O81776
PR
Gene name |
GLR2.4 (At4g31710, F28M20.100) |
Protein name |
Glutamate receptor 2.4 |
Names |
Ligand-gated ion channel 2.4 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G31710 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O81776
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O81776-F1 | Predicted | AlphaFoldDB |
59 variants for O81776
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12338394 | 6 | N>K | No | 1000Genomes | |
| tmp_4_15349220_G_A | 11 | V>M | No | 1000Genomes | |
| ENSVATH14321817 | 20 | K>* | No | 1000Genomes | |
| ENSVATH14321818 | 26 | N>K | No | 1000Genomes | |
| ENSVATH12338415 | 57 | S>* | No | 1000Genomes | |
| ENSVATH12338423 | 96 | E>K | No | 1000Genomes | |
| ENSVATH12338456 | 122 | P>A | No | 1000Genomes | |
| tmp_4_15350342_C_T | 122 | P>L | No | 1000Genomes | |
| ENSVATH06808870 | 203 | P>S | No | 1000Genomes | |
| ENSVATH06808870 | 203 | P>T | No | 1000Genomes | |
| tmp_4_15350591_C_T | 205 | A>V | No | 1000Genomes | |
| tmp_4_15350657_T_A | 227 | V>D | No | 1000Genomes | |
| ENSVATH14321822 | 234 | A>V | No | 1000Genomes | |
| ENSVATH06808872 | 253 | W>* | No | 1000Genomes | |
| tmp_4_15350909_T_G,A | 311 | L>* | No | 1000Genomes | |
| tmp_4_15350909_T_G,A | 311 | L>W | No | 1000Genomes | |
| tmp_4_15350953_G_A | 326 | E>K | No | 1000Genomes | |
| ENSVATH06808875 | 336 | K>E | No | 1000Genomes | |
| ENSVATH00547221 | 337 | M>T | No | 1000Genomes | |
| ENSVATH06808876 | 358 | I>V | No | 1000Genomes | |
| ENSVATH00547222 | 379 | Q>* | No | 1000Genomes | |
| ENSVATH12338460 | 388 | V>F | No | 1000Genomes | |
| tmp_4_15351164_T_A | 396 | I>K | No | 1000Genomes | |
| tmp_4_15351199_G_A | 408 | V>I | No | 1000Genomes | |
| tmp_4_15351235_A_T | 420 | T>S | No | 1000Genomes | |
| tmp_4_15351240_C_A,T | 421 | F>L | No | 1000Genomes | |
| ENSVATH06808877 | 422 | S>F | No | 1000Genomes | |
| ENSVATH00547224 | 434 | P>R | No | 1000Genomes | |
| tmp_4_15351299_C_A | 441 | P>Q | No | 1000Genomes | |
| tmp_4_15351317_C_T | 447 | P>L | No | 1000Genomes | |
| ENSVATH14321823 | 466 | V>A | No | 1000Genomes | |
| ENSVATH14321824 | 472 | P>H | No | 1000Genomes | |
| ENSVATH12338476 | 488 | E>G | No | 1000Genomes | |
| ENSVATH12338477 | 504 | P>S | No | 1000Genomes | |
| ENSVATH06808881 | 538 | Y>F | No | 1000Genomes | |
| ENSVATH00547228 | 546 | V>A | No | 1000Genomes | |
| ENSVATH14321835 | 547 | V>I | No | 1000Genomes | |
| tmp_4_15351770_G_A | 554 | A>T | No | 1000Genomes | |
| tmp_4_15351793_T_A | 561 | F>L | No | 1000Genomes | |
| ENSVATH12338481 | 605 | M>V | No | 1000Genomes | |
| ENSVATH06808883 | 612 | I>V | No | 1000Genomes | |
| tmp_4_15351956_G_T | 616 | A>S | No | 1000Genomes | |
| tmp_4_15352277_G_T | 695 | R>I | No | 1000Genomes | |
| ENSVATH12338483 | 736 | C>S | No | 1000Genomes | |
| ENSVATH14321836 | 737 | K>* | No | 1000Genomes | |
| ENSVATH06808886 | 739 | Y>F | No | 1000Genomes | |
| tmp_4_15352550_C_A | 760 | P>H | No | 1000Genomes | |
| tmp_4_15352588_G_T | 773 | A>S | No | 1000Genomes | |
| tmp_4_15352632_G_C | 787 | K>N | No | 1000Genomes | |
| tmp_4_15352781_G_A | 837 | C>Y | No | 1000Genomes | |
| tmp_4_15352786_T_A | 839 | L>M | No | 1000Genomes | |
| ENSVATH06808888 | 840 | I>V | No | 1000Genomes | |
| ENSVATH06808889 | 843 | R>W | No | 1000Genomes | |
| ENSVATH06808891 | 844 | I>M | No | 1000Genomes | |
| ENSVATH06808890 | 844 | I>N | No | 1000Genomes | |
| tmp_4_15352833_A_C | 854 | K>N | No | 1000Genomes | |
| tmp_4_15352831_A_C | 854 | K>Q | No | 1000Genomes | |
| ENSVATH12338541 | 869 | E>G | No | 1000Genomes | |
| ENSVATH06808893 | 869 | E>K | No | 1000Genomes |
No associated diseases with O81776
4 regional properties for O81776
