Q96C24
PR
Gene name |
SYTL4 |
Protein name |
Synaptotagmin-like protein 4 |
Names |
Exophilin-2, Granuphilin |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:94121 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q96C24
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2CSZ | NMR | - | A | 43-105 | PDB |
| 3FDW | X-ray | 220 A | A/B | 352-488 | PDB |
| 5X6T | NMR | - | A | 59-111 | PDB |
| AF-Q96C24-F1 | Predicted | AlphaFoldDB |
355 variants for Q96C24
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA10470066 rs770845882 |
2 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs188841768 CA10470064 |
3 | E>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA413947641 rs1569401232 |
6 | D>N | No |
ClinGen Ensembl |
|
| TCGA novel | 8 | S>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 15 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 18 | I>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1440002661 CA413947406 |
20 | S>N | No |
ClinGen TOPMed |
|
|
CA333075860 rs1054542770 |
20 | S>R | No |
ClinGen TOPMed |
|
|
CA413947348 COSM297781 rs1354556665 |
24 | R>Q | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs757871951 CA10470063 |
26 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1034853457 CA333075853 |
27 | E>V | No |
ClinGen TOPMed |
|
|
CA10470062 rs747639533 |
28 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs907276950 CA333075842 |
29 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs754688395 CA10470060 |
29 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750802165 CA10470059 |
31 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA413947205 rs1484003229 CA413947206 |
32 | D>E | No |
ClinGen gnomAD |
|
|
rs902240182 CA333075826 |
33 | E>D | No |
ClinGen TOPMed |
|
|
CA333075823 rs140273472 |
36 | I>F | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs1339792165 CA413947121 |
37 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
rs770756316 CA10470047 |
38 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA10470046 rs757433666 |
40 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs187695720 CA10470044 |
45 | E>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA10470045 rs760809086 |
45 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs984971149 CA333075665 |
48 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
rs867431936 CA333075652 |
52 | K>R | No |
ClinGen gnomAD |
|
|
rs1221822775 CA413946755 |
53 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
rs747634215 CA10470043 |
54 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs1331294391 CA413946746 |
54 | G>S | No |
ClinGen gnomAD |
|
|
CA413946605 rs1417146838 |
59 | S>R | No |
ClinGen TOPMed |
|
|
CA413946568 rs1349125465 |
61 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
COSM3406698 rs151147513 CA10470042 COSM3406699 |
61 | R>W | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
rs201221018 CA10470041 |
65 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1304978704 CA413946498 |
65 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
rs748987113 CA10470040 |
68 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1331779348 CA413946396 |
69 | S>R | No |
ClinGen gnomAD |
|
|
CA10470039 rs142040580 COSM140901 |
72 | R>C | skin [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
COSM1126671 rs148610544 CA10470038 |
72 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA413946320 rs148610544 |
72 | R>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 73 | L>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1375472413 CA413946286 |
74 | S>N | No |
ClinGen gnomAD |
|
|
CA413946133 rs1160802719 |
81 | R>Q | No |
ClinGen gnomAD |
|
|
CA10470036 rs764596164 |
81 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10470032 rs376514435 |
89 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10470034 rs765370816 |
89 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA10470030 rs766615479 |
92 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760447949 CA10470029 |
92 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA413945874 rs1315668006 |
93 | I>K | No |
ClinGen gnomAD |
|
|
rs759492462 CA10470028 |
93 | I>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs759492462 CA333075571 |
93 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1300548255 CA413945782 |
