Q9R0Q1
PR
Gene name |
Sytl4 (Slp4) |
Protein name |
Synaptotagmin-like protein 4 |
Names |
Exophilin-2, Granuphilin |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:27359 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9R0Q1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9R0Q1-F1 | Predicted | AlphaFoldDB |
52 variants for Q9R0Q1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs224496095 | 20 | G>S | No | EVA | |
| rs3389531717 | 21 | V>I | No | EVA | |
| rs3389553827 | 60 | D>G | No | EVA | |
| rs3389482009 | 98 | G>A | No | EVA | |
| rs3389531779 | 118 | W>C | No | EVA | |
| rs3411940374 | 167 | P>S | No | EVA | |
| rs3389573147 | 188 | K>M | No | EVA | |
| rs3411983335 | 206 | Y>C | No | EVA | |
| rs3412470702 | 246 | N>D | No | EVA | |
| rs3389523404 | 251 | C>Y | No | EVA | |
| rs3389568390 | 259 | F>I | No | EVA | |
| rs3411940440 | 282 | E>A | No | EVA | |
| rs3389577698 | 283 | D>V | No | EVA | |
| rs3412270125 | 300 | G>F | No | EVA | |
| rs3412050747 | 301 | L>F | No | EVA | |
| rs3389569644 | 302 | S>R | No | EVA | |
| rs3389541782 | 309 | E>* | No | EVA | |
| rs3389568322 | 314 | D>G | No | EVA | |
| rs3389582968 | 338 | S>N | No | EVA | |
| rs3389573129 | 353 | F>L | No | EVA | |
| rs3411602914 | 355 | N>VTEMFPKSPASL* | No | EVA | |
| rs3410552826 | 375 | L>F | No | EVA | |
| rs3389530097 | 379 | V>I | No | EVA | |
| rs3389541853 | 383 | H>R | No | EVA | |
| rs3389530113 | 393 | K>* | No | EVA | |
| rs3389530134 | 407 | K>Q | No | EVA | |
| rs3412470697 | 410 | Q>* | No | EVA | |
| rs3411841371 | 410 | Q>H | No | EVA | |
| rs3411983385 | 416 | S>C | No | EVA | |
| rs3411983314 | 417 | I>F | No | EVA | |
| rs3409312143 | 417 | I>M | No | EVA | |
| rs3389568363 | 428 | E>D | No | EVA | |
| rs3389481988 | 440 | A>T | No | EVA | |
| rs3389574526 | 446 | F>* | No | EVA | |
| rs3389541813 | 447 | S>C | No | EVA | |
| rs3389566714 | 467 | M>K | No | EVA | |
| rs3412177772 | 474 | K>E | No | EVA | |
| rs3389523430 | 486 | I>N | No | EVA | |
| rs3412270150 | 490 | S>* | No | EVA | |
| rs3412177778 | 523 | K>E | No | EVA | |
| rs3389583039 | 537 | A>G | No | EVA | |
| rs230508185 | 577 | S>N | No | EVA | |
| rs251196494 | 588 | G>A | No | EVA | |
| rs3389574559 | 593 | D>Y | No | EVA | |
| rs3389569605 | 628 | N>D | No | EVA | |
| rs3389587705 | 628 | N>K* | No | EVA | |
| rs3389568398 | 631 | V>SDG* | No | EVA | |
| rs3389553759 | 632 | V>G | No | EVA | |
| rs3389582865 | 633 | D>E | No | EVA | |
| rs3389573145 | 634 | W>G | No | EVA | |
| rs3389577659 | 636 | D>G | No | EVA | |
| rs3389585228 | 639 | G>A | No | EVA |
No associated diseases with Q9R0Q1
7 regional properties for Q9R0Q1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 358 - 481 | IPR000008-1 |
| domain | C2 domain | 509 - 635 | IPR000008-2 |
| domain | Rab-binding domain | 4 - 122 | IPR010911 |
| domain | Synaptotagmin-like protein 4/5, C2A domain | 359 - 483 | IPR037303 |
| domain | FYVE-type zinc finger | 9 - 122 | IPR041282 |
| domain | Synaptotagmin-like 1-5, C2B domain | 498 - 663 | IPR043567 |
| domain | Synaptotagmin-like protein 4, FYVE-related domain | 58 - 107 | IPR044134 |
