AiPD: Autoinhibited Protein Database

P07864

Gene name	LDHC (LDH3, LDHX)
Protein name	L-lactate dehydrogenase C chain
Names	LDH-C, Cancer/testis antigen 32, CT32, LDH testis subunit, LDH-X
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3948
EC number	1.1.1.27: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

184-253 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

184-253 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for P07864

Entry ID	Method	Resolution	Chain	Position	Source
7EPM	X-ray	300 A	A/B	2-332	PDB
AF-P07864-F1	Predicted				AlphaFoldDB

271 variants for P07864

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs769545568 CA5911517	3	T>A		No	ClinGen ExAC TOPMed gnomAD
CA379512383 rs769545568	3	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1192688509 CA379512441	4	V>L		No	ClinGen gnomAD
CA218589909 rs946276190	6	E>*		No	ClinGen TOPMed gnomAD
rs946276190 CA379512520	6	E>K		No	ClinGen TOPMed gnomAD
rs766275159 CA5911520	8	L>I		No	ClinGen ExAC TOPMed gnomAD
rs568138704 CA5911521	9	I>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1255592784 CA379512691	9	I>T		No	ClinGen Ensembl
CA5911522 rs759039260	10	E>K		No	ClinGen ExAC gnomAD
CA379512746 rs1398758294	12	L>P		No	ClinGen gnomAD
CA5911523 rs767111466	12	L>V		No	ClinGen ExAC gnomAD
RCV000962117 CA5911524 rs73436621	13	I>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs778272077 CA5911526	13	I>T		No	ClinGen ExAC TOPMed gnomAD
CA5911525 rs73436621	13	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA379512787 rs1229854441	14	E>A		No	ClinGen gnomAD
rs754459497 CA5911527	15	D>N		No	ClinGen ExAC gnomAD
CA218589946 rs372373685	16	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs779414555 CA5911529	17	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1282303005 CA379512898	18	N>D		No	ClinGen gnomAD
CA379512919 rs1487262644	18	N>K		No	ClinGen gnomAD
rs745952910 CA5911530	19	S>P		No	ClinGen ExAC TOPMed gnomAD
rs369553713 CA5911531	20	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA218589977 rs931208517	20	Q>K		No	ClinGen TOPMed gnomAD
rs1485037625 CA379512946	20	Q>L		No	ClinGen TOPMed
CA5911533 rs142289224	21	C>G		No	ClinGen ESP ExAC gnomAD
CA379512969 rs142289224	21	C>R		No	ClinGen ESP ExAC gnomAD
rs1376747348 CA379512997	22	K>E		No	ClinGen gnomAD
rs1454281645 CA379513062	25	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs769632709 CA218590042	28	T>I		No	ClinGen ExAC gnomAD
rs769632709 CA5911534	28	T>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762680632 CA5911536	30	A>T		No	ClinGen ExAC gnomAD
CA5911538 rs774305161	31	V>I		No	ClinGen ExAC TOPMed gnomAD
CA379513162 rs1357332075	33	M>T		No	ClinGen gnomAD
rs1321749595 CA379513178	34	A>T		No	ClinGen gnomAD
CA379513181 rs1370544092	34	A>V		No	ClinGen gnomAD
rs79201187 CA5911540	35	C>F		No	ClinGen ExAC gnomAD
rs752458236 CA5911541	36	A>T		No	ClinGen ExAC gnomAD
rs1351654744 CA379513204	36	A>V		No	ClinGen gnomAD
CA5911542 rs760397029	38	S>C		No	ClinGen ExAC gnomAD
rs200996269 CA218590089	39	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed
rs1232472160 CA379513237	39	I>T		No	ClinGen TOPMed
rs1486702368	42	K>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA379513271 rs1261264834	42	K>R		No	ClinGen gnomAD
CA379514152 rs1479985393	43	D>Y		No	ClinGen gnomAD
rs563217843 CA5911559	44	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	46	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763857510 CA5911560	47	E>D		No	ClinGen ExAC gnomAD
CA379514299 rs1446894864	49	A>D		No	ClinGen TOPMed
rs776379979 CA5911561	53	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1421396505 CA379514430	53	V>I		No	ClinGen gnomAD
CA379514586 rs750947492	56	D>E		No	ClinGen ExAC TOPMed gnomAD
CA5911565 rs758939071	57	K>E		No	ClinGen ExAC gnomAD
rs370079739 CA5911566 CA379514928	62	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA379514939 rs1298806855	63	M>T		No	ClinGen gnomAD
rs551119181 CA218591527	64	D>N		No	ClinGen gnomAD
TCGA novel	66	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1292620839 CA379515087	67	H>R		No	ClinGen gnomAD
TCGA novel	69	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379515228 rs1335690336	70	L>F		No	ClinGen TOPMed
rs1404637151 CA379515253	71	F>C		No	ClinGen TOPMed
