Q8C6N3

PR
Gene name
Syt15
Protein name
Synaptotagmin-15
Names
Synaptotagmin XV, SytXV
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:319508
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

24-171 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8C6N3

Entry ID Method Resolution Chain Position Source
AF-Q8C6N3-F1 Predicted AlphaFoldDB

34 variants for Q8C6N3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs46251650 13 I>T No EVA
rs3389314091 28 R>W No EVA
rs220246841 32 A>T No EVA
rs3389325822 34 F>S No EVA
rs3389311815 37 E>K No EVA
rs3389330777 49 S>T No EVA
rs3389320499 50 Y>H No EVA
rs235491505 53 R>K No EVA
rs3389330806 71 S>R No EVA
rs3389325750 78 P>H No EVA
rs3389325795 84 D>V No EVA
rs3411652467 117 D>E No EVA
rs3389335210 117 D>Y No EVA
rs47763477 135 T>M No EVA
rs3389245537 138 T>I No EVA
rs3389318998 149 W>* No EVA
rs3389320897 168 A>S No EVA
rs3389318647 173 V>I No EVA
rs3405057672 176 E>V No EVA
rs3389291583 179 S>R No EVA
rs3389315340 201 K>N No EVA
rs3389318970 202 I>N No EVA
rs3404848951 252 T>N No EVA
rs3389335231 286 N>S No EVA
rs3389311902 342 Y>H No EVA
rs3405006038 358 A>T No EVA
rs3403498582 359 S>R No EVA
rs50394686 361 S>N No EVA
rs3405057654 361 S>R No EVA
rs3404945399 363 V>A No EVA
rs226009552 378 R>L No EVA
rs3389315291 379 V>L No EVA
rs3389273271 403 K>R No EVA
rs252105910 416 T>R No EVA

No associated diseases with Q8C6N3

2 regional properties for Q8C6N3

Type Name Position InterPro Accession
domain C2 domain 144 - 262 IPR000008-1
domain C2 domain 275 - 397 IPR000008-2

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Single-pass type III membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
exocytic vesicle A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
calcium-dependent phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
clathrin binding Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
phosphatidylserine binding Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
SNARE binding Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.

5 GO annotations of biological process

Name Definition
calcium-ion regulated exocytosis The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
regulation of calcium ion-dependent exocytosis Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.
regulation of dopamine secretion Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

