AiPD: Autoinhibited Protein Database

Q5T7P8

Gene name	SYT6
Protein name	Synaptotagmin-6
Names	Synaptotagmin VI, SytVI
Species	Homo sapiens (Human)
KEGG Pathway	hsa:148281
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-264 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-264 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q5T7P8

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5T7P8-F1	Predicted				AlphaFoldDB

461 variants for Q5T7P8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs142164979 CA058406 RCV000207150	491	A>T	Ductal breast carcinoma [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA1018153 rs781638657	2	S>N		No	ClinGen ExAC gnomAD
rs1462833913 CA341726133	2	S>R		No	ClinGen TOPMed
rs771253151 CA1018152	2	S>R		No	ClinGen ExAC gnomAD
CA341726125 rs1463597301	3	G>A		No	ClinGen gnomAD
CA29038395 rs942399047	3	G>R		No	ClinGen gnomAD
CA341726122 rs1355279461	4	V>M		No	ClinGen gnomAD
CA29038393 rs868175090	5	W>*		No	ClinGen gnomAD
CA341726111 rs1397233721	5	W>C		No	ClinGen gnomAD
CA341726116 rs747391949	5	W>G		No	ClinGen ExAC TOPMed gnomAD
CA341726115 rs868175090	5	W>L		No	ClinGen gnomAD
rs747391949 CA341726117 CA1018151	5	W>R		No	ClinGen ExAC TOPMed gnomAD
CA341726103 rs912797533	7	A>P		No	ClinGen TOPMed gnomAD
CA29038387 rs912797533	7	A>S		No	ClinGen TOPMed gnomAD
rs1017132694 CA341726092 CA29038378	9	G>R		No	ClinGen TOPMed gnomAD
TCGA novel	11	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1251476217 CA341726067	13	Q>*		No	ClinGen TOPMed gnomAD
rs1005208462 CA29038370	14	E>Q		No	ClinGen TOPMed
CA341726039 rs1571911891	16	L>F		No	ClinGen Ensembl
rs913359256 CA29038343	18	V>I		No	ClinGen Ensembl
rs990741290 CA29038340	20	A>D		No	ClinGen gnomAD
rs1197743879 CA341725994	20	A>S		No	ClinGen TOPMed
CA341725984 rs1375973856	21	S>*		No	ClinGen TOPMed gnomAD
CA341725981 rs1375973856	21	S>L		No	ClinGen TOPMed gnomAD
rs1439749515 CA341725988	21	S>T		No	ClinGen gnomAD
rs1393167145 CA341725962	23	C>*		No	ClinGen gnomAD
rs1034462446 CA29038332	24	R>G		No	ClinGen gnomAD
TCGA novel	24	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341725944 rs1557775665	25	A>G		No	ClinGen Ensembl
CA341725948 rs1415590610	25	A>S		No	ClinGen TOPMed
rs971424292 CA29038295	27	P>L		No	ClinGen TOPMed gnomAD
rs971424292 CA341725929	27	P>R		No	ClinGen TOPMed gnomAD
CA1018149 rs758840771	27	P>S		No	ClinGen ExAC gnomAD
CA1018148 rs575907887	28	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA341725922 rs1419485034	28	P>S		No	ClinGen TOPMed gnomAD
CA1018147 rs779498858	29	P>A		No	ClinGen ExAC TOPMed gnomAD
rs565298820 CA341725914	29	P>H		No	ClinGen gnomAD
CA29038244 rs565298820	29	P>L		No	ClinGen gnomAD
CA341725912 rs565298820	29	P>R		No	ClinGen gnomAD
rs1186677752 CA341725900	31	G>R		No	ClinGen gnomAD
CA341725874 rs1201319137	33	D>G		No	ClinGen TOPMed gnomAD
CA29038235 rs943520762	33	D>N		No	ClinGen TOPMed
CA341725871 rs1201319137	33	D>V		No	ClinGen TOPMed gnomAD
CA341725863 rs1484483376	34	V>L		No	ClinGen TOPMed gnomAD
rs1484483376 CA341725866	34	V>M		No	ClinGen TOPMed gnomAD
rs1046872220 CA29038224	35	E>Q		No	ClinGen TOPMed gnomAD
CA341725844 rs1259187269	36	T>A		No	ClinGen gnomAD
CA1018145 rs750089985	38	R>W		No	ClinGen ExAC gnomAD
TCGA novel	39	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1317496260 CA341725791	41	E>K		No	ClinGen gnomAD
CA341725765 rs1312075217	43	Q>R		No	ClinGen gnomAD
rs946726413 CA29038198	44	P>H		No	ClinGen TOPMed gnomAD
CA29038178 rs913916791	46	E>A		No	ClinGen TOPMed
rs562471602 CA1018144	46	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA341725730 rs1259653422	47	R>W		No	ClinGen TOPMed
CA29038170 rs1039452453	48	S>N		No	ClinGen TOPMed gnomAD
rs1313728575 CA341725708	49	P>S		No	ClinGen gnomAD
CA29038158 rs988180255	50	S>N		No	ClinGen TOPMed gnomAD
rs765445385 CA29038151	50	S>R		No	ClinGen TOPMed gnomAD
rs1383298070 CA341725685	51	A>T		No	ClinGen TOPMed gnomAD
CA341725676 rs1291038336	52	A>S		No	ClinGen TOPMed gnomAD
rs865992197 CA29038133	52	A>V		No	ClinGen TOPMed
CA341725666 rs1465188111	53	G>V		No	ClinGen TOPMed
rs1194973245 CA341724784	55	G>A		No	ClinGen TOPMed gnomAD
rs1428907138 CA341724779	56	T>N		No	ClinGen gnomAD
CA29026692 rs965206354	58	V>A		No	ClinGen Ensembl
CA341724764 rs1252244066	59	S>G		No	ClinGen gnomAD
