P04642

PR
Gene name
Ldha (Ldh-1, Ldh1)
Protein name
L-lactate dehydrogenase A chain
Names
LDH-A, LDH muscle subunit, LDH-M
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:24533
EC number
1.1.1.27: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for P04642

Entry ID Method Resolution Chain Position Source
4AJ1 X-ray 187 A A/B/C/D 2-332 PDB
4AJ2 X-ray 175 A A/B/C/D 2-332 PDB
4AJ4 X-ray 190 A A/B/C/D 1-332 PDB
4AJE X-ray 235 A A/B/C/D 2-332 PDB
4AJH X-ray 193 A A/B/C/D 2-332 PDB
4AJI X-ray 193 A A/B/C/D 2-332 PDB
4AJJ X-ray 175 A A/B/C/D 2-332 PDB
4AJK X-ray 203 A A/B/C/D 2-332 PDB
4AJL X-ray 177 A A/B/C/D 2-332 PDB
4AJN X-ray 210 A A/B/C/D 2-332 PDB
4AJO X-ray 196 A A/B/C/D 2-332 PDB
4AL4 X-ray 178 A A/B/C/D 2-332 PDB
5ES3 X-ray 229 A A/B/C/D/E/F/G/H 2-332 PDB
AF-P04642-F1 Predicted AlphaFoldDB

No variants for P04642

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P04642

No associated diseases with P04642

No regional properties for P04642

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P04642

Functions

Description
EC Number 1.1.1.27 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
oxidoreductase complex Any protein complex that possesses oxidoreductase activity.
sperm fibrous sheath A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat.

5 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
lactate dehydrogenase activity Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.

15 GO annotations of biological process

Name Definition
cellular response to extracellular stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
glucose catabolic process to lactate via pyruvate The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP).
lactate metabolic process The chemical reactions and pathways involving lactate, the anion of lactic acid.
NAD metabolic process The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
post-embryonic animal organ development Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
response to cAMP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
response to estrogen Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
response to glucose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to nutrient Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
response to organic cyclic compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19858 LDHA L-lactate dehydrogenase A chain Bos taurus (Bovine) PR
Q5E9B1 LDHB L-lactate dehydrogenase B chain Bos taurus (Bovine) PR
Q5R1W9 LDHA L-lactate dehydrogenase A chain Pan troglodytes (Chimpanzee) PR
P07195 LDHB L-lactate dehydrogenase B chain Homo sapiens (Human) PR
P07864 LDHC L-lactate dehydrogenase C chain Homo sapiens (Human) PR
P00338 LDHA L-lactate dehydrogenase A chain Homo sapiens (Human) PR
P16125 Ldhb L-lactate dehydrogenase B chain Mus musculus (Mouse) PR
P06151 Ldha L-lactate dehydrogenase A chain Mus musculus (Mouse) PR
P00339 LDHA L-lactate dehydrogenase A chain Sus scrofa (Pig) PR
Q66KB7 uevld Ubiquitin-conjugating enzyme E2 variant 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6DBY5 uevld Ubiquitin-conjugating enzyme E2 variant 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAALKDQLIV NLLKEEQVPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG
70 80 90 100 110 120
EMMDLQHGSL FLKTPKIVSS KDYSVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI
130 140 150 160 170 180
IPNVVKYSPQ CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV
190 200 210 220 230 240
HPLSCHGWVL GEHGDSSVPV WSGVNVAGVS LKSLNPQLGT DADKEQWKDV HKQVVDSAYE
250 260 270 280 290 300
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPISTMIKGL YGIKEDVFLS VPCILGQNGI
310 320 330
SDVVKVTLTP DEEARLKKSA DTLWGIQKEL QF