P48018
PR
Gene name |
SYT1 |
Protein name |
Synaptotagmin-1 |
Names |
Synaptotagmin I, SytI, p65 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281511 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P48018
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P48018-F1 | Predicted | AlphaFoldDB |
85 variants for P48018
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs482929774 | 2 | V>E | No | EVA | |
| rs482929774 | 2 | V>G | No | EVA | |
| rs469258732 | 2 | V>M | No | EVA | |
| rs450810214 | 3 | S>G | No | EVA | |
| rs450810214 | 3 | S>R | No | EVA | |
| rs464527104 | 3 | S>R | No | EVA | |
| rs453414478 | 5 | S>G | No | EVA | |
| rs453414478 | 5 | S>R | No | EVA | |
| rs467208000 | 5 | S>T | No | EVA | |
| rs455869403 | 7 | H>P | No | EVA | |
| rs476122124 | 7 | H>Q | No | EVA | |
| rs455869403 | 7 | H>R | No | EVA | |
| rs444700827 | 8 | E>G | No | EVA | |
| rs451227515 | 9 | A>G | No | EVA | |
| rs460076201 | 10 | L>P | No | EVA | |
| rs460076201 | 10 | L>R | No | EVA | |
| rs440105527 | 10 | L>V | No | EVA | |
| rs462714923 | 11 | A>G | No | EVA | |
| rs442603743 | 11 | A>P | No | EVA | |
| rs464590368 | 12 | A>G | No | EVA | |
| rs445129837 | 12 | A>P | No | EVA | |
| rs464590368 | 12 | A>V | No | EVA | |
| rs478189268 | 13 | P>T | No | EVA | |
| rs467069216 | 14 | P>A | No | EVA | |
| rs435635771 | 14 | P>L | No | EVA | |
| rs435635771 | 14 | P>R | No | EVA | |
| rs438316983 | 15 | V>A | No | EVA | |
| rs438316983 | 15 | V>D | No | EVA | |
| rs469580950 | 15 | V>F | No | EVA | |
| rs438316983 | 15 | V>G | No | EVA | |
| rs469580950 | 15 | V>L | No | EVA | |
| rs451883736 | 16 | T>P | No | EVA | |
| rs471258651 | 17 | T>A | No | EVA | |
| rs433558780 | 17 | T>N | No | EVA | |
| rs471258651 | 17 | T>P | No | EVA | |
| rs473922189 | 18 | V>G | No | EVA | |
| rs442476421 | 19 | A>P | No | EVA | |
| rs476426622 | 20 | T>A | No | EVA | |
| rs438764445 | 20 | T>M | No | EVA | |
| rs476426622 | 20 | T>P | No | EVA | |
| rs438764445 | 20 | T>R | No | EVA | |
| rs478858021 | 21 | V>A | No | EVA | |
| rs458827502 | 21 | V>L | No | EVA | |
| rs446871279 | 22 | L>P | No | EVA | |
| rs446871279 | 22 | L>Q | No | EVA | |
| rs480805843 | 24 | H>N | No | EVA | |
| rs449352337 | 24 | H>Q | No | EVA | |
| rs438157899 | 25 | N>K | No | EVA | |
| rs469599505 | 25 | N>T | No | EVA | |
| rs445357859 | 26 | A>P | No | EVA | |
| rs465509618 | 27 | T>P | No | EVA | |
| rs453601441 | 28 | E>G | No | EVA | |
| rs473802835 | 29 | P>L | No | EVA | |
| rs456202723 | 30 | A>P | No | EVA | |
| rs438621602 | 33 | G>A | No | EVA | |
| rs458688363 | 36 | K>E | No | EVA | |
| rs472501777 | 37 | E>K | No | EVA | |
| rs460536320 | 38 | D>E | No | EVA | |
| rs441122071 | 38 | D>H | No | EVA | |
| rs480641782 | 42 | K>N | No | EVA | |
| rs449341244 | 43 | L>V | No | EVA | |
| rs463066122 | 45 | E>* | No | EVA | |
| rs482887966 | 45 | E>A | No | EVA | |
| rs445420495 | 46 | K>M | No | EVA | |
| rs465372744 | 49 | N>H | No | EVA | |
| rs479138688 | 51 | L>V | No | EVA | |
| rs467379363 | 53 | K>N | No | EVA | |
| rs470706776 | 59 | W>R | No | EVA | |
| rs449743896 | 68 | A>V | No | EVA | |
| rs439274462 | 111 | G>E | No | EVA | |
| rs475807236 | 164 | I>M | No | EVA | |
| rs444377876 | 167 | A>T | No | EVA | |