rs1031478781 CA29026688	60	L>F		No	ClinGen TOPMed
CA1018127 rs755618817	62	A>T		No	ClinGen ExAC TOPMed gnomAD
CA29026673 rs991048938	63	V>I		No	ClinGen TOPMed gnomAD
rs1195370146 CA341724733	64	V>A		No	ClinGen gnomAD
CA29026669 rs968461863	65	V>I		No	ClinGen Ensembl
rs540117943 CA29026666	66	I>T		No	ClinGen 1000Genomes TOPMed gnomAD
CA1018125 rs780766148	70	V>M		No	ClinGen ExAC TOPMed gnomAD
CA1018124 rs145506145	71	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs560943567 CA1018123	71	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA341724625 rs1325986710	81	W>*		No	ClinGen gnomAD
CA341724624 rs1325986710	81	W>C		No	ClinGen gnomAD
rs1394218075 CA341724595	85	W>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs752734460 CA1018120	85	W>R		No	ClinGen ExAC TOPMed gnomAD
rs751862880 CA1018119	87	P>A		No	ClinGen ExAC gnomAD
rs751862880 CA29026611	87	P>T		No	ClinGen ExAC gnomAD
CA1018118 rs759588367	88	W>C		No	ClinGen ExAC gnomAD
rs1213990126 CA341724580	88	W>G		No	ClinGen TOPMed
CA1018117 rs766511873	90	N>I		No	ClinGen ExAC TOPMed gnomAD
CA1018115 rs760843790	90	N>K		No	ClinGen ExAC gnomAD
rs766511873 CA1018116	90	N>S		No	ClinGen ExAC TOPMed gnomAD
CA1018114 rs773587694	91	K>R		No	ClinGen ExAC gnomAD
CA1018113 rs772472114	93	A>V		No	ClinGen ExAC gnomAD
rs1278620594 CA341724540	94	S>P		No	ClinGen gnomAD
TCGA novel	95	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341724528 rs1237044024	95	S>R		No	ClinGen gnomAD
rs1557765933 CA341724525	96	P>A		No	ClinGen Ensembl
CA341724503 rs1279499600	99	A>V		No	ClinGen gnomAD
CA1018111 rs774785640	100	N>I		No	ClinGen ExAC gnomAD
rs769194329 CA1018110	101	P>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	101	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341724494 rs769194329	101	P>S		No	ClinGen ExAC TOPMed gnomAD
rs769194329 CA341724495	101	P>T		No	ClinGen ExAC TOPMed gnomAD
CA341724489 rs149181288	102	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341724488 rs199728827	102	P>H		No	ClinGen 1000Genomes ExAC gnomAD
CA1018106 rs199728827	102	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA1018107 rs199728827	102	P>R		No	ClinGen 1000Genomes ExAC gnomAD
CA1018108 rs149181288	102	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341724487 rs1557765845	103	L>M		No	ClinGen Ensembl
CA341724485 rs1165990378	103	L>W		No	ClinGen TOPMed
CA341724480 rs1171450714	104	E>K		No	ClinGen gnomAD
CA1018103 rs777549517	105	A>V		No	ClinGen ExAC gnomAD
rs1035912142 CA29026499	106	L>F		No	ClinGen gnomAD
CA29026495 rs1029218488	108	S>G		No	ClinGen TOPMed
CA1018102 rs149700277	108	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140788805 CA1018101	109	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341724442 rs1333886220	110	S>G		No	ClinGen TOPMed
CA29026493 rs1036558663	110	S>T		No	ClinGen Ensembl
CA1018100 rs200324360	111	F>L		No	ClinGen ExAC TOPMed gnomAD
CA341724418 rs1182700035	113	G>A		No	ClinGen gnomAD
CA341724414 rs1255668399	114	N>H		No	ClinGen gnomAD
CA29026489 rs796474741	114	N>K		No	ClinGen TOPMed gnomAD
rs942082348 CA29026488	115	M>I		No	ClinGen Ensembl
CA341724398 rs754874998	116	A>E		No	ClinGen ExAC TOPMed gnomAD
CA29026483 rs754874998	116	A>G		No	ClinGen ExAC TOPMed gnomAD
CA1018099 rs754874998	116	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	117	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766432523 CA1018097	121	D>E		No	ClinGen ExAC TOPMed gnomAD
CA341724364 rs1226747843	121	D>G		No	ClinGen Ensembl
rs1280772394 CA341724360	122	P>A		No	ClinGen gnomAD
CA341724356 rs1228478381	122	P>L		No	ClinGen gnomAD
rs760719726 CA1018096	124	T>I		No	ClinGen ExAC gnomAD
CA341724347 rs1571892480	124	T>P		No	ClinGen Ensembl
rs750684042 CA1018095	125	L>P		No	ClinGen ExAC gnomAD
CA341724334 rs1444131214	126	G>A		No	ClinGen TOPMed gnomAD
CA341724335 rs1444131214	126	G>D		No	ClinGen TOPMed gnomAD
CA341724324 rs1416352961	128	L>M		No	ClinGen gnomAD
CA341724311 rs1399092028	130	A>T		No	ClinGen gnomAD
CA1018093 rs762223986	130	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs923271152 CA29026427	131	A>S		No	ClinGen Ensembl
CA341724301 rs553637905	132	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1018089 rs553637905	132	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA341724289 rs1254145932	133	K>N		No	ClinGen TOPMed
