P19858

PR
Gene name
LDHA
Protein name
L-lactate dehydrogenase A chain
Names
LDH-A, LDH muscle subunit, LDH-M
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281274
EC number
1.1.1.27: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P19858

Entry ID Method Resolution Chain Position Source
AF-P19858-F1 Predicted AlphaFoldDB

15 variants for P19858

Variant ID(s) Position Change Description Diseaes Association Provenance
rs475957207 2 A>E No EVA
rs457451608 6 D>G No EVA
rs435783690 8 L>Q No EVA
rs475198882 10 Q>H No EVA
rs466534296 12 L>H No EVA
rs433621060 12 L>I No EVA
rs469300500 15 E>G No EVA
rs450804602 16 E>G No EVA
rs461929529 18 V>A No EVA
rs480430222 18 V>F No EVA
rs461929529 18 V>G No EVA
rs446907850 20 Q>R No EVA
rs439289144 64 D>G No EVA
rs434963783 215 H>P No EVA
rs481990826 265 K>N No EVA

No associated diseases with P19858

3 regional properties for P19858

Type Name Position InterPro Accession
domain Lactate/malate dehydrogenase, N-terminal 22 - 160 IPR001236
active_site L-lactate dehydrogenase, active site 190 - 196 IPR018177
domain Lactate/malate dehydrogenase, C-terminal 164 - 324 IPR022383

Functions

Description
EC Number 1.1.1.27 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.

1 GO annotations of biological process

Name Definition
carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9B1 LDHB L-lactate dehydrogenase B chain Bos taurus (Bovine) PR
Q5R1W9 LDHA L-lactate dehydrogenase A chain Pan troglodytes (Chimpanzee) PR
P07195 LDHB L-lactate dehydrogenase B chain Homo sapiens (Human) PR
P07864 LDHC L-lactate dehydrogenase C chain Homo sapiens (Human) PR
P00338 LDHA L-lactate dehydrogenase A chain Homo sapiens (Human) PR
P16125 Ldhb L-lactate dehydrogenase B chain Mus musculus (Mouse) PR
P06151 Ldha L-lactate dehydrogenase A chain Mus musculus (Mouse) PR
P00339 LDHA L-lactate dehydrogenase A chain Sus scrofa (Pig) PR
P04642 Ldha L-lactate dehydrogenase A chain Rattus norvegicus (Rat) PR
Q66KB7 uevld Ubiquitin-conjugating enzyme E2 variant 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6DBY5 uevld Ubiquitin-conjugating enzyme E2 variant 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATLKDQLIQ NLLKEEHVPQ NKITIVGVGA VGMACAISIL MKDLADEVAL VDVMEDKLKG
70 80 90 100 110 120
EMMDLQHGSL FLRTPKIVSG KDYNVTANSR LVIITAGARQ QEGESRLNLV QRNVNIFKFI
130 140 150 160 170 180
IPNIVKYSPN CKLLVVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV
190 200 210 220 230 240
HPLSCHGWIL GEHGDSSVPV WSGVNVAGVS LKNLHPELGT DADKEQWKAV HKQVVDSAYE
250 260 270 280 290 300
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPISTMIKGL YGIKEDVFLS VPCILGQNGI
310 320 330
SDVVKVTLTH EEEACLKKSA DTLWGIQKEL QF