| rs440588034 | 172 | L>V | No | EVA | |
| rs460559097 | 174 | M>V | No | EVA | |
| rs480761266 | 178 | S>A | No | EVA | |
| rs463215247 | 187 | L>V | No | EVA | |
| rs451632827 | 218 | S>L | No | EVA | |
| rs432236408 | 218 | S>P | No | EVA | |
| rs433904295 | 220 | L>F | No | EVA | |
| rs465192922 | 220 | L>M | No | EVA | |
| rs454084879 | 221 | G>C | No | EVA | |
| rs473216745 | 229 | V>I | No | EVA | |
| rs462265146 | 264 | Q>K | No | EVA | |
| rs437760368 | 291 | T>N | No | EVA | |
| rs443152082 | 385 | G>W | No | EVA |
No associated diseases with P48018
6 regional properties for P48018
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 142 - 263 | IPR000008-1 |
| domain | C2 domain | 273 - 406 | IPR000008-2 |
| domain | Synaptotagmin | 277 - 292 | IPR001565-1 |
| domain | Synaptotagmin | 292 - 305 | IPR001565-2 |
| domain | Synaptotagmin | 349 - 364 | IPR001565-3 |
| domain | Synaptotagmin | 369 - 379 | IPR001565-4 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| chromaffin granule membrane | The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. |
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| dense core granule | Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. |
| exocytic vesicle | A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| synaptic vesicle membrane | The lipid bilayer surrounding a synaptic vesicle. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| clathrin binding | Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. |
| phosphatidylserine binding | Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. |
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
| syntaxin binding | Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion-regulated exocytosis of neurotransmitter | The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. |
| calcium-ion regulated exocytosis | The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cellular response to calcium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| positive regulation of calcium ion-dependent exocytosis of neurotransmitter | Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter. |
| regulation of calcium ion-dependent exocytosis | Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. |
| regulation of dopamine secretion | Any process that modulates the frequency, rate or extent of the regulated release of dopamine. |
| synaptic vesicle endocytosis | A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
45 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P21521 | Syt1 | Synaptotagmin 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q7L8C5 | SYT13 | Synaptotagmin-13 | Homo sapiens (Human) | PR |
| Q6XYQ8 | SYT10 | Synaptotagmin-10 | Homo sapiens (Human) | PR |
| Q9H2B2 | SYT4 | Synaptotagmin-4 | Homo sapiens (Human) | PR |
| Q86XP0 | PLA2G4D | Cytosolic phospholipase A2 delta | Homo sapiens (Human) | PR |
| Q9HCH5 | SYTL2 | Synaptotagmin-like protein 2 | Homo sapiens (Human) | PR |
| Q86SS6 | SYT9 | Synaptotagmin-9 | Homo sapiens (Human) | PR |
| Q9BQG1 | SYT3 | Synaptotagmin-3 | Homo sapiens (Human) | PR |
| O00445 | SYT5 | Synaptotagmin-5 | Homo sapiens (Human) | PR |
| Q9BT88 | SYT11 | Synaptotagmin-11 | Homo sapiens (Human) | PR |
| Q96C24 | SYTL4 | Synaptotagmin-like protein 4 | Homo sapiens (Human) | PR |