CA341724260 rs1474926870	137	T>M		No	ClinGen gnomAD
rs568010023 CA1018087	140	D>H		No	ClinGen 1000Genomes ExAC gnomAD
CA1018085 rs771789727	143	A>S		No	ClinGen ExAC gnomAD
rs1046410931 CA29026411	143	A>V		No	ClinGen TOPMed
rs1171375998 CA341724207	146	Q>*		No	ClinGen TOPMed
CA341724204 rs1208756336	146	Q>L		No	ClinGen gnomAD
rs543454369 CA29026383	147	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA1018082 rs754890380	147	M>K		No	ClinGen ExAC TOPMed gnomAD
rs1171370110 CA341724199	147	M>L		No	ClinGen gnomAD
rs754890380 CA1018083	147	M>T		No	ClinGen ExAC TOPMed gnomAD
CA1018081 rs753862280	148	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs976665830 CA29026376	148	S>P		No	ClinGen Ensembl
rs779934508 CA1018080	150	K>R		No	ClinGen ExAC TOPMed gnomAD
CA1018078 rs767741595	152	H>D		No	ClinGen ExAC TOPMed gnomAD
CA1018077 rs767741595	152	H>N		No	ClinGen ExAC TOPMed gnomAD
rs761957579 CA341724165	152	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA1018075 rs371783276	153	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1392333879 CA341724156	154	M>K		No	ClinGen TOPMed gnomAD
rs764473426 CA1018074	154	M>L		No	ClinGen ExAC
rs1392333879 CA341724155	154	M>T		No	ClinGen TOPMed gnomAD
CA1018073 rs144510124	155	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138691067 CA1018072	155	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs760272255 CA341724132	158	R>G		No	ClinGen ExAC TOPMed gnomAD
CA1018069 rs369527892	158	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs760272255 CA1018070	158	R>W		No	ClinGen ExAC TOPMed gnomAD
rs919737513 CA29026290	161	R>W		No	ClinGen TOPMed gnomAD
rs747784943 CA1018067	162	Q>L		No	ClinGen ExAC gnomAD
rs377145374 CA341724101	163	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs377145374 CA1018066	163	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1021291141 CA29026283	164	T>I		No	ClinGen Ensembl
rs749031646 CA1018064	166	P>L		No	ClinGen ExAC gnomAD
rs376151928 CA1018063	167	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs368541580 CA29026258	170	T>I		No	ClinGen ESP gnomAD
rs368541580 CA341724062	170	T>N		No	ClinGen ESP gnomAD
CA341724058 rs1439378949	171	R>K		No	ClinGen gnomAD
CA1018031 rs754434860	173	T>M		No	ClinGen ExAC TOPMed gnomAD
CA29025046 rs895436720	175	F>L		No	ClinGen TOPMed
CA341723504 rs1175684668	176	K>R		No	ClinGen TOPMed
rs1453654266 CA341723494	177	R>C		No	ClinGen gnomAD
rs763812187 CA1018027	177	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1571889206 CA341723479	178	H>P		No	ClinGen Ensembl
rs371848111 CA1018026	182	Q>H		No	ClinGen ESP ExAC gnomAD
CA29025017 rs989946330	183	M>V		No	ClinGen Ensembl
rs150262816 CA29025004	184	H>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA1018025 rs150262816	184	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA341723399 rs1436409134	185	V>A		No	ClinGen TOPMed
rs1347355297 CA341723404	185	V>I		No	ClinGen TOPMed
rs769628293 CA1018024	186	S>A		No	ClinGen ExAC gnomAD
CA1018023 rs759298495	186	S>C		No	ClinGen ExAC TOPMed gnomAD
rs1368076667 CA341723379	187	S>R		No	ClinGen TOPMed
rs776619825 CA1018022	187	S>T		No	ClinGen ExAC gnomAD
rs191231268 CA1018020	189	D>E		No	ClinGen 1000Genomes ExAC gnomAD
rs184423647 CA1018021	189	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA341723360 rs1258908501	190	Y>H		No	ClinGen gnomAD
rs777670870 CA1018019	191	G>R		No	ClinGen ExAC TOPMed gnomAD
rs201435875 CA29024968	192	N>H		No	ClinGen 1000Genomes
CA1018018 rs748426897	192	N>I		No	ClinGen ExAC gnomAD
CA1018017 rs748426897	192	N>S		No	ClinGen ExAC gnomAD
CA341723344 rs748426897	192	N>T		No	ClinGen ExAC gnomAD
rs779243018 CA1018016	193	E>K		No	ClinGen ExAC TOPMed gnomAD
CA1018014 rs754240600	194	L>F		No	ClinGen ExAC gnomAD
CA1018013 rs780623577	196	P>S		No	ClinGen ExAC gnomAD
CA1018012 rs756511075	197	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	199	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200991146 CA1018011	199	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1018008 rs534948461	201	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA1018007 rs566054581	202	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA1018006 rs151084905	203	S>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs151084905 CA1018005	203	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA29024921 rs200198215	204	I>N		No	ClinGen Ensembl