97 | N>S | No |
ClinGen TOPMed |
|
|
rs1315431601 CA413945766 |
98 | G>S | No |
ClinGen gnomAD |
|
|
rs868444355 CA333075562 |
99 | T>I | No |
ClinGen Ensembl |
|
| TCGA novel | 100 | W>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1346545849 CA413945633 |
103 | K>E | No |
ClinGen TOPMed |
|
|
rs1229308793 CA413945612 |
103 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs761721670 CA10470026 |
106 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA413945550 rs1436858943 |
106 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA10470016 rs778945156 |
109 | I>M | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 110 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10470015 rs755005339 |
115 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1461688224 CA413945288 |
117 | D>Y | No |
ClinGen TOPMed |
|
|
CA413945233 rs1294442024 |
118 | W>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs766561436 CA10470013 |
120 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs760860818 CA10470012 |
123 | K>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 124 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10470010 rs767254640 |
126 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA10470011 rs767254640 |
126 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs1457368761 CA413945042 |
126 | R>L | No |
ClinGen gnomAD |
|
|
CA10470009 rs761786623 |
130 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs368733554 CA10470008 |
130 | R>H | No |
ClinGen ESP ExAC gnomAD |
|
|
CA10470007 rs768745774 |
131 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1391082178 CA413944916 |
132 | G>D | No |
ClinGen gnomAD |
|
|
rs144860789 CA333075428 |
137 | R>T | No |
ClinGen ESP |
|
|
rs1205958866 CA413944789 |
138 | M>I | No |
ClinGen gnomAD |
|
|
rs974426994 CA333075416 |
140 | L>V | No |
ClinGen Ensembl |
|
|
CA10470005 rs770765299 |
141 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA413944745 COSM1636639 rs1269600130 |
141 | R>H | liver [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
CA413944722 rs1369610824 |
142 | H>R | No |
ClinGen TOPMed |
|
|
CA333075410 rs908392026 |
144 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs986866587 CA413944652 |
145 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA333075407 rs986866587 |
145 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs780062781 CA10469996 |
148 | K>E | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 149 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10469995 rs372021399 |
150 | E>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs865817612 CA333075306 |
153 | G>* | No |
ClinGen Ensembl |
|
| TCGA novel | 153 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 154 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413944396 rs1460670282 |
154 | Q>R | No |
ClinGen gnomAD |
|
|
rs1379519445 CA413944369 |
155 | S>F | No |
ClinGen gnomAD |
|
|
CA10469993 rs780830960 |
158 | H>L | No |
ClinGen 1000Genomes ExAC |
|
|
CA10469991 rs761660696 |
159 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA10469990 rs144908554 |
160 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs768237203 CA10469989 |
162 | M>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs548102581 CA333075269 COSM318094 |
166 | W>* | lung [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs1054906993 CA333075265 |
167 | P>S | No |
ClinGen Ensembl |
|
|
rs759207635 CA10469985 |
171 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA10469984 rs776102294 |
174 | E>V | No |
ClinGen ExAC gnomAD |
|
|
rs779226209 CA413943946 |
175 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10469982 rs779226209 |
175 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10469983 rs770652822 |
175 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs764998377 CA333075234 |
176 | Q>K | No |
ClinGen Ensembl |
|
|
rs147291556 CA10469981 |
180 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1411789495 CA413941402 |
183 | F>S | No |
ClinGen gnomAD |
|
|
CA333070089 rs143922155 |
186 | P>T | No |
ClinGen ESP gnomAD |
|
|
CA10469971 rs758402972 |
193 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs986109143 CA333070075 |
193 | S>R | No |
ClinGen TOPMed |
|
|
rs566866599 CA10469970 |
