AiPD: Autoinhibited Protein Database

Gene name	GLR3.7 (GLR5, At2g32400, T32F6.8)
Protein name	Glutamate receptor 3.7
Names	Ionotropic glutamate receptor GLR5, Ligand-gated ion channel 3.7
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G32400
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

869-921 (Predicted disordered autoinhibitory region) PR

869-921 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9SDQ4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_2_13756214_G_A	7	P>L	No	1000Genomes
ENSVATH13506027	9	V>I	No	1000Genomes
tmp_2_13756197_C_A	13	A>S	No	1000Genomes
ENSVATH13506026	15	I>T	No	1000Genomes
ENSVATH13506025	28	P>T	No	1000Genomes
ENSVATH00256900	32	N>K	No	1000Genomes
ENSVATH05643625	32	N>T	No	1000Genomes
ENSVATH05643623	78	A>S	No	1000Genomes
ENSVATH01938871	141	L>I	No	1000Genomes
tmp_2_13755373_G_A	171	S>L	No	1000Genomes
ENSVATH14578218	203	H>R	No	1000Genomes
ENSVATH14578217	266	S>G	No	1000Genomes
tmp_2_13755023_C_T	288	V>I	No	1000Genomes
tmp_2_13755002_G_A	295	H>Y	No	1000Genomes
ENSVATH14578216	303	M>R	No	1000Genomes
ENSVATH14578215	323	E>K	No	1000Genomes
ENSVATH13506009	331	I>V	No	1000Genomes
ENSVATH01938870	338	K>N	No	1000Genomes
ENSVATH05643617	343	R>Q	No	1000Genomes
ENSVATH05643616	354	F>I	No	1000Genomes
ENSVATH05643615	354	F>Y	No	1000Genomes
ENSVATH05643614	382	G>D	No	1000Genomes
tmp_2_13754737_C_T	383	R>Q	No	1000Genomes
ENSVATH00256897	385	V>I	No	1000Genomes
ENSVATH05643613	386	I>V	No	1000Genomes
tmp_2_13754653_C_T	411	G>D	No	1000Genomes
ENSVATH01938866	420	R>H	No	1000Genomes
ENSVATH13506007	471	E>D	No	1000Genomes
tmp_2_13754347_T_G	513	H>P	No	1000Genomes
tmp_2_13754137_G_T	542	S>R	No	1000Genomes
ENSVATH05643610	569	A>S	No	1000Genomes
ENSVATH14578211	605	E>K	No	1000Genomes
ENSVATH05643603	727	P>Q	No	1000Genomes
ENSVATH01938860	837	A>G	No	1000Genomes
ENSVATH13505998	851	R>W	No	1000Genomes
ENSVATH00256892	858	T>I	No	1000Genomes
ENSVATH05643599	898	R>K	No	1000Genomes
ENSVATH05643598	898	R>S	No	1000Genomes
tmp_2_13752715_G_A	906	P>S	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Ionotropic glutamate receptor, C-terminal	460 - 802	IPR001320-1
domain	Ionotropic glutamate receptor, C-terminal	801 - 832	IPR001320-2
domain	Solute-binding protein family 3/N-terminal domain of MltF	517 - 800	IPR001638
domain	Receptor, ligand binding region	49 - 397	IPR001828
domain	Plant glutamate receptor, periplasmic ligand-binding domain	32 - 416	IPR044440

		Description
EC Number
Subcellular Localization	Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plasmodesma	A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.

Name	Definition
calcium channel activity	Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
glutamate receptor activity	Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
ligand-gated ion channel activity	Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
signaling receptor activity	Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

Name	Definition
calcium ion transport	The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
calcium-mediated signaling	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
cellular response to amino acid stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O60391	GRIN3B	Glutamate receptor ionotropic, NMDA 3B	Homo sapiens (Human)	PR
Q12879	GRIN2A	Glutamate receptor ionotropic, NMDA 2A	Homo sapiens (Human)	PR
Q91ZU9	Grin3b	Glutamate receptor ionotropic, NMDA 3B	Mus musculus (Mouse)	PR
P23819	Gria2	Glutamate receptor 2	Mus musculus (Mouse)	PR
P35439	Grin1	Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Rat)	PR
P19491	Gria2	Glutamate receptor 2	Rattus norvegicus (Rat)	PR
Q8VHN2	Grin3b	Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Rat)	PR
O04660	GLR2.1	Glutamate receptor 2.1	Arabidopsis thaliana (Mouse-ear cress)	PR
O81078	GLR2.9	Glutamate receptor 2.9	Arabidopsis thaliana (Mouse-ear cress)	PR
O81776	GLR2.4	Glutamate receptor 2.4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q84W41	GLR3.6	Glutamate receptor 3.6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C8E7	GLR3.3	Glutamate receptor 3.3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SHV1	GLR2.2	Glutamate receptor 2.2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SHV2	GLR2.3	Glutamate receptor 2.3	Arabidopsis thaliana (Mouse-ear cress)	PR