CA341723208 rs200198215	204	I>T		No	ClinGen Ensembl
rs370559929 CA1018003	206	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs760477294 CA1018002	206	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs368319366 CA341723173	207	I>M		No	ClinGen ESP TOPMed gnomAD
CA341723183 rs1465324548	207	I>V		No	ClinGen gnomAD
CA1018001 rs773175899	208	K>R		No	ClinGen ExAC gnomAD
CA1017999 rs748232754	211	L>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1325081253 CA341723118	212	Y>*		No	ClinGen gnomAD
CA341723126 rs1227088166	212	Y>H		No	ClinGen gnomAD
rs374287808 CA1017998	215	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA29024812 rs201787036	216	S>*		No	ClinGen ExAC TOPMed gnomAD
CA1017996 rs201787036	216	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs750942963 CA1017993	219	G>E		No	ClinGen ExAC gnomAD
rs756668154 CA1017994	219	G>R		No	ClinGen ExAC TOPMed gnomAD
CA1017992 rs781702986	220	E>K		No	ClinGen ExAC TOPMed gnomAD
CA341723005 rs1449998398	221	D>E		No	ClinGen TOPMed gnomAD
rs1004811052 CA29024782	221	D>Y		No	ClinGen gnomAD
rs764887193 CA1017989	222	A>D		No	ClinGen ExAC gnomAD
rs752192289 CA1017990	222	A>S		No	ClinGen ExAC gnomAD
TCGA novel	223	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754562664 CA1017988	225	E>K		No	ClinGen ExAC gnomAD
CA1017987 rs753685693	226	A>D		No	ClinGen ExAC gnomAD
rs1334704157 CA341722906	228	K>E		No	ClinGen TOPMed
rs1195421458 CA341722896	228	K>N		No	ClinGen gnomAD
rs1337762157 CA341722877	229	S>I		No	ClinGen gnomAD
rs370907546 CA1017985	230	C>W		No	ClinGen ESP ExAC gnomAD
rs1229609356 CA341722806	233	I>T		No	ClinGen gnomAD
rs773087545 CA1017984	234	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs1301914476 CA341722749	236	S>C		No	ClinGen gnomAD
CA341722745 rs1433630497	236	S>N		No	ClinGen gnomAD
CA1017982 rs201154501	238	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201154501 CA1017983	238	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775760332 CA1017978	240	D>E		No	ClinGen ExAC gnomAD
rs140277785 CA1017979	240	D>H		No	ClinGen 1000Genomes ExAC gnomAD
CA1017980 rs140277785	240	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1571888512 CA341722631	242	E>D		No	ClinGen Ensembl
rs564717037 CA1017975	242	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA1017976 rs564717037	242	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA341722608 rs1394352128	243	T>I		No	ClinGen TOPMed gnomAD
CA1017973 rs148239218	244	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs187137326 CA1017972	247	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs964287825 CA29024632	248	V>L		No	ClinGen TOPMed
CA1017971 rs558921980	249	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA1017969 rs139165674	249	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs139165674 CA1017970	249	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA341722522 rs1416210291	250	I>V		No	ClinGen TOPMed
rs1254257015 CA341722461	253	A>G		No	ClinGen TOPMed gnomAD
rs1254257015 CA341722458	253	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA341722423 rs1571888412	255	D>A		No	ClinGen Ensembl
CA341722411 rs1164377555	255	D>E		No	ClinGen TOPMed
rs1206248062 CA341722400	256	L>R		No	ClinGen gnomAD
rs1278683225 CA341722376	257	P>L		No	ClinGen gnomAD
CA1017966 rs767566347	258	A>D		No	ClinGen ExAC gnomAD
TCGA novel	258	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1237713446 CA341722313	260	D>G		No	ClinGen gnomAD
rs1274927601 CA341722324	260	D>N		No	ClinGen gnomAD
rs761801885 CA1017965	261	F>S		No	ClinGen ExAC gnomAD
CA1017963 rs764319551	262	C>F		No	ClinGen ExAC gnomAD
rs766224738 CA29024582	263	G>E		No	ClinGen TOPMed gnomAD
rs1360000391 CA341722237	264	S>N		No	ClinGen TOPMed gnomAD
CA1017962 rs202235973	264	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA1017961 rs775644153	265	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1411882655 CA341722215	266	D>A		No	ClinGen gnomAD
CA341722222 rs1402730847	266	D>N		No	ClinGen TOPMed gnomAD
rs762576626 CA1017960	269	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1001235944 CA341722148 CA29024555	270	K>N		No	ClinGen TOPMed
rs746235237 CA1017959	271	I>F		No	ClinGen ExAC gnomAD
CA29024548 rs772791082	275	P>R		No	ClinGen Ensembl
