Q5E9B1

PR
Gene name
LDHB
Protein name
L-lactate dehydrogenase B chain
Names
LDH-B
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281275
EC number
1.1.1.27: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5E9B1

Entry ID Method Resolution Chain Position Source
AF-Q5E9B1-F1 Predicted AlphaFoldDB

53 variants for Q5E9B1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs433012419 17 T>K No EVA
rs452504423 18 R>T No EVA
rs433710881 24 I>L No EVA
rs209069846 47 D>E No EVA
rs459819903 50 A>D No EVA
rs438719934 63 M>R No EVA
rs463591350 68 H>Q No EVA
rs482073815 69 G>E No EVA
rs480026648 76 P>R No EVA
rs468082637 76 P>S No EVA
rs464034015 77 K>R No EVA
rs447021721 79 V>L No EVA
rs475728296 106 S>G No EVA
rs461313531 111 V>E No EVA
rs473679883 113 R>K No EVA
rs440689168 113 R>S No EVA
rs477581521 117 V>G No EVA
rs459279968 117 V>I No EVA
rs459279968 117 V>L No EVA
rs451145508 118 F>L No EVA
rs462613249 118 F>Y No EVA
rs481186797 119 K>E No EVA
rs448018618 122 I>L No EVA
rs466523835 122 I>T No EVA
rs445892836 124 Q>H No EVA
rs464324453 125 I>N No EVA
rs437730244 126 V>A No EVA
rs437730244 126 V>G No EVA
rs43443362 126 V>I No EVA
rs456189017 127 K>Q No EVA
rs475908976 136 V>L No EVA
rs436485088 137 V>L No EVA
rs478039576 143 I>F No EVA
rs132686773 145 T>P No EVA
rs446146527 150 K>R No EVA
rs450085337 157 H>P No EVA
rs468813035 158 R>L No EVA
rs454386653 167 D>A No EVA
rs472594743 169 A>T No EVA
rs451717292 179 L>I No EVA
rs433125318 181 I>V No EVA
rs443163385 182 H>R No EVA
rs480194328 182 H>Y No EVA
rs440384772 187 H>Q No EVA
rs473850489 188 G>E No EVA
rs459676484 189 W>R No EVA
rs457266073 281 M>R No EVA
rs475627889 282 Y>* No EVA
rs462224098 291 S>T No EVA
rs480789707 292 L>R No EVA
rs441127109 294 C>G No EVA
rs459586937 295 I>N No EVA
rs482444829 323 T>P No EVA

No associated diseases with Q5E9B1

3 regional properties for Q5E9B1

Type Name Position InterPro Accession
domain Lactate/malate dehydrogenase, N-terminal 23 - 161 IPR001236
active_site L-lactate dehydrogenase, active site 191 - 197 IPR018177
domain Lactate/malate dehydrogenase, C-terminal 165 - 325 IPR022383

Functions

Description
EC Number 1.1.1.27 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
  • Mitochondrion inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

1 GO annotations of molecular function

Name Definition
L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.

1 GO annotations of biological process

Name Definition
carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19858 LDHA L-lactate dehydrogenase A chain Bos taurus (Bovine) PR
Q5R1W9 LDHA L-lactate dehydrogenase A chain Pan troglodytes (Chimpanzee) PR
P00338 LDHA L-lactate dehydrogenase A chain Homo sapiens (Human) PR
P07864 LDHC L-lactate dehydrogenase C chain Homo sapiens (Human) PR
P07195 LDHB L-lactate dehydrogenase B chain Homo sapiens (Human) PR
P06151 Ldha L-lactate dehydrogenase A chain Mus musculus (Mouse) PR
P16125 Ldhb L-lactate dehydrogenase B chain Mus musculus (Mouse) PR
P00339 LDHA L-lactate dehydrogenase A chain Sus scrofa (Pig) PR
P04642 Ldha L-lactate dehydrogenase A chain Rattus norvegicus (Rat) PR
Q66KB7 uevld Ubiquitin-conjugating enzyme E2 variant 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6DBY5 uevld Ubiquitin-conjugating enzyme E2 variant 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATLKEKLIA PVAEEETRIP NNKITVVGVG QVGMACAISI LGKSLTDELA LVDVLEDKLK
70 80 90 100 110 120
GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR QQEGESRLNL VQRNVNVFKF
130 140 150 160 170 180
IIPQIVKYSP DCIIIVVSNP VDILTYVTWK LSGLPKHRVI GSGCNLDSAR FRYLMAEKLG
190 200 210 220 230 240
IHPSSCHGWI LGEHGDSSVA VWSGVNVAGV SLQELNPEMG TDNDSENWKE VHKMVVESAY
250 260 270 280 290 300
EVIKLKGYTN WAIGLSVADL IESMLKNLSR IHPVSTMVKG MYGIENEVFL SLPCILNARG
310 320 330
LTSVINQKLK DEEVAQLKKS ADTLWGIQKD LKDL