Q80T23
PR
Gene name |
Sytl5 (Slp5) |
Protein name |
Synaptotagmin-like protein 5 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:236643 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80T23
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80T23-F1 | Predicted | AlphaFoldDB |
54 variants for Q80T23
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389568029 | 3 | K>E | No | EVA | |
| rs3389547959 | 4 | N>S | No | EVA | |
| rs3408835505 | 44 | N>T | No | EVA | |
| rs3409154317 | 53 | S>R | No | EVA | |
| rs3409688548 | 64 | C>G | No | EVA | |
| rs3409591803 | 96 | G>R | No | EVA | |
| rs3409457949 | 105 | V>D | No | EVA | |
| rs3409154342 | 106 | C>S | No | EVA | |
| rs3409367282 | 123 | E>D | No | EVA | |
| rs3409498874 | 123 | E>K | No | EVA | |
| rs3409806199 | 125 | A>P | No | EVA | |
| rs33473744 | 147 | S>I | No | EVA | |
| rs3409561408 | 172 | V>A | No | EVA | |
| rs3409155441 | 173 | R>W | No | EVA | |
| rs3409591837 | 178 | H>D | No | EVA | |
| rs3389546330 | 191 | F>Y | No | EVA | |
| rs3389546361 | 255 | G>S | No | EVA | |
| rs248847118 | 268 | A>T | No | EVA | |
| rs3410060173 | 278 | E>* | No | EVA | |
| rs3409459118 | 279 | H>N | No | EVA | |
| rs3409644714 | 280 | G>N | No | EVA | |
| rs3408470966 | 282 | E>D* | No | EVA | |
| rs3408470968 | 283 | N>K | No | EVA | |
| rs3409644642 | 284 | S>C | No | EVA | |
| rs3409690945 | 286 | A>D | No | EVA | |
| rs3410060192 | 286 | A>S | No | EVA | |
| rs3409644682 | 288 | A>T | No | EVA | |
| rs33474177 | 292 | N>S | No | EVA | |
| rs33474175 | 300 | S>G | No | EVA | |
| rs3410060194 | 317 | S>* | No | EVA | |
| rs33474997 | 334 | A>V | No | EVA | |
| rs225953353 | 343 | I>L | No | EVA | |
| rs3389562677 | 365 | G>D | No | EVA | |
| rs3408836541 | 404 | A>G | No | EVA | |
| rs3389556177 | 440 | C>S | No | EVA | |
| rs3389553987 | 443 | T>N | No | EVA | |
| rs3389562708 | 463 | K>R | No | EVA | |
| rs3409562049 | 478 | K>* | No | EVA | |
| rs3410060242 | 478 | K>M | No | EVA | |
| rs3410060233 | 480 | R>* | No | EVA | |
| rs3409368609 | 480 | R>G | No | EVA | |
| rs3409562076 | 504 | I>S | No | EVA | |
| rs3409644698 | 515 | Q>PD* | No | EVA | |
| rs31238837 | 526 | R>H | No | EVA | |
| rs3409464698 | 579 | P>L | No | EVA | |
| rs3408393409 | 581 | E>* | No | EVA | |
| rs3409464701 | 581 | E>D | No | EVA | |
| rs236824248 | 598 | R>K | No | EVA | |
| rs266243474 | 606 | S>A | No | EVA | |
| rs3389531442 | 638 | Y>F | No | EVA | |
| rs242842435 | 672 | Y>C | No | EVA | |
| rs33480174 | 706 | S>T | No | EVA | |
| rs3389547958 | 718 | D>N | No | EVA | |
| rs3409500533 | 746 | S>P | No | EVA |
No associated diseases with Q80T23
7 regional properties for Q80T23
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 429 - 551 | IPR000008-1 |
| domain | C2 domain | 597 - 728 | IPR000008-2 |
| domain | Rab-binding domain | 7 - 123 | IPR010911 |
| domain | Synaptotagmin-like protein 4/5, C2A domain | 430 - 553 | IPR037303 |
| domain | FYVE-type zinc finger | 13 - 122 | IPR041282 |
| domain | Synaptotagmin-l, FYVE-related domain | 62 - 108 | IPR042783 |
| domain | Synaptotagmin-like 1-5, C2B domain | 567 - 745 | IPR043567 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| exocytic vesicle | A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| neurexin family protein binding | Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. |
| phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. |
| small GTPase binding | Binding to a small monomeric GTPase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
45 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48018 | SYT1 | Synaptotagmin-1 | Bos taurus (Bovine) | PR |
| P21521 | Syt1 | Synaptotagmin 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q7L8C5 | SYT13 | Synaptotagmin-13 | Homo sapiens (Human) | PR |
| Q6XYQ8 | SYT10 | Synaptotagmin-10 | Homo sapiens (Human) | PR |
| Q9H2B2 | SYT4 | Synaptotagmin-4 | Homo sapiens (Human) | PR |
| P21579 | SYT1 | Synaptotagmin-1 | Homo sapiens (Human) | PR |
| Q86XP0 | PLA2G4D | Cytosolic phospholipase A2 delta | Homo sapiens (Human) | PR |
| Q86SS6 | SYT9 | Synaptotagmin-9 | Homo sapiens (Human) | PR |