CA1017958 rs202111489	277	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1414410881 CA341721991	278	K>T		No	ClinGen gnomAD
rs771463392 CA1017957	279	C>R		No	ClinGen ExAC gnomAD
CA341721964 rs1475029029	280	K>E		No	ClinGen gnomAD
CA1017956 rs747559412	283	T>S		No	ClinGen ExAC gnomAD
rs778219099 CA1017954	284	R>Q		No	ClinGen ExAC gnomAD
rs1212768713 CA341721909	284	R>W		No	ClinGen TOPMed gnomAD
rs1191446156 CA341721872	286	H>Y		No	ClinGen gnomAD
rs199947720 CA1017949	287	R>C		No	ClinGen ExAC TOPMed gnomAD
rs373704316 CA1017948	287	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA29024520 rs373704316	287	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs373704316 CA341721849	287	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs199947720 CA1017950	287	R>S		No	ClinGen ExAC TOPMed gnomAD
CA341721810 rs1169118465	289	T>N		No	ClinGen TOPMed
rs751596042 CA1017946	292	P>S		No	ClinGen ExAC gnomAD
CA1017944 rs41274114	293	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA29024479 rs901283171	296	E>K		No	ClinGen TOPMed
CA1017943 rs369404390	297	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA1017942 rs765387738	298	F>V		No	ClinGen ExAC gnomAD
rs1160078549 CA341721646	301	P>R		No	ClinGen gnomAD
CA29024452 rs373910479	301	P>S		No	ClinGen TOPMed gnomAD
CA1017941 rs759750846	302	V>M		No	ClinGen ExAC TOPMed gnomAD
rs776807792 CA1017940	304	Y>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	304	Y>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1191628546 CA341721551	309	D>A		No	ClinGen gnomAD
rs1191628546 CA341721549	309	D>G		No	ClinGen gnomAD
CA1017938 rs761017562	310	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1017937 rs776030947	310	R>H	Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA341721539 rs776030947	310	R>P		No	ClinGen ExAC TOPMed gnomAD
CA29024419 rs950641274	311	K>R		No	ClinGen Ensembl
rs1278476764 CA341721492	314	L>R		No	ClinGen TOPMed
CA1017936 rs772565753	316	V>I		No	ClinGen ExAC TOPMed gnomAD
CA341721455 rs138297010	317	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs376972292 CA1017933	318	D>E		No	ClinGen ESP ExAC gnomAD
CA1017934 rs779569231	318	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA341721441 rs374174134	319	F>L		No	ClinGen ESP TOPMed gnomAD
rs923403733 CA29024390	320	D>A		No	ClinGen Ensembl
rs745574119 CA1017932	321	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1017931 rs549305784	321	R>H	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA341721430 rs549305784	321	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751393469 CA1017930	323	S>A		No	ClinGen ExAC gnomAD
CA1017929 rs751393469	323	S>P		No	ClinGen ExAC gnomAD
CA341721419 rs1171285997	323	S>Y		No	ClinGen TOPMed
rs117771236 CA1017928	324	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1017927 rs200072587	324	R>H	Variant assessed as Somatic; 0.002356 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA1017926 rs752738830	325	H>R		No	ClinGen ExAC gnomAD
CA1017924 rs759516642	327	M>I		No	ClinGen ExAC gnomAD
rs1466284402 CA341721372	328	I>T		No	ClinGen TOPMed
rs1249203502 CA341721351	330	E>G		No	ClinGen gnomAD
rs766586844 CA1017922	330	E>K		No	ClinGen ExAC gnomAD
CA341721334 rs1571887675	331	V>G		No	ClinGen Ensembl
rs773509835 CA1017920	333	L>P		No	ClinGen ExAC TOPMed gnomAD
rs772480599 CA1017919	336	L>F		No	ClinGen ExAC gnomAD
CA341721275 rs1321168305	336	L>H		No	ClinGen TOPMed
CA1017918 rs376788803	337	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA1017917 rs372391666	338	E>*		No	ClinGen ESP ExAC
TCGA novel	338	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341721244 rs1225911894	339	A>S		No	ClinGen TOPMed gnomAD
rs1344157308 CA341721239	339	A>V		No	ClinGen gnomAD
rs1233609444 CA341721233	340	S>A		No	ClinGen gnomAD
CA341721216 rs1340448454	341	D>E		No	ClinGen gnomAD
CA1017914 rs190665621	344	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1017915 rs745356607	344	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1354166926 CA341721155	347	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs201016097 CA1017911	348	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA29024288 rs534003664	349	W>*		No	ClinGen Ensembl