rs1467772454 CA379515248	71	F>V		No	ClinGen TOPMed
rs1170972875 CA379515334	73	S>G		No	ClinGen TOPMed
CA379515399 rs1422138875	74	T>N		No	ClinGen TOPMed
rs373834035 CA218591558	75	S>*		No	ClinGen ESP TOPMed gnomAD
CA5911571 rs781433212	75	S>T		No	ClinGen ExAC gnomAD
rs748352173 CA5911572	77	I>F		No	ClinGen ExAC gnomAD
rs1482018895 CA379515539	79	S>T		No	ClinGen gnomAD
rs930685372 CA218565336	82	D>V		No	ClinGen TOPMed gnomAD
TCGA novel	83	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379490605 rs1452591375	83	Y>C		No	ClinGen gnomAD
CA5911590 rs755103153	83	Y>N		No	ClinGen ExAC gnomAD
CA5911591 rs374002407	84	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs752931129 CA5911592	88	N>D		No	ClinGen ExAC TOPMed gnomAD
CA5911593 rs756367246	89	S>F		No	ClinGen ExAC gnomAD
rs750252706 CA5911595	90	R>G		No	ClinGen ExAC gnomAD
rs758222573 CA5911596	91	I>M		No	ClinGen ExAC gnomAD
rs1365070395 CA379490846	92	V>I		No	ClinGen gnomAD
CA379490867 rs1233188387	93	I>T		No	ClinGen gnomAD
TCGA novel	94	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1303498630 CA379490909	96	A>V		No	ClinGen gnomAD
CA218565419 rs11558333	97	G>S		No	ClinGen TOPMed gnomAD
rs139647819 CA5911598	100	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	105	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379491108 rs1590228720	105	T>P		No	ClinGen Ensembl
CA5911599 rs768339569	106	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA218565437 rs768339569	106	R>G		No	ClinGen ExAC TOPMed gnomAD
rs200332423 CA5911600	106	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200332423 CA379491141	106	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769511132 CA5911602	110	V>L		No	ClinGen ExAC gnomAD
CA379491273 CA5911604 rs144306480	111	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5911605 rs771264967	112	R>C	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs980844599 CA218565515	112	R>H		No	ClinGen TOPMed gnomAD
rs980844599 CA379491302	112	R>P		No	ClinGen TOPMed gnomAD
CA5911606 rs774900783	114	V>M		No	ClinGen ExAC gnomAD
CA5911608 rs146472745	116	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs372539242 CA5911607	116	I>V		No	ClinGen ESP ExAC gnomAD
rs1590228771 CA379491465	117	M>I		No	ClinGen Ensembl
rs1001797839 CA218565525	117	M>T		No	ClinGen TOPMed
CA379491528 rs1175158385	120	I>V		No	ClinGen TOPMed
rs760620346 CA5911610	124	I>T		No	ClinGen ExAC gnomAD
rs1476716012 CA379491625	124	I>V		No	ClinGen TOPMed
rs753971983 CA379491699	126	H>L		No	ClinGen ExAC TOPMed gnomAD
CA5911612 rs753971983	126	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1565051387 CA379491673	126	H>Y		No	ClinGen Ensembl
TCGA novel	128	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA218565612 rs1033574369	133	I>S		No	ClinGen Ensembl
CA218565630 rs897430363	134	L>R		No	ClinGen TOPMed
rs758316404 CA5911614	135	V>I		No	ClinGen ExAC gnomAD
rs141033508 CA218565635	136	V>I		No	ClinGen ESP
rs779982098 CA5911615	138	N>D		No	ClinGen ExAC gnomAD
CA5911616 rs150157978	139	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1438515905 CA379493471	144	T>K		No	ClinGen gnomAD
CA379493482 rs1188240847	145	Y>H		No	ClinGen gnomAD
rs1206488111 CA379493487	145	Y>S		No	ClinGen TOPMed gnomAD
CA5911633 rs751411987	146	I>V		No	ClinGen ExAC gnomAD
rs754780462 CA5911634	147	V>D		No	ClinGen ExAC gnomAD
rs752556850 CA5911636	149	K>N		No	ClinGen ExAC gnomAD
CA379493521 rs1474202485	150	I>V		No	ClinGen gnomAD
CA5911637 rs755708433	155	V>I		No	ClinGen ExAC gnomAD
CA5911638 rs777146300	157	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5911639 rs184986131	157	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA379493569 rs1374190317	158	V>I		No	ClinGen gnomAD
rs778491375 CA5911641	159	I>V		No	ClinGen ExAC TOPMed gnomAD
rs746259283 CA5911642	160	G>E		No	ClinGen ExAC gnomAD
rs772289571 CA5911643	162	G>S		No	ClinGen ExAC gnomAD
CA5911644 rs776111755	162	G>V		No	ClinGen ExAC gnomAD
CA5911645 rs747457421	163	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA5911646 rs768845228	166	D>H		No	ClinGen ExAC TOPMed gnomAD
rs776577627 CA5911647	166	D>V		No	ClinGen ExAC gnomAD
rs1211553780 CA379494270	167	S>C		No	ClinGen gnomAD
