AiPD: Autoinhibited Protein Database

Q9BQG1

Gene name	SYT3
Protein name	Synaptotagmin-3
Names	Synaptotagmin III, SytIII
Species	Homo sapiens (Human)
KEGG Pathway	hsa:84258
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

89-334 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

89-334 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9BQG1

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9BQG1-F1	Predicted				AlphaFoldDB

445 variants for Q9BQG1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1032771141 CA309638414	4	D>H		No	ClinGen Ensembl
rs144585182 CA309638396	6	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA
rs1021019460 CA309638401	6	E>K		No	ClinGen TOPMed
rs768504157 CA9600688	11	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs140892148 CA9600689	11	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9600686 rs779832436	12	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9600687 rs746751712	12	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1599821023 COSM1526030 CA407002283	15	I>M	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1008512890 CA309638319	15	I>T		No	ClinGen Ensembl
rs746144697 CA9600684	15	I>V		No	ClinGen ExAC gnomAD
rs757397160 CA407002250	18	S>L		No	ClinGen ExAC gnomAD
rs757397160 CA9600682	18	S>W		No	ClinGen ExAC gnomAD
CA9600680 rs778291990	20	L>F		No	ClinGen ExAC TOPMed gnomAD
CA9600677 rs768053715	22	A>V		No	ClinGen ExAC TOPMed gnomAD
rs534235847 CA407002193	23	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9600674 rs534235847	23	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9600675 rs145561187	23	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs761342827 CA9600673	25	R>*		No	ClinGen ExAC gnomAD
rs776020631 CA9600672	25	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1338365677 CA407002147	27	A>V		No	ClinGen gnomAD
CA407002122 rs1297547307	30	N>S		No	ClinGen gnomAD
rs754832010 COSM233532 CA9600670	31	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM223998 rs866625534 CA309638225	32	R>K	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA309638219 rs920052786	32	R>S		No	ClinGen Ensembl
CA407002059 rs1170440958	35	E>D		No	ClinGen gnomAD
rs775250339 CA9600669	36	F>L		No	ClinGen ExAC gnomAD
rs1423585714 CA407002042	36	F>L		No	ClinGen TOPMed
rs1038465741 CA309638178	39	R>*		No	ClinGen gnomAD
rs373338775 CA9600668	39	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA309638173 rs927327465	41	R>*		No	ClinGen TOPMed
rs929145527 CA309638171	41	R>Q		No	ClinGen TOPMed gnomAD
rs1453047793 CA407001979	42	G>D		No	ClinGen TOPMed gnomAD
rs1568417379 CA407001951	44	P>L		No	ClinGen Ensembl
CA407001949 rs1194584617	45	R>G		No	ClinGen gnomAD
rs746056284 CA9600667 COSM1228338	45	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA407001922 rs1254596826	47	P>R		No	ClinGen gnomAD
rs1444217136 CA407000596	53	V>M		No	ClinGen gnomAD
rs1398842545 CA407000561	55	L>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA309635834 rs770034923	56	L>P		No	ClinGen ExAC TOPMed gnomAD
rs770034923 CA9600643	56	L>R		No	ClinGen ExAC TOPMed gnomAD
rs1568416291 COSM418101 CA407000528	57	S>L	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1445605414 CA407000502	60	V>M		No	ClinGen gnomAD
rs1387545180 CA407000485	62	F>L		No	ClinGen gnomAD
rs1439327875 CA407000443	66	V>F		No	ClinGen gnomAD
CA407000409 rs1395942955	69	G>D		No	ClinGen TOPMed
CA9600638 rs371879019	73	F>S		No	ClinGen ESP ExAC gnomAD
rs753480602 CA9600636 COSM999771	74	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1395772407 CA407000348	75	S>F		No	ClinGen gnomAD
rs773513926 CA9600635	81	V>M		No	ClinGen ExAC TOPMed gnomAD
rs17852897 CA309635809	82	P>H		No	ClinGen Ensembl
COSM3787759 CA9600633 rs752224916	84	R>Q	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA309635797 COSM3773114 rs185774466	84	R>W	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA9600632 rs767384227	85	D>Y		No	ClinGen ExAC gnomAD
CA407000227 rs1347667934	87	G>E		No	ClinGen gnomAD
CA407000221 rs202245277	88	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759472318 CA9600631	88	G>S		No	ClinGen ExAC gnomAD
CA9600630 rs202245277	88	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9600629 rs766137464	89	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1599818552 CA407000206	90	A>T		No	ClinGen Ensembl