CA1017910 rs367659894	351	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1017909 rs367659894	351	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA1017907 rs755155836	352	I>M		No	ClinGen ExAC TOPMed gnomAD
CA1017906 rs753851590	353	Q>P		No	ClinGen ExAC gnomAD
rs564500635 CA29024242	354	Y>C		No	ClinGen 1000Genomes gnomAD
TCGA novel	355	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1017905 rs766603296	355	A>V		No	ClinGen ExAC gnomAD
rs145039274 CA1017904	357	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1017903 rs750818884	357	S>N		No	ClinGen ExAC gnomAD
CA1017885 rs767620686	358	E>G		No	ClinGen ExAC gnomAD
CA341717380 rs1292986717	358	E>K		No	ClinGen TOPMed gnomAD
CA1017883 rs778968174	360	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1453729694 CA341717356	361	D>A		No	ClinGen gnomAD
rs1458484662 CA341717334	364	E>D		No	ClinGen TOPMed gnomAD
CA1017882 rs764672894	364	E>K		No	ClinGen ExAC gnomAD
rs1412261814 CA341717302	369	L>I		No	ClinGen gnomAD
rs771229377 CA1017881	370	C>Y		No	ClinGen ExAC gnomAD
rs766024140 CA1017879	372	L>P		No	ClinGen ExAC
CA1017876 rs771560191	378	L>P		No	ClinGen ExAC gnomAD
CA341717236 rs1246257346	379	T>I		No	ClinGen TOPMed gnomAD
CA341717227 rs1330027358	381	T>I		No	ClinGen gnomAD
rs747991912 CA1017875	381	T>S		No	ClinGen ExAC gnomAD
CA1017873 rs768613392	382	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1244374226 CA341717223	382	V>L		No	ClinGen TOPMed
rs745931024 CA1017869	386	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs374176925 CA1017870	386	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	388	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1017867 rs757361800	390	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1369961301 CA341717162	391	M>T		No	ClinGen TOPMed gnomAD
rs1456109852 CA341717165	391	M>V		No	ClinGen gnomAD
rs1165298016 CA341717157	392	D>N		No	ClinGen gnomAD
rs778239423 CA1017865	393	I>T		No	ClinGen ExAC gnomAD
rs1396954290 CA341717148	393	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	394	T>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341717127 rs370807848	396	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1017863 rs370807848	396	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA341717124 rs1435715187	397	S>P		No	ClinGen TOPMed
rs1197189357 CA341715839	401	V>M		No	ClinGen TOPMed gnomAD
CA1017842 rs749981191	403	V>A		No	ClinGen ExAC
CA341715807 rs1361466798	403	V>L		No	ClinGen TOPMed
rs889443495 CA28997364	405	L>*		No	ClinGen Ensembl
CA1017839 rs751271416	407	C>R		No	ClinGen ExAC gnomAD
CA1017837 rs762741956	410	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1017838 rs200088199	410	R>W		No	ClinGen ExAC gnomAD
rs1170837245 CA341715717	411	R>G		No	ClinGen TOPMed gnomAD
rs775205575 CA1017836	411	R>K		No	ClinGen ExAC gnomAD
CA1017835 rs769744385	411	R>S		No	ClinGen ExAC
TCGA novel	415	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1017832 rs770961129	416	K>E		No	ClinGen ExAC
CA1017831 rs551632114	419	I>L		No	ClinGen ExAC gnomAD
rs551632114 CA28997319	419	I>V		No	ClinGen ExAC gnomAD
CA28997314 rs201961031	420	K>R		No	ClinGen Ensembl
TCGA novel	422	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1017830 rs773576074	424	L>V		No	ClinGen ExAC TOPMed gnomAD
CA341715522 rs1442287176	427	V>L		No	ClinGen gnomAD
rs772366530 CA1017829	429	N>H		No	ClinGen ExAC TOPMed gnomAD
rs1346470395 CA341715446	432	I>T		No	ClinGen gnomAD
rs1310887415 CA341715452	432	I>V		No	ClinGen TOPMed gnomAD
CA341715429 rs1263280869	433	I>M		No	ClinGen gnomAD
rs1300755869 CA341715419	434	F>C		No	ClinGen gnomAD
rs1051262035 CA341715413	435	D>N		No	ClinGen TOPMed
CA28997302 rs1051262035	435	D>Y		No	ClinGen TOPMed
CA28997299 rs867514138	437	P>S		No	ClinGen Ensembl
CA1017826 rs200649940	438	P>L		No	ClinGen ExAC TOPMed gnomAD
CA341715374 rs200649940	438	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1557731023	438	P>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs779383865 CA1017827	438	P>S		No	ClinGen ExAC gnomAD
CA1017823 rs756784538	441	M>V		No	ClinGen ExAC gnomAD
CA1017822 rs751002681	444	V>L		No	ClinGen ExAC gnomAD
CA1017820 rs757994972	447	L>F		No	ClinGen ExAC gnomAD
CA341715259 rs1402984095	448	I>V		No	ClinGen gnomAD
rs953213849 CA28997243	449	S>L		No	ClinGen TOPMed
CA28997239 rs773143623	451	M>T		No	ClinGen Ensembl
CA341715192 rs1373524594	453	Y>C		No	ClinGen gnomAD