| Q9BQS2 | SYT15 | Synaptotagmin-15 | Homo sapiens (Human) | PR |
| Q8N9U0 | TC2N | Tandem C2 domains nuclear protein | Homo sapiens (Human) | PR |
| Q8TDW5 | SYTL5 | Synaptotagmin-like protein 5 | Homo sapiens (Human) | PR |
| Q8IYJ3 | SYTL1 | Synaptotagmin-like protein 1 | Homo sapiens (Human) | PR |
| O43581 | SYT7 | Synaptotagmin-7 | Homo sapiens (Human) | PR |
| Q5T7P8 | SYT6 | Synaptotagmin-6 | Homo sapiens (Human) | PR |
| P21579 | SYT1 | Synaptotagmin-1 | Homo sapiens (Human) | PR |
| P40749 | Syt4 | Synaptotagmin-4 | Mus musculus (Mouse) | PR |
| Q9EQT6 | Syt13 | Synaptotagmin-13 | Mus musculus (Mouse) | PR |
| Q9R0N4 | Syt10 | Synaptotagmin-10 | Mus musculus (Mouse) | PR |
| Q99N80 | Sytl1 | Synaptotagmin-like protein 1 | Mus musculus (Mouse) | PR |
| Q9R0Q1 | Sytl4 | Synaptotagmin-like protein 4 | Mus musculus (Mouse) | PR |
| Q8C6N3 | Syt15 | Synaptotagmin-15 | Mus musculus (Mouse) | PR |
| Q920N7 | Syt12 | Synaptotagmin-12 | Mus musculus (Mouse) | PR |
| Q80T23 | Sytl5 | Synaptotagmin-like protein 5 | Mus musculus (Mouse) | PR |
| Q9R0N5 | Syt5 | Synaptotagmin-5 | Mus musculus (Mouse) | PR |
| Q9R0N9 | Syt9 | Synaptotagmin-9 | Mus musculus (Mouse) | PR |
| Q9R0N8 | Syt6 | Synaptotagmin-6 | Mus musculus (Mouse) | PR |
| Q50L43 | Pla2g4d | Cytosolic phospholipase A2 delta | Mus musculus (Mouse) | PR |
| Q9R0N3 | Syt11 | Synaptotagmin-11 | Mus musculus (Mouse) | PR |
| O35681 | Syt3 | Synaptotagmin-3 | Mus musculus (Mouse) | PR |
| P46097 | Syt2 | Synaptotagmin-2 | Mus musculus (Mouse) | PR |
| Q91XT6 | Tc2n | Tandem C2 domains nuclear protein | Mus musculus (Mouse) | PR |
| P46096 | Syt1 | Synaptotagmin-1 | Mus musculus (Mouse) | PR |
| Q812E4 | Sytl5 | Synaptotagmin-like protein 5 | Rattus norvegicus (Rat) | PR |
| Q925B5 | Syt13 | Synaptotagmin-13 | Rattus norvegicus (Rat) | PR |
| O08625 | Syt10 | Synaptotagmin-10 | Rattus norvegicus (Rat) | PR |
| P47861 | Syt5 | Synaptotagmin-5 | Rattus norvegicus (Rat) | PR |
| Q62746 | Syt6 | Synaptotagmin-6 | Rattus norvegicus (Rat) | PR |
| P97610 | Syt12 | Synaptotagmin-12 | Rattus norvegicus (Rat) | PR |
| P40748 | Syt3 | Synaptotagmin-3 | Rattus norvegicus (Rat) | PR |
| Q925C0 | Syt9 | Synaptotagmin-9 | Rattus norvegicus (Rat) | PR |
| P59926 | Syt15 | Synaptotagmin-15 | Rattus norvegicus (Rat) | PR |
| P21707 | Syt1 | Synaptotagmin-1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVSESHHEAL | AAPPVTTVAT | VLPHNATEPA | SPGEGKEDAF | SKLKEKFMNE | LHKIPLPPWA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIAIAIVAVL | LVLTCCFCIC | KKCLFKKKNK | KKGKEKGGKN | AINMKDVKDL | GKTMKDQALK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DDDAETGLTD | GEEKEEPKEE | EKLGKLQYSL | DYDFQNNQLL | VGIIQAAELP | ALDMGGTSDP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YVKVFLLPDK | KKKFETKVHR | KTLNPVFNEQ | FTFKVPYSEL | GGKTLVMAVY | DFDRFSKHDI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IGEFKVPMNT | VDFGHVTEEW | RDLQSAEKEE | QEKLGDICFS | LRYVPTAGKL | TVVILEAKNL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KKMDVGGLSD | PYVKIHLMQN | GKRLKKKKTT | IKKNTLNPYY | NESFSFEVPF | EQIQKVQVVV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVLDYDKIGK | NDAIGKVFVG | YNSTGAELRH | WSDMLANPRR | PIAQWHTLQV | EEEVDAMLAV |
| KK |