Q9SHV1

PR
Gene name
GLR2.2 (At2g24720, F27A10.3)
Protein name
Glutamate receptor 2.2
Names
Ligand-gated ion channel 2.2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G24720
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

313-387 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SHV1

Entry ID Method Resolution Chain Position Source
AF-Q9SHV1-F1 Predicted AlphaFoldDB

287 variants for Q9SHV1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14546125 2 K>R No 1000Genomes
ENSVATH09378770 4 S>A No 1000Genomes
ENSVATH01886527 6 L>I No 1000Genomes
ENSVATH01886526 9 R>C No 1000Genomes
ENSVATH05581112 9 R>H No 1000Genomes
ENSVATH01886525 12 F>L No 1000Genomes
tmp_2_10525798_A_T 15 F>I No 1000Genomes
ENSVATH01886524 15 F>L No 1000Genomes
ENSVATH01886523 16 F>L No 1000Genomes
ENSVATH01886522 17 F>L No 1000Genomes
ENSVATH01886520 26 D>N No 1000Genomes
ENSVATH01886518 34 I>V No 1000Genomes
ENSVATH00245539 38 S>T No 1000Genomes
ENSVATH01886515 45 P>S No 1000Genomes
ENSVATH01886514 46 D>E No 1000Genomes
ENSVATH01886513 53 N>D No 1000Genomes
ENSVATH00245536 57 A>D No 1000Genomes
ENSVATH00245536 57 A>V No 1000Genomes
tmp_2_10525666_A_G 59 F>L No 1000Genomes
tmp_2_10525659_G_A 61 S>F No 1000Genomes
tmp_2_10525653_C_T 63 R>H No 1000Genomes
tmp_2_10525650_G_A 64 P>L No 1000Genomes
ENSVATH13381225 66 F>Y No 1000Genomes
ENSVATH07895147 72 V>F No 1000Genomes
ENSVATH07895147 72 V>I No 1000Genomes
ENSVATH01886502 79 N>S No 1000Genomes
ENSVATH05581107 82 V>A No 1000Genomes
ENSVATH01886500 82 V>L No 1000Genomes
tmp_2_10525588_C_T 85 A>T No 1000Genomes
ENSVATH07895145 88 A>T No 1000Genomes
ENSVATH01886481 89 I>L No 1000Genomes
ENSVATH00245534 90 D>E No 1000Genomes
ENSVATH01886480 98 K>R No 1000Genomes
ENSVATH14546099 107 M>I No 1000Genomes
ENSVATH07895133 111 F>L No 1000Genomes
ENSVATH01886477 119 S>T No 1000Genomes
ENSVATH13381199 120 R>Q No 1000Genomes
ENSVATH01886475 123 V>I No 1000Genomes
ENSVATH00245532 124 V>D No 1000Genomes
ENSVATH01886473 128 A>S No 1000Genomes
ENSVATH01886472 130 S>I No 1000Genomes
ENSVATH13381198 134 T>N No 1000Genomes
ENSVATH01886469 138 S>I No 1000Genomes
ENSVATH00245531 139 P>A No 1000Genomes
ENSVATH00245531 139 P>S No 1000Genomes
ENSVATH01886467 144 A>P No 1000Genomes
ENSVATH01886466 152 V>L No 1000Genomes
ENSVATH01886464 153 H>N No 1000Genomes
ENSVATH01886462 158 I>V No 1000Genomes
ENSVATH01886460 160 K>N No 1000Genomes
ENSVATH01886458 170 V>I No 1000Genomes
tmp_2_10525194_A_T 176 F>L No 1000Genomes
ENSVATH13381196 185 T>I No 1000Genomes
ENSVATH00245529 187 S>A No 1000Genomes
ENSVATH01886453 194 R>W No 1000Genomes
ENSVATH01886449 202 P>A No 1000Genomes
ENSVATH01886448 208 Q>H No 1000Genomes
ENSVATH00245528 209 D>E No 1000Genomes
ENSVATH05581096 212 V>M No 1000Genomes
ENSVATH01886446 219 N>T No 1000Genomes
ENSVATH01886444 220 M>I No 1000Genomes
ENSVATH01886445 220 M>K No 1000Genomes
ENSVATH05581095 226 I>M No 1000Genomes
ENSVATH01886442 230 S>F No 1000Genomes