194 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA413941083 rs1459670660 |
198 | E>D | No |
ClinGen gnomAD |
|
|
rs765230684 CA10469969 |
199 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10469968 CA333070030 rs758900268 |
200 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA413940911 rs1328479591 |
206 | T>K | No |
ClinGen gnomAD |
|
|
COSM1126663 CA413940853 rs1246781328 |
209 | S>L | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA413940836 rs1185896796 |
210 | D>Y | No |
ClinGen TOPMed |
|
|
rs760363498 CA10469965 |
212 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10469952 rs745825779 |
214 | R>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 216 | D>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 217 | S>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413940620 rs1243416470 |
221 | S>P | No |
ClinGen gnomAD |
|
|
CA10469950 rs754996341 |
230 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA413940469 rs1602785100 |
231 | S>F | No |
ClinGen Ensembl |
|
|
CA10469948 rs765943937 |
232 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760310179 CA10469947 |
233 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA413940434 rs1365835965 |
234 | K>R | No |
ClinGen TOPMed |
|
| TCGA novel | 236 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413940361 rs1216197723 |
239 | K>N | No |
ClinGen TOPMed |
|
|
CA333069323 rs926356926 |
240 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs144599593 CA10469940 |
245 | G>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs551180010 CA10469939 |
250 | F>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs150825185 CA10469938 |
252 | D>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 253 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs778071562 TCGA novel CA10469937 |
256 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC gnomAD NCI-TCGA |
|
rs1268507477 CA413939602 |
257 | I>L | No |
ClinGen gnomAD |
|
| TCGA novel | 257 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10469936 rs772451038 |
259 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA333069285 rs373929720 |
264 | K>I | No |
ClinGen ESP TOPMed gnomAD |
|
| TCGA novel | 265 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10469935 rs747878078 |
265 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764306136 CA413939316 |
268 | P>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA413939304 rs1372829389 |
268 | P>L | No |
ClinGen gnomAD |
|
|
rs764306136 CA10469934 |
268 | P>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1569386375 CA413939297 |
269 | S>A | No |
ClinGen Ensembl |
|
|
rs1352806110 CA413939183 |
271 | Y>C | No |
ClinGen gnomAD |
|
|
CA10469922 rs369007373 |
272 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1347839620 CA413939092 |
276 | I>L | No |
ClinGen TOPMed |
|
|
rs1441925384 CA413939080 |
276 | I>T | No |
ClinGen gnomAD |
|
|
rs141441277 CA10469921 |
279 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs375861902 CA10469920 |
279 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA413938904 rs1404761236 |
284 | V>A | No |
ClinGen gnomAD |
|
|
CA333069090 rs372777624 |
286 | E>D | No |
ClinGen ESP |
|
|
rs1173574563 CA413938830 |
287 | S>T | No |
ClinGen gnomAD |
|
|
rs1473541948 CA413938813 |
288 | G>C | No |
ClinGen gnomAD |
|
|
CA10469918 rs748472710 |
293 | R>K | No |
ClinGen ExAC gnomAD |
|
|
rs200772252 CA10469917 |
294 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs775808649 CA10469916 |
296 | S>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs779928492 CA10469914 |
297 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1461901143 CA413938585 |
298 | P>R | No |
ClinGen gnomAD |
|
|
CA333069022 rs941097311 |
299 | G>A | No |
ClinGen Ensembl |
|
|
CA413938581 rs1393164142 |
299 | G>S | No |
ClinGen TOPMed |
|
|
CA10469913 rs756069824 |
300 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA413938561 rs745360884 |
301 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780720282 CA10469911 |
301 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA10469912 rs745360884 |
301 | N>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 304 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 304 | M>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1212098809 CA413938514 |
