Q9R0N8
PR
Gene name |
Syt6 |
Protein name |
Synaptotagmin-6 |
Names |
Synaptotagmin VI, SytVI |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:54524 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9R0N8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9R0N8-F1 | Predicted | AlphaFoldDB |
23 variants for Q9R0N8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388652462 | 12 | C>W | No | EVA | |
| rs3388651544 | 27 | P>S | No | EVA | |
| rs3393439835 | 57 | S>T | No | EVA | |
| rs3393304475 | 63 | V>M | No | EVA | |
| rs3388650441 | 66 | I>F | No | EVA | |
| rs226936016 | 109 | P>S | No | EVA | |
| rs247528650 | 113 | G>S | No | EVA | |
| rs3388655579 | 120 | K>N | No | EVA | |
| rs3388648631 | 136 | H>P | No | EVA | |
| rs3388658363 | 159 | L>Q | No | EVA | |
| rs3388657549 | 162 | Q>H | No | EVA | |
| rs3388651431 | 166 | P>L | No | EVA | |
| rs3388651383 | 195 | P>S | No | EVA | |
| rs3388651464 | 207 | R>H | No | EVA | |
| rs3388655571 | 263 | C>W | No | EVA | |
| rs3388657480 | 280 | C>G | No | EVA | |
| rs3388652427 | 316 | S>N | No | EVA | |
| rs3388636087 | 425 | L>I | No | EVA | |
| rs3393428366 | 428 | I>V | No | EVA | |
| rs3388650442 | 456 | R>K | No | EVA | |
| rs3388647108 | 470 | I>F | No | EVA | |
| rs3388651459 | 488 | R>* | No | EVA | |
| rs3388650492 | 494 | W>R | No | EVA |
No associated diseases with Q9R0N8
6 regional properties for Q9R0N8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 230 - 351 | IPR000008-1 |
| domain | C2 domain | 362 - 495 | IPR000008-2 |
| domain | Synaptotagmin | 234 - 249 | IPR001565-1 |
| domain | Synaptotagmin | 249 - 262 | IPR001565-2 |
| domain | Synaptotagmin | 304 - 319 | IPR001565-3 |
| domain | Synaptotagmin | 324 - 334 | IPR001565-4 |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| exocytic vesicle | A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. |
| extrinsic component of membrane | The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of synaptic membrane | The component of the synaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| perinuclear endoplasmic reticulum | The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| synaptic vesicle membrane | The lipid bilayer surrounding a synaptic vesicle. |
10 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
| calcium-dependent protein binding | Binding to a protein or protein complex in the presence of calcium. |
| clathrin binding | Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. |
| identical protein binding | Binding to an identical protein or proteins. |
| phosphatidylserine binding | Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
| syntaxin binding | Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| acrosomal vesicle exocytosis | The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction. |
| acrosome reaction | The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida. |
| calcium-ion regulated exocytosis | The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. |
| cellular response to calcium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| presynaptic dense core vesicle exocytosis | The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels. |
| regulation of calcium ion-dependent exocytosis | Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. |
| regulation of dopamine secretion | Any process that modulates the frequency, rate or extent of the regulated release of dopamine. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
45 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48018 | SYT1 | Synaptotagmin-1 | Bos taurus (Bovine) | PR |
| P21521 | Syt1 | Synaptotagmin 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q7L8C5 | SYT13 | Synaptotagmin-13 | Homo sapiens (Human) | PR |
| Q6XYQ8 | SYT10 | Synaptotagmin-10 | Homo sapiens (Human) | PR |
| Q9H2B2 | SYT4 | Synaptotagmin-4 | Homo sapiens (Human) | PR |