ENSVATH01886443 230 S>P No 1000Genomes
ENSVATH01886441 235 S>L No 1000Genomes
ENSVATH00245527 236 T>I No 1000Genomes
ENSVATH00245527 236 T>R No 1000Genomes
ENSVATH07895109 237 V>L No 1000Genomes
ENSVATH14546081 240 K>R No 1000Genomes
tmp_2_10525000_G_T 241 A>E No 1000Genomes
ENSVATH14546080 242 K>N No 1000Genomes
ENSVATH01886437 244 L>I No 1000Genomes
tmp_2_10524964_C_T 253 W>* No 1000Genomes
tmp_2_10524955_G_A 256 T>I No 1000Genomes
ENSVATH01886432 257 N>I No 1000Genomes
ENSVATH01886432 257 N>S No 1000Genomes
tmp_2_10524950_C_G 258 G>R No 1000Genomes
ENSVATH00245525 260 M>I No 1000Genomes
ENSVATH01886431 260 M>T No 1000Genomes
ENSVATH01886429 262 G>D No 1000Genomes
ENSVATH01886427 264 R>L No 1000Genomes
ENSVATH01886425 267 N>S No 1000Genomes
tmp_2_10524920_C_T 268 E>K No 1000Genomes
ENSVATH01886423 269 T>M No 1000Genomes
ENSVATH01886422 271 I>V No 1000Genomes
tmp_2_10524872_T_G 284 I>L No 1000Genomes
ENSVATH01886417 285 P>R No 1000Genomes
ENSVATH01886418 285 P>T No 1000Genomes
ENSVATH01886414 291 E>D No 1000Genomes
ENSVATH01886413 292 T>K No 1000Genomes
tmp_2_10524838_G_A 295 S>L No 1000Genomes
ENSVATH01886411 297 W>* No 1000Genomes
ENSVATH00245523 303 Q>H No 1000Genomes
ENSVATH01886410 303 Q>L No 1000Genomes
ENSVATH01886409 304 M>I No 1000Genomes
ENSVATH01886408 305 E>K No 1000Genomes
ENSVATH00245522 308 V>G No 1000Genomes
ENSVATH14546079 310 G>E No 1000Genomes
ENSVATH01886406 312 W>S No 1000Genomes
ENSVATH13381162 318 T>N No 1000Genomes
ENSVATH01886402 322 M>I No 1000Genomes
ENSVATH01886403 322 M>T No 1000Genomes
tmp_2_10524749_C_T 325 E>K No 1000Genomes
ENSVATH01886401 326 D>E No 1000Genomes
tmp_2_10524746_C_A 326 D>Y No 1000Genomes
ENSVATH01886399 328 G>* No 1000Genomes
ENSVATH01886399 328 G>R No 1000Genomes
tmp_2_10524736_A_G 329 I>T No 1000Genomes
tmp_2_10524737_T_C 329 I>V No 1000Genomes
ENSVATH14546078 331 N>Y No 1000Genomes
ENSVATH05581092 336 N>S No 1000Genomes
ENSVATH01886397 339 T>M No 1000Genomes
ENSVATH13381161 340 G>W No 1000Genomes
ENSVATH01886396 341 K>R No 1000Genomes
ENSVATH01886396 341 K>T No 1000Genomes
tmp_2_10524697_T_C 342 N>S No 1000Genomes
tmp_2_10524695_C_T 343 V>I No 1000Genomes
tmp_2_10524691_G_A 344 S>F No 1000Genomes
ENSVATH01886395 347 D>E No 1000Genomes
ENSVATH07895097 348 G>A No 1000Genomes
ENSVATH07895098 348 G>S No 1000Genomes
tmp_2_10524655_G_A 356 P>L No 1000Genomes
ENSVATH01886393 361 T>A No 1000Genomes
ENSVATH01886392 361 T>M No 1000Genomes
ENSVATH00245518 362 V>L No 1000Genomes
ENSVATH01886391 364 T>I No 1000Genomes
ENSVATH01886391 364 T>K No 1000Genomes
ENSVATH01886389 365 V>D No 1000Genomes
ENSVATH01886390 365 V>I No 1000Genomes
ENSVATH01886388 366 Q>H No 1000Genomes
ENSVATH01886387 368 K>N No 1000Genomes
ENSVATH05581091 368 K>R No 1000Genomes
tmp_2_10524611_C_T 371 A>T No 1000Genomes
tmp_2_10524605_C_G 373 D>H No 1000Genomes
ENSVATH00245515 375 H>R No 1000Genomes
ENSVATH00245514 377 V>F No 1000Genomes
ENSVATH01886386 378 S>N No 1000Genomes