45 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P48018 SYT1 Synaptotagmin-1 Bos taurus (Bovine) PR
P21521 Syt1 Synaptotagmin 1 Drosophila melanogaster (Fruit fly) PR
Q7L8C5 SYT13 Synaptotagmin-13 Homo sapiens (Human) PR
Q6XYQ8 SYT10 Synaptotagmin-10 Homo sapiens (Human) PR
Q9H2B2 SYT4 Synaptotagmin-4 Homo sapiens (Human) PR
P21579 SYT1 Synaptotagmin-1 Homo sapiens (Human) PR
Q86XP0 PLA2G4D Cytosolic phospholipase A2 delta Homo sapiens (Human) PR
Q9HCH5 SYTL2 Synaptotagmin-like protein 2 Homo sapiens (Human) PR
Q86SS6 SYT9 Synaptotagmin-9 Homo sapiens (Human) PR
Q9BQG1 SYT3 Synaptotagmin-3 Homo sapiens (Human) PR
O00445 SYT5 Synaptotagmin-5 Homo sapiens (Human) PR
Q9BT88 SYT11 Synaptotagmin-11 Homo sapiens (Human) PR
Q96C24 SYTL4 Synaptotagmin-like protein 4 Homo sapiens (Human) PR
Q8N9U0 TC2N Tandem C2 domains nuclear protein Homo sapiens (Human) PR
Q8TDW5 SYTL5 Synaptotagmin-like protein 5 Homo sapiens (Human) PR
Q8IYJ3 SYTL1 Synaptotagmin-like protein 1 Homo sapiens (Human) PR
O43581 SYT7 Synaptotagmin-7 Homo sapiens (Human) PR
Q5T7P8 SYT6 Synaptotagmin-6 Homo sapiens (Human) PR
Q9BQS2 SYT15 Synaptotagmin-15 Homo sapiens (Human) PR
Q99N80 Sytl1 Synaptotagmin-like protein 1 Mus musculus (Mouse) PR
Q9R0Q1 Sytl4 Synaptotagmin-like protein 4 Mus musculus (Mouse) PR
Q80T23 Sytl5 Synaptotagmin-like protein 5 Mus musculus (Mouse) PR
Q50L43 Pla2g4d Cytosolic phospholipase A2 delta Mus musculus (Mouse) PR
Q91XT6 Tc2n Tandem C2 domains nuclear protein Mus musculus (Mouse) PR
O35681 Syt3 Synaptotagmin-3 Mus musculus (Mouse) PR
Q9R0N9 Syt9 Synaptotagmin-9 Mus musculus (Mouse) PR
Q9R0N5 Syt5 Synaptotagmin-5 Mus musculus (Mouse) PR
P46096 Syt1 Synaptotagmin-1 Mus musculus (Mouse) PR
P46097 Syt2 Synaptotagmin-2 Mus musculus (Mouse) PR
Q920N7 Syt12 Synaptotagmin-12 Mus musculus (Mouse) PR
Q9R0N3 Syt11 Synaptotagmin-11 Mus musculus (Mouse) PR
P40749 Syt4 Synaptotagmin-4 Mus musculus (Mouse) PR
Q9EQT6 Syt13 Synaptotagmin-13 Mus musculus (Mouse) PR
Q9R0N4 Syt10 Synaptotagmin-10 Mus musculus (Mouse) PR
Q9R0N8 Syt6 Synaptotagmin-6 Mus musculus (Mouse) PR
Q812E4 Sytl5 Synaptotagmin-like protein 5 Rattus norvegicus (Rat) PR
Q925B5 Syt13 Synaptotagmin-13 Rattus norvegicus (Rat) PR
O08625 Syt10 Synaptotagmin-10 Rattus norvegicus (Rat) PR
P47861 Syt5 Synaptotagmin-5 Rattus norvegicus (Rat) PR
Q62746 Syt6 Synaptotagmin-6 Rattus norvegicus (Rat) PR
P97610 Syt12 Synaptotagmin-12 Rattus norvegicus (Rat) PR
P40748 Syt3 Synaptotagmin-3 Rattus norvegicus (Rat) PR
Q925C0 Syt9 Synaptotagmin-9 Rattus norvegicus (Rat) PR
P21707 Syt1 Synaptotagmin-1 Rattus norvegicus (Rat) PR
P59926 Syt15 Synaptotagmin-15 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAEQLAFLIG GIIGGLLLLI GVSCCLWRRF CATFTYEELP ETSDPATISY FSRKEDRLYQ
70 80 90 100 110 120
YSGTPPGRLP SVPFVVPPSH QGRDWVPLHG GDWAVAPQDP CPVPEHMACT SSAKPGDACE
130 140 150 160 170 180
MGSINPELYK SPEDTSETGF PDGCLGRLWF SVEYQQESER LLVGLIKAQQ LQVPSETCST
190 200 210 220 230 240
LVKLHLLPDE RRFLQSKTKH KICNPQFDEN FIFQVSSKSV TQRVLKFSVY HVNKKRKHQL
250 260 270 280 290 300
LGQVLFPLKN ETLAGDHHRI IWRDLEAKNL EPPSEFGDIQ FCLSYNDYLS RLTVVVLRAK
310 320 330 340 350 360
GLQLQEDRSV VSVFVKVSLM NHNKFVKCKR TSAVLGSVNP VYNETFSFKV DTNELDTASL
370 380 390 400 410
SLVVLQTTEG NKSSPLGRVV VGPYMYTRGK ELEHWGEMLR KPKELVKRWH ALCRPTEP