Q9C8E7
PR
Gene name |
GLR3.3 |
Protein name |
Glutamate receptor 3.3 |
Names |
AtGLR3.3, Glutamate receptor-like protein 3.3, Ligand-gated ion channel 3.3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G42540 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q9C8E7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6R85 | X-ray | 200 A | PDB | ||
| 6R88 | X-ray | 160 A | PDB | ||
| 6R89 | X-ray | 250 A | PDB | ||
| 6R8A | X-ray | 310 A | PDB | ||
| AF-Q9C8E7-F1 | Predicted | AlphaFoldDB |
58 variants for Q9C8E7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00076090 | 5 | W>S | No | 1000Genomes | |
| tmp_1_15973516_T_A | 10 | L>M | No | 1000Genomes | |
| tmp_1_15973547_G_A | 20 | R>K | No | 1000Genomes | |
| ENSVATH01256454 | 38 | D>N | No | 1000Genomes | |
| ENSVATH04823513 | 51 | E>K | No | 1000Genomes | |
| ENSVATH04823514 | 54 | K>N | No | 1000Genomes | |
| ENSVATH14179055 | 58 | S>L | No | 1000Genomes | |
| tmp_1_15973969_G_C | 130 | M>I | No | 1000Genomes | |
| ENSVATH13261443 | 194 | Y>C | No | 1000Genomes | |
| tmp_1_15974203_G_C | 208 | E>D | No | 1000Genomes | |
| tmp_1_15974217_T_A | 213 | L>Q | No | 1000Genomes | |
| tmp_1_15974339_G_A | 254 | A>T | No | 1000Genomes | |
| ENSVATH14179057 | 260 | T>M | No | 1000Genomes | |
| tmp_1_15974373_C_A | 265 | S>Y | No | 1000Genomes | |
| tmp_1_15974376_C_T | 266 | S>L | No | 1000Genomes | |
| ENSVATH13261465 | 267 | P>L | No | 1000Genomes | |
| tmp_1_15974390_G_A | 271 | E>K | No | 1000Genomes | |
| ENSVATH04823522 | 272 | R>S | No | 1000Genomes | |
| ENSVATH04823524 | 290 | D>Y | No | 1000Genomes | |
| tmp_1_15974452_T_A | 291 | F>L | No | 1000Genomes | |
| tmp_1_15974466_T_A | 296 | F>Y | No | 1000Genomes | |
| tmp_1_15974473_G_T | 298 | R>S | No | 1000Genomes | |
| ENSVATH01256461 | 308 | A>V | No | 1000Genomes | |
| tmp_1_15974611_G_C | 344 | M>I | No | 1000Genomes | |
| ENSVATH13261470 | 376 | R>G | No | 1000Genomes | |
| ENSVATH13261470 | 376 | R>S | No | 1000Genomes | |
| tmp_1_15974714_G_A | 379 | G>S | No | 1000Genomes | |
| tmp_1_15974757_C_A | 393 | T>N | No | 1000Genomes | |
| tmp_1_15974759_C_T | 394 | R>C | No | 1000Genomes | |
| ENSVATH04823531 | 398 | D>N | No | 1000Genomes | |
| ENSVATH04823532 | 405 | T>S | No | 1000Genomes | |
| ENSVATH04823533 | 426 | L>F | No | 1000Genomes | |
| ENSVATH14179059 | 432 | K>N | No | 1000Genomes | |
| tmp_1_15974877_C_T | 433 | P>L | No | 1000Genomes | |
| ENSVATH04823534 | 434 | N>S | No | 1000Genomes | |
| ENSVATH01256462 | 437 | T>I | No | 1000Genomes | |
| tmp_1_15974891_A_G | 438 | S>G | No | 1000Genomes | |
| tmp_1_15974892_G_A | 438 | S>N | No | 1000Genomes | |
| ENSVATH00076095 | 442 | K>R | No | 1000Genomes | |
| ENSVATH01256463 | 476 | Y>F | No | 1000Genomes | |
| ENSVATH13261474 | 477 | K>M | No | 1000Genomes | |
| ENSVATH04823538 | 493 | F>V | No | 1000Genomes | |
| ENSVATH01256464 | 511 | V>I | No | 1000Genomes | |
| tmp_1_15975119_A_G | 514 | I>V | No | 1000Genomes | |
| tmp_1_15975156_C_T | 526 | T>M | No | 1000Genomes | |
| tmp_1_15975286_G_A | 544 | V>I | No | 1000Genomes | |
| ENSVATH13261477 | 559 | P>L | No | 1000Genomes | |
| tmp_1_15975376_C_A | 574 | L>M | No | 1000Genomes | |
| tmp_1_15975416_G_A | 587 | R>H | No | 1000Genomes | |
| ENSVATH04823552 | 692 | D>E | No | 1000Genomes | |
| ENSVATH13261481 | 723 | T>K | No | 1000Genomes | |
| tmp_1_15976039_A_G | 737 | K>R | No | 1000Genomes | |
| tmp_1_15976252_T_C | 784 | I>T | No | 1000Genomes | |
| ENSVATH04823562 | 867 | D>E | No | 1000Genomes | |
| tmp_1_15976609_A_G | 903 | K>R | No | 1000Genomes | |
| ENSVATH01256468 | 915 | T>R | No | 1000Genomes | |
| ENSVATH04823564 | 924 | R>K | No | 1000Genomes | |
| tmp_1_15976681_A_C | 927 | N>T | No | 1000Genomes |
No associated diseases with Q9C8E7