rs1483230503 CA407000200	91	V>M		No	ClinGen TOPMed
rs763204858 CA9600628	92	G>D		No	ClinGen ExAC gnomAD
CA407000193 rs1193059710	92	G>S		No	ClinGen TOPMed gnomAD
CA9600625 rs748185607	93	G>D		No	ClinGen ExAC gnomAD
rs770163135 CA9600626	93	G>S		No	ClinGen ExAC TOPMed gnomAD
rs765263349	96	L>C	Variant assessed as Somatic; 0.000135 impact. [NCI-TCGA]	No	NCI-TCGA
rs769285279 CA9600622	97	R>C		No	ClinGen ExAC TOPMed gnomAD
rs781302664 CA9600621 COSM1228340	97	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1465983426 CA407000141	98	K>Q		No	ClinGen TOPMed
CA9600620 rs780441588	99	D>V		No	ClinGen ExAC gnomAD
CA9600619 rs758727682	101	G>D		No	ClinGen ExAC gnomAD
rs1021057468 CA309635742	101	G>S		No	ClinGen Ensembl
rs1171296188 CA407000090	103	G>D		No	ClinGen TOPMed
rs145378162 CA9600616	105	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs752134579 CA9600615	106	L>V		No	ClinGen ExAC TOPMed gnomAD
CA407000059 rs1347967152	107	A>T		No	ClinGen gnomAD
rs1296927555 CA407000053	107	A>V		No	ClinGen gnomAD
rs1346222867 CA407000027	110	V>L		No	ClinGen gnomAD
CA9600612 rs751492794	112	G>R		No	ClinGen ExAC TOPMed gnomAD
rs766373341 CA9600611	113	G>D		No	ClinGen ExAC gnomAD
CA406999966 rs1446549971	114	G>E		No	ClinGen Ensembl
CA9600610 rs762608374	114	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	116	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406999925 rs1220505161	116	H>Q		No	ClinGen gnomAD
rs750248893 CA9600609	117	L>V		No	ClinGen ExAC gnomAD
rs765491405 COSM1228341 CA9600608	118	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA406999890 rs1269265874	119	A>V		No	ClinGen TOPMed gnomAD
CA309635709 rs919878717	122	G>R		No	ClinGen TOPMed
rs372144881 CA309635705	123	G>S		No	ClinGen TOPMed gnomAD
rs761209975 CA9600604	125	P>L		No	ClinGen ExAC TOPMed gnomAD
rs747211137 COSM1724659 CA9600600	129	G>S	NS [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1450635556 CA406999702	130	P>L		No	ClinGen TOPMed
rs1291014341 CA406999689	131	H>Y		No	ClinGen TOPMed gnomAD
rs769431324 CA9600598	133	H>Y		No	ClinGen ExAC gnomAD
rs780650624 CA9600597	134	A>D		No	ClinGen ExAC gnomAD
CA9600596 rs780650624	134	A>G		No	ClinGen ExAC gnomAD
rs370189724 CA9600595	135	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs868648216 CA309635666	136	A>V		No	ClinGen TOPMed gnomAD
CA9600593 rs193002389	137	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406999540 rs1427860395	138	H>R		No	ClinGen gnomAD
CA406999493 rs1419900902	140	P>L		No	ClinGen gnomAD
rs1599818324 CA406999466	142	F>S		No	ClinGen Ensembl
TCGA novel	144	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406999424 rs1188082587	144	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9600591 rs147608314	147	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758364283 CA9600592	147	E>K		No	ClinGen ExAC TOPMed gnomAD
CA309635649 rs1018064840	148	P>L		No	ClinGen TOPMed gnomAD
CA406999329 rs1462267700	149	G>R		No	ClinGen gnomAD
rs1255615446 CA406999299	150	S>I		No	ClinGen gnomAD
rs762108460 CA9600590	152	G>A		No	ClinGen ExAC gnomAD
CA9600589 rs762108460	152	G>E		No	ClinGen ExAC gnomAD
rs754150487 CA9600588	153	G>A		No	ClinGen ExAC TOPMed gnomAD
CA406999227 rs1365912161	153	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA406999207 rs1382570240	154	S>F		No	ClinGen TOPMed gnomAD
CA406999208 rs1382570240	154	S>Y		No	ClinGen TOPMed gnomAD
rs139241700 CA9600586	156	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA406999159 rs1599818298	156	T>P		No	ClinGen Ensembl
rs1398127746 CA406999132	157	P>S		No	ClinGen gnomAD
CA9600583 rs760153559	158	E>D		No	ClinGen ExAC gnomAD
TCGA novel	163	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9600580 rs749685489	164	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1172506040 CA406998992	164	M>T		No	ClinGen gnomAD
rs1031155261 CA309635609	164	M>V		No	ClinGen TOPMed
rs553969864 CA9600579	165	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs553969864 CA406998975	165	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9600577 rs746441568	166	S>L		No	ClinGen ExAC gnomAD
rs768369027 CA9600578	166	S>P		No	ClinGen ExAC gnomAD
CA309635594 rs746441568	166	S>W		No	ClinGen ExAC gnomAD
rs1235775840 CA406998942	167	Y>H		No	ClinGen gnomAD