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| exocytic vesicle | A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. |
| extrinsic component of membrane | The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| secretory granule | A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. |
| secretory granule membrane | The lipid bilayer surrounding a secretory granule. |
| transport vesicle membrane | The lipid bilayer surrounding a transport vesicle. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| neurexin family protein binding | Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. |
| phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. |
| small GTPase binding | Binding to a small monomeric GTPase. |
| zinc ion binding | Binding to a zinc ion (Zn). |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| insulin secretion | The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| lysosome localization | Any process in which a lysosome is transported to, and/or maintained in, a specific location. |
| multivesicular body sorting pathway | A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. |
| negative regulation of insulin secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. |
| plasma membrane repair | The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress. |
| positive regulation of exocytosis | Any process that activates or increases the frequency, rate or extent of exocytosis. |
| positive regulation of protein secretion | Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. |
| regulation of plasma membrane repair | Any process that modulates the frequency, rate or extent of plasma membrane repair. |
45 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48018 | SYT1 | Synaptotagmin-1 | Bos taurus (Bovine) | PR |
| P21521 | Syt1 | Synaptotagmin 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q7L8C5 | SYT13 | Synaptotagmin-13 | Homo sapiens (Human) | PR |
| Q6XYQ8 | SYT10 | Synaptotagmin-10 | Homo sapiens (Human) | PR |
| Q9H2B2 | SYT4 | Synaptotagmin-4 | Homo sapiens (Human) | PR |
| P21579 | SYT1 | Synaptotagmin-1 | Homo sapiens (Human) | PR |
| Q86XP0 | PLA2G4D | Cytosolic phospholipase A2 delta | Homo sapiens (Human) | PR |
| Q86SS6 | SYT9 | Synaptotagmin-9 | Homo sapiens (Human) | PR |
| Q9BQG1 | SYT3 | Synaptotagmin-3 | Homo sapiens (Human) | PR |
| O00445 | SYT5 | Synaptotagmin-5 | Homo sapiens (Human) | PR |
| Q9BT88 | SYT11 | Synaptotagmin-11 | Homo sapiens (Human) | PR |
| Q9BQS2 | SYT15 | Synaptotagmin-15 | Homo sapiens (Human) | PR |
| Q8N9U0 | TC2N | Tandem C2 domains nuclear protein | Homo sapiens (Human) | PR |
| O43581 | SYT7 | Synaptotagmin-7 | Homo sapiens (Human) | PR |
| Q5T7P8 | SYT6 | Synaptotagmin-6 | Homo sapiens (Human) | PR |
| Q8IYJ3 | SYTL1 | Synaptotagmin-like protein 1 | Homo sapiens (Human) | PR |
| Q8TDW5 | SYTL5 | Synaptotagmin-like protein 5 | Homo sapiens (Human) | PR |
| Q9HCH5 | SYTL2 | Synaptotagmin-like protein 2 | Homo sapiens (Human) | PR |
| Q96C24 | SYTL4 | Synaptotagmin-like protein 4 | Homo sapiens (Human) | PR |
| P40749 | Syt4 | Synaptotagmin-4 | Mus musculus (Mouse) | PR |