rs148817816 CA5911648	169	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1480534867 CA379494352	169	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5911649 rs201168555	171	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5911650 rs773537130	171	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs759454589 CA5911651	174	I>T		No	ClinGen ExAC TOPMed gnomAD
CA379494577 rs1476077824	175	G>E		No	ClinGen gnomAD
CA379494629 rs1171190604	176	E>G		No	ClinGen gnomAD
rs767205516 CA5911652	177	K>E		No	ClinGen ExAC gnomAD
rs752749723 CA5911653	178	L>*		No	ClinGen ExAC gnomAD
CA5911654 rs756011979	178	L>F		No	ClinGen ExAC TOPMed gnomAD
CA379494835 rs1590231127	181	H>P		No	ClinGen Ensembl
rs1380888967 CA379494822	181	H>Y		No	ClinGen gnomAD
rs1208531070 CA379494912	182	P>L		No	ClinGen TOPMed
CA379494891 rs1230975220	182	P>S		No	ClinGen gnomAD
rs764039083 CA5911656	183	T>P		No	ClinGen ExAC
CA218569863 rs1007827759	185	C>R		No	ClinGen TOPMed gnomAD
CA5911657 rs753372115	186	H>L		No	ClinGen ExAC TOPMed gnomAD
CA218569872 rs753372115	186	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1257718550 CA379495042	186	H>Y		No	ClinGen gnomAD
CA5911658 rs756713645	188	W>*		No	ClinGen ExAC gnomAD
rs1204348577 CA379495096	188	W>*		No	ClinGen gnomAD
CA379495250 rs1191404824	193	H>R		No	ClinGen TOPMed gnomAD
rs778572910 CA5911659	193	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1454352044 CA379495274	194	G>D		No	ClinGen gnomAD
TCGA novel	198	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5911680 rs148004611	201	W>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs751890722 CA5911681	202	S>C		No	ClinGen ExAC TOPMed gnomAD
CA379495683 rs1352059319	202	S>N		No	ClinGen gnomAD
rs973288590 CA218572677	203	G>E		No	ClinGen TOPMed
rs1292508124 CA379495702	203	G>R		No	ClinGen gnomAD
rs145871249 CA5911684	206	V>I		No	ClinGen ESP ExAC
rs765321986 CA5911685	207	A>S		No	ClinGen ExAC gnomAD
TCGA novel	210	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5911686 rs778007351	212	K>E		No	ClinGen ExAC gnomAD
TCGA novel	215	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1457467265 CA379496037	217	K>I		No	ClinGen TOPMed
TCGA novel	219	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5911689 rs771085598	220	T>A		No	ClinGen ExAC TOPMed gnomAD
CA5911691 rs181881801	220	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5911690 rs181881801	220	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	222	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA218572784 rs867366990	222	S>L		No	ClinGen Ensembl
CA5911695 rs202072443	223	D>E		No	ClinGen ExAC TOPMed gnomAD
rs776605528 CA5911693	223	D>N		No	ClinGen ExAC gnomAD
rs761731055 CA5911694	223	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1427613833 CA379496266	226	H>N		No	ClinGen gnomAD
rs749946913 CA5911696	226	H>R		No	ClinGen ExAC gnomAD
CA5911698 rs765977484	227	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5911699 rs765977484	227	W>C		No	ClinGen ExAC TOPMed gnomAD
rs762476748 CA5911697	227	W>G		No	ClinGen ExAC gnomAD
rs1412928214 CA379496360	228	K>E		No	ClinGen gnomAD
CA379496385 rs1312009699	229	N>H		No	ClinGen gnomAD
TCGA novel	229	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379496390 rs1355900430	229	N>S		No	ClinGen gnomAD
rs888732937 CA218572819	231	H>Q		No	ClinGen Ensembl
rs755357039 CA5911700	231	H>R		No	ClinGen ExAC gnomAD
CA5911701 rs781688533	232	K>E		No	ClinGen ExAC gnomAD
rs1477929477 CA379496502	233	Q>E		No	ClinGen gnomAD
CA218572820 rs375291929	234	V>G		No	ClinGen ESP TOPMed
TCGA novel	236	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379496617 rs1173633069	236	Q>R		No	ClinGen gnomAD
CA5911702 rs753045145	237	S>N		No	ClinGen ExAC gnomAD
rs930572377 CA379499076	238	A>D		No	ClinGen TOPMed
rs1330263492 CA379499068	238	A>T		No	ClinGen gnomAD
rs930572377 CA218576957	238	A>V		No	ClinGen TOPMed
CA5911717 rs773944156	239	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1240785602 CA379499156	242	I>M		No	ClinGen gnomAD
TCGA novel	243	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1189504767 CA379499270	247	Y>*		No	ClinGen gnomAD
rs759268494 CA5911718	247	Y>C		No	ClinGen ExAC gnomAD
rs1590236802 CA379499280	248	T>S		No	ClinGen Ensembl