CA9600576 rs779684367	168	P>S		No	ClinGen ExAC TOPMed gnomAD
CA406998863 rs1417857374	170	A>G		No	ClinGen TOPMed
CA406998832 rs778815816	172	A>G		No	ClinGen ExAC gnomAD
rs367963156 CA9600574	172	A>T		No	ClinGen ESP ExAC gnomAD
CA9600573 rs778815816	172	A>V		No	ClinGen ExAC gnomAD
rs1359084188 CA406998826	173	A>T		No	ClinGen gnomAD
CA309635562 rs914048250	175	V>A		No	ClinGen Ensembl
CA9600572 rs757073773	175	V>L		No	ClinGen ExAC gnomAD
TCGA novel	176	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406998747 rs141570463	177	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1235948 CA9600568 rs141570463	177	A>T	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA9600567 rs756363150	177	A>V		No	ClinGen ExAC gnomAD
CA406998714 rs1375690668	178	G>A		No	ClinGen TOPMed gnomAD
rs1599818194 CA406998688	179	V>G		No	ClinGen Ensembl
CA9600564 rs760013880	181	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs760013880 CA9600565	181	P>R		No	ClinGen ExAC gnomAD
rs1164004794 CA406998540	185	S>F		No	ClinGen TOPMed gnomAD
CA406998558 rs1364668409	185	S>P		No	ClinGen gnomAD
CA406998480 rs1426122088	189	P>S		No	ClinGen gnomAD
rs148772753 CA9600561 CA9600560	191	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9600556 rs771656522	192	G>A		No	ClinGen ExAC TOPMed gnomAD
CA406998397 rs771656522	192	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs376869372 CA9600558 CA406998403	192	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA9600557 rs771656522	192	G>V		No	ClinGen ExAC TOPMed gnomAD
rs376869372 CA9600559 COSM72891	192	G>W	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA406998380 rs1197818694	193	G>A		No	ClinGen TOPMed gnomAD
rs1197818694 COSM567454 CA406998379	193	G>V	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
TCGA novel	194	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1047574921 CA309635517	195	G>A		No	ClinGen TOPMed gnomAD
CA9600553 rs757271846	196	S>P		No	ClinGen ExAC gnomAD
rs749021783 CA9600552	200	L>Q		No	ClinGen ExAC
rs1240110679 CA406998217	201	L>P		No	ClinGen gnomAD
CA406998202 rs1484519538	202	P>H		No	ClinGen TOPMed
rs777689783 CA9600551	202	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1299302724 CA406998172	203	P>L		No	ClinGen gnomAD
rs756275781 CA9600550	204	S>G		No	ClinGen ExAC gnomAD
rs753013056 CA406998157	204	S>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs753013056 CA9600549	204	S>N		No	ClinGen ExAC gnomAD
rs751653950 CA9600546	210	S>N		No	ClinGen ExAC gnomAD
rs1599818090 CA406998019	210	S>R		No	ClinGen Ensembl
CA9600545 rs146108083	211	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA309635484 rs866328089	212	Q>*		No	ClinGen Ensembl
rs1412107395 CA406997900	214	H>Y		No	ClinGen TOPMed
TCGA novel	215	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1456285800 CA406997827	216	Q>H		No	ClinGen TOPMed
CA9600544 rs201030888	217	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA406997814 rs1599818069	217	V>G		No	ClinGen Ensembl
rs773437586 CA406997747	222	P>S		No	ClinGen ExAC gnomAD
rs773437586 CA9600543	222	P>T		No	ClinGen ExAC gnomAD
CA9600542 rs765686951	223	T>I		No	ClinGen ExAC TOPMed gnomAD
rs760217677 CA9600541	225	R>K		No	ClinGen ExAC gnomAD
RCV000889136 rs188199665 CA9600512	226	Y>H		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1383854505 CA406996642	227	P>T		No	ClinGen gnomAD
rs577362591 CA406996630	228	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs577362591 CA9600511	228	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780081190 CA9600510	229	L>V		No	ClinGen ExAC gnomAD
rs1235455746 CA406996614	230	P>L		No	ClinGen TOPMed
rs371022999 CA9600509	230	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs750487782 CA9600508	231	R>*		No	ClinGen ExAC TOPMed gnomAD
rs757705902 CA9600507	231	R>L		No	ClinGen ExAC gnomAD
CA9600506 rs757705902	231	R>Q		No	ClinGen ExAC gnomAD
CA9600505 rs754223325	232	P>R		No	ClinGen ExAC gnomAD
rs1310072033 CA406996592	233	L>H		No	ClinGen TOPMed
CA406996582 rs1289336155	234	T>I		No	ClinGen gnomAD
rs1599816713 CA406996586	234	T>P		No	ClinGen Ensembl
CA406996573 rs1383115817	235	Q>R		No	ClinGen gnomAD
rs1285637910 CA406996556	236	Q>H		No	ClinGen gnomAD
rs1479333889 CA406996546	237	T>I		No	ClinGen gnomAD
TCGA novel	238	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1439368216 CA406996543	238	L>V		No	ClinGen gnomAD