CA28997230 rs149899868	455	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA341715165 rs752518998	455	R>L		No	ClinGen ExAC TOPMed gnomAD
rs752518998 CA1017819	455	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1017800 rs754792159	459	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1017799 rs753615074	460	E>K		No	ClinGen ExAC gnomAD
rs555279971 CA1017798	461	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs760652485 CA1017797	462	I>M		No	ClinGen ExAC gnomAD
CA29017540 rs943865498	462	I>T		No	ClinGen Ensembl
rs1348367286 CA341722823	463	G>A		No	ClinGen gnomAD
CA29017539 rs999442501	465	C>G		No	ClinGen TOPMed
CA1017796 rs150717431	466	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA1017795 rs148168972	466	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341722739 rs1281755576	467	V>E		No	ClinGen TOPMed
rs761973499 CA1017794	468	G>E		No	ClinGen ExAC gnomAD
CA341722720 rs1370445205	468	G>W		No	ClinGen gnomAD
rs1391477453 CA341722686	469	I>T		No	ClinGen gnomAD
rs1186597433 CA341722658	471	A>V		No	ClinGen gnomAD
rs763240286 CA1017791	474	L>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	476	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775874924 CA1017790	480	N>D		No	ClinGen ExAC gnomAD
CA1017787 rs370048571	481	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1017788 rs370048571	481	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs771626746 CA1017786	482	M>T		No	ClinGen ExAC TOPMed gnomAD
CA1017785 rs747649131	485	Y>*		No	ClinGen ExAC gnomAD
CA1017784 rs201418447	486	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs181310527 CA1017781	487	R>Q	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs753611915 CA1017783	487	R>W		No	ClinGen ExAC TOPMed gnomAD
CA341722270 rs1276865065	488	K>Q		No	ClinGen gnomAD
TCGA novel	488	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1405824591 CA341722193	490	I>T		No	ClinGen gnomAD
rs1350182329 CA341722199	490	I>V		No	ClinGen gnomAD
rs767558303 CA1017779	492	H>N		No	ClinGen ExAC gnomAD
CA341722011 rs1355637687	496	L>F		No	ClinGen gnomAD
rs761989852 CA1017778	497	V>G		No	ClinGen ExAC TOPMed
CA341722009 rs1571815658	497	V>M		No	ClinGen Ensembl
CA1017776 rs764244920	499	V>I		No	ClinGen ExAC gnomAD
rs1571815615 CA341721811	505	E>*		No	ClinGen Ensembl
CA341720964 rs1328692408	506	G>V		No	ClinGen gnomAD
CA341720959 rs1266501111	507	N>S		No	ClinGen gnomAD
rs538699584 CA29015262	508	P>T		No	ClinGen 1000Genomes
rs200158005 CA1017755	509	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200158005 CA1017756	509	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201785218 CA1017757	509	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368421482 CA29015240	510	L>F		No	ClinGen ESP TOPMed gnomAD

No associated diseases with Q5T7P8

6 regional properties for Q5T7P8

Type	Name	Position	InterPro Accession
domain	C2 domain	229 - 350	IPR000008-1
domain	C2 domain	361 - 494	IPR000008-2
domain	Synaptotagmin	233 - 248	IPR001565-1
domain	Synaptotagmin	248 - 261	IPR001565-2
domain	Synaptotagmin	303 - 318	IPR001565-3
domain	Synaptotagmin	323 - 333	IPR001565-4

Functions

		Description
EC Number
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
exocytic vesicle	A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
extrinsic component of membrane	The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
perinuclear endoplasmic reticulum	The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
synaptic vesicle membrane	The lipid bilayer surrounding a synaptic vesicle.

6 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
clathrin binding	Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
phosphatidylserine binding	Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
SNARE binding	Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
syntaxin binding	Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.

6 GO annotations of biological process

Name	Definition
acrosomal vesicle exocytosis	The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction.
calcium-ion regulated exocytosis	The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
cellular response to calcium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
regulation of calcium ion-dependent exocytosis	Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.