| Q9BQG1 | SYT3 | Synaptotagmin-3 | Homo sapiens (Human) | PR |
| O00445 | SYT5 | Synaptotagmin-5 | Homo sapiens (Human) | PR |
| Q9BT88 | SYT11 | Synaptotagmin-11 | Homo sapiens (Human) | PR |
| Q9BQS2 | SYT15 | Synaptotagmin-15 | Homo sapiens (Human) | PR |
| Q8N9U0 | TC2N | Tandem C2 domains nuclear protein | Homo sapiens (Human) | PR |
| O43581 | SYT7 | Synaptotagmin-7 | Homo sapiens (Human) | PR |
| Q5T7P8 | SYT6 | Synaptotagmin-6 | Homo sapiens (Human) | PR |
| Q8IYJ3 | SYTL1 | Synaptotagmin-like protein 1 | Homo sapiens (Human) | PR |
| Q96C24 | SYTL4 | Synaptotagmin-like protein 4 | Homo sapiens (Human) | PR |
| Q9HCH5 | SYTL2 | Synaptotagmin-like protein 2 | Homo sapiens (Human) | PR |
| Q8TDW5 | SYTL5 | Synaptotagmin-like protein 5 | Homo sapiens (Human) | PR |
| P40749 | Syt4 | Synaptotagmin-4 | Mus musculus (Mouse) | PR |
| Q9EQT6 | Syt13 | Synaptotagmin-13 | Mus musculus (Mouse) | PR |
| Q9R0N4 | Syt10 | Synaptotagmin-10 | Mus musculus (Mouse) | PR |
| Q8C6N3 | Syt15 | Synaptotagmin-15 | Mus musculus (Mouse) | PR |
| Q920N7 | Syt12 | Synaptotagmin-12 | Mus musculus (Mouse) | PR |
| Q9R0N5 | Syt5 | Synaptotagmin-5 | Mus musculus (Mouse) | PR |
| Q9R0N9 | Syt9 | Synaptotagmin-9 | Mus musculus (Mouse) | PR |
| Q9R0N8 | Syt6 | Synaptotagmin-6 | Mus musculus (Mouse) | PR |
| Q50L43 | Pla2g4d | Cytosolic phospholipase A2 delta | Mus musculus (Mouse) | PR |
| P46096 | Syt1 | Synaptotagmin-1 | Mus musculus (Mouse) | PR |
| Q9R0N3 | Syt11 | Synaptotagmin-11 | Mus musculus (Mouse) | PR |
| O35681 | Syt3 | Synaptotagmin-3 | Mus musculus (Mouse) | PR |
| P46097 | Syt2 | Synaptotagmin-2 | Mus musculus (Mouse) | PR |
| Q91XT6 | Tc2n | Tandem C2 domains nuclear protein | Mus musculus (Mouse) | PR |
| Q9R0Q1 | Sytl4 | Synaptotagmin-like protein 4 | Mus musculus (Mouse) | PR |
| Q99N80 | Sytl1 | Synaptotagmin-like protein 1 | Mus musculus (Mouse) | PR |
| Q925B5 | Syt13 | Synaptotagmin-13 | Rattus norvegicus (Rat) | PR |
| O08625 | Syt10 | Synaptotagmin-10 | Rattus norvegicus (Rat) | PR |
| P47861 | Syt5 | Synaptotagmin-5 | Rattus norvegicus (Rat) | PR |
| Q62746 | Syt6 | Synaptotagmin-6 | Rattus norvegicus (Rat) | PR |
| P97610 | Syt12 | Synaptotagmin-12 | Rattus norvegicus (Rat) | PR |
| P40748 | Syt3 | Synaptotagmin-3 | Rattus norvegicus (Rat) | PR |
| Q925C0 | Syt9 | Synaptotagmin-9 | Rattus norvegicus (Rat) | PR |
| P59926 | Syt15 | Synaptotagmin-15 | Rattus norvegicus (Rat) | PR |
| P21707 | Syt1 | Synaptotagmin-1 | Rattus norvegicus (Rat) | PR |
| Q812E4 | Sytl5 | Synaptotagmin-like protein 5 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKNSEFINL | SFLLDHEKEM | ILGVLKRDEY | LKKVEDKRIR | KLKNELLEAK | RRSGKTHQEA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SRVCVHCHKT | LGLIFDRGDP | CQACSLRVCS | ECRVTGLDGS | WKCTVCAKVA | QLRIISGEWF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LEEKAKRFKQ | VNVLGTDVVR | QSILRRSPGS | EETQNQEQAQ | QCVDKSDTLS | SVRQKTTHDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PKKKGFLLSK | FRSATRGEIR | TPKPESGRSY | SLDLDSQNLQ | SFKSASGSDR | GSTTSSDLID |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QEAGRRTSKS | SYSNGGIPVT | QRSPVPSAHS | VTSINSREHG | FENSMALATI | ENTCEELTKS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HRRNTSGTPS | IAVSGTSLSS | ERSRSEVDLS | ESFAEDLEDT | SSIRSRSVPG | ALDKDLNSLE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DTEDGVDLVS | SRFSANTHSL | ASGLSTNSQA | GSDRKRSYLN | VPDADSDTTS | LNSMMSVYSE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TGDYGNVKVT | GEILLHISYC | YKTGGLYIFV | KSCRNLATGD | EKKQRTDAYV | KSYLLPDKSR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NNKRKTKIRT | GTNPEFNETL | KYTISHTQLE | TRTLQLSVWH | YDRFGRNSFL | GEVEIAFDSW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NFENPCDEWF | VLQPKVELAP | DISLQYKGEL | TIVLRYIPPE | ENLIFPAGQR | QEKKIFKRGK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KKESSSISGG | ILEVFIKKAK | NLTAVKSGGT | SDSFVKGYLL | PDDNKATKHK | TAVVKKSVNP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EWNHTFIFSG | LYPQDIKNAC | LELTIWDKEA | FSSNVFLGGV | RLNSGSGMSY | GKTVDWMDSH |
| 730 | 740 | 750 | |||
| GEEQRLWQKM | ADNPGTSVEG | VLMLRSSMAK | CRL |