305 | E>D | No |
ClinGen gnomAD |
|
|
rs774568147 CA10469897 |
315 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs768792635 CA10469896 |
318 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs749034988 CA10469895 |
321 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA10469894 rs775314066 |
321 | R>H | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 321 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1247094264 CA413938352 |
328 | S>N | No |
ClinGen gnomAD |
|
|
CA333068186 rs1041105107 |
329 | M>V | No |
ClinGen Ensembl |
|
|
CA413938338 rs1381681563 |
330 | Q>E | No |
ClinGen gnomAD |
|
| TCGA novel | 332 | G>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1243849025 CA413938304 |
335 | M>V | No |
ClinGen TOPMed |
|
|
CA10469878 rs763203069 |
337 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA413938000 rs769639083 |
337 | T>K | No |
ClinGen gnomAD |
|
|
COSM1559122 CA333067492 rs769639083 |
337 | T>M | lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA333067481 rs200707071 |
341 | M>V | No |
ClinGen Ensembl |
|
|
rs1404154527 CA413937957 |
343 | S>N | No |
ClinGen gnomAD |
|
| TCGA novel | 344 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1421871786 CA413937943 |
344 | I>T | No |
ClinGen TOPMed |
|
|
rs1363520415 CA413937925 |
346 | S>G | No |
ClinGen gnomAD |
|
|
rs745369696 CA10469874 |
352 | G>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10469873 rs770803524 |
353 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs767345850 CA333067466 |
354 | I>L | No |
ClinGen Ensembl |
|
|
CA10469871 rs777193426 |
360 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA10469870 rs771850997 |
363 | S>F | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 365 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413937591 rs1490314798 |
368 | Q>* | No |
ClinGen gnomAD |
|
|
CA10469869 rs747872392 |
372 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA413937449 rs1296483634 |
375 | V>A | No |
ClinGen TOPMed |
|
|
rs778723827 CA10469868 |
379 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10469866 rs750785416 |
385 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
CA413937180 rs1283326367 |
385 | Y>H | No |
ClinGen TOPMed gnomAD |
|
|
CA10469865 rs781690454 |
387 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1377365044 CA413937110 |
387 | D>V | No |
ClinGen TOPMed |
|
|
CA10469864 rs367700683 |
389 | A>T | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1397557140 CA413936989 |
391 | K>R | Variant assessed as Somatic; 6.271e-05 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA10469862 rs764146719 |
392 | R>C | No |
ClinGen ExAC TOPMed |
|
|
rs748075948 CA10469861 |
392 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs748075948 CA333067411 |
392 | R>L | No |
ClinGen ExAC gnomAD |
|
|
rs1177165020 CA413936934 |
393 | S>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1360988625 CA413936945 |
393 | S>P | No |
ClinGen gnomAD |
|
|
CA413936864 COSM1469974 rs1203029035 |
395 | P>L | large_intestine Variant assessed as Somatic; impact. breast [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
rs1356550767 CA413936880 |
395 | P>S | No |
ClinGen TOPMed |
|
|
CA333067201 rs905904134 |
399 | T>I | No |
ClinGen TOPMed |
|
|
CA10469845 rs757779606 |
406 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA10469844 rs752062501 |
407 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA333067198 rs58615372 |
411 | R>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA10469842 rs142643452 |
417 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10469843 rs758559503 |
417 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs966579210 CA333067190 |
418 | D>G | No |
ClinGen Ensembl |
|
|
rs2022039 CA413936106 |
420 | I>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA413936096 rs1402864734 |
420 | I>M | No |
ClinGen TOPMed |
|
| TCGA novel | 420 | I>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
VAR_016076 rs2022039 CA10469841 |
420 | I>V | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
TCGA novel rs753633649 CA10469838 |
426 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen ExAC TOPMed gnomAD |
|
rs766149390 COSM241831 CA10469837 |
427 | T>M | prostate [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs776508842 CA10469835 |