rs1599816689 CA406996535	239	T>P		No	ClinGen Ensembl
rs751297126 CA9600502	242	P>A		No	ClinGen ExAC gnomAD
rs766161130 CA9600501	242	P>L		No	ClinGen ExAC gnomAD
TCGA novel	243	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9600500 rs762468525	244	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1176654650 CA406996470	245	S>N		No	ClinGen TOPMed
CA406996466 rs1425729136	245	S>R		No	ClinGen gnomAD
rs772603261 CA9600499	248	E>G		No	ClinGen ExAC gnomAD
rs761715733 CA9600497	249	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs200843293 CA9600498	249	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9600495 rs768482342	250	P>L		No	ClinGen ExAC gnomAD
rs1221422109 CA406996404	251	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA309633979 rs922804895	251	P>S		No	ClinGen TOPMed gnomAD
rs922804895 CA406996411	251	P>T		No	ClinGen TOPMed gnomAD
CA406996395 rs1291562334	252	A>V		No	ClinGen gnomAD
CA406996392 rs1349259181	253	L>M		No	ClinGen gnomAD
CA406996388 rs1465141646	253	L>P		No	ClinGen TOPMed
rs138564908 CA9600492	255	L>S		No	ClinGen ESP ExAC gnomAD
CA406996359 rs1599816579	256	P>R		No	ClinGen Ensembl
CA406996363 rs1412169854	256	P>S		No	ClinGen gnomAD
TCGA novel	256	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs980164528 CA309633915	258	P>A		No	ClinGen Ensembl
rs1442188615 CA406996336	259	G>R		No	ClinGen TOPMed
rs989503467 CA309633902	261	E>K		No	ClinGen TOPMed gnomAD
CA406996282 rs1599816541	263	K>N		No	ClinGen Ensembl
rs749807070 CA9600487	266	L>F		No	ClinGen ExAC gnomAD
rs1306455055 CA406996246	267	I>T		No	ClinGen TOPMed
rs778249706 CA9600486	267	I>V		No	ClinGen ExAC gnomAD
rs1427089383 CA406996229	269	Q>K		No	ClinGen gnomAD
CA406996226 rs1198677176	269	Q>R		No	ClinGen gnomAD
rs1196184200 CA406996208	271	K>T		No	ClinGen TOPMed
rs756505974 CA9600485	276	Q>R		No	ClinGen ExAC gnomAD
CA9600482 CA9600483 rs758055177	277	G>R		No	ClinGen ExAC gnomAD
rs1446090928 CA406996144	281	G>C		No	ClinGen gnomAD
rs373678232 CA406996132	283	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA9600481 COSM1744509 rs373678232	283	R>Q	biliary_tract [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA406996133 rs1229670779	283	R>W		No	ClinGen TOPMed gnomAD
CA9600480 rs764704614	284	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1420472277 CA406996113	286	G>S		No	ClinGen TOPMed
rs764044903 CA9600476	288	G>D		No	ClinGen ExAC gnomAD
CA406996091 rs150387707	288	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs150387707 CA9600477	288	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1468288601 CA406996075	289	P>L		No	ClinGen gnomAD
rs760400344 CA9600475	292	G>R		No	ClinGen ExAC gnomAD
CA406996042 rs1568763316	293	E>Q		No	ClinGen Ensembl
rs1175540038 CA406995992	297	G>V		No	ClinGen gnomAD
TCGA novel	298	A>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9600474 rs775265173	298	A>T		No	ClinGen ExAC gnomAD
CA309633829 rs971804881	300	C>R		No	ClinGen Ensembl
CA406995957 rs1184597967	301	G>S		No	ClinGen gnomAD
rs1474986921 CA406995944	302	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs772331102 CA406995942	302	R>H		No	ClinGen ExAC gnomAD
CA9600472 rs772331102	302	R>L		No	ClinGen ExAC gnomAD
CA406995927 rs1348456734	303	I>M		No	ClinGen TOPMed
rs746131765 CA406995800	305	F>L		No	ClinGen ExAC gnomAD
rs770954912 CA9600469	306	A>G		No	ClinGen ExAC gnomAD
rs140350128 CA9600470	306	A>T		No	ClinGen ESP ExAC
TCGA novel	307	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778375950 CA406995788	308	R>L		No	ClinGen ExAC gnomAD
CA9600467 COSM247684 rs778375950	308	R>Q	prostate [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA9600468 COSM999769 rs749409227	308	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA406995769 rs1294108334	311	Y>C		No	ClinGen gnomAD
TCGA novel	312	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756693870 CA9600466	313	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1014261692 CA309633763	314	D>A		No	ClinGen Ensembl
CA406995729 rs1337500031	317	V>G		No	ClinGen gnomAD
rs1405371056 CA406995734	317	V>M		No	ClinGen gnomAD
rs764975315 CA9600461	319	R>K		No	ClinGen ExAC TOPMed
rs1409146403 CA406995696	323	A>T		No	ClinGen gnomAD
rs866347364 CA309633741	324	L>P		No	ClinGen Ensembl