| Q9EQT6 | Syt13 | Synaptotagmin-13 | Mus musculus (Mouse) | PR |
| Q9R0N4 | Syt10 | Synaptotagmin-10 | Mus musculus (Mouse) | PR |
| Q8C6N3 | Syt15 | Synaptotagmin-15 | Mus musculus (Mouse) | PR |
| Q920N7 | Syt12 | Synaptotagmin-12 | Mus musculus (Mouse) | PR |
| Q9R0N5 | Syt5 | Synaptotagmin-5 | Mus musculus (Mouse) | PR |
| Q9R0N9 | Syt9 | Synaptotagmin-9 | Mus musculus (Mouse) | PR |
| Q9R0N8 | Syt6 | Synaptotagmin-6 | Mus musculus (Mouse) | PR |
| Q50L43 | Pla2g4d | Cytosolic phospholipase A2 delta | Mus musculus (Mouse) | PR |
| P46096 | Syt1 | Synaptotagmin-1 | Mus musculus (Mouse) | PR |
| Q9R0N3 | Syt11 | Synaptotagmin-11 | Mus musculus (Mouse) | PR |
| O35681 | Syt3 | Synaptotagmin-3 | Mus musculus (Mouse) | PR |
| P46097 | Syt2 | Synaptotagmin-2 | Mus musculus (Mouse) | PR |
| Q91XT6 | Tc2n | Tandem C2 domains nuclear protein | Mus musculus (Mouse) | PR |
| Q80T23 | Sytl5 | Synaptotagmin-like protein 5 | Mus musculus (Mouse) | PR |
| Q99N80 | Sytl1 | Synaptotagmin-like protein 1 | Mus musculus (Mouse) | PR |
| Q812E4 | Sytl5 | Synaptotagmin-like protein 5 | Rattus norvegicus (Rat) | PR |
| Q925B5 | Syt13 | Synaptotagmin-13 | Rattus norvegicus (Rat) | PR |
| O08625 | Syt10 | Synaptotagmin-10 | Rattus norvegicus (Rat) | PR |
| P47861 | Syt5 | Synaptotagmin-5 | Rattus norvegicus (Rat) | PR |
| Q62746 | Syt6 | Synaptotagmin-6 | Rattus norvegicus (Rat) | PR |
| P97610 | Syt12 | Synaptotagmin-12 | Rattus norvegicus (Rat) | PR |
| P40748 | Syt3 | Synaptotagmin-3 | Rattus norvegicus (Rat) | PR |
| Q925C0 | Syt9 | Synaptotagmin-9 | Rattus norvegicus (Rat) | PR |
| P59926 | Syt15 | Synaptotagmin-15 | Rattus norvegicus (Rat) | PR |
| P21707 | Syt1 | Synaptotagmin-1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEILDLSFL | SEMERDLILG | VLQRDEELRK | ADEKRIRRLK | NELLEIKRKG | AKRGSQHYSD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RTCARCQEGL | GRLIPKSSTC | VGCNHLVCRE | CRVLESNGSW | RCKVCSKEIE | LKKATGDWFY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DQKVNRFDYR | TGSEIIRMSL | RQKPAVNKRE | TAGQSLLQQT | QMGDIWPGRR | IIQEQQQREQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVLFEVPKTR | SGKSALEAES | ESLDSYTADS | DSTSRRDSLD | KSGLFPEWKK | MSAPKSQVEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EIPPGNQNAV | CGDEGDMVFK | KNTKKVLRPS | EYTKSVIDLR | PEDVAQESGI | LGDRSKSVPG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSVDMEEEEE | EEEDIDHLVK | LHRQKLARGS | MQSGSSMSTL | GSIMSIYSEA | GDFGNISVTG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KIAFSLKFEQ | KTQTLVIHVK | ECHQLAYADE | AKKRSNPYVK | TYLLPDKSRQ | GKRKTSIKRD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TINPLYDETF | RYEISESLLA | QRTLQFSVWH | HGRFGRNTFL | GEAEVHMDSW | KLDKKLDHCL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PLHGKISTES | SPGLPAHKGE | LVVSLKYIPA | SKLPVGGDRK | KSKGGEGGEL | QVWIKEAKNL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TAAKSGGTSD | SFVKGYLLPM | RNKASKRKTP | VMKKTLSPHY | NHTFVYNGVR | LEDLQHMCLE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LTVWDREPLA | SNDFLGGVRL | GVGTGISNGE | VVDWMDSTGE | EVSLWQKMRQ | YPGSWAEGTL |
| 670 | |||||
| QLRSSMVKQK | LGV |