Q6DBY5
Gene name |
uevld (uev3, zgc:100959) |
Protein name |
Ubiquitin-conjugating enzyme E2 variant 3 |
Names |
UEV-3, EV and lactate/malate dehydrogenase domain-containing protein |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:445225 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6DBY5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DBY5-F1 | Predicted | AlphaFoldDB |
No variants for Q6DBY5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6DBY5 | |||||
No associated diseases with Q6DBY5
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| ESCRT I complex | An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| carboxylic acid metabolic process | The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). |
| endosome to lysosome transport | The directed movement of substances from endosomes to lysosomes. |
| protein modification process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P19858 | LDHA | L-lactate dehydrogenase A chain | Bos taurus (Bovine) | PR |
| Q5E9B1 | LDHB | L-lactate dehydrogenase B chain | Bos taurus (Bovine) | PR |
| Q5R1W9 | LDHA | L-lactate dehydrogenase A chain | Pan troglodytes (Chimpanzee) | PR |
| Q99816 | TSG101 | Tumor susceptibility gene 101 protein | Homo sapiens (Human) | PR |
| P00338 | LDHA | L-lactate dehydrogenase A chain | Homo sapiens (Human) | PR |
| P07195 | LDHB | L-lactate dehydrogenase B chain | Homo sapiens (Human) | PR |
| P07864 | LDHC | L-lactate dehydrogenase C chain | Homo sapiens (Human) | PR |
| Q61187 | Tsg101 | Tumor susceptibility gene 101 protein | Mus musculus (Mouse) | PR |
| P06151 | Ldha | L-lactate dehydrogenase A chain | Mus musculus (Mouse) | PR |
| P16125 | Ldhb | L-lactate dehydrogenase B chain | Mus musculus (Mouse) | PR |
| P00339 | LDHA | L-lactate dehydrogenase A chain | Sus scrofa (Pig) | PR |
| Q6IRE4 | Tsg101 | Tumor susceptibility gene 101 protein | Rattus norvegicus (Rat) | PR |
| P04642 | Ldha | L-lactate dehydrogenase A chain | Rattus norvegicus (Rat) | PR |
| Q9FFY6 | ELCL | Protein ELC-like | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q66KB7 | uevld | Ubiquitin-conjugating enzyme E2 variant 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDVNSEPVKK | VLSKYKFRDV | AVEELQKVYR | VYPDMKIMAG | TYTSSDSLQK | DLLKLVGNIP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VVYQGRSYNI | PILLWLLDSF | PFTPPICYLR | PTSSMVIREG | KHVDSKGRIH | LPALHNWDHP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KSSVNALLAE | MIGKFEEEPP | LGTKSSAHGD | TPSNLLDYVS | NLTITEGGNR | PDQEVKVSVI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GGGDLGIAAV | LSIMAKSCVD | KLVLIDIPEN | STKGGTMDLE | IFSLPKVEVS | KDLSASAGSK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLVITANAWS | DEQSYLSVVQ | TNVDMYRGII | PRLAQLSPNA | VLVIASQPVD | VMTHVAWRQS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HLLPTQVIGV | GCNLDSQRLS | HIINISLVAN | NTGKQAWVIG | ELSENKVAVW | GNMGPGTDQL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QALTPVSNST | KPLMDRAFEM | IKGRGQRSWS | VGLSIADITH | SIVTNQKKVH | SVTTLAEGWG |
| 430 | 440 | 450 | 460 | 470 | |
| GIGSKVFLSL | PCILGETGST | RLPGVALGSE | DEMKLRESVA | CQVNLFMQLR | L |