rs1599816327 CA406995684	325	D>A		No	ClinGen Ensembl
rs756676284 CA9600460	325	D>N		No	ClinGen ExAC TOPMed gnomAD
CA406995666 rs763948624	328	A>S		No	ClinGen ExAC gnomAD
CA9600458 rs763948624	328	A>T		No	ClinGen ExAC gnomAD
TCGA novel	329	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406995653 rs1241943477	330	D>H		No	ClinGen gnomAD
rs1483975806 CA406995645	331	S>P		No	ClinGen TOPMed gnomAD
CA9600456 rs775248622	332	N>S		No	ClinGen ExAC gnomAD
CA9600454 rs147829151	333	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs375171876 CA9600452	339	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1402866963 CA406995575	341	I>T		No	ClinGen TOPMed
rs943153850 CA309633673	342	Y>H		No	ClinGen Ensembl
CA9600448 rs370714728	347	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA406995538 rs370714728	347	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs770412233 CA9600449	347	R>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs768865820 CA9600446	352	Q>H		No	ClinGen ExAC gnomAD
rs1221616929 CA406995456	357	R>K		No	ClinGen gnomAD
CA309633313 rs142151643	363	V>F		No	ClinGen ESP ExAC gnomAD
CA9600419 rs142151643	363	V>I		No	ClinGen ESP ExAC gnomAD
CA406995368 rs1165629855	365	N>S		No	ClinGen TOPMed
CA9600418 rs751298710	367	T>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	370	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9600416 rs763235130	371	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA406995308 rs1219443490	372	V>M		No	ClinGen TOPMed gnomAD
rs750630684 CA9600415	373	P>R		No	ClinGen ExAC TOPMed gnomAD
CA406995293 rs1297697723	374	L>Q		No	ClinGen TOPMed
TCGA novel	375	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406995290 rs1346426570	375	A>S		No	ClinGen TOPMed gnomAD
rs993194151 CA309633296	375	A>V		No	ClinGen Ensembl
rs375139764 CA406995287	376	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA9600414 rs375139764	376	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA406995271 rs1321633975	378	A>G		No	ClinGen TOPMed
CA309633282 rs866886368	380	R>C		No	ClinGen Ensembl
rs761922692 CA9600413	380	R>L		No	ClinGen ExAC gnomAD
CA309633274 rs1037325536	382	L>R		No	ClinGen Ensembl
CA406995228 rs1568762773	385	S>G		No	ClinGen Ensembl
CA309633264 rs200694411	385	S>N		No	ClinGen Ensembl
CA406995221 rs200430574	386	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200430574 CA9600410	386	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772468572 CA9600408	387	Y>C		No	ClinGen ExAC gnomAD
CA9600407 rs372317846	388	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA309633245 rs372317846	388	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA9600406 rs772803460	391	R>C		No	ClinGen ExAC gnomAD
CA9600405 rs769451420	391	R>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	394	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM3423017 rs754849075 CA9600402	394	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA9600403 rs780811810	394	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	396	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780170593 CA9600400	398	I>F		No	ClinGen ExAC gnomAD
rs765485144 CA9600397	400	Q>R		No	ClinGen ExAC gnomAD
CA406995109 rs1451587607	404	D>N		No	ClinGen gnomAD
rs1005935891 CA309633141	406	L>I		No	ClinGen TOPMed gnomAD
CA406995091 rs1343125226	406	L>P		No	ClinGen Ensembl
rs764287285 CA9600394	407	L>P		No	ClinGen ExAC gnomAD
rs759838070 CA9600390	411	E>D		No	ClinGen ExAC gnomAD
CA406995065 rs1273671821	411	E>K		No	ClinGen gnomAD
rs1379098638 CA406995047	413	P>S		No	ClinGen TOPMed
CA406995042 rs1394747697	414	P>T		No	ClinGen TOPMed
rs1599815603 CA406995025	415	D>A		No	ClinGen Ensembl
rs769432992 CA9600388	416	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs368534907 CA9600387	416	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9600385 rs768170643	417	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9600386 rs768170643	417	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA309633105 rs768170643	417	P>R		No	ClinGen ExAC TOPMed gnomAD
CA406995007 rs1340623771	417	P>T		No	ClinGen gnomAD
rs1396167099 CA406994983	419	W>R		No	ClinGen gnomAD
rs956103263 CA309633101	421	D>G		No	ClinGen Ensembl
CA309633092 rs796357681	423	V>M		No	ClinGen TOPMed gnomAD
rs1383598574 CA406994921	424	E>V		No	ClinGen gnomAD