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | 227 - 404 | IPR002314 |
| domain | Aminoacyl-tRNA synthetase, class II | 178 - 414 | IPR006195 |
| domain | Serine-tRNA synthetase, type1, N-terminal | 1 - 112 | IPR015866 |
| domain | Serine-tRNA ligase catalytic core domain | 124 - 421 | IPR033729 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| glutamate receptor activity | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| signaling receptor activity | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| calcium-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. |
| cellular response to amino acid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O60391 | GRIN3B | Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (Human) | PR |
| Q12879 | GRIN2A | Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (Human) | PR |
| Q91ZU9 | Grin3b | Glutamate receptor ionotropic, NMDA 3B | Mus musculus (Mouse) | PR |
| P23819 | Gria2 | Glutamate receptor 2 | Mus musculus (Mouse) | PR |
| P35439 | Grin1 | Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Rat) | PR |
| P19491 | Gria2 | Glutamate receptor 2 | Rattus norvegicus (Rat) | PR |
| Q8VHN2 | Grin3b | Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Rat) | PR |
| O04660 | GLR2.1 | Glutamate receptor 2.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81078 | GLR2.9 | Glutamate receptor 2.9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84W41 | GLR3.6 | Glutamate receptor 3.6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C8E7 | GLR3.3 | Glutamate receptor 3.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SDQ4 | GLR3.7 | Glutamate receptor 3.7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHV1 | GLR2.2 | Glutamate receptor 2.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHV2 | GLR2.3 | Glutamate receptor 2.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRHLNDVVL | VFLVFIFGVK | LGKGQNTTIQ | VINVGVVTDV | GTTASNLSLL | AINMSLSDFY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSRPESRTRL | LLNFADSRDD | VVGAAAAALD | LIKNKEVKAI | LGPRTTMQAS | FVIEVGQKSQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPIISFSATS | PFLDSGRSPY | FFRSTYDDSS | QVQAISEIIK | VFGWREVVPV | YENNAFGEGI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MPGLTDALQA | INIRIPYRTV | ISPNATDDEI | SVDLLKLMTK | PTRVFVVHMN | RFLASRVFSK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ARETGLMKQG | YAWILTNGVI | DHLVLMNGTD | IEAMQGVIGI | RTHFPISEEL | QTFRSRLAKA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FPVSELNIYG | LRAYDATTAL | AMAVEEAGTT | NLTFSKMDGR | NISDLEALSV | SEYGPKLIRS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSQIQFKGLS | GDYHFVDGQL | HASVFEIVNV | IDGGGILVGF | WTQDKGLVKD | LSPSSGTTRT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FSSWKNHLNP | ILWPGITLTV | PKGWEIPTNG | KELQIGVPVG | TFPQFVKVTT | DPLTHETIVT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GFCIDFFEAV | IQAMPYDVSH | RFIPFGDDDG | KTNVFDAVVG | DTTILANRSS | YVDFTLPYTT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SGVGMVVPLK | DNVARSSLIF | FKPLTPGLWG | MTLGSFFVVG | FVVWILEHRV | NSEFTGPPQY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QISTMFWFAF | SIMVFAPRER | VMSFTARVVV | ITWYFIVLVL | TQSYTASLSS | LLTTQQLNPT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ETSIKNVLAK | GGPVAYQRDS | FVLGKLRESG | FPESRLVPFT | SPEKCEELLN | KGPSKGGVSA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AFMEVPYVRV | FLGQYCKKYK | MVEVPFDVDG | FGFVFPIGSP | LVADVSRAIL | KVAESNKATQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LETAWFKNID | KTCPDPMNNP | DPNPTVSFRK | LSLDSFLLLF | VAAATVCTLA | LLKFVICFLI |
| 850 | 860 | 870 | 880 | 890 | |
| QNRIILNDEF | YRGKRMKEMW | LKFMESDGES | YISRVRSTCP | QVLIQPREED | IDPING |