428 | L>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA413933937 rs1417348271 |
430 | Y>C | No |
ClinGen TOPMed |
|
|
rs1417348271 CA413933935 |
430 | Y>F | No |
ClinGen TOPMed |
|
|
CA333066837 rs971330125 |
432 | I>V | No |
ClinGen gnomAD |
|
|
rs1290706977 CA413933834 |
433 | P>L | No |
ClinGen gnomAD |
|
|
CA333066816 rs1044441937 |
441 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA413933661 rs1227033878 |
443 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
rs748202932 CA413933670 |
443 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
rs748202932 CA10469824 |
443 | Q>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs779000265 CA10469823 |
444 | F>V | No |
ClinGen ExAC gnomAD |
|
|
CA333066800 rs1012664054 |
447 | W>C | No |
ClinGen gnomAD |
|
|
rs755219463 CA10469821 |
449 | H>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753953306 CA10469820 |
449 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA10469819 rs766632925 |
451 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10469818 rs190102282 |
455 | N>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA10469817 rs750268764 |
456 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs767541931 CA10469816 |
458 | L>I | No |
ClinGen ExAC |
|
|
rs1168046085 CA413933221 |
458 | L>P | No |
ClinGen gnomAD |
|
| TCGA novel | 461 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs761883829 CA10469815 |
462 | E>A | No |
ClinGen ExAC gnomAD |
|
|
rs1371306124 CA413932995 |
464 | Q>L | No |
ClinGen gnomAD |
|
|
rs934736661 CA333066729 |
465 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA413932916 rs1201538981 |
466 | D>H | No |
ClinGen gnomAD |
|
|
rs1490478591 CA413932524 |
478 | L>F | No |
ClinGen gnomAD |
|
|
rs773994286 CA10469814 |
479 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs185273284 CA333066713 COSM3944513 |
481 | H>R | lung [Cosmic] | No |
ClinGen cosmic curated 1000Genomes TOPMed gnomAD |
|
rs1275365188 CA413932448 |
482 | G>R | No |
ClinGen gnomAD |
|
|
rs1264657550 CA413930479 |
485 | S>R | No |
ClinGen TOPMed |
|
|
CA10469802 rs749418535 COSM1190593 |
485 | S>T | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA413930434 rs1197087574 |
486 | A>V | No |
ClinGen gnomAD |
|
|
rs184576220 CA10469801 |
487 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA333063977 rs867077097 |
488 | S>F | No |
ClinGen Ensembl |
|
|
CA10469800 rs756408531 |
489 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs562068812 CA333063974 |
491 | G>A | No |
ClinGen TOPMed |
|
|
rs757247580 CA10469797 |
495 | H>L | No |
ClinGen ExAC gnomAD |
|
|
rs747053500 CA10469798 |
495 | H>Y | No |
ClinGen 1000Genomes ExAC |
|
|
rs751483395 CA10469796 |
498 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA10469795 rs111659690 |
500 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10469791 rs759224777 |
505 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs370019475 CA10469792 |
505 | Y>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10469790 rs773557143 |
514 | G>* | No |
ClinGen ExAC gnomAD |
|
|
rs1338211801 CA413929275 |
514 | G>E | No |
ClinGen gnomAD |
|
|
rs1469858823 CA413929258 |
515 | G>D | No |
ClinGen gnomAD |
|
|
CA10469789 COSM166828 rs772480125 |
517 | R>Q | Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
| TCGA novel | 518 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs900120012 CA333063865 |
519 | K>N | No |
ClinGen gnomAD |
|
| TCGA novel | 520 | S>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413928659 rs1319191822 |
522 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
rs1319191822 CA413928655 |
522 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
rs140740598 CA10469783 |
524 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA333063111 rs955605409 |
525 | G>A | No |
ClinGen TOPMed gnomAD |
|
|
CA10469782 rs746151730 |
526 | G>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs941039264 CA333063107 |
526 | G>R | No |
ClinGen Ensembl |
|
| TCGA novel | 527 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413928392 rs1316693661 |
530 | V>A | No |
ClinGen gnomAD |
|
| TCGA novel | 531 | W>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 535 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10469780 rs769237439 |