tmp_2_10524590_T_G 378 S>R No 1000Genomes
ENSVATH01886385 379 G>E No 1000Genomes
ENSVATH00245513 379 G>R No 1000Genomes
ENSVATH00245513 379 G>W No 1000Genomes
tmp_2_10524544_C_T 393 G>E No 1000Genomes
ENSVATH01886378 393 G>R No 1000Genomes
ENSVATH01886376 395 G>R No 1000Genomes
ENSVATH01886375 397 R>K No 1000Genomes
ENSVATH01886374 398 S>* No 1000Genomes
ENSVATH05581090 404 E>K No 1000Genomes
ENSVATH01886370 405 G>E No 1000Genomes
tmp_2_10524509_C_T 405 G>R No 1000Genomes
ENSVATH01886369 413 D>Y No 1000Genomes
ENSVATH00245510 414 Q>K No 1000Genomes
ENSVATH01886367 419 I>L No 1000Genomes
ENSVATH01886367 419 I>V No 1000Genomes
ENSVATH01886363 426 P>Q No 1000Genomes
ENSVATH01886364 426 P>S No 1000Genomes
ENSVATH01886364 426 P>T No 1000Genomes
ENSVATH01886362 427 D>H No 1000Genomes
ENSVATH01886362 427 D>N No 1000Genomes
ENSVATH01886362 427 D>Y No 1000Genomes
tmp_2_10524437_G_A 429 L>F No 1000Genomes
ENSVATH01886361 431 H>Q No 1000Genomes
ENSVATH07895086 433 I>T No 1000Genomes
ENSVATH13381156 434 W>* No 1000Genomes
ENSVATH01886359 439 V>D No 1000Genomes
ENSVATH01886359 439 V>G No 1000Genomes
ENSVATH01886360 439 V>I No 1000Genomes
ENSVATH01886358 440 S>F No 1000Genomes
ENSVATH13381155 442 P>L No 1000Genomes
ENSVATH01886355 455 R>H No 1000Genomes
ENSVATH13381134 458 V>F No 1000Genomes
ENSVATH01886349 474 P>L No 1000Genomes
ENSVATH01886347 482 K>T No 1000Genomes
ENSVATH13381132 490 E>K No 1000Genomes
ENSVATH01886341 491 A>V No 1000Genomes
ENSVATH00245506 494 Q>P No 1000Genomes
ENSVATH00245506 494 Q>R No 1000Genomes
tmp_2_10524236_T_C 496 M>V No 1000Genomes
ENSVATH13381131 497 P>H No 1000Genomes
tmp_2_10524214_T_C 503 E>G No 1000Genomes
ENSVATH13381130 504 F>L No 1000Genomes
ENSVATH01886336 505 F>I No 1000Genomes
ENSVATH09378701 505 F>S No 1000Genomes
ENSVATH01886335 511 N>D No 1000Genomes
ENSVATH01886332 513 E>* No 1000Genomes
ENSVATH01886332 513 E>K No 1000Genomes
ENSVATH01886330 523 H>Y No 1000Genomes
ENSVATH13381127 526 Y>* No 1000Genomes
ENSVATH01886328 526 Y>F No 1000Genomes
tmp_2_10524143_G_C 527 L>V No 1000Genomes
ENSVATH01886326 528 G>R No 1000Genomes
ENSVATH01886319 530 F>V No 1000Genomes
tmp_2_10524044_A_T 530 F>Y No 1000Genomes
tmp_2_10524005_C_A 543 R>M No 1000Genomes
ENSVATH00245501 546 F>S No 1000Genomes
ENSVATH00245501 546 F>Y No 1000Genomes
ENSVATH01886314 554 M>I No 1000Genomes
ENSVATH01886310 587 T>S No 1000Genomes
ENSVATH01886309 589 V>G No 1000Genomes
ENSVATH13381094 595 G>* No 1000Genomes
ENSVATH13381093 595 G>A No 1000Genomes
ENSVATH13381092 596 I>S No 1000Genomes
ENSVATH14546051 597 S>R No 1000Genomes
ENSVATH01886307 597 S>T No 1000Genomes
ENSVATH01886305 600 T>I No 1000Genomes
tmp_2_10523832_G_T 601 L>I No 1000Genomes
tmp_2_10523826_G_T 603 H>N No 1000Genomes
ENSVATH00245499 607 S>P No 1000Genomes
ENSVATH07895054 612 P>R No 1000Genomes
ENSVATH07895053 613 A>G No 1000Genomes
tmp_2_10523779_A_T 618 S>R No 1000Genomes
ENSVATH05581086 631 A>V No 1000Genomes
ENSVATH01886290 640 G>W No 1000Genomes
