GDITITANRS | LYADFTLPFT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ESGVSMMVPV | RDNENKDTWV | FLEPWSLELW | VTTGCFFVFI | GFVVWLFEHR | VNTDFRGPPQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YQIGTSLWFS | FSTMVFAHRE | NVVSNLARFV | VVVWCFVVLV | LTQSYTASLT | SFLTVQSLQP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TVTNVNDLIK | NRDCVGYQGG | AFVKDILLGL | GFHEDQLKPF | DSAKDADDLL | SKGKSKGIAA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AFDEVAYLKA | ILSQSCSKYV | MVEPTFKTGG | FGFAFPKNSP | LTGEFSRAIL | NLTQNNVTQQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IEDRWFPKKN | DCPDPMTALS | SNRLNLSSFL | GLFLIAGTAI | SFSLLVFVAL | FLYEHRHTLG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DDSEDSLWRK | LKFLFKIFDE | KDMNSHTFKN | SAIHNISSPM | THKTPSPSTV | QITPWPQSPS |
| 910 | 920 | 930 | |||
| QNREFELRRV | SFSPSEERFT | TQPIIHHEDG | ESDIECRVEQ |