539 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10469781 rs781579257 |
539 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1432828579 CA413928051 |
543 | A>T | No |
ClinGen gnomAD |
|
|
rs185265268 CA10469778 |
545 | G>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1456810149 CA413928002 |
545 | G>R | No |
ClinGen TOPMed |
|
|
CA10469777 rs758409685 |
552 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA10469776 rs752113372 |
553 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1569370965 CA413927546 |
554 | Y>H | No |
ClinGen Ensembl |
|
|
CA413927495 rs1232744977 |
555 | L>F | No |
ClinGen TOPMed |
|
|
rs769013325 CA10469767 |
557 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775421517 CA10469765 |
558 | M>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 559 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA333062770 rs895189954 |
561 | K>E | No |
ClinGen TOPMed |
|
|
rs769855816 CA10469764 |
561 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA413927201 rs781522142 |
563 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10469762 rs781522142 |
563 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10469763 rs781522142 |
563 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10469761 rs369394234 |
565 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs746777604 CA10469760 |
565 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs758259732 CA10469759 |
566 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA10469758 rs758259732 |
566 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs777405794 CA333062726 |
567 | T>P | No |
ClinGen Ensembl |
|
| TCGA novel | 568 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10469756 rs755705478 |
572 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10469755 rs77778840 |
574 | L>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1186478789 CA413926667 |
580 | H>D | No |
ClinGen gnomAD |
|
|
CA413926627 rs1477102212 |
581 | T>A | No |
ClinGen gnomAD |
|
|
rs201705918 CA10469754 |
581 | T>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs201705918 CA333062712 |
581 | T>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs372078023 CA10469752 |
585 | N>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10469751 rs751866118 |
585 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs147721765 CA333062677 |
586 | G>A | No |
ClinGen ESP |
|
| TCGA novel | 588 | R>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs764577704 CA10469750 |
588 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 591 | D>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10469749 rs763242388 |
595 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA10469748 rs775999680 |
596 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA413925958 rs1322811578 |
600 | T>I | No |
ClinGen TOPMed |
|
|
CA10469747 rs765874299 |
602 | W>G | No |
ClinGen ExAC gnomAD |
|
|
CA413925921 rs765874299 |
602 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA10469746 rs759638251 |
604 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1569370573 CA413925827 |
605 | E>G | No |
ClinGen Ensembl |
|
|
CA10469744 rs771246287 |
606 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10469745 rs776899422 COSM1736442 |
606 | P>S | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1291973059 CA413925753 |
607 | L>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 611 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1169760616 CA413925412 |
616 | V>F | No |
ClinGen gnomAD |
|
|
rs771840367 CA10469741 |
617 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs771840367 CA413925397 |
617 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA10469740 rs747928834 |
621 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA10469739 rs778864041 |
622 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1480294319 CA413925277 |
622 | T>P | No |
ClinGen gnomAD |
|
| TCGA novel | 623 | G>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1177823085 CA413923621 |
624 | I>N | No |
ClinGen gnomAD |
|
|
CA10469728 rs760160020 |
625 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1364699668 CA413923443 |
628 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
CA413923294 rs1355391189 |
632 | W>R | No |