rs745650170 CA9600381	426	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1239295358 CA406994885	427	S>L		No	ClinGen gnomAD
TCGA novel	428	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA309630685 rs866261528	428	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1432667529 CA406993936	430	A>T		No	ClinGen TOPMed
rs1289191090 CA406993879	434	E>D		No	ClinGen TOPMed
rs778823813 COSM418102 CA9600363	436	N>S	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA309630678 rs915905376	440	C>Y		No	ClinGen TOPMed
rs749062235 CA9600361	443	P>S		No	ClinGen ExAC gnomAD
rs756296350 CA9600359	446	G>R		No	ClinGen ExAC gnomAD
rs1568761038 CA406993737	447	R>H		No	ClinGen Ensembl
CA309630651 rs982169965	450	V>M		No	ClinGen TOPMed gnomAD
CA9600356 rs755446640	451	T>S		No	ClinGen ExAC gnomAD
rs1463998892 CA406993655	454	K>N		No	ClinGen gnomAD
CA406993660 rs1213299570	454	K>R		No	ClinGen TOPMed gnomAD
rs1444730050 CA406993607	459	K>E		No	ClinGen TOPMed
rs750754857 CA9600352	461	M>T		No	ClinGen ExAC gnomAD
CA406993524 rs1411577834	466	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA406993502 rs1484289495	468	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA406993079 rs202126818	470	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1369584913 CA406993084	470	Y>F		No	ClinGen TOPMed
CA406993074 rs1390345233	471	V>M		No	ClinGen gnomAD
rs938179936 CA309630237	473	A>T		No	ClinGen Ensembl
rs1170103035 CA406993034	473	A>V		No	ClinGen gnomAD
VAR_036389	474	S>F	a breast cancer sample; somatic mutation [UniProt]	No	UniProt
rs750782856 CA9600332	477	S>I		No	ClinGen ExAC TOPMed gnomAD
CA406992957 rs1231704250	478	E>A		No	ClinGen gnomAD
rs778886012 CA309630209	478	E>K		No	ClinGen Ensembl
rs1568760621 CA406992939	479	G>V		No	ClinGen Ensembl
CA9600329 rs188228927	480	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9600330 rs755801316	480	R>W		No	ClinGen ExAC gnomAD
CA9600328 rs767302874	481	R>C		No	ClinGen ExAC gnomAD
CA9600327 COSM298030 rs759062700	481	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs945436221 CA309630180	482	L>M		No	ClinGen TOPMed gnomAD
CA9600325 rs766336772	485	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9600323 rs773038739	489	I>T		No	ClinGen ExAC gnomAD
rs762856222 CA9600324	489	I>V		No	ClinGen ExAC gnomAD
rs769537404 CA9600322	490	K>N		No	ClinGen ExAC gnomAD
CA309630141 rs936652611	492	N>K		No	ClinGen Ensembl
CA9600320 rs747958139	493	T>M		No	ClinGen ExAC TOPMed gnomAD
CA9600318 rs768869008	501	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9600317 COSM999765 rs747084464	505	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA309630099 rs376860461	506	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs376860461 CA9600316	506	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs78175900 CA9600314	507	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs78175900 CA9600315	507	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	508	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs193068522 CA309630081	509	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed
TCGA novel	509	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs193068522 CA9600312	509	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed
CA406992559 rs754271371	511	V>L		No	ClinGen ExAC gnomAD
rs754271371 CA9600311	511	V>M		No	ClinGen ExAC gnomAD
CA309630061 rs377637160	514	V>L		No	ClinGen ESP TOPMed gnomAD
rs377637160 CA309630073	514	V>M		No	ClinGen ESP TOPMed gnomAD
rs1350863028 CA406992521	515	G>R		No	ClinGen TOPMed gnomAD
rs754747321 CA9600309	519	A>S		No	ClinGen ExAC TOPMed gnomAD
CA406992476 rs754747321	519	A>T		No	ClinGen ExAC TOPMed gnomAD
CA406992466 rs1293764257	520	V>M		No	ClinGen TOPMed gnomAD
CA9600305 rs374266955	524	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs761528525 CA9600303	524	D>V		No	ClinGen ExAC
CA9600304 rs374266955	524	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs776473488 CA9600302	525	C>S		No	ClinGen ExAC
rs1366824485 CA406992322	529	N>K		No	ClinGen TOPMed gnomAD
rs1332760280 CA406992318	530	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9600286 rs199907904	532	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406992297 rs1304918028	533	G>S		No	ClinGen gnomAD
CA9600285 rs753605562	534	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1389719687 CA406992278	536	R>G		No	ClinGen TOPMed gnomAD
rs548116502 CA9600284	536	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs775530017 CA9600282	538	G>A		No	ClinGen ExAC TOPMed gnomAD
rs1441808369 CA406992259	539	P>R		No	ClinGen gnomAD
CA406992252 rs1039630055	540	D>E		No	ClinGen TOPMed gnomAD
rs759469898 CA9600280	540	D>N		No	ClinGen ExAC TOPMed gnomAD
CA406992250 rs1273466282	541	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA406992241 rs1228762739	542	A>D		No	ClinGen gnomAD
rs1228762739 CA406992240	542	A>V		No	ClinGen gnomAD
CA9600278 rs771552981	543	D>N		No	ClinGen ExAC gnomAD
COSM233533 CA9600276 rs778253329	544	P>L	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs749859807 CA9600277	544	P>S		No	ClinGen ExAC gnomAD
CA309629728 rs144438301	546	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA9600274 rs144438301	546	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs779504372 CA9600273 COSM1395514	547	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1599812754 CA406992213	547	R>H		No	ClinGen Ensembl
CA406992208 rs1436968395	548	E>A		No	ClinGen TOPMed
rs951216533 CA309629722	548	E>K		No	ClinGen Ensembl
CA309629716 rs201612676	549	H>Q		No	ClinGen Ensembl
rs758135430 CA9600272	550	W>*		No	ClinGen ExAC gnomAD
TCGA novel	550	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs919690205 CA309629703	551	A>T		No	ClinGen Ensembl
CA406992184 rs1162693694	551	A>V		No	ClinGen gnomAD
CA9600271 rs569101828	555	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406992147 rs1368919581	557	P>A		No	ClinGen gnomAD
rs1190070708 CA406992140	558	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA406992138 rs1568760212	558	R>H		No	ClinGen Ensembl
COSM999762 rs757150838 CA9600269	561	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs753731210 CA9600268	563	H>Q		No	ClinGen ExAC gnomAD
rs1385367396 CA406992105	563	H>R		No	ClinGen TOPMed
CA406992107 rs1205391555	563	H>Y		No	ClinGen gnomAD
rs760334228 CA9600266	567	L>I		No	ClinGen ExAC gnomAD
CA9600264 rs767632801	568	V>A		No	ClinGen ExAC TOPMed gnomAD
CA309629670 rs1034011323	568	V>L		No	ClinGen Ensembl
rs1228016429 CA406991663	576	F>L		No	ClinGen gnomAD
CA9600222 rs372064620	579	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs372064620 CA9600221	579	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA406991563 CA406991567 rs1226713144	582	G>R		No	ClinGen TOPMed gnomAD
TCGA novel	589	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1377112676 CA406991400	590	E>G		No	ClinGen gnomAD
CA9600218 rs760966257	590	E>K		No	ClinGen ExAC gnomAD

No associated diseases with Q9BQG1

7 regional properties for Q9BQG1

Type	Name	Position	InterPro Accession
domain	C2 domain	429 - 551	IPR000008-1
domain	C2 domain	590 - 728	IPR000008-2
domain	Rab-binding domain	7 - 123	IPR010911
domain	Synaptotagmin-like protein 4/5, C2A domain	430 - 553	IPR037303
domain	FYVE-type zinc finger	13 - 122	IPR041282
domain	Synaptotagmin-l, FYVE-related domain	62 - 108	IPR042783
domain	Synaptotagmin-like 1-5, C2B domain	567 - 745	IPR043567

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
endosome	A vacuole to which materials ingested by endocytosis are delivered.
exocytic vesicle	A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
transport vesicle membrane	The lipid bilayer surrounding a transport vesicle.

6 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
calcium-dependent phospholipid binding	Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
clathrin binding	Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
phosphatidylserine binding	Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
SNARE binding	Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
syntaxin binding	Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.

7 GO annotations of biological process

Name	Definition
calcium-ion regulated exocytosis	The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cellular response to calcium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
positive regulation of dendrite extension	Any process that activates or increases the frequency, rate or extent of dendrite extension.
regulation of calcium ion-dependent exocytosis	Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.