rs753137116 CA5911720	249	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA379499347 rs1172863734	250	W>C		No	ClinGen gnomAD
CA218576964 rs985674643	252	I>V		No	ClinGen Ensembl
rs756510241 CA5911721	253	G>E		No	ClinGen ExAC gnomAD
CA379499511 rs1416158656	255	S>F		No	ClinGen TOPMed gnomAD
TCGA novel	256	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1466639452 CA379499516	256	V>L		No	ClinGen TOPMed
rs386751173 CA218576978	258	D>G		No	ClinGen Ensembl
CA379499580 rs2658565	259	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2658565 CA379499579	259	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201957484 CA5911724	261	G>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1344431284 CA379499619	261	G>R		No	ClinGen TOPMed gnomAD
rs779043876 CA5911725	263	I>V		No	ClinGen ExAC gnomAD
CA379499769 rs1413890510	266	N>D		No	ClinGen TOPMed
rs745865996 CA5911726	266	N>K		No	ClinGen ExAC TOPMed gnomAD
CA5911727 rs758630371	267	L>R		No	ClinGen ExAC gnomAD
rs1004683428 CA218577016	269	R>G		No	ClinGen TOPMed
CA379500058 rs1368902927	272	P>L		No	ClinGen gnomAD
rs144032917 CA218577030	273	V>A		No	ClinGen ESP TOPMed
CA5911729 rs573083696	274	S>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1181884811 CA379500166	275	T>I		No	ClinGen TOPMed
CA5911731 rs773081314	276	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1316715794 CA379500206	276	M>T		No	ClinGen gnomAD
rs1274724226 CA379500178	276	M>V		No	ClinGen TOPMed gnomAD
CA379500248 rs1270255339	278	K>Q		No	ClinGen gnomAD
rs375667359 CA218579988	279	G>E		No	ClinGen TOPMed
rs375667359 CA379501313	279	G>V		No	ClinGen TOPMed
CA379501335 rs1461129170	281	Y>C		No	ClinGen TOPMed
CA5911747 rs187999716	281	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
rs117703340 CA5911748	284	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA379501379 rs117703340	284	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2230150 CA5911750	285	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5911751 rs770926658	285	E>D		No	ClinGen ExAC gnomAD
CA5911749 rs2230150 VAR_034068	285	E>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA379501417 rs1163502049	286	E>D		No	ClinGen gnomAD
CA5911752 rs778679570	286	E>Q		No	ClinGen ExAC gnomAD
rs745415561 CA5911754	290	S>I		No	ClinGen ExAC TOPMed gnomAD
rs745415561 CA379501479	290	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1327371373 CA379501486	291	I>V		No	ClinGen gnomAD
rs1411046576 CA379501502	292	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1310206871 CA379501549	293	C>S		No	ClinGen gnomAD
CA379501616 rs1354011066	295	L>M		No	ClinGen gnomAD
rs760395380 CA5911757	297	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs200582503 CA5911756	297	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	299	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379502074 rs1212899360	302	D>E		No	ClinGen gnomAD
rs567978312 CA5911758	305	K>N		No	ClinGen ExAC TOPMed gnomAD
rs777065377 CA5911759	306	I>S		No	ClinGen ExAC gnomAD
rs1207265723 CA379502343	310	S>P		No	ClinGen gnomAD
rs1255074794 CA379502361	310	S>Y		No	ClinGen gnomAD
CA5911760 rs762032479	311	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1356622317 CA379502443	313	E>Q		No	ClinGen gnomAD
CA5911761 rs534491896	314	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5911762 rs534491896	314	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs763069709 CA5911763	315	L>F		No	ClinGen ExAC gnomAD
CA379502496 rs1474255625	315	L>P		No	ClinGen gnomAD
rs766443248 CA218580096 CA5911764	317	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1390293150 CA379502539	317	K>R		No	ClinGen gnomAD
rs965914521 CA218580102	320	A>T		No	ClinGen Ensembl
CA379502645 rs1171061282	320	A>V		No	ClinGen gnomAD
rs1373984613 CA379502754	322	T>I		No	ClinGen gnomAD
rs139520541 CA5911765	324	W>R		No	ClinGen ESP ExAC
rs1387931247 CA379502823	326	I>V		No	ClinGen TOPMed
rs1395813597 CA379502850	327	Q>*		No	ClinGen gnomAD
rs755243567 CA5911766	327	Q>P		No	ClinGen ExAC gnomAD
rs755243567 CA379502855	327	Q>R		No	ClinGen ExAC gnomAD
rs781224542 CA5911767	329	D>V		No	ClinGen ExAC gnomAD
rs146040369 CA5911768	330	L>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1028773342 CA218580123	331	I>L		No	ClinGen Ensembl
rs1296931433 CA379502943	331	I>T		No	ClinGen gnomAD