regulation of dopamine secretion	Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
vesicle-mediated transport	A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

45 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P48018	SYT1	Synaptotagmin-1	Bos taurus (Bovine)	PR
P21521	Syt1	Synaptotagmin 1	Drosophila melanogaster (Fruit fly)	PR
Q86XP0	PLA2G4D	Cytosolic phospholipase A2 delta	Homo sapiens (Human)	PR
Q9HCH5	SYTL2	Synaptotagmin-like protein 2	Homo sapiens (Human)	PR
Q96C24	SYTL4	Synaptotagmin-like protein 4	Homo sapiens (Human)	PR
Q8N9U0	TC2N	Tandem C2 domains nuclear protein	Homo sapiens (Human)	PR
Q8TDW5	SYTL5	Synaptotagmin-like protein 5	Homo sapiens (Human)	PR
Q8IYJ3	SYTL1	Synaptotagmin-like protein 1	Homo sapiens (Human)	PR
Q9BQG1	SYT3	Synaptotagmin-3	Homo sapiens (Human)	PR
Q86SS6	SYT9	Synaptotagmin-9	Homo sapiens (Human)	PR
O00445	SYT5	Synaptotagmin-5	Homo sapiens (Human)	PR
P21579	SYT1	Synaptotagmin-1	Homo sapiens (Human)	PR
Q9BT88	SYT11	Synaptotagmin-11	Homo sapiens (Human)	PR
Q9H2B2	SYT4	Synaptotagmin-4	Homo sapiens (Human)	PR
O43581	SYT7	Synaptotagmin-7	Homo sapiens (Human)	PR
Q9BQS2	SYT15	Synaptotagmin-15	Homo sapiens (Human)	PR
Q7L8C5	SYT13	Synaptotagmin-13	Homo sapiens (Human)	PR
Q6XYQ8	SYT10	Synaptotagmin-10	Homo sapiens (Human)	PR
P40749	Syt4	Synaptotagmin-4	Mus musculus (Mouse)	PR
Q9EQT6	Syt13	Synaptotagmin-13	Mus musculus (Mouse)	PR
Q9R0N4	Syt10	Synaptotagmin-10	Mus musculus (Mouse)	PR
Q99N80	Sytl1	Synaptotagmin-like protein 1	Mus musculus (Mouse)	PR
Q9R0Q1	Sytl4	Synaptotagmin-like protein 4	Mus musculus (Mouse)	PR
Q8C6N3	Syt15	Synaptotagmin-15	Mus musculus (Mouse)	PR
Q920N7	Syt12	Synaptotagmin-12	Mus musculus (Mouse)	PR
Q80T23	Sytl5	Synaptotagmin-like protein 5	Mus musculus (Mouse)	PR
Q9R0N5	Syt5	Synaptotagmin-5	Mus musculus (Mouse)	PR
Q9R0N9	Syt9	Synaptotagmin-9	Mus musculus (Mouse)	PR
Q50L43	Pla2g4d	Cytosolic phospholipase A2 delta	Mus musculus (Mouse)	PR
P46096	Syt1	Synaptotagmin-1	Mus musculus (Mouse)	PR
Q9R0N3	Syt11	Synaptotagmin-11	Mus musculus (Mouse)	PR
O35681	Syt3	Synaptotagmin-3	Mus musculus (Mouse)	PR
P46097	Syt2	Synaptotagmin-2	Mus musculus (Mouse)	PR
Q91XT6	Tc2n	Tandem C2 domains nuclear protein	Mus musculus (Mouse)	PR
Q9R0N8	Syt6	Synaptotagmin-6	Mus musculus (Mouse)	PR
Q812E4	Sytl5	Synaptotagmin-like protein 5	Rattus norvegicus (Rat)	PR
Q925B5	Syt13	Synaptotagmin-13	Rattus norvegicus (Rat)	PR
O08625	Syt10	Synaptotagmin-10	Rattus norvegicus (Rat)	PR
P47861	Syt5	Synaptotagmin-5	Rattus norvegicus (Rat)	PR
P97610	Syt12	Synaptotagmin-12	Rattus norvegicus (Rat)	PR
P40748	Syt3	Synaptotagmin-3	Rattus norvegicus (Rat)	PR
Q925C0	Syt9	Synaptotagmin-9	Rattus norvegicus (Rat)	PR
P59926	Syt15	Synaptotagmin-15	Rattus norvegicus (Rat)	PR
P21707	Syt1	Synaptotagmin-1	Rattus norvegicus (Rat)	PR
Q62746	Syt6	Synaptotagmin-6	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSGVWGAGGP	RCQEALAVLA	SLCRARPPPL	GLDVETCRSF	ELQPPERSPS	AAGAGTSVSL
70	80	90	100	110	120
LAVVVIVCGV	ALVAVFLFLF	WKLCWMPWRN	KEASSPSSAN	PPLEALQSPS	FRGNMADKLK
130	140	150	160	170	180
DPSTLGFLEA	AVKISHTSPD	IPAEVQMSVK	EHIMRHTRLQ	RQTTEPASST	RHTSFKRHLP
190	200	210	220	230	240
RQMHVSSVDY	GNELPPAAEQ	PTSIGRIKPE	LYKQKSVDGE	DAKSEATKSC	GKINFSLRYD
250	260	270	280	290	300
YETETLIVRI	LKAFDLPAKD	FCGSSDPYVK	IYLLPDRKCK	LQTRVHRKTL	NPTFDENFHF
310	320	330	340	350	360
PVPYEELADR	KLHLSVFDFD	RFSRHDMIGE	VILDNLFEAS	DLSRETSIWK	DIQYATSESV
370	380	390	400	410	420
DLGEIMFSLC	YLPTAGRLTL	TVIKCRNLKA	MDITGYSDPY	VKVSLLCDGR	RLKKKKTTIK
430	440	450	460	470	480
KNTLNPVYNE	AIIFDIPPEN	MDQVSLLISV	MDYDRVGHNE	IIGVCRVGIT	AEGLGRDHWN
490	500
EMLAYPRKPI	AHWHSLVEVK	KSFKEGNPRL