| P21579 | SYT1 | Synaptotagmin-1 | Homo sapiens (Human) | PR |
| Q86XP0 | PLA2G4D | Cytosolic phospholipase A2 delta | Homo sapiens (Human) | PR |
| Q9HCH5 | SYTL2 | Synaptotagmin-like protein 2 | Homo sapiens (Human) | PR |
| Q86SS6 | SYT9 | Synaptotagmin-9 | Homo sapiens (Human) | PR |
| Q9BQG1 | SYT3 | Synaptotagmin-3 | Homo sapiens (Human) | PR |
| O00445 | SYT5 | Synaptotagmin-5 | Homo sapiens (Human) | PR |
| Q9BT88 | SYT11 | Synaptotagmin-11 | Homo sapiens (Human) | PR |
| Q96C24 | SYTL4 | Synaptotagmin-like protein 4 | Homo sapiens (Human) | PR |
| Q9BQS2 | SYT15 | Synaptotagmin-15 | Homo sapiens (Human) | PR |
| Q8N9U0 | TC2N | Tandem C2 domains nuclear protein | Homo sapiens (Human) | PR |
| Q8TDW5 | SYTL5 | Synaptotagmin-like protein 5 | Homo sapiens (Human) | PR |
| Q8IYJ3 | SYTL1 | Synaptotagmin-like protein 1 | Homo sapiens (Human) | PR |
| O43581 | SYT7 | Synaptotagmin-7 | Homo sapiens (Human) | PR |
| Q5T7P8 | SYT6 | Synaptotagmin-6 | Homo sapiens (Human) | PR |
| Q99N80 | Sytl1 | Synaptotagmin-like protein 1 | Mus musculus (Mouse) | PR |
| Q9R0Q1 | Sytl4 | Synaptotagmin-like protein 4 | Mus musculus (Mouse) | PR |
| Q80T23 | Sytl5 | Synaptotagmin-like protein 5 | Mus musculus (Mouse) | PR |
| Q50L43 | Pla2g4d | Cytosolic phospholipase A2 delta | Mus musculus (Mouse) | PR |
| Q91XT6 | Tc2n | Tandem C2 domains nuclear protein | Mus musculus (Mouse) | PR |
| O35681 | Syt3 | Synaptotagmin-3 | Mus musculus (Mouse) | PR |
| Q9R0N9 | Syt9 | Synaptotagmin-9 | Mus musculus (Mouse) | PR |
| Q9R0N5 | Syt5 | Synaptotagmin-5 | Mus musculus (Mouse) | PR |
| P46096 | Syt1 | Synaptotagmin-1 | Mus musculus (Mouse) | PR |
| P46097 | Syt2 | Synaptotagmin-2 | Mus musculus (Mouse) | PR |
| Q920N7 | Syt12 | Synaptotagmin-12 | Mus musculus (Mouse) | PR |
| Q9R0N3 | Syt11 | Synaptotagmin-11 | Mus musculus (Mouse) | PR |
| P40749 | Syt4 | Synaptotagmin-4 | Mus musculus (Mouse) | PR |
| Q8C6N3 | Syt15 | Synaptotagmin-15 | Mus musculus (Mouse) | PR |
| Q9EQT6 | Syt13 | Synaptotagmin-13 | Mus musculus (Mouse) | PR |
| Q9R0N4 | Syt10 | Synaptotagmin-10 | Mus musculus (Mouse) | PR |
| Q812E4 | Sytl5 | Synaptotagmin-like protein 5 | Rattus norvegicus (Rat) | PR |
| Q925B5 | Syt13 | Synaptotagmin-13 | Rattus norvegicus (Rat) | PR |
| O08625 | Syt10 | Synaptotagmin-10 | Rattus norvegicus (Rat) | PR |
| P47861 | Syt5 | Synaptotagmin-5 | Rattus norvegicus (Rat) | PR |
| P97610 | Syt12 | Synaptotagmin-12 | Rattus norvegicus (Rat) | PR |
| P40748 | Syt3 | Synaptotagmin-3 | Rattus norvegicus (Rat) | PR |
| Q925C0 | Syt9 | Synaptotagmin-9 | Rattus norvegicus (Rat) | PR |
| P59926 | Syt15 | Synaptotagmin-15 | Rattus norvegicus (Rat) | PR |
| P21707 | Syt1 | Synaptotagmin-1 | Rattus norvegicus (Rat) | PR |
| Q62746 | Syt6 | Synaptotagmin-6 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGVWGAGGP | RCQAALAVLA | SLCRARPPPL | GLDVETCRSF | ELQSPEQSPS | AADSGTSVSL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LAVVVIVCGV | ALVAVFLFLF | WKLCWMPWRK | KEASSPSSAN | PASETLQSPS | SRGNMADKLK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DPSALGFLEA | AVKISHTSPD | IPAEVQMSVK | EHIMRHTKLQ | RQTTEPASST | RHTSFKRHLP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RQMHVSSVDY | GNELPPAAAE | QPTSIGRIKP | ELYKQKSVDG | DDAKSEAAKS | CGKINFSLRY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DYESETLIVR | ILKAFDLPAK | DFCGSSDPYV | KIYLLPDRKC | KLQTRVHRKT | LNPTFDENFH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FPVPYEELAD | RKLHLSVFDF | DRFSRHDMIG | EVILDNLFEA | SDLSRETSIW | KDIQYATSES |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VDLGEIMFSL | CYLPTAGRLT | LTVIKCRNLK | AMDITGYSDP | YVKVSLLCDG | RRLKKKKTTI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KKNTLNPIYN | EAIIFDIPPE | NMDQVSLLIS | VMDYDRVGHN | EIIGVCRVGI | NAEGLGRDHW |
| 490 | 500 | 510 | |||
| NEMLAYPRKP | IAHWHSLVEV | KKSFKEGTPR | L |