Q5R1W9

PR
Gene name
LDHA
Protein name
L-lactate dehydrogenase A chain
Names
LDH-A, LDH muscle subunit, LDH-M
Species
Pan troglodytes (Chimpanzee)
KEGG Pathway
ptr:451063
EC number
1.1.1.27: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R1W9

Entry ID Method Resolution Chain Position Source
AF-Q5R1W9-F1 Predicted AlphaFoldDB

No variants for Q5R1W9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R1W9

No associated diseases with Q5R1W9

2 regional properties for Q5R1W9

Type Name Position InterPro Accession
domain Peptidase C2, calpain, catalytic domain 16 - 339 IPR001300
domain Peptidase C2, calpain, large subunit, domain III 359 - 474 IPR022682

Functions

Description
EC Number 1.1.1.27 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.

1 GO annotations of biological process

Name Definition
carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19858 LDHA L-lactate dehydrogenase A chain Bos taurus (Bovine) PR
Q5E9B1 LDHB L-lactate dehydrogenase B chain Bos taurus (Bovine) PR
P07195 LDHB L-lactate dehydrogenase B chain Homo sapiens (Human) PR
P07864 LDHC L-lactate dehydrogenase C chain Homo sapiens (Human) PR
P00338 LDHA L-lactate dehydrogenase A chain Homo sapiens (Human) PR
P16125 Ldhb L-lactate dehydrogenase B chain Mus musculus (Mouse) PR
P06151 Ldha L-lactate dehydrogenase A chain Mus musculus (Mouse) PR
P00339 LDHA L-lactate dehydrogenase A chain Sus scrofa (Pig) PR
P04642 Ldha L-lactate dehydrogenase A chain Rattus norvegicus (Rat) PR
Q66KB7 uevld Ubiquitin-conjugating enzyme E2 variant 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6DBY5 uevld Ubiquitin-conjugating enzyme E2 variant 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATLKDQLIH NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG
70 80 90 100 110 120
EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI
130 140 150 160 170 180
IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV
190 200 210 220 230 240
HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE
250 260 270 280 290 300
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI
310 320 330
SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF