Q50L43

PR
Gene name
Pla2g4d
Protein name
Cytosolic phospholipase A2 delta
Names
cPLA2-delta, Phospholipase A2 group IVD
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:78390
EC number
3.1.1.4: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q50L43

Entry ID Method Resolution Chain Position Source
AF-Q50L43-F1 Predicted AlphaFoldDB

43 variants for Q50L43

Variant ID(s) Position Change Description Diseaes Association Provenance
rs27459603 19 H>P No EVA
rs3388579385 124 L>F No EVA
rs3388582542 144 D>G No EVA
rs3388586995 184 A>S No EVA
rs3388582572 196 L>F No EVA
rs3388576981 205 T>I No EVA
rs261527603 209 F>S No EVA
rs27459610 210 P>L No EVA
rs3388584922 213 A>S No EVA
rs221728879 245 S>L No EVA
rs253192542 264 I>V No EVA
rs3388574591 349 G>A No EVA
rs3388582019 364 T>I No EVA
rs3388584919 370 S>T No EVA
rs3388582833 406 L>M No EVA
rs3388576956 411 P>L No EVA
rs27459619 418 R>H No EVA
rs262203308 420 T>I No EVA
rs3388585745 424 R>L No EVA
rs3388584965 437 W>* No EVA
rs3388584957 456 G>R No EVA
rs3388584960 465 Q>H No EVA
rs3388585037 470 L>F No EVA
rs3388582605 475 N>D No EVA
rs3388582894 476 V>I No EVA
rs3388576985 481 L>P No EVA
rs3388584917 532 L>P No EVA
rs3388584905 535 I>T No EVA
rs3388574616 545 M>I No EVA
rs232602598 571 F>L No EVA
rs265665220 573 G>A No EVA
rs3388577228 607 Q>K No EVA
rs3388578494 634 C>S No EVA
rs3388584926 640 P>Q No EVA
rs3388579409 656 G>D No EVA
rs3388582829 666 L>M No EVA
rs239537126 701 G>D No EVA
rs3388580859 736 H>D No EVA
rs3388585782 749 A>V No EVA
rs3388577241 796 V>D No EVA
rs3388584958 810 V>A No EVA
rs3388580852 812 K>R No EVA
rs3388583544 826 T>S No EVA

No associated diseases with Q50L43

4 regional properties for Q50L43

Type Name Position InterPro Accession
domain C2 domain 14 - 135 IPR000008
domain Lysophospholipase, catalytic domain 263 - 825 IPR002642
domain Cytosolic phospholipases A2, C2-domain 173 - 276 IPR040723
domain Cytosolic phospholipase A2, C2 domain 32 - 151 IPR041847

Functions

Description
EC Number 3.1.1.4 Carboxylic ester hydrolases
Subcellular Localization
  • Cytoplasm, cytosol
  • Membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Translocates to perinuclear membranes that may correspond to endoplasmic reticulum or Golgi in a calcium-dependent fashion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
calcium-dependent phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+.
calcium-dependent phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
phospholipase A2 activity Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.

2 GO annotations of biological process

Name Definition
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
glycerophospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.