ENSVATH01886289 643 S>A No 1000Genomes
ENSVATH05581084 645 V>I No 1000Genomes
ENSVATH05581083 651 V>L No 1000Genomes
ENSVATH00245494 652 L>V No 1000Genomes
tmp_2_10523522_G_A 675 T>I No 1000Genomes
tmp_2_10523507_C_A 680 S>I No 1000Genomes
ENSVATH13381086 683 L>F No 1000Genomes
ENSVATH01886283 684 H>D No 1000Genomes
ENSVATH01886281 685 R>K No 1000Genomes
tmp_2_10523481_C_T 689 V>M No 1000Genomes
tmp_2_10523465_G_A 694 T>I No 1000Genomes
ENSVATH01886277 702 N>K No 1000Genomes
ENSVATH00245493 707 P>R No 1000Genomes
ENSVATH01886273 721 D>N No 1000Genomes
ENSVATH01886271 722 E>A No 1000Genomes
ENSVATH05581081 722 E>D No 1000Genomes
tmp_2_10523367_C_G 727 G>R No 1000Genomes
ENSVATH14546045 728 P>Q No 1000Genomes
ENSVATH01886270 730 N>K No 1000Genomes
tmp_2_10523348_A_G 733 V>A No 1000Genomes
ENSVATH01886269 734 A>S No 1000Genomes
ENSVATH05581080 739 G>E No 1000Genomes
ENSVATH05581079 743 V>M No 1000Genomes
ENSVATH05581078 745 L>P No 1000Genomes
tmp_2_10523259_C_T 763 V>I No 1000Genomes
tmp_2_10523246_C_T 767 G>D No 1000Genomes
tmp_2_10523225_G_C 774 S>* No 1000Genomes
ENSVATH13381085 779 D>N No 1000Genomes
ENSVATH13381074 786 K>Q No 1000Genomes
ENSVATH01886259 786 K>R No 1000Genomes
ENSVATH01886258 794 V>M No 1000Genomes
ENSVATH01886257 797 E>D No 1000Genomes
ENSVATH13381073 798 H>R No 1000Genomes
tmp_2_10523127_T_G 807 S>R No 1000Genomes
ENSVATH14546033 812 V>F No 1000Genomes
ENSVATH01886255 820 T>S No 1000Genomes
ENSVATH01886252 823 A>S No 1000Genomes
tmp_2_10523060_C_T 829 G>D No 1000Genomes
ENSVATH01886250 829 G>R No 1000Genomes
ENSVATH01886248 832 W>* No 1000Genomes
ENSVATH01886249 832 W>G No 1000Genomes
ENSVATH07895033 836 L>R No 1000Genomes
ENSVATH07895034 836 L>V No 1000Genomes
ENSVATH07895032 837 V>F No 1000Genomes
ENSVATH07895031 839 F>S No 1000Genomes
ENSVATH05581076 843 V>A No 1000Genomes
tmp_2_10523016_G_C 844 L>V No 1000Genomes
ENSVATH09378677 850 T>I No 1000Genomes
ENSVATH01886246 851 F>L No 1000Genomes
ENSVATH13381071 851 F>V No 1000Genomes
ENSVATH01886245 852 C>S No 1000Genomes
ENSVATH09378676 852 C>Y No 1000Genomes
tmp_2_10522985_A_T 854 L>Q No 1000Genomes
ENSVATH01886244 862 L>F No 1000Genomes
ENSVATH07895023 864 K>I No 1000Genomes
ENSVATH01886243 867 L>Q No 1000Genomes
ENSVATH05581075 870 D>G No 1000Genomes
ENSVATH13381068 872 D>E No 1000Genomes
ENSVATH00245488 872 D>N No 1000Genomes
tmp_2_10522916_T_G 877 D>A No 1000Genomes
ENSVATH01886241 882 L>* No 1000Genomes
tmp_2_10522890_C_A 886 E>* No 1000Genomes
ENSVATH01886240 886 E>D No 1000Genomes
ENSVATH01886239 888 P>R No 1000Genomes
ENSVATH01886238 890 N>D No 1000Genomes
ENSVATH13381067 894 A>P No 1000Genomes
ENSVATH13381066 895 T>R No 1000Genomes
ENSVATH00245487 899 N>D No 1000Genomes
ENSVATH13381065 900 Y>N No 1000Genomes
ENSVATH00245486 902 M>I No 1000Genomes
ENSVATH07895020 910 V>A No 1000Genomes
ENSVATH07895017 914 Q>L No 1000Genomes
ENSVATH01886236 917 P>R No 1000Genomes
ENSVATH01886237 917 P>T No 1000Genomes