regulation of dopamine secretion	Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
vesicle-mediated transport	A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

45 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P48018	SYT1	Synaptotagmin-1	Bos taurus (Bovine)	PR
P21521	Syt1	Synaptotagmin 1	Drosophila melanogaster (Fruit fly)	PR
Q86XP0	PLA2G4D	Cytosolic phospholipase A2 delta	Homo sapiens (Human)	PR
Q9HCH5	SYTL2	Synaptotagmin-like protein 2	Homo sapiens (Human)	PR
Q96C24	SYTL4	Synaptotagmin-like protein 4	Homo sapiens (Human)	PR
Q8N9U0	TC2N	Tandem C2 domains nuclear protein	Homo sapiens (Human)	PR
Q8TDW5	SYTL5	Synaptotagmin-like protein 5	Homo sapiens (Human)	PR
Q8IYJ3	SYTL1	Synaptotagmin-like protein 1	Homo sapiens (Human)	PR
P21579	SYT1	Synaptotagmin-1	Homo sapiens (Human)	PR
Q6XYQ8	SYT10	Synaptotagmin-10	Homo sapiens (Human)	PR
Q7L8C5	SYT13	Synaptotagmin-13	Homo sapiens (Human)	PR
Q86SS6	SYT9	Synaptotagmin-9	Homo sapiens (Human)	PR
Q9BT88	SYT11	Synaptotagmin-11	Homo sapiens (Human)	PR
O00445	SYT5	Synaptotagmin-5	Homo sapiens (Human)	PR
Q9H2B2	SYT4	Synaptotagmin-4	Homo sapiens (Human)	PR
O43581	SYT7	Synaptotagmin-7	Homo sapiens (Human)	PR
Q9BQS2	SYT15	Synaptotagmin-15	Homo sapiens (Human)	PR
Q5T7P8	SYT6	Synaptotagmin-6	Homo sapiens (Human)	PR
P40749	Syt4	Synaptotagmin-4	Mus musculus (Mouse)	PR
Q9EQT6	Syt13	Synaptotagmin-13	Mus musculus (Mouse)	PR
Q9R0N4	Syt10	Synaptotagmin-10	Mus musculus (Mouse)	PR
Q99N80	Sytl1	Synaptotagmin-like protein 1	Mus musculus (Mouse)	PR
Q9R0Q1	Sytl4	Synaptotagmin-like protein 4	Mus musculus (Mouse)	PR
Q8C6N3	Syt15	Synaptotagmin-15	Mus musculus (Mouse)	PR
Q920N7	Syt12	Synaptotagmin-12	Mus musculus (Mouse)	PR
Q80T23	Sytl5	Synaptotagmin-like protein 5	Mus musculus (Mouse)	PR
Q9R0N5	Syt5	Synaptotagmin-5	Mus musculus (Mouse)	PR
Q9R0N9	Syt9	Synaptotagmin-9	Mus musculus (Mouse)	PR
Q9R0N8	Syt6	Synaptotagmin-6	Mus musculus (Mouse)	PR
Q50L43	Pla2g4d	Cytosolic phospholipase A2 delta	Mus musculus (Mouse)	PR
P46096	Syt1	Synaptotagmin-1	Mus musculus (Mouse)	PR
Q9R0N3	Syt11	Synaptotagmin-11	Mus musculus (Mouse)	PR
P46097	Syt2	Synaptotagmin-2	Mus musculus (Mouse)	PR
Q91XT6	Tc2n	Tandem C2 domains nuclear protein	Mus musculus (Mouse)	PR
O35681	Syt3	Synaptotagmin-3	Mus musculus (Mouse)	PR
Q812E4	Sytl5	Synaptotagmin-like protein 5	Rattus norvegicus (Rat)	PR
Q925B5	Syt13	Synaptotagmin-13	Rattus norvegicus (Rat)	PR
O08625	Syt10	Synaptotagmin-10	Rattus norvegicus (Rat)	PR
P47861	Syt5	Synaptotagmin-5	Rattus norvegicus (Rat)	PR
Q62746	Syt6	Synaptotagmin-6	Rattus norvegicus (Rat)	PR
P97610	Syt12	Synaptotagmin-12	Rattus norvegicus (Rat)	PR
Q925C0	Syt9	Synaptotagmin-9	Rattus norvegicus (Rat)	PR
P59926	Syt15	Synaptotagmin-15	Rattus norvegicus (Rat)	PR
P21707	Syt1	Synaptotagmin-1	Rattus norvegicus (Rat)	PR
P40748	Syt3	Synaptotagmin-3	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSGDYEDDLC	RRALILVSDL	CARVRDADTN	DRCQEFNDRI	RGYPRGPDAD	ISVSLLSVIV
70	80	90	100	110	120
TFCGIVLLGV	SLFVSWKLCW	VPWRDKGGSA	VGGGPLRKDL	GPGVGLAGLV	GGGGHHLAAG
130	140	150	160	170	180
LGGHPLLGGP	HHHAHAAHHP	PFAELLEPGS	LGGSDTPEPS	YLDMDSYPEA	AAAAVAAGVK
190	200	210	220	230	240
PSQTSPELPS	EGGAGSGLLL	LPPSGGGLPS	AQSHQQVTSL	APTTRYPALP	RPLTQQTLTS
250	260	270	280	290	300
QPDPSSEERP	PALPLPLPGG	EEKAKLIGQI	KPELYQGTGP	GGRRSGGGPG	SGEAGTGAPC
310	320	330	340	350	360
GRISFALRYL	YGSDQLVVRI	LQALDLPAKD	SNGFSDPYVK	IYLLPDRKKK	FQTKVHRKTL
370	380	390	400	410	420
NPVFNETFQF	SVPLAELAQR	KLHFSVYDFD	RFSRHDLIGQ	VVLDNLLELA	EQPPDRPLWR
430	440	450	460	470	480
DIVEGGSEKA	DLGELNFSLC	YLPTAGRLTV	TIIKASNLKA	MDLTGFSDPY	VKASLISEGR
490	500	510	520	530	540
RLKKRKTSIK	KNTLNPTYNE	ALVFDVAPES	VENVGLSIAV	VDYDCIGHNE	VIGVCRVGPD
550	560	570	580
AADPHGREHW	AEMLANPRKP	VEHWHQLVEE	KTVTSFTKGS	KGLSEKENSE