46 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P48018 SYT1 Synaptotagmin-1 Bos taurus (Bovine) PR
P21521 Syt1 Synaptotagmin 1 Drosophila melanogaster (Fruit fly) PR
Q7L8C5 SYT13 Synaptotagmin-13 Homo sapiens (Human) PR
Q6XYQ8 SYT10 Synaptotagmin-10 Homo sapiens (Human) PR
Q9H2B2 SYT4 Synaptotagmin-4 Homo sapiens (Human) PR
P21579 SYT1 Synaptotagmin-1 Homo sapiens (Human) PR
Q9HCH5 SYTL2 Synaptotagmin-like protein 2 Homo sapiens (Human) PR
Q86SS6 SYT9 Synaptotagmin-9 Homo sapiens (Human) PR
Q9BQG1 SYT3 Synaptotagmin-3 Homo sapiens (Human) PR
O00445 SYT5 Synaptotagmin-5 Homo sapiens (Human) PR
Q9BT88 SYT11 Synaptotagmin-11 Homo sapiens (Human) PR
Q96C24 SYTL4 Synaptotagmin-like protein 4 Homo sapiens (Human) PR
Q9BQS2 SYT15 Synaptotagmin-15 Homo sapiens (Human) PR
Q8N9U0 TC2N Tandem C2 domains nuclear protein Homo sapiens (Human) PR
Q8TDW5 SYTL5 Synaptotagmin-like protein 5 Homo sapiens (Human) PR
Q8IYJ3 SYTL1 Synaptotagmin-like protein 1 Homo sapiens (Human) PR
O43581 SYT7 Synaptotagmin-7 Homo sapiens (Human) PR
Q5T7P8 SYT6 Synaptotagmin-6 Homo sapiens (Human) PR
Q9UP65 PLA2G4C Cytosolic phospholipase A2 gamma Homo sapiens (Human) PR
Q86XP0 PLA2G4D Cytosolic phospholipase A2 delta Homo sapiens (Human) PR
P40749 Syt4 Synaptotagmin-4 Mus musculus (Mouse) PR
Q9EQT6 Syt13 Synaptotagmin-13 Mus musculus (Mouse) PR
Q9R0N4 Syt10 Synaptotagmin-10 Mus musculus (Mouse) PR
Q99N80 Sytl1 Synaptotagmin-like protein 1 Mus musculus (Mouse) PR
Q9R0Q1 Sytl4 Synaptotagmin-like protein 4 Mus musculus (Mouse) PR
Q8C6N3 Syt15 Synaptotagmin-15 Mus musculus (Mouse) PR
Q920N7 Syt12 Synaptotagmin-12 Mus musculus (Mouse) PR
Q80T23 Sytl5 Synaptotagmin-like protein 5 Mus musculus (Mouse) PR
Q9R0N5 Syt5 Synaptotagmin-5 Mus musculus (Mouse) PR
Q9R0N9 Syt9 Synaptotagmin-9 Mus musculus (Mouse) PR
Q9R0N8 Syt6 Synaptotagmin-6 Mus musculus (Mouse) PR
P46096 Syt1 Synaptotagmin-1 Mus musculus (Mouse) PR
Q9R0N3 Syt11 Synaptotagmin-11 Mus musculus (Mouse) PR
O35681 Syt3 Synaptotagmin-3 Mus musculus (Mouse) PR
P46097 Syt2 Synaptotagmin-2 Mus musculus (Mouse) PR
Q91XT6 Tc2n Tandem C2 domains nuclear protein Mus musculus (Mouse) PR
Q812E4 Sytl5 Synaptotagmin-like protein 5 Rattus norvegicus (Rat) PR
Q925B5 Syt13 Synaptotagmin-13 Rattus norvegicus (Rat) PR
O08625 Syt10 Synaptotagmin-10 Rattus norvegicus (Rat) PR
P47861 Syt5 Synaptotagmin-5 Rattus norvegicus (Rat) PR
Q62746 Syt6 Synaptotagmin-6 Rattus norvegicus (Rat) PR
P97610 Syt12 Synaptotagmin-12 Rattus norvegicus (Rat) PR
P40748 Syt3 Synaptotagmin-3 Rattus norvegicus (Rat) PR
Q925C0 Syt9 Synaptotagmin-9 Rattus norvegicus (Rat) PR
P59926 Syt15 Synaptotagmin-15 Rattus norvegicus (Rat) PR
P21707 Syt1 Synaptotagmin-1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MWSGDRRVGM ESLSPERLHG HPYQEEASVF CRLTVKILEA RSLPRADLLS QADPYVTVQL
70 80 90 100 110 120
PTASGMKFKT QTVTNSSHPV WNETFSFLIQ SQVKNILELT IYDEDVITKD DICFKVSYDV
130 140 150 160 170 180
SEILPGQLLQ KTFSLNPQGP EELDVELLME RTWDPPENLI TNNVLVAREL SHLDVSLDRA
190 200 210 220 230 240
GNTAMAAGQD KLELELMLKG SYEDTQTFFP DTAFTFSFHY MRGQDTELNG YLRGPRNSGW
250 260 270 280 290 300
NSDTSVTPFN VPLMSLAAGK EMTIDIPAMK APEGKLQLKT DCCPKELSVR LSYGLCPEEQ
310 320 330 340 350 360
AFLSRRKKVV AAALKQALQL DEDLNEDEVP VVGINAEGGG MRAMISLYGH LLALQKLGLL
370 380 390 400 410 420
DCVTYFSGIS GSTWTMAHLY RDPEWSQRDL EGPISHAREH VAKTLLKEFL PEHLASYRQT
430 440 450 460 470 480
LKLREEQGYT VTVADLWGLV LESKLHGQVT DQKLSGQRAA LERGQNPLPL YLSLNVKENH
490 500 510 520 530 540
LETLHFKEWV EFSPYEVGFL KYGGFVPSEL FGSEFFMGRL MKRLPESQIC FLEGIWSNLF
550 560 570 580 590 600
SVNLMDIWYD ITYGKDSNNF PVDVRNSEKE FSGSAGTSSG VEAPWLESGT ALAQALKGFL
610 620 630 640 650 660
TGRPFHQRSA NFLHGLQLHR DYCNQRHFST WADCNLDDTP NQLTPQDPQL CLIDAGCFMN
670 680 690 700 710 720
SSCPSLFRPG RQVDLIISFN YNQSLPFKGL QQSEKYSRAR GLPFPRVEPS PEDHSQPQEC
730 740 750 760 770 780
YLFSDPTCPE APVVLHFPLV NDSFRDHSAP GVRRSPDELK AGQVNLTGAA SPYFMYNMTY
790 800 810 820
KNEDFDRLLQ LSDYNVQNNQ GTILQALRTV LKRRASETRP LGVKT