No associated diseases with Q9SHV1

No regional properties for Q9SHV1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9SHV1

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
calcium channel activity Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
glutamate receptor activity Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
ligand-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

3 GO annotations of biological process

Name Definition
calcium ion transport The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
calcium-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
cellular response to amino acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O60391 GRIN3B Glutamate receptor ionotropic, NMDA 3B Homo sapiens (Human) PR
Q12879 GRIN2A Glutamate receptor ionotropic, NMDA 2A Homo sapiens (Human) PR
Q91ZU9 Grin3b Glutamate receptor ionotropic, NMDA 3B Mus musculus (Mouse) PR
P23819 Gria2 Glutamate receptor 2 Mus musculus (Mouse) PR
P35439 Grin1 Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Rat) PR
P19491 Gria2 Glutamate receptor 2 Rattus norvegicus (Rat) PR
Q8VHN2 Grin3b Glutamate receptor ionotropic, NMDA 3B Rattus norvegicus (Rat) PR
O04660 GLR2.1 Glutamate receptor 2.1 Arabidopsis thaliana (Mouse-ear cress) PR
O81078 GLR2.9 Glutamate receptor 2.9 Arabidopsis thaliana (Mouse-ear cress) PR
O81776 GLR2.4 Glutamate receptor 2.4 Arabidopsis thaliana (Mouse-ear cress) PR
Q84W41 GLR3.6 Glutamate receptor 3.6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8E7 GLR3.3 Glutamate receptor 3.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SDQ4 GLR3.7 Glutamate receptor 3.7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SHV2 GLR2.3 Glutamate receptor 2.3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKNSKLFFRF LFLFFFFCLE SSRGQDNGKT QVNIGVVSDV GTSYPDVAML CINMSLADFY
70 80 90 100 110 120
SSRPQFQTRL VVNVGDSKND VVGAATAAID LIKNKQVKAI LGPWTSMQAH FLIEIGQKSR
130 140 150 160 170 180
VPVVSYSATS PSLTSLRSPY FFRATYEDSS QVHAIKAIIK LFGWREVVPV YIDNTFGEGI
190 200 210 220 230 240
MPRLTDSLQD INVRIPYRSV IPLNATDQDI SVELLKMMNM PTRVFIVHMS SSLASTVFIK
250 260 270 280 290 300
AKELGLMKPG YVWILTNGVM DGLRSINETG IEAMEGVLGI KTYIPKSKDL ETFRSRWKRR
310 320 330 340 350 360
FPQMELNVYG LWAYDATTAL AMAIEDAGIN NMTFSNVDTG KNVSELDGLG LSQFGPKLLQ
370 380 390 400 410 420
TVSTVQFKGL AGDFHFVSGQ LQPSVFEIVN MIGTGERSIG FWTEGNGLVK KLDQEPRSIG
430 440 450 460 470 480
TLSTWPDHLK HIIWPGEAVS VPKGWEIPTN GKKLRIGVPK RIGFTDLVKV TRDPITNSTV
490 500 510 520 530 540
VKGFCIDFFE AVIQAMPYDV SYEFFPFEKP NGEPAGNHND LVHQVYLGQF DAVVGDTTIL
550 560 570 580 590 600
ANRSSFVDFT LPFMKSGVGL IVPLKDEVKR DKFSFLKPLS IELWLTTLVF FFLVGISVWT
610 620 630 640 650 660
LEHRVNSDFR GPANYQASTI FWFAFSTMVF APRERVLSFG ARSLVVTWYF VLLVLTQSYT
670 680 690 700 710 720
ASLASLLTSQ QLNPTITSMS SLLHRGETVG YQRTSFILGK LNETGFPQSS LVPFDTAEEC
730 740 750 760 770 780
DELLKKGPKN GGVAAAFLGT PYVRLFLGQY CNTYKMVEEP FNVDGFGFVF PIGSPLVADV
790 800 810 820 830 840
SRAILKVAES PKAVELEHAW FKKKEQSCPD PVTNPDSNPT VTAIQLGVGS FWFLFLVVFV
850 860 870 880 890 900
VCVLALGKFT FCFLWKTKGK DLWKEFLKRD TDSYINDIEK CLCSQEMPEN SNKATNQTNY
910
GMELRVRNIV QVNQTDPDCL