ClinGen TOPMed |
|
|
CA10469727 rs776842282 |
635 | S>A | No |
ClinGen ExAC gnomAD |
|
|
rs775187605 CA10469726 |
635 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs1446574122 CA413923069 |
636 | T>I | No |
ClinGen TOPMed |
|
|
rs868291409 CA333061377 |
637 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA413923037 rs868291409 |
637 | G>V | No |
ClinGen gnomAD |
|
|
rs143469082 CA10469723 |
646 | M>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1202985842 CA413922689 |
647 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA10469722 rs747955441 |
647 | R>Q | No |
ClinGen ExAC |
|
|
CA10469719 rs749283202 |
650 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA333061316 rs937097691 |
655 | E>K | No |
ClinGen TOPMed |
|
|
CA10469717 rs755586303 |
656 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs755586303 CA413922267 |
656 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA413922226 rs1441788401 |
657 | T>I | No |
ClinGen TOPMed |
|
|
rs926812087 CA333061290 |
658 | L>P | No |
ClinGen TOPMed |
|
|
rs780848178 CA10469715 |
659 | Q>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745368437 CA10469714 |
661 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs139707843 CA10469713 |
661 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs755524501 CA10469711 |
664 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA413921723 rs1379344429 |
667 | Q>K | No |
ClinGen gnomAD |
|
|
CA413921645 COSM1715276 rs1156491667 |
670 | G>D | skin [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1156491667 CA413921635 |
670 | G>V | No |
ClinGen gnomAD |
|
| TCGA novel | 671 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
No associated diseases with Q96C24
11 regional properties for Q96C24
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 356 - 479 | IPR000008-1 |
| domain | C2 domain | 507 - 633 | IPR000008-2 |
| domain | Synaptotagmin | 360 - 375 | IPR001565-1 |
| domain | Synaptotagmin | 375 - 388 | IPR001565-2 |
| domain | Synaptotagmin | 433 - 448 | IPR001565-3 |
| domain | Synaptotagmin | 453 - 463 | IPR001565-4 |
| domain | Rab-binding domain | 4 - 122 | IPR010911 |
| domain | Synaptotagmin-like protein 4/5, C2A domain | 357 - 481 | IPR037303 |
| domain | FYVE-type zinc finger | 9 - 122 | IPR041282 |
| domain | Synaptotagmin-like 1-5, C2B domain | 496 - 661 | IPR043567 |
| domain | Synaptotagmin-like protein 4, FYVE-related domain | 58 - 107 | IPR044134 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| exocytic vesicle | A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. |
| extrinsic component of membrane | The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| platelet alpha granule membrane | The lipid bilayer surrounding the platelet alpha granule. |
| transport vesicle membrane | The lipid bilayer surrounding a transport vesicle. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| neurexin family protein binding | Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. |
| phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. |
| small GTPase binding | Binding to a small monomeric GTPase. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| insulin secretion | The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| lysosome localization | Any process in which a lysosome is transported to, and/or maintained in, a specific location. |
| multivesicular body sorting pathway | A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. |
| negative regulation of insulin secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. |
| plasma membrane repair | The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress. |
| positive regulation of exocytosis | Any process that activates or increases the frequency, rate or extent of exocytosis. |
| positive regulation of protein secretion | Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. |
| regulation of plasma membrane repair | Any process that modulates the frequency, rate or extent of plasma membrane repair. |
45 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48018 | SYT1 | Synaptotagmin-1 | Bos taurus (Bovine) | PR |
| P21521 | Syt1 | Synaptotagmin 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q7L8C5 | SYT13 | Synaptotagmin-13 | Homo sapiens (Human) | PR |
| Q6XYQ8 | SYT10 | Synaptotagmin-10 | Homo sapiens (Human) | PR |