No regional properties for Q9C8E7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9C8E7 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| glutamate receptor activity | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| signaling receptor activity | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| calcium-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. |
| cell-cell signaling | Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
| cellular response to amino acid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. |
| defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
| gravitropism | The orientation of plant parts under the stimulation of gravity. |
| induced systemic resistance, jasmonic acid mediated signaling pathway | The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| response to wounding | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O60391 | GRIN3B | Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (Human) | PR |
| Q12879 | GRIN2A | Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (Human) | PR |
| Q91ZU9 | Grin3b | Glutamate receptor ionotropic, NMDA 3B | Mus musculus (Mouse) | PR |
| P23819 | Gria2 | Glutamate receptor 2 | Mus musculus (Mouse) | PR |
| P35439 | Grin1 | Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Rat) | PR |
| P19491 | Gria2 | Glutamate receptor 2 | Rattus norvegicus (Rat) | PR |
| Q8VHN2 | Grin3b | Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Rat) | PR |
| O04660 | GLR2.1 | Glutamate receptor 2.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81078 | GLR2.9 | Glutamate receptor 2.9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81776 | GLR2.4 | Glutamate receptor 2.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84W41 | GLR3.6 | Glutamate receptor 3.6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SDQ4 | GLR3.7 | Glutamate receptor 3.7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHV1 | GLR2.2 | Glutamate receptor 2.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHV2 | GLR2.3 | Glutamate receptor 2.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKQLWTFFFL | SFLCSGLFRR | THSEKPKVVK | IGSIFSFDSV | IGKVAKIAID | EAVKDVNSNP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DILSGTKFSV | SMQNSNCSGF | MGMVEALRFM | EKDIVGIIGP | QCSVVAHMIS | HMANELRVPL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSFAVTDPVM | SPLQFPYFIR | TTQSDLYQMD | AIASIVDFYG | WKEVIAVFVD | DDFGRNGVAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LNDKLASRRL | RITYKAGLHP | DTAVNKNEIM | NMLIKIMLLQ | PRIVVIHVYS | ELGFAVFKEA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KYLGMMGNGY | VWIATDWLST | NLDSSSPLPA | ERLETIQGVL | VLRPHTPDSD | FKREFFKRWR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KMSGASLALN | TYGLYAYDSV | MLLARGLDKF | FKDGGNISFS | NHSMLNTLGK | SGNLNLEAMT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VFDGGEALLK | DILGTRMVGL | TGQLQFTPDR | SRTRPAYDII | NVAGTGVRQI | GYWSNHSGLS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TVLPELLYTK | EKPNMSTSPK | LKHVIWPGET | FTKPRGWVFS | NNGKELKIGV | PLRVSYKEFV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SQIRGTENMF | KGFCIDVFTA | AVNLLPYAVP | VKFIPYGNGK | ENPSYTHMVE | MITTGNFDGV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VGDVAIVTNR | TKIVDFTQPY | AASGLVVVAP | FKKLNSGAWA | FLRPFNRLMW | AVTGCCFLFV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GIVVWILEHR | TNDEFRGPPK | RQCVTILWFS | FSTMFFAHRE | NTVSTLGRLV | LIIWLFVVLI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| INSSYTASLT | SILTVQQLSS | PIKGIESLRE | RDDPIGYQVG | SFAESYLRNE | LNISESRLVP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LGTPEAYAKA | LKDGPSKGGV | AAIVDERPYV | ELFLSSNCAY | RIVGQEFTKS | GWGFAFPRDS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PLAIDLSTAI | LELAENGDLQ | RIHDKWLMKN | ACTLENAELE | SDRLHLKSFW | GLFLICGVAC |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LLALFLYFVQ | IIRQLYKKPT | DDAIARDQQQ | NHDSSSMRST | RLQRFLSLMD | EKEESKHESK |
| 910 | 920 | 930 | |||
| KRKIDGSMND | TSGSTRSRGF | DRERSFNSVN | PLD |