No associated diseases with P07864

3 regional properties for P07864

Type	Name	Position	InterPro Accession
domain	Lactate/malate dehydrogenase, N-terminal	21 - 160	IPR001236
active_site	L-lactate dehydrogenase, active site	190 - 196	IPR018177
domain	Lactate/malate dehydrogenase, C-terminal	164 - 327	IPR022383

Functions

		Description
EC Number	1.1.1.27	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
motile cilium	A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
oxidoreductase complex	Any protein complex that possesses oxidoreductase activity.

1 GO annotations of molecular function

Name	Definition
L-lactate dehydrogenase activity	Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.

6 GO annotations of biological process

Name	Definition
ATP biosynthetic process	The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
flagellated sperm motility	The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
lactate biosynthetic process from pyruvate	The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate.
lactate metabolic process	The chemical reactions and pathways involving lactate, the anion of lactic acid.
lactate oxidation	The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons.
pyruvate metabolic process	The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P19858	LDHA	L-lactate dehydrogenase A chain	Bos taurus (Bovine)	PR
Q5E9B1	LDHB	L-lactate dehydrogenase B chain	Bos taurus (Bovine)	PR
Q5R1W9	LDHA	L-lactate dehydrogenase A chain	Pan troglodytes (Chimpanzee)	PR
P07195	LDHB	L-lactate dehydrogenase B chain	Homo sapiens (Human)	PR
P00338	LDHA	L-lactate dehydrogenase A chain	Homo sapiens (Human)	PR
P06151	Ldha	L-lactate dehydrogenase A chain	Mus musculus (Mouse)	PR
P16125	Ldhb	L-lactate dehydrogenase B chain	Mus musculus (Mouse)	PR
P00339	LDHA	L-lactate dehydrogenase A chain	Sus scrofa (Pig)	PR
P04642	Ldha	L-lactate dehydrogenase A chain	Rattus norvegicus (Rat)	PR
Q66KB7	uevld	Ubiquitin-conjugating enzyme E2 variant 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6DBY5	uevld	Ubiquitin-conjugating enzyme E2 variant 3	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSTVKEQLIE	KLIEDDENSQ	CKITIVGTGA	VGMACAISIL	LKDLADELAL	VDVALDKLKG
70	80	90	100	110	120
EMMDLQHGSL	FFSTSKITSG	KDYSVSANSR	IVIVTAGARQ	QEGETRLALV	QRNVAIMKSI
130	140	150	160	170	180
IPAIVHYSPD	CKILVVSNPV	DILTYIVWKI	SGLPVTRVIG	SGCNLDSARF	RYLIGEKLGV
190	200	210	220	230	240
HPTSCHGWII	GEHGDSSVPL	WSGVNVAGVA	LKTLDPKLGT	DSDKEHWKNI	HKQVIQSAYE
250	260	270	280	290	300
IIKLKGYTSW	AIGLSVMDLV	GSILKNLRRV	HPVSTMVKGL	YGIKEELFLS	IPCVLGRNGV
310	320	330
SDVVKINLNS	EEEALFKKSA	ETLWNIQKDL	IF