| Q9H2B2 | SYT4 | Synaptotagmin-4 | Homo sapiens (Human) | PR |
| P21579 | SYT1 | Synaptotagmin-1 | Homo sapiens (Human) | PR |
| Q86XP0 | PLA2G4D | Cytosolic phospholipase A2 delta | Homo sapiens (Human) | PR |
| Q86SS6 | SYT9 | Synaptotagmin-9 | Homo sapiens (Human) | PR |
| Q9BQG1 | SYT3 | Synaptotagmin-3 | Homo sapiens (Human) | PR |
| O00445 | SYT5 | Synaptotagmin-5 | Homo sapiens (Human) | PR |
| Q9BT88 | SYT11 | Synaptotagmin-11 | Homo sapiens (Human) | PR |
| Q9BQS2 | SYT15 | Synaptotagmin-15 | Homo sapiens (Human) | PR |
| Q8N9U0 | TC2N | Tandem C2 domains nuclear protein | Homo sapiens (Human) | PR |
| O43581 | SYT7 | Synaptotagmin-7 | Homo sapiens (Human) | PR |
| Q5T7P8 | SYT6 | Synaptotagmin-6 | Homo sapiens (Human) | PR |
| Q8IYJ3 | SYTL1 | Synaptotagmin-like protein 1 | Homo sapiens (Human) | PR |
| Q9HCH5 | SYTL2 | Synaptotagmin-like protein 2 | Homo sapiens (Human) | PR |
| Q8TDW5 | SYTL5 | Synaptotagmin-like protein 5 | Homo sapiens (Human) | PR |
| P40749 | Syt4 | Synaptotagmin-4 | Mus musculus (Mouse) | PR |
| Q9EQT6 | Syt13 | Synaptotagmin-13 | Mus musculus (Mouse) | PR |
| Q9R0N4 | Syt10 | Synaptotagmin-10 | Mus musculus (Mouse) | PR |
| Q99N80 | Sytl1 | Synaptotagmin-like protein 1 | Mus musculus (Mouse) | PR |
| Q8C6N3 | Syt15 | Synaptotagmin-15 | Mus musculus (Mouse) | PR |
| Q920N7 | Syt12 | Synaptotagmin-12 | Mus musculus (Mouse) | PR |
| Q9R0N5 | Syt5 | Synaptotagmin-5 | Mus musculus (Mouse) | PR |
| Q9R0N9 | Syt9 | Synaptotagmin-9 | Mus musculus (Mouse) | PR |
| Q9R0N8 | Syt6 | Synaptotagmin-6 | Mus musculus (Mouse) | PR |
| Q50L43 | Pla2g4d | Cytosolic phospholipase A2 delta | Mus musculus (Mouse) | PR |
| P46096 | Syt1 | Synaptotagmin-1 | Mus musculus (Mouse) | PR |
| Q9R0N3 | Syt11 | Synaptotagmin-11 | Mus musculus (Mouse) | PR |
| O35681 | Syt3 | Synaptotagmin-3 | Mus musculus (Mouse) | PR |
| P46097 | Syt2 | Synaptotagmin-2 | Mus musculus (Mouse) | PR |
| Q91XT6 | Tc2n | Tandem C2 domains nuclear protein | Mus musculus (Mouse) | PR |
| Q80T23 | Sytl5 | Synaptotagmin-like protein 5 | Mus musculus (Mouse) | PR |
| Q9R0Q1 | Sytl4 | Synaptotagmin-like protein 4 | Mus musculus (Mouse) | PR |
| Q812E4 | Sytl5 | Synaptotagmin-like protein 5 | Rattus norvegicus (Rat) | PR |
| Q925B5 | Syt13 | Synaptotagmin-13 | Rattus norvegicus (Rat) | PR |
| O08625 | Syt10 | Synaptotagmin-10 | Rattus norvegicus (Rat) | PR |
| P47861 | Syt5 | Synaptotagmin-5 | Rattus norvegicus (Rat) | PR |
| Q62746 | Syt6 | Synaptotagmin-6 | Rattus norvegicus (Rat) | PR |
| P97610 | Syt12 | Synaptotagmin-12 | Rattus norvegicus (Rat) | PR |
| P40748 | Syt3 | Synaptotagmin-3 | Rattus norvegicus (Rat) | PR |
| Q925C0 | Syt9 | Synaptotagmin-9 | Rattus norvegicus (Rat) | PR |
| P59926 | Syt15 | Synaptotagmin-15 | Rattus norvegicus (Rat) | PR |
| P21707 | Syt1 | Synaptotagmin-1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSELLDLSFL | SEEEKDLILS | VLQRDEEVRK | ADEKRIRRLK | NELLEIKRKG | AKRGSQHYSD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RTCARCQESL | GRLSPKTNTC | RGCNHLVCRD | CRIQESNGTW | RCKVCAKEIE | LKKATGDWFY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DQKVNRFAYR | TGSEIIRMSL | RHKPAVSKRE | TVGQSLLHQT | QMGDIWPGRK | IIQERQKEPS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLFEVPKLKS | GKSALEAESE | SLDSFTADSD | STSRRDSLDK | SGLFPEWKKM | SAPKSQVEKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TQPGGQNVVF | VDEGEMIFKK | NTRKILRPSE | YTKSVIDLRP | EDVVHESGSL | GDRSKSVPGL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NVDMEEEEEE | EDIDHLVKLH | RQKLARSSMQ | SGSSMSTIGS | MMSIYSEAGD | FGNIFVTGRI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AFSLKYEQQT | QSLVVHVKEC | HQLAYADEAK | KRSNPYVKTY | LLPDKSRQGK | RKTSIKRDTI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NPLYDETLRY | EIPESLLAQR | TLQFSVWHHG | RFGRNTFLGE | AEIQMDSWKL | DKKLDHCLPL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HGKISAESPT | GLPSHKGELV | VSLKYIPASK | TPVGGDRKKS | KGGEGGELQV | WIKEAKNLTA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AKAGGTSDSF | VKGYLLPMRN | KASKRKTPVM | KKTLNPHYNH | TFVYNGVRLE | DLQHMCLELT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VWDREPLASN | DFLGGVRLGV | GTGISNGEVV | DWMDSTGEEV | SLWQKMRQYP | GSWAEGTLQL |
| 670 | |||||
| RSSMAKQKLG | L |